{"id":"https://openalex.org/W2020901039","doi":"https://doi.org/10.1182/blood-2009-06-227447","title":"Left ventricular hypertrophy and diastolic dysfunction in children with sickle cell disease are related to asleep and waking oxygen desaturation","display_name":"Left ventricular hypertrophy and diastolic dysfunction in children with sickle cell disease are related to asleep and waking oxygen desaturation","publication_year":2010,"publication_date":"2010-04-09","ids":{"openalex":"https://openalex.org/W2020901039","doi":"https://doi.org/10.1182/blood-2009-06-227447","mag":"2020901039","pmid":"https://pubmed.ncbi.nlm.nih.gov/20378754"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2009-06-227447","doi":"https://doi.org/10.1182/blood-2009-06-227447","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2009-06-227447","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2904578","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056442479","display_name":"Mark C. Johnson","orcid":"https://orcid.org/0000-0002-6136-7055","observed_orcids":["https://orcid.org/0000-0002-6136-7055"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark C. Johnson","raw_affiliation_strings":["Department of Pediatrics, Washington University School of Medicine, St Louis, MO;","Department of Pediatrics, Washington University, School of Medicine, St Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Washington University School of Medicine, St Louis, MO;","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Pediatrics, Washington University, School of Medicine, St Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002772850","display_name":"Fenella Jane Kirkham","orcid":"https://orcid.org/0000-0002-2443-7958","observed_orcids":["https://orcid.org/0000-0002-2443-7958"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fenella J. Kirkham","raw_affiliation_strings":["Neurosciences Unit, UCL Institute of Child Health, London, United Kingdom;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosciences Unit, UCL Institute of Child Health, London, United Kingdom;","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050330450","display_name":"Susan S Redline","orcid":"https://orcid.org/0000-0002-6585-1610","observed_orcids":["https://orcid.org/0000-0002-6585-1610"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan Redline","raw_affiliation_strings":["Center for Clinical Investigation and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical Investigation and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030033537","display_name":"CAROL LYNN ROSEN","orcid":"https://orcid.org/0000-0002-3070-4266","observed_orcids":["https://orcid.org/0000-0002-3070-4266"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol L. Rosen","raw_affiliation_strings":["Department of Pediatrics, Case Western Reserve University, Cleveland, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Case Western Reserve University, Cleveland, OH;","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100395068","display_name":"Yan Yan","orcid":"https://orcid.org/0000-0002-5917-1475","observed_orcids":["https://orcid.org/0000-0002-5917-1475","https://orcid.org/0009-0003-4258-1149"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Yan","raw_affiliation_strings":["Division of Biostatistics, Washington University School of Medicine, St Louis, MO;","Division of Biostatistics, Washington University School of Medicine, St Louis, Mo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biostatistics, Washington University School of Medicine, St Louis, MO;","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Division of Biostatistics, Washington University School of Medicine, St Louis, Mo","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051182162","display_name":"Irene A.G. Roberts","orcid":"https://orcid.org/0000-0002-6094-6397","observed_orcids":["https://orcid.org/0000-0002-6094-6397"]},"institutions":[{"id":"https://openalex.org/I125671874","display_name":"National Health Service","ror":"https://ror.org/02wnqcb97","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I125671874","https://openalex.org/I1311074006"]},{"id":"https://openalex.org/I153355300","display_name":"Imperial College Healthcare NHS Trust","ror":"https://ror.org/056ffv270","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300"]},{"id":"https://openalex.org/I4210106957","display_name":"St Mary's Hospital","ror":"https://ror.org/01aysdw42","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I153355300","https://openalex.org/I4210106957"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Irene Roberts","raw_affiliation_strings":["Department of Haematology, Imperial College Healthcare National Health Service Trust (St Mary's Hospital), London, United Kingdom; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Imperial College Healthcare National Health Service Trust (St Mary's Hospital), London, United Kingdom; and","institution_ids":["https://openalex.org/I125671874","https://openalex.org/I153355300","https://openalex.org/I4210106957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024276831","display_name":"Jeanine Gruenwald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800129641","display_name":"Great Ormond Street Hospital","ror":"https://ror.org/00zn2c847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jeanine Gruenwald","raw_affiliation_strings":["Department of Cardiology, Great Ormond Street Hospital for Children, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Great Ormond Street Hospital for Children, London, United Kingdom","institution_ids":["https://openalex.org/I2800129641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103844096","display_name":"Jan Marek","orcid":"https://orcid.org/0000-0001-9471-4298","observed_orcids":["https://orcid.org/0000-0001-9471-4298"]},"institutions":[{"id":"https://openalex.org/I2800129641","display_name":"Great Ormond Street Hospital","ror":"https://ror.org/00zn2c847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jan Marek","raw_affiliation_strings":["Department of Cardiology, Great Ormond Street Hospital for Children, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Great Ormond Street Hospital for Children, London, United Kingdom","institution_ids":["https://openalex.org/I2800129641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047418153","display_name":"Michael Rutledge DeBaun","orcid":"https://orcid.org/0000-0002-0574-1604","observed_orcids":["https://orcid.org/0000-0002-0574-1604"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. DeBaun","raw_affiliation_strings":["Department of Pediatrics, Washington University School of Medicine, St Louis, MO;","Department of Pediatrics, Washington University, School of Medicine, St Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Washington University School of Medicine, St Louis, MO;","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Pediatrics, Washington University, School of Medicine, St Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":3.7565,"has_fulltext":false,"cited_by_count":100,"citation_normalized_percentile":{"value":0.93283823,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"116","issue":"1","first_page":"16","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.9779999852180481},{"id":"https://openalex.org/keywords/diastolic-dysfunction","display_name":"diastolic dysfunction","score":0.9369999766349792},{"id":"https://openalex.org/keywords/sleep-disordered-breathing","display_name":"sleep-disordered breathing","score":0.8960000276565552},{"id":"https://openalex.org/keywords/oxygen-desaturation","display_name":"oxygen desaturation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/nocturnal-hypoxemia","display_name":"nocturnal hypoxemia","score":0.7350000143051147},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.4909999966621399},{"id":"https://openalex.org/keywords/left-ventricular-mass","display_name":"left ventricular mass","score":0.8510000109672546},{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.7540000081062317},{"id":"https://openalex.org/keywords/tricuspid-regurgitation","display_name":"tricuspid regurgitation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/cardiac-abnormalities","display_name":"cardiac anomalies","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7149649858474731},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6916061639785767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6107348799705505},{"id":"https://openalex.org/C2778205975","wikidata":"https://www.wikidata.org/wiki/Q1754874","display_name":"Polysomnography","level":3,"score":0.5637150406837463},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.5298882126808167},{"id":"https://openalex.org/C2776002628","wikidata":"https://www.wikidata.org/wiki/Q1628627","display_name":"Left ventricular hypertrophy","level":3,"score":0.4865816831588745},{"id":"https://openalex.org/C2780346441","wikidata":"https://www.wikidata.org/wiki/Q55609890","display_name":"Doppler echocardiography","level":4,"score":0.43626949191093445},{"id":"https://openalex.org/C2781326671","wikidata":"https://www.wikidata.org/wiki/Q754424","display_name":"Apnea","level":2,"score":0.26304516196250916},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.25431761145591736}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003971","descriptor_name":"Diastole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012891","descriptor_name":"Sleep Apnea Syndromes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012891","descriptor_name":"Sleep Apnea Syndromes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012891","descriptor_name":"Sleep Apnea Syndromes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012891","descriptor_name":"Sleep Apnea Syndromes","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012891","descriptor_name":"Sleep Apnea Syndromes","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012891","descriptor_name":"Sleep Apnea Syndromes","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015150","descriptor_name":"Echocardiography, Doppler","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015150","descriptor_name":"Echocardiography, Doppler","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015150","descriptor_name":"Echocardiography, Doppler","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017286","descriptor_name":"Polysomnography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017286","descriptor_name":"Polysomnography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017286","descriptor_name":"Polysomnography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018487","descriptor_name":"Ventricular Dysfunction, Left","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1182/blood-2009-06-227447","doi":"https://doi.org/10.1182/blood-2009-06-227447","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2009-06-227447","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:20378754","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20378754","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2904578","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2904578","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood","raw_type":"Text"},{"id":"pmh:oai:eprints.soton.ac.uk:429376","doi":null,"is_oa":false,"landing_page_url":"https://eprints.soton.ac.uk/429376/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:122791","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/122791/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BLOOD , 116 (1) 16 - 21. (2010)","raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2904578","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2904578","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7200000286102295,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G147739852","display_name":null,"funder_award_id":"R01 HL079937","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2777558329","display_name":null,"funder_award_id":"5-RO1-HL079937","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1965006942","https://openalex.org/W1972959375","https://openalex.org/W1975250867","https://openalex.org/W1976072594","https://openalex.org/W1979259098","https://openalex.org/W1980658866","https://openalex.org/W1988154057","https://openalex.org/W1992141724","https://openalex.org/W2001054363","https://openalex.org/W2007590326","https://openalex.org/W2008757048","https://openalex.org/W2014113114","https://openalex.org/W2014867851","https://openalex.org/W2022195092","https://openalex.org/W2023285558","https://openalex.org/W2024424774","https://openalex.org/W2027302201","https://openalex.org/W2035822743","https://openalex.org/W2039651623","https://openalex.org/W2040007392","https://openalex.org/W2040765188","https://openalex.org/W2045690184","https://openalex.org/W2047558252","https://openalex.org/W2049224577","https://openalex.org/W2049292864","https://openalex.org/W2050322371","https://openalex.org/W2052039979","https://openalex.org/W2054903745","https://openalex.org/W2068921607","https://openalex.org/W2069007014","https://openalex.org/W2074855128","https://openalex.org/W2082072250","https://openalex.org/W2082801114","https://openalex.org/W2083632638","https://openalex.org/W2084073739","https://openalex.org/W2086659954","https://openalex.org/W2087225497","https://openalex.org/W2090743889","https://openalex.org/W2103939721","https://openalex.org/W2106542853","https://openalex.org/W2119838614","https://openalex.org/W2121471263","https://openalex.org/W2137988289","https://openalex.org/W2139537565","https://openalex.org/W2145860140","https://openalex.org/W2148547093","https://openalex.org/W2150737405","https://openalex.org/W2153274073","https://openalex.org/W2158733959","https://openalex.org/W2159871219","https://openalex.org/W2166179774","https://openalex.org/W2288605373","https://openalex.org/W2312070181","https://openalex.org/W2334263927","https://openalex.org/W2334499091","https://openalex.org/W2785563066","https://openalex.org/W2795536332","https://openalex.org/W2884525847","https://openalex.org/W3016133651"],"related_works":["https://openalex.org/W2068824179","https://openalex.org/W1996744115","https://openalex.org/W2064569258","https://openalex.org/W2154974629","https://openalex.org/W2079126658","https://openalex.org/W2033393595","https://openalex.org/W2327257216","https://openalex.org/W2400393952","https://openalex.org/W3014732564","https://openalex.org/W2168993378"],"abstract_inverted_index":{"Premature":[0],"death":[1],"and":[2,55,66,101,139,186],"cardiac":[3,26],"abnormalities":[4,27,194],"are":[5,17,32,190],"described":[6],"in":[7,28,50,71,84,109,121,136,195],"individuals":[8],"with":[9,30,41,143,174,192,197],"sickle":[10],"cell":[11],"disease":[12],"(SCD),":[13],"but":[14],"the":[15,23,110,131],"mechanisms":[16],"not":[18,165],"well":[19],"characterized.":[20],"We":[21,37],"tested":[22],"hypothesis":[24],"that":[25,183],"children":[29,40,196],"SCD":[31,42],"related":[33,97],"to":[34,98],"sleep-disordered":[35],"breathing.":[36],"enrolled":[38],"44":[39],"(mean":[43],"age,":[44],"10.1":[45],"years;":[46],"range,":[47],"4-18":[48],"years)":[49],"an":[51],"observational":[52],"study.":[53],"Standard":[54],"tissue":[56],"Doppler":[57],"echocardiography,":[58],"waking":[59,102,187],"oxygen":[60,103,113,145,169,188],"saturation":[61,146,170],"averaged":[62],"over":[63],"5":[64],"minutes,":[65],"overnight":[67],"polysomnography":[68],"were":[69],"obtained":[70],"participants,":[72],"each":[73],"within":[74],"7":[75],"days.":[76],"Eccentric":[77],"left":[78],"ventricular":[79],"(LV)":[80],"hypertrophy":[81],"was":[82,95,116,134,140,164],"present":[83,135],"46%":[85],"of":[86,161],"our":[87,137],"cohort.":[88],"After":[89],"multivariable":[90,175],"adjustment,":[91],"LV":[92,122,125,193],"mass":[93,123],"index":[94],"inversely":[96],"average":[99,111],"asleep":[100,112,185],"saturation.":[104],"For":[105],"every":[106],"1%":[107],"drop":[108],"saturation,":[114],"there":[115],"a":[117,159],"2.1":[118],"g/m(2.7)":[119],"increase":[120],"index.":[124],"diastolic":[126],"dysfunction,":[127],"as":[128],"measured":[129],"by":[130,167],"E/E'":[132],"ratio,":[133],"subjects":[138],"also":[141],"associated":[142,191],"low":[144,184],"(sleep":[147],"or":[148,155,171],"waking).":[149],"Elevated":[150],"tricuspid":[151],"regurgitant":[152],"velocity":[153],"(>":[154],"=":[156],"2.5":[157],"m/sec),":[158],"measure":[160],"pulmonary":[162],"hypertension,":[163],"predicted":[166],"either":[168],"sleep":[172],"variables":[173],"logistic":[176],"regression":[177],"analysis.":[178],"These":[179],"data":[180],"provide":[181],"evidence":[182],"saturations":[189],"SCD.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":14}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}
