{"id":"https://openalex.org/W2020900573","doi":"https://doi.org/10.1002/pros.2990260207","title":"Evaluation of three different AgNOR counting methods in advanced carcinoma of the prostate","display_name":"Evaluation of three different AgNOR counting methods in advanced carcinoma of the prostate","publication_year":1995,"publication_date":"1995-02-01","ids":{"openalex":"https://openalex.org/W2020900573","doi":"https://doi.org/10.1002/pros.2990260207","mag":"2020900573","pmid":"https://pubmed.ncbi.nlm.nih.gov/7531845"},"language":"en","primary_location":{"id":"doi:10.1002/pros.2990260207","doi":"https://doi.org/10.1002/pros.2990260207","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pros.2990260207","pdf_url":null,"source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11424/91788","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5098544425","display_name":"Rengin Ahiskah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Rengin Ahiskah","raw_affiliation_strings":["Departments of Pathology, Marmara University School of Medicine, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, Marmara University School of Medicine, Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026572681","display_name":"G\u00fcls\u00fcn Ekicio\u01e7lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"G\u00fcls\u00fcn Ekicio\u01e7lu","raw_affiliation_strings":["Departments of Pathology, Marmara University School of Medicine, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, Marmara University School of Medicine, Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047769853","display_name":"Sevgi K\u00fcll\u00fc","orcid":"https://orcid.org/0000-0002-5477-4752","observed_orcids":["https://orcid.org/0000-0002-5477-4752"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sevgi K\u00fcll\u00fc","raw_affiliation_strings":["Departments of Pathology, Marmara University School of Medicine, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, Marmara University School of Medicine, Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003453967","display_name":"Yusuf Alican","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Yusuf Alican","raw_affiliation_strings":["Departments of Urology, Marmara University School of Medicine, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Urology, Marmara University School of Medicine, Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079735788","display_name":"\u0130brahim \u00c7evik","orcid":"https://orcid.org/0000-0002-6491-0404","observed_orcids":["https://orcid.org/0000-0002-6491-0404"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ibrahim \u00c7evik","raw_affiliation_strings":["Departments of Urology, Marmara University School of Medicine, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Urology, Marmara University School of Medicine, Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048370283","display_name":"A. Akda\u015f","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Atif Akda\u015f","raw_affiliation_strings":["Departments of Urology, Marmara University School of Medicine, Istanbul, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Urology, Marmara University School of Medicine, Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5098544425"],"corresponding_institution_ids":["https://openalex.org/I74897591"],"apc_list":{"value":4600,"currency":"USD","value_usd":4600},"apc_paid":null,"fwci":0.3173,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.50972981,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"2","first_page":"105","last_page":"110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.5615000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.5615000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.34790000319480896,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.025299999862909317,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/advanced-prostate-cancer","display_name":"advanced prostate cancer","score":0.9810000061988831},{"id":"https://openalex.org/keywords/gleason-grade","display_name":"Gleason grade","score":0.7910000085830688},{"id":"https://openalex.org/keywords/intratumor-heterogeneity","display_name":"intratumoral heterogeneity","score":0.8510000109672546},{"id":"https://openalex.org/keywords/interobserver-reproducibility","display_name":"interobserver reproducibility","score":0.8629999756813049},{"id":"https://openalex.org/keywords/intraobserver-reproducibility","display_name":"intraobserver reproducibility","score":0.8569999933242798},{"id":"https://openalex.org/keywords/prognostic-value","display_name":"prognostic value","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C2993388676","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate carcinoma","level":4,"score":0.7344040274620056},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6896118521690369},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6459364891052246},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5939508676528931},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.5633915662765503},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.5149117708206177},{"id":"https://openalex.org/C184604658","wikidata":"https://www.wikidata.org/wiki/Q968963","display_name":"Nucleolus organizer region","level":4,"score":0.49829602241516113},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.45817017555236816},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41882389783859253},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.34852129220962524},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3253825902938843},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32237452268600464},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.06563326716423035},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.06207484006881714},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C183873130","wikidata":"https://www.wikidata.org/wiki/Q30869","display_name":"Nucleolus","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006652","descriptor_name":"Histological Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009697","descriptor_name":"Nucleolus Organizer Region","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009697","descriptor_name":"Nucleolus Organizer Region","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012834","descriptor_name":"Silver","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015588","descriptor_name":"Observer Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1002/pros.2990260207","doi":"https://doi.org/10.1002/pros.2990260207","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pros.2990260207","pdf_url":null,"source":{"id":"https://openalex.org/S197000376","display_name":"The Prostate","issn_l":"0270-4137","issn":["0270-4137","1097-0045"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"journal-article"},{"id":"pmid:7531845","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7531845","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Prostate","raw_type":"Clinical Trial"},{"id":"pmh:oai:openaccess.marmara.edu.tr:11424/119788","doi":null,"is_oa":false,"landing_page_url":"https://www.scopus.com/inward/record.url?eid=2-s2.0-0028796751&partnerID=40&md5=2fcf6a067ab1ad0790262aadd623f117","pdf_url":null,"source":{"id":"https://openalex.org/S4306401380","display_name":"Dspace Repository (Marmara \u00dcniversitesi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74897591","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/I74897591"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:openaccess.marmara.edu.tr:11424/226485","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11424/226485","pdf_url":null,"source":{"id":"https://openalex.org/S4306401380","display_name":"Dspace Repository (Marmara \u00dcniversitesi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74897591","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/I74897591"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:openaccess.marmara.edu.tr:11424/91788","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11424/91788","pdf_url":null,"source":{"id":"https://openalex.org/S4306401380","display_name":"Dspace Repository (Marmara \u00dcniversitesi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74897591","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/I74897591"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:openaccess.marmara.edu.tr:11424/91788","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11424/91788","pdf_url":null,"source":{"id":"https://openalex.org/S4306401380","display_name":"Dspace Repository (Marmara \u00dcniversitesi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74897591","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/I74897591"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W96969021","https://openalex.org/W1965493439","https://openalex.org/W1972486081","https://openalex.org/W1974230206","https://openalex.org/W1983712904","https://openalex.org/W1986550738","https://openalex.org/W1991080739","https://openalex.org/W1999257805","https://openalex.org/W2002914206","https://openalex.org/W2010003049","https://openalex.org/W2013186045","https://openalex.org/W2018824234","https://openalex.org/W2039259884","https://openalex.org/W2039685885","https://openalex.org/W2060346866","https://openalex.org/W2088712225","https://openalex.org/W2097131678","https://openalex.org/W2164973714","https://openalex.org/W2395915765","https://openalex.org/W2397842152","https://openalex.org/W2400551685","https://openalex.org/W2415198913","https://openalex.org/W2433538528","https://openalex.org/W2471857435","https://openalex.org/W2474365908","https://openalex.org/W2499387497"],"related_works":["https://openalex.org/W2097131678","https://openalex.org/W1986550738","https://openalex.org/W2018824234","https://openalex.org/W2567051819","https://openalex.org/W1973442347","https://openalex.org/W2376320477","https://openalex.org/W4233531973","https://openalex.org/W2409424547","https://openalex.org/W2013186045","https://openalex.org/W96969021"],"abstract_inverted_index":{"We":[0],"applied":[1],"the":[2,12,29,98,128,137],"silver":[3],"staining":[4],"of":[5,15,18,31,39,43,64,68,112,116,123,130,136],"nucleolar":[6],"organizer":[7],"regions":[8],"(AgNOR)":[9],"technique":[10],"to":[11,71,75],"pretreatment":[13],"biopsies":[14],"50":[16],"cases":[17],"advanced":[19,134],"prostate":[20],"cancer.":[21],"Three":[22],"different":[23],"counting":[24,100],"methods":[25,34],"were":[26,84],"utilized":[27],"in":[28,86,133],"enumeration":[30],"AgNORs.":[32],"All":[33],"yielded":[35,102],"statistically":[36],"significant":[37,109],"differences":[38],"mean":[40],"AgNOR":[41,113,131],"counts":[42,65,83,132],"groups":[44],"defined":[45],"by":[46,52,66,94],"high":[47,93],"and":[48,51,61,77,121],"low":[49,119],"WHO,":[50],"Gleason":[53],"grades.":[54],"However,":[55],"there":[56],"was":[57,79,92,107],"overlap":[58],"among":[59],"groups,":[60],"further":[62],"analysis":[63],"grouping":[67],"patients":[69],"according":[70],"their":[72],"stage,":[73],"response":[74],"treatment,":[76],"prognosis":[78,126],"not":[80],"conclusive.":[81],"Replicate":[82],"performed":[85],"10":[87],"cases.":[88],"While":[89],"intraobserver":[90],"reproducibility":[91],"all":[95],"methods,":[96],"only":[97],"second":[99],"method":[101],"nonsignificant":[103],"interobserver":[104],"variability.":[105],"There":[106],"a":[108],"intratumoral":[110],"heterogeneity":[111],"scores.":[114],"Lack":[115],"technical":[117],"standardization,":[118],"reproducibility,":[120],"lack":[122],"correlation":[124],"with":[125],"limit":[127],"use":[129],"carcinoma":[135],"prostate.":[138]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}