{"id":"https://openalex.org/W2020755018","doi":"https://doi.org/10.1016/j.eururo.2006.05.002","title":"Alterations in the Transforming Growth Factor (TGF)-\u03b2 Pathway as a Potential Factor in the Pathogenesis of Peyronie\u2019s Disease","display_name":"Alterations in the Transforming Growth Factor (TGF)-\u03b2 Pathway as a Potential Factor in the Pathogenesis of Peyronie\u2019s Disease","publication_year":2006,"publication_date":"2006-05-20","ids":{"openalex":"https://openalex.org/W2020755018","doi":"https://doi.org/10.1016/j.eururo.2006.05.002","mag":"2020755018","pmid":"https://pubmed.ncbi.nlm.nih.gov/16782264"},"language":"en","primary_location":{"id":"doi:10.1016/j.eururo.2006.05.002","doi":"https://doi.org/10.1016/j.eururo.2006.05.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.eururo.2006.05.002","pdf_url":null,"source":{"id":"https://openalex.org/S96871409","display_name":"European Urology","issn_l":"0302-2838","issn":["0302-2838","1421-993X","1873-7560"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Urology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089314044","display_name":"Simone M. Haag","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Simone M. Haag","raw_affiliation_strings":["Department of Urology and Pediatric Urology, Justus Liebig University Giessen, Rudolf-Buchheim-Str. 7, 35385 Giessen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology and Pediatric Urology, Justus Liebig University Giessen, Rudolf-Buchheim-Str. 7, 35385 Giessen, Germany","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111632297","display_name":"Ekkehard W. Hauck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ekkehard W. Hauck","raw_affiliation_strings":["Department of Urology and Pediatric Urology, Justus Liebig University Giessen, Rudolf-Buchheim-Str. 7, 35385 Giessen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology and Pediatric Urology, Justus Liebig University Giessen, Rudolf-Buchheim-Str. 7, 35385 Giessen, Germany","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087211966","display_name":"Carolin Szardening-Kirchner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carolin Szardening-Kirchner","raw_affiliation_strings":["Department of Urology and Pediatric Urology, Justus Liebig University Giessen, Rudolf-Buchheim-Str. 7, 35385 Giessen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology and Pediatric Urology, Justus Liebig University Giessen, Rudolf-Buchheim-Str. 7, 35385 Giessen, Germany","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088519516","display_name":"Thorsten Diemer A","orcid":"https://orcid.org/0000-0003-2788-198X","observed_orcids":["https://orcid.org/0000-0003-2788-198X"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thorsten Diemer","raw_affiliation_strings":["Department of Urology and Pediatric Urology, Justus Liebig University Giessen, Rudolf-Buchheim-Str. 7, 35385 Giessen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology and Pediatric Urology, Justus Liebig University Giessen, Rudolf-Buchheim-Str. 7, 35385 Giessen, Germany","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Eun-Sook Cha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Eun-Sook Cha","raw_affiliation_strings":["University of Giessen Lung Center, Department of Medicine II, Justus Liebig University Giessen, Aulweg 123, 35395 Giessen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Giessen Lung Center, Department of Medicine II, Justus Liebig University Giessen, Aulweg 123, 35395 Giessen, Germany","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111599674","display_name":"W. Weidner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang Weidner","raw_affiliation_strings":["Department of Urology and Pediatric Urology, Justus Liebig University Giessen, Rudolf-Buchheim-Str. 7, 35385 Giessen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology and Pediatric Urology, Justus Liebig University Giessen, Rudolf-Buchheim-Str. 7, 35385 Giessen, Germany","institution_ids":["https://openalex.org/I200763008"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009672774","display_name":"Oliver Eickelberg","orcid":"https://orcid.org/0000-0001-7170-0360","observed_orcids":["https://orcid.org/0000-0001-7170-0360"]},"institutions":[{"id":"https://openalex.org/I200763008","display_name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen","ror":"https://ror.org/033eqas34","country_code":"DE","type":"education","lineage":["https://openalex.org/I200763008"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Eickelberg","raw_affiliation_strings":["University of Giessen Lung Center, Department of Medicine II, Justus Liebig University Giessen, Aulweg 123, 35395 Giessen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Giessen Lung Center, Department of Medicine II, Justus Liebig University Giessen, Aulweg 123, 35395 Giessen, Germany","institution_ids":["https://openalex.org/I200763008"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I200763008"],"apc_list":{"value":5250,"currency":"USD","value_usd":5250},"apc_paid":null,"fwci":4.3759,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.94200145,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"51","issue":"1","first_page":"255","last_page":"261"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13313","display_name":"Dupuytren's Contracture and Treatments","score":0.8119999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13313","display_name":"Dupuytren's Contracture and Treatments","score":0.8119999766349792,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.06480000168085098,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11815","display_name":"Urological Disorders and Treatments","score":0.061900001019239426,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peyronie-s-disease","display_name":"Peyronie's disease","score":1.0},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8090000152587891},{"id":"https://openalex.org/keywords/smad-transcription-factors","display_name":"Smad transcription factors","score":0.8870000243186951},{"id":"https://openalex.org/keywords/smad3","display_name":"Smad3","score":0.9470000267028809},{"id":"https://openalex.org/keywords/smad4","display_name":"SMAD4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/smad2-3-nuclear-translocation","display_name":"Smad2/3 nuclear translocation","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tunica-albuginea","display_name":"tunica albuginea","score":0.8809999823570251},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.6869999766349792},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.6639999747276306}],"concepts":[{"id":"https://openalex.org/C2779145901","wikidata":"https://www.wikidata.org/wiki/Q874586","display_name":"Peyronie's disease","level":3,"score":0.9841282367706299},{"id":"https://openalex.org/C2781080636","wikidata":"https://www.wikidata.org/wiki/Q700000","display_name":"SMAD","level":3,"score":0.8325159549713135},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.7157686948776245},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7078567147254944},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.603452205657959},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.5914467573165894},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5611861348152161},{"id":"https://openalex.org/C2780350170","wikidata":"https://www.wikidata.org/wiki/Q7853103","display_name":"Tunica albuginea (penis)","level":3,"score":0.49654799699783325},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44019052386283875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4275066554546356},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.4256942868232727},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4083299934864044},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34742099046707153},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2604265809059143},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1868586540222168},{"id":"https://openalex.org/C2777786686","wikidata":"https://www.wikidata.org/wiki/Q58","display_name":"Penis","level":2,"score":0.11626726388931274},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.09795570373535156},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09624883532524109},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010411","descriptor_name":"Penile Induration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010413","descriptor_name":"Penis","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051900","descriptor_name":"Smad3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051901","descriptor_name":"Smad4 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.eururo.2006.05.002","doi":"https://doi.org/10.1016/j.eururo.2006.05.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.eururo.2006.05.002","pdf_url":null,"source":{"id":"https://openalex.org/S96871409","display_name":"European Urology","issn_l":"0302-2838","issn":["0302-2838","1421-993X","1873-7560"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Urology","raw_type":"journal-article"},{"id":"pmid:16782264","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16782264","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European urology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1636022999","https://openalex.org/W1989052193","https://openalex.org/W2010229018","https://openalex.org/W2018454809","https://openalex.org/W2027064430","https://openalex.org/W2029954991","https://openalex.org/W2033243834","https://openalex.org/W2035653659","https://openalex.org/W2063474948","https://openalex.org/W2091620221","https://openalex.org/W2092109362","https://openalex.org/W2116902092","https://openalex.org/W2117701700","https://openalex.org/W2119180373","https://openalex.org/W2141486934","https://openalex.org/W4253606585"],"related_works":["https://openalex.org/W106989259","https://openalex.org/W2119180373","https://openalex.org/W2080401480","https://openalex.org/W2054595128","https://openalex.org/W2810956018","https://openalex.org/W1978577414","https://openalex.org/W2792871440","https://openalex.org/W2004918684","https://openalex.org/W2124313358","https://openalex.org/W2334785913"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}