{"id":"https://openalex.org/W2020689971","doi":"https://doi.org/10.1002/jps.2600720611","title":"Simultaneous Assay of Thioridazine and Its Major Metabolites in Plasma at Single Dosage Levels with a Novel Report of Two Ring Sulfoxides of Thioridazine","display_name":"Simultaneous Assay of Thioridazine and Its Major Metabolites in Plasma at Single Dosage Levels with a Novel Report of Two Ring Sulfoxides of Thioridazine","publication_year":1983,"publication_date":"1983-06-01","ids":{"openalex":"https://openalex.org/W2020689971","doi":"https://doi.org/10.1002/jps.2600720611","mag":"2020689971","pmid":"https://pubmed.ncbi.nlm.nih.gov/6875822"},"language":"en","primary_location":{"id":"doi:10.1002/jps.2600720611","doi":"https://doi.org/10.1002/jps.2600720611","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jps.2600720611","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029627097","display_name":"Clyde E. Wells","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Clyde E. Wells","raw_affiliation_strings":["National Center for Drug Analysis, Food and Drug Administration, St. Louis, MO 63101"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Drug Analysis, Food and Drug Administration, St. Louis, MO 63101","institution_ids":["https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001285244","display_name":"Eric C. Juenge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric C. Juenge","raw_affiliation_strings":["National Center for Drug Analysis, Food and Drug Administration, St. Louis, MO 63101"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Drug Analysis, Food and Drug Administration, St. Louis, MO 63101","institution_ids":["https://openalex.org/I1320320070"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059418071","display_name":"William B. Furman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William B. Furman","raw_affiliation_strings":["National Center for Drug Analysis, Food and Drug Administration, St. Louis, MO 63101"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Drug Analysis, Food and Drug Administration, St. Louis, MO 63101","institution_ids":["https://openalex.org/I1320320070"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029627097"],"corresponding_institution_ids":["https://openalex.org/I1320320070"],"apc_list":{"value":3620,"currency":"USD","value_usd":3620},"apc_paid":null,"fwci":3.2188,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.90535525,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"6","first_page":"622","last_page":"625"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.4982999861240387,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.4982999861240387,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.4880000054836273,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thioridazine","display_name":"thioridazine","score":1.0},{"id":"https://openalex.org/keywords/plasma-drug-determination","display_name":"plasma drug determination","score":0.7039999961853027},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.7260000109672546},{"id":"https://openalex.org/keywords/fluorometric-detection","display_name":"fluorometric determination","score":0.9850000143051147},{"id":"https://openalex.org/keywords/high-performance-liquid-chromatography","display_name":"HPLC","score":0.5320000052452087},{"id":"https://openalex.org/keywords/single-dose-pharmacokinetics","display_name":"single-dose pharmacokinetics","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C2780688371","wikidata":"https://www.wikidata.org/wiki/Q58375","display_name":"Thioridazine","level":3,"score":0.9850246906280518},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7854411602020264},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6968926191329956},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.514253556728363},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.4868830740451813},{"id":"https://openalex.org/C2778448320","wikidata":"https://www.wikidata.org/wiki/Q408395","display_name":"Sulfoxide","level":2,"score":0.4602344036102295},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4347047805786133},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34604930877685547},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15235239267349243},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08166095614433289},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06545078754425049},{"id":"https://openalex.org/C2778775820","wikidata":"https://www.wikidata.org/wiki/Q407972","display_name":"Chlorpromazine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003499","descriptor_name":"Cyclic S-Oxides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003499","descriptor_name":"Cyclic S-Oxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008653","descriptor_name":"Mesoridazine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013881","descriptor_name":"Thioridazine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013881","descriptor_name":"Thioridazine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jps.2600720611","doi":"https://doi.org/10.1002/jps.2600720611","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jps.2600720611","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmid:6875822","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6875822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmaceutical sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1972040732","https://openalex.org/W1978097226","https://openalex.org/W1985719542","https://openalex.org/W1986885846","https://openalex.org/W1989502120","https://openalex.org/W2011710616","https://openalex.org/W2102381323","https://openalex.org/W2113973316","https://openalex.org/W2127611493","https://openalex.org/W2131224567","https://openalex.org/W2146856256","https://openalex.org/W2313764802","https://openalex.org/W2338438296"],"related_works":["https://openalex.org/W1982981487","https://openalex.org/W2612008454","https://openalex.org/W2463372599","https://openalex.org/W2030307706","https://openalex.org/W1985719542","https://openalex.org/W1993164440","https://openalex.org/W2049800934","https://openalex.org/W2127611493","https://openalex.org/W4417313680","https://openalex.org/W2082071156"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}