{"id":"https://openalex.org/W2020798985","doi":"https://doi.org/10.1172/jci200523640","title":"The IL-6\u2013gp130\u2013STAT3 pathway in hepatocytes triggers liver protection in T cell\u2013mediated liver injury","display_name":"The IL-6\u2013gp130\u2013STAT3 pathway in hepatocytes triggers liver protection in T cell\u2013mediated liver injury","publication_year":2005,"publication_date":"2005-03-03","ids":{"openalex":"https://openalex.org/W2020798985","doi":"https://doi.org/10.1172/jci200523640","mag":"2020798985","pmid":"https://pubmed.ncbi.nlm.nih.gov/15761498","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1059450"},"language":"en","primary_location":{"id":"doi:10.1172/jci200523640","doi":"https://doi.org/10.1172/jci200523640","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci200523640","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://www.jci.org/articles/view/23640/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Christian Klein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Klein","raw_affiliation_strings":["Department of Gastroenterology, Hepatology & Endocrinology, Hannover Medical School, Hannover, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Hepatology & Endocrinology, Hannover Medical School, Hannover, Germany","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023581314","display_name":"Torsten W\u00fcstefeld","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Torsten W\u00fcstefeld","raw_affiliation_strings":["Hannover Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hannover Medical School","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030344954","display_name":"Ulrike Assmus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrike Assmus","raw_affiliation_strings":["Hannover Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hannover Medical School","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067200658","display_name":"Tania Roskams","orcid":"https://orcid.org/0000-0002-2816-1530","observed_orcids":["https://orcid.org/0000-0002-2816-1530"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Tania Roskams","raw_affiliation_strings":["Katholieke Universiteit Leuven (KU Leuven) (Catholic University of Leuven)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Katholieke Universiteit Leuven (KU Leuven) (Catholic University of Leuven)","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089057275","display_name":"Stefan Rose\u2010John","orcid":"https://orcid.org/0000-0002-7519-3279","observed_orcids":["https://orcid.org/0000-0002-7519-3279"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Rose-John","raw_affiliation_strings":["Christian-Albrechts-Universitat zu Kiel (Christian-Albrechts University of Kiel)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christian-Albrechts-Universitat zu Kiel (Christian-Albrechts University of Kiel)","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100725135","display_name":"Michael M. M\u00fcller","orcid":"https://orcid.org/0000-0002-5930-9905","observed_orcids":["https://orcid.org/0000-0002-5930-9905"]},"institutions":[{"id":"https://openalex.org/I913481162","display_name":"Wageningen University & Research","ror":"https://ror.org/04qw24q55","country_code":"NL","type":"education","lineage":["https://openalex.org/I913481162"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Michael M\u00fcller","raw_affiliation_strings":["Wageningen University and Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wageningen University and Research","institution_ids":["https://openalex.org/I913481162"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002183557","display_name":"Michael Peter Manns","orcid":"https://orcid.org/0000-0002-4485-8856","observed_orcids":["https://orcid.org/0000-0002-4485-8856"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael P. Manns","raw_affiliation_strings":["Hannover Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hannover Medical School","institution_ids":["https://openalex.org/I34809795"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mattias Ernst","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mattias Ernst","raw_affiliation_strings":["Royal Melbourne Hospital;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Melbourne Hospital;","institution_ids":["https://openalex.org/I1320473756"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006242340","display_name":"Christian Trautwein","orcid":"https://orcid.org/0000-0003-2762-8247","observed_orcids":["https://orcid.org/0000-0003-2762-8247"]},"institutions":[{"id":"https://openalex.org/I34809795","display_name":"Medizinische Hochschule Hannover","ror":"https://ror.org/00f2yqf98","country_code":"DE","type":"education","lineage":["https://openalex.org/I34809795"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Trautwein","raw_affiliation_strings":["Hannover Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hannover Medical School","institution_ids":["https://openalex.org/I34809795"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":3.8721,"has_fulltext":true,"cited_by_count":200,"citation_normalized_percentile":{"value":0.94269696,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"115","issue":"4","first_page":"860","last_page":"869"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.03530000150203705,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9610000252723694},{"id":"https://openalex.org/keywords/gp130","display_name":"gp130","score":0.9629999995231628},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.8519999980926514},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.8820000290870667},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.7160000205039978},{"id":"https://openalex.org/keywords/immune-mediated-hepatitis","display_name":"immune-mediated hepatitis","score":0.8119999766349792},{"id":"https://openalex.org/keywords/concanavalin-a-induced-hepatitis","display_name":"concanavalin A-induced hepatitis","score":0.906000018119812},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.7080000042915344},{"id":"https://openalex.org/keywords/saa2","display_name":"SAA2","score":0.9800000190734863},{"id":"https://openalex.org/keywords/stat1","display_name":"STAT1","score":0.7269999980926514},{"id":"https://openalex.org/keywords/hepatocyte-specific-knockout-mice","display_name":"hepatocyte-specific knockout mice","score":0.8130000233650208},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C126037660","wikidata":"https://www.wikidata.org/wiki/Q21116066","display_name":"Glycoprotein 130","level":4,"score":0.8224852085113525},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.5879759192466736},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.5610100030899048},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.5398740768432617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5390415191650391},{"id":"https://openalex.org/C2777003663","wikidata":"https://www.wikidata.org/wiki/Q14912030","display_name":"STAT1","level":3,"score":0.5017578601837158},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4086795449256897},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38560760021209717},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3776854872703552},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3363310694694519},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31038832664489746},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10087105631828308},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08825165033340454},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06372863054275513}],"mesh":[{"descriptor_ui":"D000685","descriptor_name":"Serum Amyloid A Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003208","descriptor_name":"Concanavalin A","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006505","descriptor_name":"Hepatitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050822","descriptor_name":"Cytokine Receptor gp130","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1172/jci200523640","doi":"https://doi.org/10.1172/jci200523640","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci200523640","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"doi:10.1172/jci23640","doi":"https://doi.org/10.1172/jci23640","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci23640","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1059450","doi":null,"is_oa":true,"landing_page_url":"http://dx.doi.org/10.1172/JCI200523640","pdf_url":"http://www.jci.org/articles/view/23640/files/pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:15761498","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15761498","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:library.wur.nl:wurpubs/348244","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/the-il-6-gp130-stat3-pathway-in-hepatocytes-triggers-liver-protec","pdf_url":null,"source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ISSN: 0021-9738","raw_type":"Article/Letter to editor"},{"id":"pmh:oai:publications.rwth-aachen.de:162327","doi":null,"is_oa":false,"landing_page_url":"https://publications.rwth-aachen.de/record/162327","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The journal of clinical investigation : JCI 115(4), 860-869 (2005). doi:10.1172/JCI23640","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ueaeprints.uea.ac.uk:47737","doi":null,"is_oa":false,"landing_page_url":"https://ueaeprints.uea.ac.uk/id/eprint/47737/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400384","display_name":"UEA Digital Repository (University of East Anglia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1118541","host_organization_name":"University of East Anglia","host_organization_lineage":["https://openalex.org/I1118541"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:wur:oai:library.wur.nl:wurpubs/348244","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/the-il-6-gp130-stat3-pathway-in-hepatocytes-triggers-liver-protec","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Clinical Investigation, 115(4), 860 - 869","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1059450","doi":null,"is_oa":true,"landing_page_url":"http://dx.doi.org/10.1172/JCI200523640","pdf_url":"http://www.jci.org/articles/view/23640/files/pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2062816395","display_name":null,"funder_award_id":"SFB 566","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5789789850","display_name":null,"funder_award_id":"Project B8","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2020798985.pdf","grobid_xml":"https://content.openalex.org/works/W2020798985.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W3597883","https://openalex.org/W1486923517","https://openalex.org/W1496109170","https://openalex.org/W1516719898","https://openalex.org/W1522632313","https://openalex.org/W1571743853","https://openalex.org/W1571951314","https://openalex.org/W1779691448","https://openalex.org/W1900386759","https://openalex.org/W1919845622","https://openalex.org/W1966330632","https://openalex.org/W1967173904","https://openalex.org/W1968303555","https://openalex.org/W1977213133","https://openalex.org/W1988917700","https://openalex.org/W1995139611","https://openalex.org/W2006650058","https://openalex.org/W2009008191","https://openalex.org/W2030624761","https://openalex.org/W2044128918","https://openalex.org/W2053208260","https://openalex.org/W2057210516","https://openalex.org/W2058498759","https://openalex.org/W2058866971","https://openalex.org/W2064679083","https://openalex.org/W2067144379","https://openalex.org/W2069284462","https://openalex.org/W2077007602","https://openalex.org/W2084150021","https://openalex.org/W2088244239","https://openalex.org/W2095959011","https://openalex.org/W2105620133","https://openalex.org/W2107682360","https://openalex.org/W2113744229","https://openalex.org/W2113859808","https://openalex.org/W2117908470","https://openalex.org/W2119120508","https://openalex.org/W2121209580","https://openalex.org/W2121640904","https://openalex.org/W2125415295","https://openalex.org/W2131520834","https://openalex.org/W2138107240","https://openalex.org/W2143163223","https://openalex.org/W2147495692","https://openalex.org/W2147700544","https://openalex.org/W2151718718","https://openalex.org/W2156196408","https://openalex.org/W2158204425","https://openalex.org/W2168370480","https://openalex.org/W2255266097","https://openalex.org/W2326751371"],"related_works":["https://openalex.org/W2626244736","https://openalex.org/W2626902964","https://openalex.org/W2067385855","https://openalex.org/W2048196702","https://openalex.org/W1571743853","https://openalex.org/W1516719898","https://openalex.org/W1987718270","https://openalex.org/W2347075443","https://openalex.org/W2620064324","https://openalex.org/W2167065253"],"abstract_inverted_index":{"Increasing":[0],"evidence":[1],"demonstrates":[2],"that":[3,49,179],"IL-6":[4,12],"has":[5],"a":[6,38],"protective":[7,71],"role":[8],"during":[9,165],"liver":[10,29,163,204],"injury.":[11],"activates":[13],"intracellular":[14],"pathways":[15,25,51],"via":[16],"the":[17,69,148,191],"gp130":[18,34],"receptor.":[19],"In":[20,169],"order":[21],"to":[22],"identify":[23,94],"IL-6-gp130":[24],"involved":[26],"in":[27,37,52,60,66,81,91,109,116,177,183,203],"mediating":[28],"protection,":[30],"we":[31,100,189],"analyzed":[32],"hepatocyte-specific":[33,110],"knockout":[35],"mice":[36,82,112],"concanavalin":[39],"A-induced":[40,62,167,186],"(Con":[41],"A-induced)":[42],"model":[43],"of":[44,78,105,143,151],"immune-mediated":[45,184],"hepatitis.":[46,63,168,187],"We":[47],"demonstrated":[48,75],"IL-6-gp130-dependent":[50],"hepatocytes":[53,67,178],"alone":[54],"are":[55],"sufficient":[56],"for":[57,85,200],"triggering":[58],"protection":[59,80,182],"Con":[61,166,185],"gp130-STAT3":[64],"signaling":[65,90],"mediates":[68,180],"IL-6-triggered":[70,181],"effect.":[72],"This":[73],"was":[74,135],"by":[76],"analysis":[77,104],"IL-6-induced":[79],"selectively":[83],"deficient":[84],"gp130-dependent":[86],"STAT1/3":[87],"or":[88,158],"gp130-SHP2-RAS":[89],"hepatocytes.":[92],"To":[93],"IL-6-gp130-STAT1/3":[95],"dependently":[96],"expressed":[97],"liver-protective":[98,149],"factors,":[99],"performed":[101],"gene":[102,107,175],"array":[103],"hepatic":[106],"expression":[108,142,176],"gp130(-/-)":[111],"as":[113,115,128,137,197],"well":[114],"gp130-STAT1/3-":[117],"and":[118,130,145,195],"gp130-SHP2-RAS-MAPK-deficient":[119],"mice.":[120],"The":[121],"mouse":[122],"IL-8":[123],"ortholog":[124],"KC":[125,144,157,194],"(also":[126],"known":[127],"Gro-alpha)":[129],"serum":[131,159],"amyloid":[132],"A2":[133],"(SAA2)":[134],"identified":[136,190],"differentially":[138],"IL-6-gp130-STAT3-regulated":[139],"genes.":[140],"Hepatic":[141],"SAA2":[146,160,196],"mediate":[147],"potential":[150],"IL-6,":[152],"since":[153],"treatment":[154],"with":[155],"recombinant":[156],"effectively":[161],"reduced":[162],"injury":[164],"summary,":[170],"this":[171],"study":[172],"defines":[173],"IL-6-gp130-STAT3-dependent":[174,192],"Additionally,":[188],"proteins":[193],"new":[198],"candidates":[199],"therapeutic":[201],"targets":[202],"diseases.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
