{"id":"https://openalex.org/W2020887779","doi":"https://doi.org/10.1002/ijc.10842","title":"Induction of IL\u20108 and monoclyte chemoattractant protein\u20101 by doxorubicin in human small cell lung carcinoma cells","display_name":"Induction of IL\u20108 and monoclyte chemoattractant protein\u20101 by doxorubicin in human small cell lung carcinoma cells","publication_year":2002,"publication_date":"2002-11-15","ids":{"openalex":"https://openalex.org/W2020887779","doi":"https://doi.org/10.1002/ijc.10842","mag":"2020887779","pmid":"https://pubmed.ncbi.nlm.nih.gov/12471621"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.10842","doi":"https://doi.org/10.1002/ijc.10842","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.10842","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.10842","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.10842","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012652636","display_name":"Misako Shibakura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Misako Shibakura","raw_affiliation_strings":["Department of Health Sciences, Okayama University Medical School, Japan","Department of Health Sciences, Okayama University Medical School, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, Okayama University Medical School, Japan","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Department of Health Sciences, Okayama University Medical School, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112643122","display_name":"Kenji Niiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kenji Niiya","raw_affiliation_strings":["","Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan","Fax: +81 86-235-7225"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]},{"raw_affiliation_string":"Fax: +81 86-235-7225","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030597247","display_name":"Toru Kiguchi","orcid":"https://orcid.org/0000-0003-2322-4798","observed_orcids":["https://orcid.org/0000-0003-2322-4798"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Kiguchi","raw_affiliation_strings":["Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033446220","display_name":"Isao Kitajima","orcid":"https://orcid.org/0000-0001-6156-4481","observed_orcids":["https://orcid.org/0000-0001-6156-4481"]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Isao Kitajima","raw_affiliation_strings":["Department of Clinical Laboratory Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036918582","display_name":"Masami Niiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masami Niiya","raw_affiliation_strings":["Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083355735","display_name":"Noboru Asaumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noboru Asaumi","raw_affiliation_strings":["Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110185723","display_name":"Nam\u2010ho Huh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nam\u2010ho Huh","raw_affiliation_strings":["Department of Cell Biology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004230500","display_name":"Yasunari Nakata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasunari Nakata","raw_affiliation_strings":["Department of Health Sciences, Okayama University Medical School, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Sciences, Okayama University Medical School, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112697053","display_name":"Mine Harada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mine Harada","raw_affiliation_strings":["First Department of Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111977970","display_name":"Mitsune Tanimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsune Tanimoto","raw_affiliation_strings":["Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan","institution_ids":["https://openalex.org/I163770644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5112643122"],"corresponding_institution_ids":["https://openalex.org/I163770644"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":0.6789,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.68671464,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"103","issue":"3","first_page":"380","last_page":"386"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":1.0},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.9679999947547913},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.8880000114440918},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9259999990463257},{"id":"https://openalex.org/keywords/chemokine-induction","display_name":"chemokine induction","score":0.7749999761581421},{"id":"https://openalex.org/keywords/h69-cells","display_name":"H69 cells","score":0.7639999985694885},{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.6349999904632568},{"id":"https://openalex.org/keywords/chemokine-expression","display_name":"chemokine expression","score":0.6819999814033508},{"id":"https://openalex.org/keywords/tumor-inflammation","display_name":"tumor inflammation","score":0.35199999809265137}],"concepts":[{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.8931236267089844},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.658704400062561},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5917342901229858},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5237034559249878},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5047241449356079},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4627506732940674},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3645351827144623},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.20101726055145264},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.14432480931282043},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015500","descriptor_name":"Chloramphenicol O-Acetyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.10842","doi":"https://doi.org/10.1002/ijc.10842","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.10842","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.10842","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:12471621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12471621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/ijc.10842","doi":"https://doi.org/10.1002/ijc.10842","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.10842","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.10842","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G512399931","display_name":"INHIBITION OF INVASIVENESS AND METASTATIC POTENTIAL OF HUMAN PE-B LYMPHOME CELLS BY INHIBITING UROKINASE EXPRESSIN","funder_award_id":"08671222","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5663501974","display_name":"Regulation of the Expression of Fibrinolysis-related Factors by Inflammatory Cytokines and Oxidative Stress","funder_award_id":"10670937","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6690813325","display_name":"\u6d3b\u6027\u5316\u9178\u7d20\u7a2e\u7523\u751f\u30a2\u30f3\u30c8\u30e9\u30b5\u30a4\u30af\u30ea\u30f3\u306e\u767a\u73fe\u8a98\u5c0e\u3059\u308b\u907a\u4f1d\u5b50\u7fa4\u306e\u540c\u5b9a\u3068\u305d\u306e\u767a\u73fe\u6a5f\u5e8f","funder_award_id":"14771350","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2020887779.pdf","grobid_xml":"https://content.openalex.org/works/W2020887779.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W30214070","https://openalex.org/W155521797","https://openalex.org/W169444311","https://openalex.org/W1534395710","https://openalex.org/W1658946241","https://openalex.org/W1780460389","https://openalex.org/W1863566879","https://openalex.org/W1924003041","https://openalex.org/W1964167504","https://openalex.org/W1971298806","https://openalex.org/W1975426912","https://openalex.org/W1975742983","https://openalex.org/W1980022601","https://openalex.org/W1981854366","https://openalex.org/W1988081818","https://openalex.org/W1991338445","https://openalex.org/W1998986106","https://openalex.org/W2016038212","https://openalex.org/W2016730049","https://openalex.org/W2025394877","https://openalex.org/W2026305659","https://openalex.org/W2029009116","https://openalex.org/W2029790299","https://openalex.org/W2031481616","https://openalex.org/W2039149747","https://openalex.org/W2044374425","https://openalex.org/W2048397453","https://openalex.org/W2066729041","https://openalex.org/W2068593333","https://openalex.org/W2077765749","https://openalex.org/W2079866862","https://openalex.org/W2092005640","https://openalex.org/W2103269080","https://openalex.org/W2110105332","https://openalex.org/W2110271221","https://openalex.org/W2115324329","https://openalex.org/W2141503579","https://openalex.org/W2159156763","https://openalex.org/W2166947053","https://openalex.org/W2168939691","https://openalex.org/W2294348289","https://openalex.org/W2314225431","https://openalex.org/W2318772898","https://openalex.org/W2394505409","https://openalex.org/W4296792904","https://openalex.org/W6711482565"],"related_works":["https://openalex.org/W2019349688","https://openalex.org/W2531770465","https://openalex.org/W2062686920","https://openalex.org/W7046120079","https://openalex.org/W2410169780","https://openalex.org/W1976051281","https://openalex.org/W3207011187","https://openalex.org/W2034271518","https://openalex.org/W2083432026","https://openalex.org/W2372790538"],"abstract_inverted_index":{"We":[0,57],"previously":[1],"demonstrated":[2],"doxorubicin-induced":[3],"urokinase":[4],"expression":[5,70,181],"in":[6,25,93,110,120,155,165,182,224,232],"human":[7,28,95,144,225],"H69":[8,98,112,157,167],"SCLC":[9,96,186,226],"cells":[10,227,263,266],"by":[11,63,105,228],"the":[12,54,61,65,72,88,130,195,207,259],"microarray":[13],"technique":[14],"using":[15,138,170,191],"Human":[16],"Cancer":[17,41],"CHIP":[18],"version":[19],"2":[20,94],"(Takara":[21],"Shuzo,":[22],"Kyoto,":[23],"Japan),":[24],"which":[26,233],"425":[27],"cancer-related":[29],"genes":[30],"were":[31,107],"spotted":[32],"on":[33,69,129],"glass":[34],"plates":[35],"(Kiguchi":[36],"et":[37],"al.,":[38],"Int":[39],"J":[40],"2001;93:792-7).":[42],"Microarray":[43],"analysis":[44,190],"also":[45,153,178],"revealed":[46,146],"significant":[47],"induction":[48,147,252],"of":[49,53,67,71,87,132,148,206,253,274],"IL-8,":[50],"a":[51,139],"member":[52],"CXC":[55],"chemokines.":[56],"have,":[58],"therefore,":[59,250],"extended":[60],"observation":[62],"testing":[64],"effects":[66],"doxorubicin":[68,81,118,177,218,268],"chemokine":[73],"family":[74],"and":[75,84,99,113,125,184,209,221,240,247,255,264,270],"provide":[76],"here":[77],"definitive":[78],"evidence":[79],"that":[80,176,217],"induces":[82,219],"IL-8":[83,101,151,192,220,239,254],"MCP-1,":[85],"one":[86],"CC":[89],"chemokines,":[90,145],"at":[91,234],"least":[92,235],"cells,":[97],"SBC-1.":[100],"antigen":[102,160],"levels,":[103],"measured":[104],"ELISA,":[106],"markedly":[108],"increased":[109,162],"both":[111],"SBC-1":[114,183],"conditioned":[115],"media":[116],"after":[117],"treatment,":[119],"parallel":[121],"with":[122],"mRNA":[123],"levels;":[124],"this":[126],"was":[127,202],"dependent":[128],"dose":[131],"doxorubicin.":[133],"The":[134],"ribonuclease":[135],"protection":[136],"assay,":[137],"multiprobe":[140],"template":[141],"set":[142],"for":[143,173,245],"not":[149],"only":[150],"but":[152],"MCP-1":[154,159,174,180,222,241,256],"doxorubicin-treated":[156,166],"cells.":[158,168,187],"levels":[161],"approximately":[163],"100-fold":[164],"RT-PCR":[169],"specific":[171],"primers":[172],"suggested":[175,216],"induced":[179],"SBC-3":[185],"Futhermore,":[188],"CAT":[189],"promoter":[193],"implicated":[194],"PEA3":[196,236],"transcriptional":[197],"factor,":[198],"whose":[199],"binding":[200,211],"site":[201],"located":[203],"immediately":[204],"upstream":[205],"AP-1":[208],"NF-kappaB":[210],"sites.":[212],"Thus,":[213],"it":[214],"is":[215,237],"chemokines":[223],"activating":[229],"gene":[230],"expression,":[231],"involved.":[238],"are":[242],"major":[243],"chemoattractants":[244],"neutrophils":[246],"monocytes/macrophages,":[248],"respectively;":[249],"extensive":[251],"may":[257],"provoke":[258],"interaction":[260],"between":[261],"inflammatory/immune":[262],"tumor":[265,275],"under":[267],"stimulation":[269],"influence":[271],"many":[272],"aspects":[273],"cell":[276],"biology.":[277]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
