{"id":"https://openalex.org/W2020764074","doi":"https://doi.org/10.1016/j.urols.2011.08.005","title":"Effect of solifenacin with and without antioxidant supplements on the response to experimental outlet obstruction and overactive bladder dysfunction in rabbits: Part 1","display_name":"Effect of solifenacin with and without antioxidant supplements on the response to experimental outlet obstruction and overactive bladder dysfunction in rabbits: Part 1","publication_year":2011,"publication_date":"2011-09-01","ids":{"openalex":"https://openalex.org/W2020764074","doi":"https://doi.org/10.1016/j.urols.2011.08.005","mag":"2020764074"},"language":"en","primary_location":{"id":"doi:10.1016/j.urols.2011.08.005","doi":"https://doi.org/10.1016/j.urols.2011.08.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.urols.2011.08.005","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1879522611000091/pdf","source":{"id":"https://openalex.org/S50263657","display_name":"Urological Science","issn_l":"1879-5226","issn":["1879-5226","1879-5234"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Urological Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.sciencedirect.com/science/article/pii/S1879522611000091/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009198867","display_name":"Turgut Topol","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Turgut Topol","raw_affiliation_strings":["Gulhane Military Medical Academy, Department of Physiology, Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gulhane Military Medical Academy, Department of Physiology, Ankara, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084381832","display_name":"Catherine Schuler","orcid":"https://orcid.org/0000-0002-4141-0845","observed_orcids":["https://orcid.org/0000-0002-4141-0845"]},"institutions":[{"id":"https://openalex.org/I4210109456","display_name":"Albany Stratton VA Medical Center Albany","ror":"https://ror.org/01rpj9v06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210109456"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Schuler","raw_affiliation_strings":["Stratton VA Medical Center, Albany, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stratton VA Medical Center, Albany, NY, USA","institution_ids":["https://openalex.org/I4210109456"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042293933","display_name":"Robert E. Leggett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert E. Leggett","raw_affiliation_strings":["Albany College of Pharmacy and Health Sciences, Albany, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albany College of Pharmacy and Health Sciences, Albany, NY, USA","institution_ids":["https://openalex.org/I365282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071809940","display_name":"Tasmina Hydery","orcid":"https://orcid.org/0000-0002-7206-1668","observed_orcids":["https://orcid.org/0000-0002-7206-1668"]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tasmina Hydery","raw_affiliation_strings":["Albany College of Pharmacy and Health Sciences, Albany, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albany College of Pharmacy and Health Sciences, Albany, NY, USA","institution_ids":["https://openalex.org/I365282"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051502498","display_name":"Sandra Benyamin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Benyamin","raw_affiliation_strings":["Albany College of Pharmacy and Health Sciences, Albany, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albany College of Pharmacy and Health Sciences, Albany, NY, USA","institution_ids":["https://openalex.org/I365282"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042687042","display_name":"Robert M. Levin","orcid":"https://orcid.org/0000-0003-1578-6870","observed_orcids":["https://orcid.org/0000-0003-1578-6870"]},"institutions":[{"id":"https://openalex.org/I365282","display_name":"Albany College of Pharmacy and Health Sciences","ror":"https://ror.org/014hfaw95","country_code":"US","type":"education","lineage":["https://openalex.org/I365282"]},{"id":"https://openalex.org/I4210109456","display_name":"Albany Stratton VA Medical Center Albany","ror":"https://ror.org/01rpj9v06","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210109456"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert M. Levin","raw_affiliation_strings":["Albany College of Medicine, Division of Urology, Albany, NY, USA","Albany College of Pharmacy and Health Sciences, Albany, NY, USA","Stratton VA Medical Center, Albany, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albany College of Medicine, Division of Urology, Albany, NY, USA","institution_ids":[]},{"raw_affiliation_string":"Albany College of Pharmacy and Health Sciences, Albany, NY, USA","institution_ids":["https://openalex.org/I365282"]},{"raw_affiliation_string":"Stratton VA Medical Center, Albany, NY, USA","institution_ids":["https://openalex.org/I4210109456"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042687042"],"corresponding_institution_ids":["https://openalex.org/I365282","https://openalex.org/I4210109456"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.14973436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"22","issue":"3","first_page":"110","last_page":"115"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10418","display_name":"Pelvic floor disorders treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/solifenacin","display_name":"solifenacin","score":0.9240000247955322},{"id":"https://openalex.org/keywords/overactive-bladder","display_name":"overactive bladder","score":0.9179999828338623},{"id":"https://openalex.org/keywords/outlet-obstruction","display_name":"outlet obstruction","score":0.8820000290870667},{"id":"https://openalex.org/keywords/coenzyme-q10","display_name":"coenzyme Q10","score":0.9139999747276306},{"id":"https://openalex.org/keywords/alpha-lipoic-acid","display_name":"alpha-lipoic acid","score":0.9900000095367432},{"id":"https://openalex.org/keywords/antioxidant-supplementation","display_name":"antioxidant supplementation","score":0.6779999732971191},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6380000114440918},{"id":"https://openalex.org/keywords/bladder-dysfunction","display_name":"bladder dysfunction","score":0.8209999799728394},{"id":"https://openalex.org/keywords/antimuscarinic-agents","display_name":"antimuscarinic agents","score":0.9070000052452087},{"id":"https://openalex.org/keywords/synergistic-drug-combination","display_name":"synergistic drug combination","score":0.6840000152587891},{"id":"https://openalex.org/keywords/cystometry","display_name":"cystometry","score":0.7229999899864197},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C2779502394","wikidata":"https://www.wikidata.org/wiki/Q59575279","display_name":"Solifenacin","level":4,"score":0.9959737062454224},{"id":"https://openalex.org/C2778941218","wikidata":"https://www.wikidata.org/wiki/Q331231","display_name":"Overactive bladder","level":3,"score":0.912502646446228},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8858602046966553},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.6106427907943726},{"id":"https://openalex.org/C2779384338","wikidata":"https://www.wikidata.org/wiki/Q321285","display_name":"Coenzyme Q10","level":2,"score":0.5342622995376587},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3892127573490143},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3344281315803528},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.04682663083076477},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.urols.2011.08.005","doi":"https://doi.org/10.1016/j.urols.2011.08.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.urols.2011.08.005","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1879522611000091/pdf","source":{"id":"https://openalex.org/S50263657","display_name":"Urological Science","issn_l":"1879-5226","issn":["1879-5226","1879-5234"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Urological Science","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.urols.2011.08.005","doi":"https://doi.org/10.1016/j.urols.2011.08.005","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.urols.2011.08.005","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1879522611000091/pdf","source":{"id":"https://openalex.org/S50263657","display_name":"Urological Science","issn_l":"1879-5226","issn":["1879-5226","1879-5234"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-4"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Urological Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320309037","display_name":"Office of Research and Development","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320323024","display_name":"Astellas Pharma","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320332563","display_name":"Astellas Pharma Global Development","ror":"https://ror.org/05pw69n24"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2020764074.pdf","grobid_xml":"https://content.openalex.org/works/W2020764074.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W63727678","https://openalex.org/W191793640","https://openalex.org/W213704492","https://openalex.org/W829757908","https://openalex.org/W1487501255","https://openalex.org/W1504077734","https://openalex.org/W1543952105","https://openalex.org/W1552751776","https://openalex.org/W1574291747","https://openalex.org/W1586519380","https://openalex.org/W1909295958","https://openalex.org/W1967944340","https://openalex.org/W1969898317","https://openalex.org/W1975490401","https://openalex.org/W1982412708","https://openalex.org/W1984442864","https://openalex.org/W1985008357","https://openalex.org/W1987772033","https://openalex.org/W1998415593","https://openalex.org/W2001565942","https://openalex.org/W2003196128","https://openalex.org/W2009579341","https://openalex.org/W2014373182","https://openalex.org/W2015484640","https://openalex.org/W2021199089","https://openalex.org/W2022087400","https://openalex.org/W2022437401","https://openalex.org/W2026826283","https://openalex.org/W2043138693","https://openalex.org/W2044468716","https://openalex.org/W2044710430","https://openalex.org/W2048723349","https://openalex.org/W2049881120","https://openalex.org/W2051602091","https://openalex.org/W2057386428","https://openalex.org/W2058112299","https://openalex.org/W2060853186","https://openalex.org/W2062046975","https://openalex.org/W2062282965","https://openalex.org/W2062520727","https://openalex.org/W2065155483","https://openalex.org/W2066288167","https://openalex.org/W2070450773","https://openalex.org/W2072658132","https://openalex.org/W2073839177","https://openalex.org/W2074465935","https://openalex.org/W2076615613","https://openalex.org/W2079098771","https://openalex.org/W2080077565","https://openalex.org/W2087953382","https://openalex.org/W2088976730","https://openalex.org/W2089084026","https://openalex.org/W2095428984","https://openalex.org/W2097451628","https://openalex.org/W2106339870","https://openalex.org/W2112835658","https://openalex.org/W2116775609","https://openalex.org/W2118526472","https://openalex.org/W2122687066","https://openalex.org/W2123311854","https://openalex.org/W2126601364","https://openalex.org/W2136037976","https://openalex.org/W2136500714","https://openalex.org/W2146022249","https://openalex.org/W2147647029","https://openalex.org/W2149642092","https://openalex.org/W2161063483","https://openalex.org/W2162271532","https://openalex.org/W2166148397","https://openalex.org/W2396902056","https://openalex.org/W2406257615","https://openalex.org/W4230679426","https://openalex.org/W6666045581","https://openalex.org/W6672726053"],"related_works":["https://openalex.org/W4245622479","https://openalex.org/W4250059080","https://openalex.org/W2153137083","https://openalex.org/W1820126864","https://openalex.org/W2365289793","https://openalex.org/W2136500714","https://openalex.org/W4405827465","https://openalex.org/W2787086320","https://openalex.org/W3173668286","https://openalex.org/W2353031517"],"abstract_inverted_index":{"One":[0],"of":[1,6,14,56,72,105,153,181,209,221,237,250],"the":[2,12,54,63,67,70,89,179,207,219,238,248],"most":[3],"common":[4],"forms":[5],"urinary":[7],"dysfunction":[8,38,205,253],"is":[9,20,51,82],"related":[10],"to":[11,31,62,115,162],"development":[13],"overactive":[15],"bladder":[16,204,252],"(OAB)":[17],"dysfunction.":[18],"Solifenacin":[19],"a":[21],"relatively":[22],"new":[23],"selective":[24],"antimuscarinic":[25],"agent":[26],"that":[27,49,69,202],"has":[28],"been":[29],"shown":[30],"be":[32],"particularly":[33],"useful":[34],"in":[35,39,85,159,193,213,247],"treating":[36,86],"OAB":[37,50,87,210],"both":[40],"men":[41],"and":[42,59,120,127,133,139,142,189,206,254],"women.":[43],"Experimentally,":[44],"we":[45],"have":[46],"previously":[47],"demonstrated":[48,201],"associated":[52],"with":[53,245],"generation":[55],"free":[57],"radicals":[58],"oxidative":[60],"damage":[61],"bladder.":[64],"We":[65],"tested":[66],"hypothesis":[68],"combination":[71,220],"solifenacin":[73,145,222,231,246],"+":[74,78,137,146,148,223,241],"coenzyme":[75],"Q10":[76],"(CoQ10)":[77],"\u03b1-lipoic":[79],"acid":[80],"(\u03b1-LA)":[81],"more":[83,227],"effective":[84,228],"than":[88,229],"individual":[90],"compounds.":[91],"In":[92],"total,":[93],"48":[94],"male":[95],"New":[96],"Zealand":[97],"White":[98],"rabbits":[99,107,158,169],"were":[100,113,211],"separated":[101],"into":[102],"8":[103,143],"groups":[104,118,125,131,140,160],"6":[106,128],"each.":[108],"The":[109,168,198,235],"following":[110,176],"oral":[111,156],"treatments":[112,172],"given":[114],"each":[116,185],"group:":[117],"1":[119,161],"5":[121],"received":[122,129,135,144,164,187],"vehicle":[123],"(saline);":[124],"2":[126],"solifenacin;":[130],"3":[132,151],"7":[134],"CoQ10":[136,147,240],"\u03b1-LA;":[138],"4":[141,163,174],"\u03b1-LA.":[149],"After":[150],"weeks":[152,175],"treatment":[154,216,249],"(by":[155],"gavage),":[157],"partial":[165],"outlet":[166],"obstruction.":[167],"continued":[170],"their":[171],"for":[173,196],"surgery.":[177],"At":[178],"end":[180],"this":[182],"4-week":[183],"period,":[184],"rabbit":[186],"cystometry":[188],"then":[190],"underwent":[191],"an":[192],"situ":[194],"study":[195],"OAB.":[197,255],"results":[199],"clearly":[200],"obstructive":[203,251],"level":[208],"reduced":[212],"all":[214],"three":[215],"groups,":[217],"but":[218],"antioxidants":[224,233,239],"was":[225],"significantly":[226],"either":[230],"or":[232],"alone.":[234],"addition":[236],"\u03b1-LA":[242],"worked":[243],"synergistically":[244]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}