{"id":"https://openalex.org/W2020876508","doi":"https://doi.org/10.1002/jps.10194","title":"Noncovalent dimerization of paclitaxel in solution: Evidence from electrospray ionization mass spectrometry","display_name":"Noncovalent dimerization of paclitaxel in solution: Evidence from electrospray ionization mass spectrometry","publication_year":2002,"publication_date":"2002-09-01","ids":{"openalex":"https://openalex.org/W2020876508","doi":"https://doi.org/10.1002/jps.10194","mag":"2020876508","pmid":"https://pubmed.ncbi.nlm.nih.gov/12210052"},"language":"en","primary_location":{"id":"doi:10.1002/jps.10194","doi":"https://doi.org/10.1002/jps.10194","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jps.10194","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112536733","display_name":"Sarah A. Lorenz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah A. Lorenz","raw_affiliation_strings":["Department of Chemistry, Natural Sciences Complex, State University of New York at Buffalo, Buffalo, New York 14260-3000, USA","Department of Chemistry, Natural Sciences Complex, State University of New York at Buffalo, Buffalo, New York 14260-3000"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Natural Sciences Complex, State University of New York at Buffalo, Buffalo, New York 14260-3000, USA","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Department of Chemistry, Natural Sciences Complex, State University of New York at Buffalo, Buffalo, New York 14260-3000","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037300087","display_name":"Paul M. Bigwarfe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul M. Bigwarfe","raw_affiliation_strings":["Department of Chemistry, Natural Sciences Complex, State University of New York at Buffalo, Buffalo, New York 14260\u20103000"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Natural Sciences Complex, State University of New York at Buffalo, Buffalo, New York 14260\u20103000","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108411788","display_name":"Sathyamangalam V. Balasubramanian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sathyamangalam V. Balasubramanian","raw_affiliation_strings":["Department of Pharmaceutics, Cooke Hall, State University of New York at Buffalo, Buffalo, New York 14260"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Cooke Hall, State University of New York at Buffalo, Buffalo, New York 14260","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062284417","display_name":"Gerald J. Fetterly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald J. Fetterly","raw_affiliation_strings":["Department of Pharmaceutics, Cooke Hall, State University of New York at Buffalo, Buffalo, New York 14260"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, Cooke Hall, State University of New York at Buffalo, Buffalo, New York 14260","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057883761","display_name":"Robert M. Straubinger","orcid":"https://orcid.org/0000-0003-0870-9236","observed_orcids":["https://orcid.org/0000-0003-0870-9236"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Straubinger","raw_affiliation_strings":["Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263","Department of Pharmaceutics, Cooke Hall, State University of New York at Buffalo, Buffalo, New York 14260"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Pharmaceutics, Cooke Hall, State University of New York at Buffalo, Buffalo, New York 14260","institution_ids":["https://openalex.org/I63190737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076358242","display_name":"Troy D. Wood","orcid":"https://orcid.org/0000-0002-2556-8511","observed_orcids":["https://orcid.org/0000-0002-2556-8511"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I63190737","display_name":"University at Buffalo, State University of New York","ror":"https://ror.org/01y64my43","country_code":"US","type":"education","lineage":["https://openalex.org/I63190737"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Troy D. Wood","raw_affiliation_strings":["Department of Chemistry, Natural Sciences Complex, State University of New York at Buffalo, Buffalo, New York 14260\u20103000","Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Natural Sciences Complex, State University of New York at Buffalo, Buffalo, New York 14260\u20103000","institution_ids":["https://openalex.org/I63190737"]},{"raw_affiliation_string":"Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263","institution_ids":["https://openalex.org/I1292894508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5076358242"],"corresponding_institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I63190737"],"apc_list":{"value":3620,"currency":"USD","value_usd":3620},"apc_paid":null,"fwci":0.8503,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.67266592,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"91","issue":"9","first_page":"2057","last_page":"2066"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9580000042915344,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":1.0},{"id":"https://openalex.org/keywords/drug-aggregation","display_name":"drug aggregation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/microtubule-stabilization","display_name":"microtubule stabilization","score":0.7910000085830688},{"id":"https://openalex.org/keywords/ion-molecule-reactions","display_name":"ion-molecule reactions","score":0.6460000276565552},{"id":"https://openalex.org/keywords/hydrogen-deuterium-exchange","display_name":"hydrogen-deuterium exchange","score":0.9419999718666077},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.7699999809265137},{"id":"https://openalex.org/keywords/aqueous-stability","display_name":"aqueous stability","score":0.675000011920929},{"id":"https://openalex.org/keywords/antimitotic-agents","display_name":"antimitotic agents","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8131340742111206},{"id":"https://openalex.org/C40684141","wikidata":"https://www.wikidata.org/wiki/Q902061","display_name":"Electrospray ionization","level":3,"score":0.756695032119751},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.720821738243103},{"id":"https://openalex.org/C2777463227","wikidata":"https://www.wikidata.org/wiki/Q408047","display_name":"Acetonitrile","level":2,"score":0.6111977100372314},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.570088267326355},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.555513858795166},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.5362282395362854},{"id":"https://openalex.org/C167569220","wikidata":"https://www.wikidata.org/wiki/Q5954985","display_name":"Hydrogen\u2013deuterium exchange","level":3,"score":0.41954272985458374},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.357998788356781},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.24090290069580078},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000097","descriptor_name":"Acetonitriles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019346","descriptor_name":"Sodium Acetate","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jps.10194","doi":"https://doi.org/10.1002/jps.10194","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jps.10194","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmid:12210052","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12210052","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmaceutical sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.47999998927116394}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1224163906","display_name":"Circular Dichroism Spectropolarimeter with fluorescence acquisition and temperatu","funder_award_id":"S10RR027232","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320329113","display_name":"Universidad de Extremadura","ror":"https://ror.org/0174shg90"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1968965382","https://openalex.org/W1975984615","https://openalex.org/W1976033985","https://openalex.org/W1979308321","https://openalex.org/W1986731271","https://openalex.org/W1988158069","https://openalex.org/W1991153138","https://openalex.org/W1996491270","https://openalex.org/W1998579067","https://openalex.org/W1999094083","https://openalex.org/W2001247738","https://openalex.org/W2004516195","https://openalex.org/W2005575116","https://openalex.org/W2014661246","https://openalex.org/W2014775893","https://openalex.org/W2018066854","https://openalex.org/W2036088145","https://openalex.org/W2037184977","https://openalex.org/W2037490361","https://openalex.org/W2037584280","https://openalex.org/W2037605675","https://openalex.org/W2043750157","https://openalex.org/W2054549443","https://openalex.org/W2065043732","https://openalex.org/W2066674793","https://openalex.org/W2069031182","https://openalex.org/W2071956933","https://openalex.org/W2072261174","https://openalex.org/W2073722571","https://openalex.org/W2077214112","https://openalex.org/W2088114261","https://openalex.org/W2108112365","https://openalex.org/W2119245248","https://openalex.org/W2120463093","https://openalex.org/W2139236845","https://openalex.org/W2253729940","https://openalex.org/W2401691189","https://openalex.org/W2403451635","https://openalex.org/W2415001843","https://openalex.org/W2489559924","https://openalex.org/W2500436803","https://openalex.org/W4285719527","https://openalex.org/W6691914951"],"related_works":["https://openalex.org/W2066674793","https://openalex.org/W2599622399","https://openalex.org/W2086653554","https://openalex.org/W2379887980","https://openalex.org/W2740236296","https://openalex.org/W2604302578","https://openalex.org/W2049364118","https://openalex.org/W2989611741","https://openalex.org/W1999094083","https://openalex.org/W4410287243"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}