{"id":"https://openalex.org/W2020934472","doi":"https://doi.org/10.3109/07357909109032797","title":"Protracted Infusion of 5-FU with Weekly Low-Dose Cisplatin as Second-Line Therapy in Patients with Metastatic Colorectal Cancer Who Have Failed 5-FU Monotherapy","display_name":"Protracted Infusion of 5-FU with Weekly Low-Dose Cisplatin as Second-Line Therapy in Patients with Metastatic Colorectal Cancer Who Have Failed 5-FU Monotherapy","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2020934472","doi":"https://doi.org/10.3109/07357909109032797","mag":"2020934472","pmid":"https://pubmed.ncbi.nlm.nih.gov/2012994"},"language":"en","primary_location":{"id":"doi:10.3109/07357909109032797","doi":"https://doi.org/10.3109/07357909109032797","is_oa":false,"landing_page_url":"https://doi.org/10.3109/07357909109032797","pdf_url":null,"source":{"id":"https://openalex.org/S121125331","display_name":"Cancer Investigation","issn_l":"0735-7907","issn":["0735-7907","1532-4192"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029342165","display_name":"James D. Ahlgren","orcid":"https://orcid.org/0000-0002-5907-3891","observed_orcids":["https://orcid.org/0000-0002-5907-3891"]},"institutions":[{"id":"https://openalex.org/I1286207013","display_name":"George Washington University Hospital","ror":"https://ror.org/00fwdyt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286207013"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James D. Ahlgren","raw_affiliation_strings":["Division of Hematology-Oncology, George Washington University Medical Center, Washington, DC","Division of Hematology-Oncology, The George Washington University Medical Center, Washington, DC, 20007"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology, George Washington University Medical Center, Washington, DC","institution_ids":["https://openalex.org/I1286207013","https://openalex.org/I193531525"]},{"raw_affiliation_string":"Division of Hematology-Oncology, The George Washington University Medical Center, Washington, DC, 20007","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111584076","display_name":"Orrawin Trocki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Orrawin Trocki","raw_affiliation_strings":["Division of Medical Oncology, Georgetown University Hospital, Washington, DC, 20007"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Georgetown University Hospital, Washington, DC, 20007","institution_ids":["https://openalex.org/I2799903593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083826233","display_name":"John J. Gullo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104338","display_name":"Hematology Oncology Associates of Central New York","ror":"https://ror.org/00y6n9757","country_code":"US","type":"other","lineage":["https://openalex.org/I4210104338"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John J. Gullo","raw_affiliation_strings":["Hematology-Oncology Associates of Central New York, Syracuse, New York, 13210"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology-Oncology Associates of Central New York, Syracuse, New York, 13210","institution_ids":["https://openalex.org/I4210104338"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080788977","display_name":"Richard M. Goldberg","orcid":"https://orcid.org/0000-0003-0308-8223","observed_orcids":["https://orcid.org/0000-0003-0308-8223","https://orcid.org/0000-0003-3713-6895"]},"institutions":[{"id":"https://openalex.org/I1293487830","display_name":"Geisinger Medical Center","ror":"https://ror.org/03j9npf54","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1293487830","https://openalex.org/I54713919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Goldberg","raw_affiliation_strings":["Division of Hematology-Oncology, Geisinger Medical Center, Danville, Pennsylvania, 17822"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology, Geisinger Medical Center, Danville, Pennsylvania, 17822","institution_ids":["https://openalex.org/I1293487830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104031654","display_name":"Walter Muir","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W. Angus Muir","raw_affiliation_strings":["Cancer Center of Virginia, Fredericksburg, Virginia, 22401"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Center of Virginia, Fredericksburg, Virginia, 22401","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049976866","display_name":"Regina Sisk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Regina Sisk","raw_affiliation_strings":["Division of Medical Oncology, Georgetown University Hospital, Washington, DC, 20007"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Georgetown University Hospital, Washington, DC, 20007","institution_ids":["https://openalex.org/I2799903593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087518302","display_name":"Lee Schacter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee Schacter","raw_affiliation_strings":["Bristol-Myers Research Division, Wallingford, Connecticut, 06492"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol-Myers Research Division, Wallingford, Connecticut, 06492","institution_ids":["https://openalex.org/I4210091812"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9579,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.78538813,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"9","issue":"1","first_page":"27","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.9750000238418579},{"id":"https://openalex.org/keywords/infusional-5-fluorouracil","display_name":"infusional 5-fluorouracil","score":0.8809999823570251},{"id":"https://openalex.org/keywords/low-dose-cisplatin","display_name":"low-dose cisplatin","score":0.9010000228881836},{"id":"https://openalex.org/keywords/second-line-chemotherapy","display_name":"second-line chemotherapy","score":0.9150000214576721},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.4480000138282776},{"id":"https://openalex.org/keywords/time-to-progression","display_name":"time to progression","score":0.9580000042915344},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.8600000143051147},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.35100001096725464}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9619611501693726},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.8425561189651489},{"id":"https://openalex.org/C43376680","wikidata":"https://www.wikidata.org/wiki/Q6580786","display_name":"Bolus (digestion)","level":2,"score":0.7796550989151001},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6860681772232056},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6521300077438354},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.616044282913208},{"id":"https://openalex.org/C3018112808","wikidata":"https://www.wikidata.org/wiki/Q640448","display_name":"Continuous infusion","level":2,"score":0.49070799350738525},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4660917818546295},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38475072383880615},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3615954518318176},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3380967676639557}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/07357909109032797","doi":"https://doi.org/10.3109/07357909109032797","is_oa":false,"landing_page_url":"https://doi.org/10.3109/07357909109032797","pdf_url":null,"source":{"id":"https://openalex.org/S121125331","display_name":"Cancer Investigation","issn_l":"0735-7907","issn":["0735-7907","1532-4192"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Investigation","raw_type":"journal-article"},{"id":"pmid:2012994","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2012994","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer investigation","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1820173822","https://openalex.org/W1902766545","https://openalex.org/W1979300931","https://openalex.org/W2064920797","https://openalex.org/W2069183803","https://openalex.org/W2093658700","https://openalex.org/W2150872288","https://openalex.org/W2399862211","https://openalex.org/W2400950617","https://openalex.org/W2411742056","https://openalex.org/W2412380795","https://openalex.org/W2416450954","https://openalex.org/W3041047318","https://openalex.org/W4239498835"],"related_works":["https://openalex.org/W2161174144","https://openalex.org/W2061725427","https://openalex.org/W7164824327","https://openalex.org/W2047434150","https://openalex.org/W2396139752","https://openalex.org/W2411742056","https://openalex.org/W177976942","https://openalex.org/W2428278761","https://openalex.org/W2103354587","https://openalex.org/W2114228850"],"abstract_inverted_index":{"Forty":[0],"four":[1],"patients":[2,55,73,101,117],"who":[3,57,74,102,110,118],"had":[4,58,75,103,111,119],"documented":[5],"progression":[6,86],"of":[7,37,40,53],"metastatic":[8],"colorectal":[9],"cancer":[10],"while":[11],"receiving":[12],"5-fluorouracil":[13],"(5-FU)":[14],"monotherapy":[15],"were":[16,97],"treated":[17],"with":[18,116],"continuous":[19],"infusion":[20],"5-FU,":[21],"300":[22],"mg/mg2/day,":[23],"plus":[24],"weekly":[25],"low-dose":[26],"cisplatin,":[27],"20":[28],"mg/m2.":[29],"Treatment":[30],"was":[31,49],"given":[32],"in":[33],"12-week":[34],"cycles,":[35],"consisting":[36],"8":[38],"weeks":[39],"chemotherapy":[41],"followed":[42],"by":[43],"a":[44],"4-week":[45],"rest":[46],"period,":[47],"and":[48,91],"well":[50],"tolerated.":[51],"Three":[52],"23":[54],"(13%)":[56],"failed":[59,76,112,121],"bolus":[60,113],"5-FU":[61,69,108,123],"but":[62,109],"not":[63,104],"been":[64],"exposed":[65],"previously":[66,105,120],"to":[67,85],"infusional":[68,77,107,122],"responded.":[70,83],"Of":[71],"21":[72],"55-FU":[78],"monotherapy,":[79],"only":[80],"one":[81],"(5%)":[82],"Time":[84],"(5.7":[87],"vs.":[88,94],"1.8":[89],"months)":[90,96],"survival":[92],"(12":[93],"5.5":[95],"significantly":[98],"longer":[99],"for":[100],"received":[106],"schedules,":[114],"compared":[115],"(p":[124],"less":[125],"than":[126],".001).":[127]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}