{"id":"https://openalex.org/W2020891041","doi":"https://doi.org/10.1016/j.jep.2013.11.048","title":"Chondroprotective activity of a detoxicated traditional Chinese medicine (Fuzi) of Aconitum carmichaeli Debx against severe-stage osteoarthritis model induced by mono-iodoacetate","display_name":"Chondroprotective activity of a detoxicated traditional Chinese medicine (Fuzi) of Aconitum carmichaeli Debx against severe-stage osteoarthritis model induced by mono-iodoacetate","publication_year":2013,"publication_date":"2013-12-04","ids":{"openalex":"https://openalex.org/W2020891041","doi":"https://doi.org/10.1016/j.jep.2013.11.048","mag":"2020891041","pmid":"https://pubmed.ncbi.nlm.nih.gov/24315981"},"language":"en","primary_location":{"id":"doi:10.1016/j.jep.2013.11.048","doi":"https://doi.org/10.1016/j.jep.2013.11.048","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jep.2013.11.048","pdf_url":null,"source":{"id":"https://openalex.org/S29564236","display_name":"Journal of Ethnopharmacology","issn_l":"0378-8741","issn":["0378-8741","1872-7573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ethnopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050038706","display_name":"Peijian Tong","orcid":"https://orcid.org/0000-0003-0948-8674","observed_orcids":["https://orcid.org/0000-0003-0948-8674","https://orcid.org/0000-0003-1647-1934","https://orcid.org/0009-0003-3544-8913"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peijian Tong","raw_affiliation_strings":["Department of Orthopaedic Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China; Institute of Orthopaedics and Traumatology, Zhejiang Chinese Medical University, Hangzhou 310053, China","Department of Orthopaedic Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China","Institute of Orthopaedics and Traumatology, Zhejiang Chinese Medical University, Hangzhou 310053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China; Institute of Orthopaedics and Traumatology, Zhejiang Chinese Medical University, Hangzhou 310053, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"Institute of Orthopaedics and Traumatology, Zhejiang Chinese Medical University, Hangzhou 310053, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073672288","display_name":"Shibing Xu","orcid":"https://orcid.org/0000-0001-5211-1173","observed_orcids":["https://orcid.org/0000-0001-5211-1173"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shibing Xu","raw_affiliation_strings":["Institute of Orthopaedics and Traumatology, Zhejiang Chinese Medical University, Hangzhou 310053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Orthopaedics and Traumatology, Zhejiang Chinese Medical University, Hangzhou 310053, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070498523","display_name":"Gang Cao","orcid":"https://orcid.org/0000-0002-0819-0430","observed_orcids":["https://orcid.org/0000-0002-0819-0430"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gang Cao","raw_affiliation_strings":["Research Center of TCM Processing Technology, Zhejiang Chinese Medical University, Hangzhou 310053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center of TCM Processing Technology, Zhejiang Chinese Medical University, Hangzhou 310053, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012610750","display_name":"Wangdong Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wangdong Jin","raw_affiliation_strings":["College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074758874","display_name":"Yanwei Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanwei Guo","raw_affiliation_strings":["College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112465700","display_name":"Yu Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Cheng","raw_affiliation_strings":["College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023872965","display_name":"Hongting Jin","orcid":"https://orcid.org/0000-0001-8795-0874","observed_orcids":["https://orcid.org/0000-0001-8795-0874"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongting Jin","raw_affiliation_strings":["Institute of Orthopaedics and Traumatology, Zhejiang Chinese Medical University, Hangzhou 310053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Orthopaedics and Traumatology, Zhejiang Chinese Medical University, Hangzhou 310053, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102742396","display_name":"Letian Shan","orcid":"https://orcid.org/0000-0001-7585-4527","observed_orcids":["https://orcid.org/0000-0001-7585-4527"]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Letian Shan","raw_affiliation_strings":["Institute of Orthopaedics and Traumatology, Zhejiang Chinese Medical University, Hangzhou 310053, China. Electronic address: letian.shan@hotmail.com","Institute of Orthopaedics and Traumatology, Zhejiang Chinese Medical University, Hangzhou 310053, China"],"raw_orcid":"https://orcid.org/0000-0001-7585-4527","affiliations":[{"raw_affiliation_string":"Institute of Orthopaedics and Traumatology, Zhejiang Chinese Medical University, Hangzhou 310053, China. Electronic address: letian.shan@hotmail.com","institution_ids":["https://openalex.org/I114539943"]},{"raw_affiliation_string":"Institute of Orthopaedics and Traumatology, Zhejiang Chinese Medical University, Hangzhou 310053, China","institution_ids":["https://openalex.org/I114539943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100945907","display_name":"Luwei Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114539943","display_name":"Zhejiang Chinese Medical University","ror":"https://ror.org/04epb4p87","country_code":"CN","type":"education","lineage":["https://openalex.org/I114539943"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Luwei Xiao","raw_affiliation_strings":["Institute of Orthopaedics and Traumatology, Zhejiang Chinese Medical University, Hangzhou 310053, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Orthopaedics and Traumatology, Zhejiang Chinese Medical University, Hangzhou 310053, China","institution_ids":["https://openalex.org/I114539943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102742396"],"corresponding_institution_ids":["https://openalex.org/I114539943"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":1.0939,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.77363231,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"151","issue":"1","first_page":"740","last_page":"744"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13095","display_name":"Plant-based Medicinal Research","score":0.06549999862909317,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fuzi","display_name":"Fuzi","score":0.8870000243186951},{"id":"https://openalex.org/keywords/aconitum-carmichaelii","display_name":"Aconitum carmichaelii","score":0.9919999837875366},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9419999718666077},{"id":"https://openalex.org/keywords/chondroprotection","display_name":"chondroprotection","score":0.9599999785423279},{"id":"https://openalex.org/keywords/aconite-alkaloids","display_name":"aconite alkaloids","score":0.8859999775886536},{"id":"https://openalex.org/keywords/chondrocyte-viability","display_name":"chondrocyte viability","score":0.9190000295639038},{"id":"https://openalex.org/keywords/articular-cartilage-degeneration","display_name":"articular cartilage degeneration","score":0.8040000200271606},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.7639999985694885},{"id":"https://openalex.org/keywords/mankin-score","display_name":"Mankin score","score":0.8289999961853027},{"id":"https://openalex.org/keywords/chemical-profile","display_name":"chemical profile","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7653719782829285},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7258718609809875},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.606666624546051},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4985826015472412},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.48051461577415466},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4643312990665436},{"id":"https://openalex.org/C2780029364","wikidata":"https://www.wikidata.org/wiki/Q155904","display_name":"Aconitum","level":3,"score":0.4509517550468445},{"id":"https://openalex.org/C2777547430","wikidata":"https://www.wikidata.org/wiki/Q342108","display_name":"Aconitine","level":2,"score":0.4284825921058655},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22596025466918945},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.2075839340686798},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1980459988117218},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.07344040274620056},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0681411623954773},{"id":"https://openalex.org/C2777667214","wikidata":"https://www.wikidata.org/wiki/Q70702","display_name":"Alkaloid","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004224","descriptor_name":"Diterpenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019807","descriptor_name":"Iodoacetic Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jep.2013.11.048","doi":"https://doi.org/10.1016/j.jep.2013.11.048","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jep.2013.11.048","pdf_url":null,"source":{"id":"https://openalex.org/S29564236","display_name":"Journal of Ethnopharmacology","issn_l":"0378-8741","issn":["0378-8741","1872-7573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ethnopharmacology","raw_type":"journal-article"},{"id":"pmid:24315981","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24315981","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of ethnopharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4399999976158142}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6982914186","display_name":null,"funder_award_id":"Grant no.: 81302989","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W14496186","https://openalex.org/W206711978","https://openalex.org/W1970232171","https://openalex.org/W1972475829","https://openalex.org/W1981511795","https://openalex.org/W2013414053","https://openalex.org/W2022219238","https://openalex.org/W2026123588","https://openalex.org/W2039871355","https://openalex.org/W2068854110","https://openalex.org/W2073414019","https://openalex.org/W2073582491","https://openalex.org/W2077460391","https://openalex.org/W2088858180","https://openalex.org/W2115601182","https://openalex.org/W4255310732","https://openalex.org/W4292542165"],"related_works":["https://openalex.org/W4220729278","https://openalex.org/W4280627690","https://openalex.org/W4414559050","https://openalex.org/W4313061022","https://openalex.org/W4413908980","https://openalex.org/W3045404805","https://openalex.org/W4411414538","https://openalex.org/W3135416948","https://openalex.org/W4390012444","https://openalex.org/W2027537461"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}