{"id":"https://openalex.org/W202091398","doi":null,"title":"Abstract 20946: Gene Deletion of Dipeptidyl Peptidase I Prevents Myocyte Apoptosis and Adverse Cardiac Remodeling During the Development of Diabetic Cardiomyopathy","display_name":"Abstract 20946: Gene Deletion of Dipeptidyl Peptidase I Prevents Myocyte Apoptosis and Adverse Cardiac Remodeling During the Development of Diabetic Cardiomyopathy","publication_year":2010,"publication_date":"2010-11-23","ids":{"openalex":"https://openalex.org/W202091398","mag":"202091398"},"language":"en","primary_location":{"id":"mag:202091398","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/10.1161/circ.122.suppl_21.A20946","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null},"volume":null,"type":"conference-abstract","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041867835","display_name":"Mikhail A. Kolpakov","orcid":"https://orcid.org/0000-0001-6448-2094","observed_orcids":["https://orcid.org/0000-0001-6448-2094"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mikhail A. Kolpakov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108457084","display_name":"Jianfen Guo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianfen Guo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060429191","display_name":"Danielle Feather","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Danielle Feather","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089912252","display_name":"Rosario G. Scalia","orcid":"https://orcid.org/0000-0002-1829-943X","observed_orcids":["https://orcid.org/0000-0002-1829-943X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosario Scalia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021845859","display_name":"Christine T. N. Pham","orcid":"https://orcid.org/0000-0003-1127-3699","observed_orcids":["https://orcid.org/0000-0003-1127-3699"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine T. N. Pham","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1127-3699","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051015751","display_name":"Abdelkarim Sabri","orcid":"https://orcid.org/0000-0003-0553-790X","observed_orcids":["https://orcid.org/0000-0003-0553-790X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdelkarim Sabri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5082964755","display_name":"Khadija Rafiq","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khadija Rafiq","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"122","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-cardiomyopathy","display_name":"diabetic cardiomyopathy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/dipeptidyl-peptidase-i","display_name":"dipeptidyl peptidase I","score":0.996999979019165},{"id":"https://openalex.org/keywords/gene-deletion","display_name":"gene deletion","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cardiomyocyte-apoptosis","display_name":"cardiomyocyte apoptosis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.9750000238418579},{"id":"https://openalex.org/keywords/neutrophil-serine-proteases","display_name":"neutrophil serine proteases","score":0.906000018119812},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9210000038146973},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.8119999766349792},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.8040000200271606},{"id":"https://openalex.org/keywords/myocarditis","display_name":"myocarditis","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8090150356292725},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.7890191078186035},{"id":"https://openalex.org/C2776553924","wikidata":"https://www.wikidata.org/wiki/Q5270132","display_name":"Diabetic cardiomyopathy","level":4,"score":0.7859465479850769},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6069660782814026},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.6014577746391296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6005921959877014},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.5599479079246521},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5557724237442017},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.53586345911026},{"id":"https://openalex.org/C156490143","wikidata":"https://www.wikidata.org/wiki/Q412214","display_name":"Dipeptidyl peptidase-4","level":4,"score":0.5234443545341492},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4983687400817871},{"id":"https://openalex.org/C2777420927","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Cardiac fibrosis","level":3,"score":0.4872213900089264},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.4618837237358093},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.4198472499847412},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.41694965958595276},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.40440797805786133},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.2175304889678955},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2038622796535492},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1192169189453125},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10702958703041077},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08725672960281372}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:202091398","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/10.1161/circ.122.suppl_21.A20946","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2998274131","https://openalex.org/W2624284676","https://openalex.org/W7613878","https://openalex.org/W1971446033","https://openalex.org/W2083237611","https://openalex.org/W2893352733","https://openalex.org/W2156868640","https://openalex.org/W2019439059","https://openalex.org/W7169789136","https://openalex.org/W3202874200"],"abstract_inverted_index":{"Background:":[0],"Diabetic":[1],"cardiomyopathy":[2],"is":[3],"characterized":[4],"by":[5],"intramyocardial":[6],"inflammation,":[7],"cardiomyocyte":[8],"apoptosis,":[9],"and":[10,19,47,73,89,94,126,136],"cardiac":[11],"fibrosis.":[12],"Since":[13],"inflammatory":[14,28],"proteases":[15,29],"induce":[16],"myocyte":[17],"death":[18],"extracellular":[20],"matrix":[21],"proteins":[22],"processing,":[23],"we":[24],"hypothesized":[25],"that":[26],"increased":[27],"may":[30],"contribute":[31],"to":[32,50],"the":[33,38,41,66],"pathophysiological":[34],"changes":[35],"observed":[36,133],"in":[37,65],"heart":[39],"during":[40],"development":[42],"of":[43,57,68,97,99,128],"diabetic":[44,112],"cardiomyopathy.":[45],"Methods":[46],"Results:":[48],"Ten":[49],"twelve":[51],"weeks":[52,96,138],"old":[53],"mice":[54,77],"with":[55,81,104],"deletion":[56,117],"dipeptidyl":[58],"peptidase":[59],"I":[60],"(DPPI),":[61],"an":[62],"enzyme":[63],"involved":[64],"maturation":[67],"major":[69],"neutrophil":[70,124],"serine":[71,131],"proteases,":[72,132],"wild":[74],"type":[75],"(WT)":[76],"controls":[78],"were":[79,110],"injected":[80],"streptozotocin":[82,140],"(50":[83],"mg/kg":[84],"for":[85,113],"5":[86],"days)":[87],"intraperitoneally":[88],"studied":[90],"after":[91,139],"1,":[92],"3":[93,135],"8":[95,137],"induction":[98],"diabetes":[100],"mellitus":[101],"(DM).":[102],"Mice":[103],"blood":[105],"sugar":[106],"above":[107],"300":[108],"mg/dl":[109],"considered":[111],"this":[114],"study.":[115],"DPPI":[116],"had":[118],"no":[119],"effect":[120],"on":[121],"hyperglycemia.":[122],"However,":[123],"infiltration":[125],"activation":[127],"their":[129],"derived":[130],"at":[134],"(STZ)...":[141]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}