{"id":"https://openalex.org/W2020690629","doi":"https://doi.org/10.1002/jnr.20836","title":"Temporal responses in the disruption of iron regulation by manganese","display_name":"Temporal responses in the disruption of iron regulation by manganese","publication_year":2006,"publication_date":"2006-03-27","ids":{"openalex":"https://openalex.org/W2020690629","doi":"https://doi.org/10.1002/jnr.20836","mag":"2020690629","pmid":"https://pubmed.ncbi.nlm.nih.gov/16568477"},"language":"en","primary_location":{"id":"doi:10.1002/jnr.20836","doi":"https://doi.org/10.1002/jnr.20836","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jnr.20836","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067204793","display_name":"Catherine L. Kwik-Uribe","orcid":"https://orcid.org/0000-0001-5684-039X","observed_orcids":["https://orcid.org/0000-0001-5684-039X"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Kwik\u2010Uribe","raw_affiliation_strings":["Department of Environmental Toxicology, University of California, Santa Cruz, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Toxicology, University of California, Santa Cruz, California, USA","institution_ids":["https://openalex.org/I185103710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074940124","display_name":"Donald R. Smith","orcid":"https://orcid.org/0000-0002-4919-1042","observed_orcids":["https://orcid.org/0000-0002-4919-1042"]},"institutions":[{"id":"https://openalex.org/I185103710","display_name":"University of California, Santa Cruz","ror":"https://ror.org/03s65by71","country_code":"US","type":"education","lineage":["https://openalex.org/I185103710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald R. Smith","raw_affiliation_strings":["Department of Environmental Toxicology, University of California, Santa Cruz, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Toxicology, University of California, Santa Cruz, California","institution_ids":["https://openalex.org/I185103710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I185103710"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":2.2816,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.85171126,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"83","issue":"8","first_page":"1601","last_page":"1610"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9496999979019165,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.04560000076889992,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/manganese-neurotoxicity","display_name":"manganese neurotoxicity","score":0.8769999742507935},{"id":"https://openalex.org/keywords/manganese-exposure","display_name":"manganese exposure","score":0.6629999876022339},{"id":"https://openalex.org/keywords/iron-homeostasis","display_name":"iron homeostasis","score":0.7680000066757202},{"id":"https://openalex.org/keywords/iron-regulatory-proteins","display_name":"iron regulatory proteins","score":0.8330000042915344},{"id":"https://openalex.org/keywords/transferrin-receptor","display_name":"transferrin receptor","score":0.9929999709129333},{"id":"https://openalex.org/keywords/ferritin","display_name":"ferritin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitochondrial-aconitase","display_name":"mitochondrial aconitase","score":0.9160000085830688},{"id":"https://openalex.org/keywords/labile-iron","display_name":"labile iron","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.8140000104904175},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.6620000004768372},{"id":"https://openalex.org/keywords/exposure-duration","display_name":"exposure duration","score":0.5720000267028809},{"id":"https://openalex.org/keywords/compensatory-response","display_name":"compensatory response","score":0.6259999871253967}],"concepts":[{"id":"https://openalex.org/C528890316","wikidata":"https://www.wikidata.org/wiki/Q731","display_name":"Manganese","level":2,"score":0.9192488193511963},{"id":"https://openalex.org/C2778319317","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Ferritin","level":2,"score":0.767002522945404},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6247276067733765},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6182208061218262},{"id":"https://openalex.org/C32264632","wikidata":"https://www.wikidata.org/wiki/Q1134983","display_name":"Transferrin receptor","level":3,"score":0.5693700909614563},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5420668125152588},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.49121659994125366},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.473020076751709},{"id":"https://openalex.org/C22814914","wikidata":"https://www.wikidata.org/wiki/Q410473","display_name":"Transferrin","level":2,"score":0.45508697628974915},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38956037163734436},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3855924606323242},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35589247941970825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2849460244178772},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000154","descriptor_name":"Aconitate Hydratase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005293","descriptor_name":"Ferritins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007424","descriptor_name":"Intracellular Fluid","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007424","descriptor_name":"Intracellular Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011990","descriptor_name":"Receptors, Transferrin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011990","descriptor_name":"Receptors, Transferrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015636","descriptor_name":"Magnesium Chloride","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020149","descriptor_name":"Manganese Poisoning","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035941","descriptor_name":"Iron Regulatory Protein 1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D035941","descriptor_name":"Iron Regulatory Protein 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035942","descriptor_name":"Iron Regulatory Protein 2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D035942","descriptor_name":"Iron Regulatory Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jnr.20836","doi":"https://doi.org/10.1002/jnr.20836","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jnr.20836","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},{"id":"pmid:16568477","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16568477","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroscience research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5895875523","display_name":null,"funder_award_id":"ES 010788","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G7071047706","display_name":null,"funder_award_id":"F32 ES/NS05936-01","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G8802593550","display_name":"Role of Manganese in Neurodegenrative Disease","funder_award_id":"R01ES010788","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W13199988","https://openalex.org/W38866710","https://openalex.org/W207389187","https://openalex.org/W1237982461","https://openalex.org/W1248810041","https://openalex.org/W1507286155","https://openalex.org/W1511974550","https://openalex.org/W1557916203","https://openalex.org/W1597336164","https://openalex.org/W1603713494","https://openalex.org/W1844080681","https://openalex.org/W1943372705","https://openalex.org/W1965857385","https://openalex.org/W1979832635","https://openalex.org/W1985841747","https://openalex.org/W1996988384","https://openalex.org/W2002450298","https://openalex.org/W2009619647","https://openalex.org/W2017107298","https://openalex.org/W2021505809","https://openalex.org/W2025403494","https://openalex.org/W2028075356","https://openalex.org/W2036330482","https://openalex.org/W2039142811","https://openalex.org/W2044523838","https://openalex.org/W2046663690","https://openalex.org/W2053188966","https://openalex.org/W2056459247","https://openalex.org/W2060458138","https://openalex.org/W2061606022","https://openalex.org/W2069702585","https://openalex.org/W2074700700","https://openalex.org/W2082567923","https://openalex.org/W2122130406","https://openalex.org/W2141319776","https://openalex.org/W2155506096","https://openalex.org/W2158347535","https://openalex.org/W2163905055","https://openalex.org/W2167860376","https://openalex.org/W2290851825","https://openalex.org/W2330436374","https://openalex.org/W2339241266","https://openalex.org/W3123172076"],"related_works":["https://openalex.org/W2021505809","https://openalex.org/W2779611247","https://openalex.org/W2044523838","https://openalex.org/W2114341050","https://openalex.org/W3010728570","https://openalex.org/W2030348183","https://openalex.org/W2784052446","https://openalex.org/W3170413859","https://openalex.org/W2061606022","https://openalex.org/W2373250967"],"abstract_inverted_index":{"Manganese":[0,134,223],"(Mn)":[1],"is":[2,12],"an":[3,189,234],"essential":[4],"trace":[5],"element,":[6],"though":[7],"at":[8,30,126],"elevated":[9,93],"exposures":[10,32,221],"it":[11],"also":[13],"a":[14,25,65,106,205],"neurotoxicant.":[15],"Several":[16],"mechanisms":[17],"underlying":[18],"manganese":[19,47,68,94,103,127,171,187,239],"toxicity":[20],"have":[21],"been":[22,35],"investigated,":[23],"although":[24,173],"consistent":[26],"mechanism(s)":[27],"of":[28,44,67,112,139,146,153,164,183,238],"action":[29],"low":[31,130,218],"has":[33],"not":[34],"fully":[36],"elucidated.":[37],"Here":[38],"we":[39],"systematically":[40],"evaluated":[41],"the":[42,89,137,143,150,199],"effects":[43,117,184],"in":[45,60,224],"vitro":[46,225],"exposure":[48,69,79,95,104,124,135],"on":[49],"intracellular":[50,144],"iron":[51,98,114,166,176,195,229],"(Fe)":[52],"homeostasis":[53],"and":[54,74,78,84,108,125,142,148,157],"iron-regulatory":[55],"protein":[56,160],"(IRP)":[57],"binding":[58,141],"activity":[59],"undifferentiated":[61],"PC12":[62],"cells":[63,200],"over":[64],"range":[66],"concentrations":[70],"(1,":[71],"10,":[72],"50,":[73],"200":[75],"microM":[76],"MnCl(2))":[77],"durations":[80],"(12,":[81],"24,":[82],"36,":[83],"48":[85],"hr),":[86],"to":[87,194,197,203,219,222],"test":[88],"hypothesis":[90],"that":[91,102,186,216],"moderately":[92],"disrupts":[96],"cellular":[97,113,151,175,191,228],"regulation.":[99],"Results":[100],"demonstrate":[101],"produces":[105],"rapid":[107],"sustained":[109],"dose-dependent":[110],"dysregulation":[111],"metabolism,":[115,230],"with":[116,170,209],"occurring":[118],"as":[119,121,129,131],"early":[120],"12":[122],"hr":[123],"doses":[128],"1":[132],"microM.":[133],"altered":[136,149],"dynamics":[138],"IRP-1":[140],"abundance":[145,152],"IRP-2,":[147],"transferrin":[154],"receptor,":[155],"ferritin,":[156],"mitochondrial":[158],"aconitase":[159],"levels.":[161],"Cellular":[162],"levels":[163,177],"labile":[165],"were":[167,178,201],"significantly":[168,226],"increased":[169],"exposure,":[172],"total":[174],"not.":[179],"The":[180],"overall":[181],"pattern":[182],"shows":[185],"produced":[188],"inappropriate":[190],"response":[192],"akin":[193],"deficiency,":[196],"which":[198,231],"able":[202],"mount":[204],"compensatory":[206],"response.":[207],"Consistent":[208],"our":[210],"previous":[211],"studies,":[212],"these":[213],"data":[214],"indicate":[215],"even":[217],"moderate":[220],"disrupt":[227],"may":[232],"be":[233],"important":[235],"contributory":[236],"mechanism":[237],"neurotoxicity.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
