{"id":"https://openalex.org/W2020884631","doi":"https://doi.org/10.1158/1538-7445.am2012-1816","title":"Abstract 1816: Blocking synthesis of oncogenic proteins in breast tumor cells through pharmacologic inhibition of the IRES","display_name":"Abstract 1816: Blocking synthesis of oncogenic proteins in breast tumor cells through pharmacologic inhibition of the IRES","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W2020884631","doi":"https://doi.org/10.1158/1538-7445.am2012-1816","mag":"2020884631"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2012-1816","doi":"https://doi.org/10.1158/1538-7445.am2012-1816","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-1816","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063423721","display_name":"Christos Vaklavas","orcid":"https://orcid.org/0000-0002-9919-2748","observed_orcids":["https://orcid.org/0000-0002-9919-2748"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christos Vaklavas","raw_affiliation_strings":["1University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075612912","display_name":"Zheng Meng","orcid":"https://orcid.org/0000-0002-6803-1570","observed_orcids":["https://orcid.org/0000-0002-6803-1570"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zheng Meng","raw_affiliation_strings":["1University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113764335","display_name":"E. Lucile White","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108109523","display_name":"Southern Research Institute","ror":"https://ror.org/0153ngy95","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I108109523"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Lucile White","raw_affiliation_strings":["2Southern Research Institute, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Southern Research Institute, Birmingham, AL","institution_ids":["https://openalex.org/I108109523"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058420313","display_name":"Lynn A. Rasmussen","orcid":"https://orcid.org/0000-0001-6211-2364","observed_orcids":["https://orcid.org/0000-0001-6211-2364"]},"institutions":[{"id":"https://openalex.org/I108109523","display_name":"Southern Research Institute","ror":"https://ror.org/0153ngy95","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I108109523"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynn Rasmussen","raw_affiliation_strings":["2Southern Research Institute, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Southern Research Institute, Birmingham, AL","institution_ids":["https://openalex.org/I108109523"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033612242","display_name":"Joseph A. Maddry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108109523","display_name":"Southern Research Institute","ror":"https://ror.org/0153ngy95","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I108109523"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph A. Maddry","raw_affiliation_strings":["2Southern Research Institute, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Southern Research Institute, Birmingham, AL","institution_ids":["https://openalex.org/I108109523"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049032476","display_name":"Miranda Nebane","orcid":"https://orcid.org/0000-0002-5354-4875","observed_orcids":["https://orcid.org/0000-0002-5354-4875"]},"institutions":[{"id":"https://openalex.org/I108109523","display_name":"Southern Research Institute","ror":"https://ror.org/0153ngy95","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I108109523"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miranda Nebane-Akah","raw_affiliation_strings":["2Southern Research Institute, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Southern Research Institute, Birmingham, AL","institution_ids":["https://openalex.org/I108109523"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076077003","display_name":"William E. Grizzle","orcid":"https://orcid.org/0000-0001-9245-0401","observed_orcids":["https://orcid.org/0000-0001-9245-0401"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Grizzle","raw_affiliation_strings":["1University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040167645","display_name":"Kurt R. Zinn","orcid":"https://orcid.org/0000-0001-7463-4741","observed_orcids":["https://orcid.org/0000-0001-7463-4741"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kurt R. Zinn","raw_affiliation_strings":["1University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111951219","display_name":"Andra R. Frost","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andra R. Frost","raw_affiliation_strings":["1University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058987373","display_name":"Cecil R. Stockard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cecil R. Stockard","raw_affiliation_strings":["1University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008120184","display_name":"Sharon L. Samuel","orcid":"https://orcid.org/0000-0002-5211-0661","observed_orcids":["https://orcid.org/0000-0002-5211-0661"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon L. Samuel","raw_affiliation_strings":["1University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014287678","display_name":"Maaike Everts","orcid":"https://orcid.org/0000-0001-7421-4691","observed_orcids":["https://orcid.org/0000-0001-7421-4691"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maaike Everts","raw_affiliation_strings":["1University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022971416","display_name":"Richard J. Whitley","orcid":"https://orcid.org/0000-0001-9959-9276","observed_orcids":["https://orcid.org/0000-0001-9959-9276"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard J. Whitley","raw_affiliation_strings":["1University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002349745","display_name":"Scott W. Blume","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott W. Blume","raw_affiliation_strings":["1University of Alabama at Birmingham, Birmingham, AL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1University of Alabama at Birmingham, Birmingham, AL","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"8_Supplement","first_page":"1816","last_page":"1816"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/internal-ribosome-entry-site","display_name":"internal ribosome entry site","score":0.8830000162124634},{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.949999988079071},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8640000224113464},{"id":"https://openalex.org/keywords/translational-control","display_name":"translational regulation","score":0.7889999747276306},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.6919999718666077},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5429999828338623},{"id":"https://openalex.org/keywords/doxorubicin-synergy","display_name":"doxorubicin synergy","score":0.8109999895095825},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5070000290870667},{"id":"https://openalex.org/keywords/high-throughput-compound-screening","display_name":"high-throughput compound screening","score":0.6460000276565552},{"id":"https://openalex.org/keywords/t47d-cells","display_name":"T47D cells","score":0.7929999828338623},{"id":"https://openalex.org/keywords/sum159-cells","display_name":"SUM159 cells","score":0.875},{"id":"https://openalex.org/keywords/cancer-therapeutics","display_name":"cancer therapeutics","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C77430603","wikidata":"https://www.wikidata.org/wiki/Q166992","display_name":"Internal ribosome entry site","level":5,"score":0.978569507598877},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.6998134851455688},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6123151183128357},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4672035574913025},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.45665088295936584},{"id":"https://openalex.org/C4718897","wikidata":"https://www.wikidata.org/wiki/Q5408698","display_name":"Eukaryotic translation","level":5,"score":0.444672167301178},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3980885446071625},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.36175262928009033},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33037689328193665},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24424436688423157},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16408371925354004}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2012-1816","doi":"https://doi.org/10.1158/1538-7445.am2012-1816","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-1816","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1030609836","https://openalex.org/W2416392072","https://openalex.org/W2078266225","https://openalex.org/W2092165028","https://openalex.org/W2325186406","https://openalex.org/W2071672251","https://openalex.org/W2478485623","https://openalex.org/W7057159675","https://openalex.org/W2792733901","https://openalex.org/W2490065090"],"abstract_inverted_index":{"Abstract":[0],"Many":[1],"genes":[2],"involved":[3],"in":[4,147,172,232,238,244,263,287,297,306,381,421],"the":[5,27,38,57,94,110,116,121,125,129,132,192,201,252,283,291,298,307,339,373,377,433,438],"control":[6,190],"of":[7,56,70,109,163,191,213,261,285,309,331,353,363,379,404,432,437],"cell":[8,289,300,389],"proliferation":[9,80],"and":[10,79,123,152,195,229,265,278,357,376,385,415],"survival,":[11,290],"i.e.":[12],"those":[13],"most":[14],"important":[15],"to":[16,22,30,74,86,185,324,334,370,398,411],"cancer":[17,150,173,181,268,388,393,422],"biology,":[18],"are":[19,396],"now":[20],"known":[21],"be":[23,53,144,168],"regulated":[24],"specifically":[25],"at":[26],"translational":[28],"(RNA":[29],"protein)":[31],"level.":[32],"An":[33],"intriguing":[34],"translation-regulatory":[35],"element":[36],"is":[37,407],"internal":[39],"ribosomal":[40],"entry":[41],"site":[42],"(IRES),":[43],"which":[44,49,128,200],"provides":[45],"a":[46,169,196,207,209,248,303,345,408,418],"mechanism":[47,126],"by":[48,127],"oncogene-associated":[50],"mRNAs":[51],"can":[52],"translated":[54],"independently":[55],"global":[58],"controls":[59],"on":[60,67,155,273],"protein":[61],"synthesis.":[62],"Tumor":[63],"cells":[64,151,182,269,320,395],"may":[65,143],"rely":[66],"IRES-mediated":[68,161,240,405],"translation":[69,162,241,406],"key":[71,164],"oncogenic":[72,165],"proteins":[73,118,166],"promote":[75],"their":[76],"own":[77],"survival":[78,375],"under":[81,189],"adverse":[82],"conditions":[83],"or":[84],"exposure":[85,323],"cytotoxic":[87,346],"chemotherapy.":[88],"We":[89,113,135],"have":[90,114,136,226],"previously":[91],"shown":[92,243,369],"that":[93,119,139,160,392],"mRNA":[95],"for":[96,361,441],"type":[97],"1":[98],"insulin-like":[99],"growth":[100],"factor":[101],"receptor":[102],"(IGF1R)":[103],"contains":[104],"an":[105,271],"IRES":[106,130,141,202,292,326,340,399],"immediately":[107],"upstream":[108],"initiation":[111],"codon.":[112],"characterized":[115],"RNA-binding":[117],"regulate":[120],"IRES,":[122,194],"elucidated":[124],"recruits":[131],"40S":[133],"ribosome.":[134],"accumulated":[137],"evidence":[138],"IGF1R":[140,193,253,262,286,325],"activity":[142],"aberrantly":[145],"upregulated":[146],"human":[148,317],"breast":[149,180,267,387],"tissues.":[153],"Based":[154],"these":[156,366],"observations,":[157],"we":[158],"hypothesized":[159],"could":[167,416],"rational":[170],"target":[171],"therapeutics":[174],"with":[175,222,270,282,302,344,350],"pharmacologic":[176,402],"potential.":[177],"Using":[178],"T47D":[179,264],"genetically":[183],"engineered":[184],"produce":[186],"firefly":[187],"luciferace":[188],"similar":[197],"construct":[198,250],"from":[199],"has":[203],"been":[204,227],"deleted":[205],"as":[206],"control,":[208],"high":[210,329],"throughput":[211],"screen":[212],"135000":[214],"compounds":[215,221,256,367],"was":[216,242,336,342],"performed.":[217],"Four":[218],"promising":[219],"lead":[220],"distinct":[223],"chemical":[224],"scaffolds":[225],"identified":[228],"further":[230],"validated":[231],"dose":[233,358],"response":[234],"titrations.":[235],"Their":[236],"specificity":[237],"blocking":[239],"reticulocyte":[245],"lysates":[246],"using":[247],"bicistronic":[249],"containing":[251],"IRES.":[254],"The":[255,401],"inhibited":[257],"de":[258],"novo":[259],"synthesis":[260],"SUM159":[266],"IC50":[272],"Western":[274],"blots":[275],"between":[276],"<2":[277],"10":[279],"\u00b5g/mL.":[280,313],"Consistent":[281],"importance":[284],"tumor":[288],"inhibitors":[293],"induced":[294],"massive":[295],"apoptosis":[296],"same":[299],"lines":[301],"toxic":[304],"concentration-90":[305],"range":[308],"<1":[310],"-":[311,355],"8":[312],"In":[314],"contrast,":[315],"normal":[316],"mammary":[318],"epithelial":[319],"tolerated":[321],"prolonged":[322],"inhibitors.":[327],"A":[328],"degree":[330],"synergism":[332],"(3+":[333],"4+)":[335],"observed":[337],"when":[338],"inhibitor":[341],"combined":[343],"chemotherapeutic":[347],"agent":[348],"(doxorubicin),":[349],"combination":[351],"indices":[352,360],"0.153":[354],"0.334":[356],"reduction":[359],"doxorubicin":[362],"5.0-14.9.":[364],"Furthermore,":[365],"were":[368],"completely":[371],"block":[372],"clonogenic":[374],"formation":[378],"mammospheres":[380],"both":[382],"ER":[383],"positive":[384],"negative":[386],"lines,":[390],"suggesting":[391],"stem":[394],"sensitive":[397],"inhibition.":[400],"inhibition":[403],"novel":[409],"strategy":[410],"modulate":[412],"oncogene":[413],"expression":[414],"represent":[417],"new":[419],"paradigm":[420],"therapeutics.":[423],"Citation":[424],"Format:":[425],"{Authors}.":[426],"{Abstract":[427],"title}":[428],"[abstract].":[429],"In:":[430],"Proceedings":[431],"103rd":[434],"Annual":[435],"Meeting":[436],"American":[439],"Association":[440],"Cancer":[442,453],"Research;":[443],"2012":[444],"Mar":[445],"31-Apr":[446],"4;":[447],"Chicago,":[448],"IL.":[449],"Philadelphia":[450],"(PA):":[451],"AACR;":[452],"Res":[454],"2012;72(8":[455],"Suppl):Abstract":[456],"nr":[457],"1816.":[458],"doi:1538-7445.AM2012-1816":[459]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}
