{"id":"https://openalex.org/W2020678474","doi":"https://doi.org/10.1074/jbc.m406224200","title":"Identification of a Zinc Finger Domain in the Human NEIL2 (Nei-like-2) Protein","display_name":"Identification of a Zinc Finger Domain in the Human NEIL2 (Nei-like-2) Protein","publication_year":2004,"publication_date":"2004-09-01","ids":{"openalex":"https://openalex.org/W2020678474","doi":"https://doi.org/10.1074/jbc.m406224200","mag":"2020678474","pmid":"https://pubmed.ncbi.nlm.nih.gov/15339932"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m406224200","doi":"https://doi.org/10.1074/jbc.m406224200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m406224200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m406224200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081204904","display_name":"Aditi Das","orcid":"https://orcid.org/0000-0002-6731-6726","observed_orcids":["https://orcid.org/0000-0002-6731-6726"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aditi Das","raw_affiliation_strings":["Sealy Center for Molecular Science and Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555-1079, USA","Sealy Center for Molecular Science and Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555-1079"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sealy Center for Molecular Science and Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555-1079, USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Sealy Center for Molecular Science and Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555-1079","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000437384","display_name":"Lavanya Rajagopalan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lavanya Rajagopalan","raw_affiliation_strings":["Sealy Center for Molecular Science and Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555-1079"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sealy Center for Molecular Science and Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555-1079","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075392671","display_name":"Venkatarajan Subramanian Mathura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59283426","display_name":"Roskamp Institute","ror":"https://ror.org/02b10nq15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I59283426"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Venkatarajan S. Mathura","raw_affiliation_strings":["Roskamp Institute, Sarasota, Florida 34243","Roskamp Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roskamp Institute, Sarasota, Florida 34243","institution_ids":["https://openalex.org/I59283426"]},{"raw_affiliation_string":"Roskamp Institute","institution_ids":["https://openalex.org/I59283426"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037407925","display_name":"Samuel J. Rigby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150209017","display_name":"Scripps Institution of Oceanography","ror":"https://ror.org/04v7hvq31","country_code":"US","type":"facility","lineage":["https://openalex.org/I150209017","https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel J. Rigby","raw_affiliation_strings":["Department of Geology, Scripps Institution of Oceanography, La Jolla, California 92093"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geology, Scripps Institution of Oceanography, La Jolla, California 92093","institution_ids":["https://openalex.org/I150209017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082029120","display_name":"SANKAR P. MITRA","orcid":"https://orcid.org/0000-0002-9053-8589","observed_orcids":["https://orcid.org/0000-0002-9053-8589"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sankar Mitra","raw_affiliation_strings":["Sealy Center for Molecular Science and Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555-1079"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sealy Center for Molecular Science and Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555-1079","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061702912","display_name":"Tapas K. Hazra","orcid":"https://orcid.org/0000-0002-4587-687X","observed_orcids":["https://orcid.org/0000-0002-4587-687X"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tapas K. Hazra","raw_affiliation_strings":["Sealy Center for Molecular Science and Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555-1079"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sealy Center for Molecular Science and Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555-1079","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5061702912"],"corresponding_institution_ids":["https://openalex.org/I55302922"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.6465,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.81476306,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"279","issue":"45","first_page":"47132","last_page":"47138"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7792999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7792999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.1363999992609024,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.028300000354647636,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neil2","display_name":"NEIL2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/zinc-finger","display_name":"zinc finger","score":0.7799999713897705},{"id":"https://openalex.org/keywords/zinc-binding","display_name":"zinc binding","score":0.5640000104904175},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.9929999709129333},{"id":"https://openalex.org/keywords/protein-secondary-structure","display_name":"protein secondary structure","score":0.5609999895095825},{"id":"https://openalex.org/keywords/dna-binding-activity","display_name":"DNA-binding activity","score":0.6899999976158142},{"id":"https://openalex.org/keywords/enzyme-inactivation","display_name":"enzyme inactivation","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.712690532207489},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6907463073730469},{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.53199702501297},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.48777323961257935},{"id":"https://openalex.org/C186055190","wikidata":"https://www.wikidata.org/wiki/Q24788168","display_name":"RING finger domain","level":5,"score":0.45549261569976807},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4514164924621582},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4110400080680847},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2337726652622223},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16924288868904114},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.09780079126358032},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08040791749954224},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.06257638335227966},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.060876548290252686},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014498","descriptor_name":"Uracil","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014498","descriptor_name":"Uracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016335","descriptor_name":"Zinc Fingers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043603","descriptor_name":"DNA-(Apurinic or Apyrimidinic Site) Lyase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045647","descriptor_name":"DNA Glycosylases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D045647","descriptor_name":"DNA Glycosylases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m406224200","doi":"https://doi.org/10.1074/jbc.m406224200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m406224200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:15339932","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15339932","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m406224200","doi":"https://doi.org/10.1074/jbc.m406224200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m406224200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6608250270","display_name":"Repair of Oxidized Bases in Mammalian Genomes","funder_award_id":"R01CA081063","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000887026","display_name":"Structural Cell Biology of DNA Repair Machines","funder_award_id":"P01CA092584","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W110914021","https://openalex.org/W1488153834","https://openalex.org/W1511650223","https://openalex.org/W1531234455","https://openalex.org/W1605551606","https://openalex.org/W1845321470","https://openalex.org/W1953968639","https://openalex.org/W1966193664","https://openalex.org/W1977911529","https://openalex.org/W1985154852","https://openalex.org/W1986670774","https://openalex.org/W1992661805","https://openalex.org/W1998701978","https://openalex.org/W2000936373","https://openalex.org/W2002195659","https://openalex.org/W2005845638","https://openalex.org/W2016907728","https://openalex.org/W2017626786","https://openalex.org/W2019345165","https://openalex.org/W2023677185","https://openalex.org/W2030593751","https://openalex.org/W2031595029","https://openalex.org/W2038392802","https://openalex.org/W2042907868","https://openalex.org/W2042937673","https://openalex.org/W2053389329","https://openalex.org/W2064066975","https://openalex.org/W2068407072","https://openalex.org/W2074559096","https://openalex.org/W2082431983","https://openalex.org/W2084505555","https://openalex.org/W2089126365","https://openalex.org/W2090219305","https://openalex.org/W2091403301","https://openalex.org/W2110032853","https://openalex.org/W2113104146","https://openalex.org/W2125534385","https://openalex.org/W2140244239","https://openalex.org/W2142348616","https://openalex.org/W2142529984","https://openalex.org/W2149480059","https://openalex.org/W2158742644","https://openalex.org/W2159434963","https://openalex.org/W2160118680","https://openalex.org/W2161688851","https://openalex.org/W2163076785","https://openalex.org/W2163392206","https://openalex.org/W2168882862","https://openalex.org/W2397178761"],"related_works":["https://openalex.org/W1986670774","https://openalex.org/W4388722437","https://openalex.org/W1973345217","https://openalex.org/W1758398606","https://openalex.org/W1948839817","https://openalex.org/W1605551606","https://openalex.org/W4212934250","https://openalex.org/W2076875527","https://openalex.org/W2568806721","https://openalex.org/W3081765743"],"abstract_inverted_index":{"The":[0],"recently":[1],"identified":[2],"human":[3],"NEIL2":[4,36,56,84,143,180],"(Nei-like-2)":[5],"protein,":[6],"a":[7,41,125,146],"DNA":[8,26,110],"glycosylase/AP":[9],"lyase":[10],"specific":[11],"for":[12,101,183],"oxidatively":[13],"damaged":[14],"bases,":[15],"shares":[16],"structural":[17,185],"features":[18],"and":[19,29,97,114,124,187],"reaction":[20],"mechanism":[21],"with":[22],"the":[23,46,52,60,69,75,105,159,167,175],"Escherichia":[24],"coli":[25],"glycosylases,":[27],"Nei":[28],"Fpg.":[30],"Amino":[31],"acid":[32],"sequence":[33],"analysis":[34],"of":[35,55,64,68,77,81,93,142,169],"suggested":[37],"it":[38],"to":[39,120,144],"have":[40],"zinc":[42,61,82,151,176],"finger-like":[43],"Nei/Fpg.":[44],"However,":[45],"Cys-X2-His-X16-Cys-X2-Cys":[47],"(CHCC)":[48],"motif":[49,178],"present":[50],"near":[51],"C":[53],"terminus":[54],"is":[57,155,181],"distinct":[58],"from":[59],"finger":[62,177],"motifs":[63],"Nei/Fpg,":[65],"which":[66,154],"are":[67],"C4":[70],"type.":[71],"Here":[72],"we":[73],"show":[74],"presence":[76],"an":[78],"equimolar":[79],"amount":[80],"in":[83,128,149,179],"by":[85,107,134],"inductively":[86],"coupled":[87],"plasma":[88],"mass":[89],"spectrometry.":[90],"Individual":[91],"mutations":[92],"Cys-291,":[94],"His-295,":[95],"Cys-315,":[96],"Cys-318,":[98],"candidate":[99],"residues":[100],"coordinating":[102],"zinc,":[103,123],"inactivated":[104],"enzyme":[106,188],"abolishing":[108],"its":[109,150,184],"binding":[111,152],"activity.":[112,189],"H295A":[113],"C318S":[115],"mutants":[116],"were":[117],"also":[118],"shown":[119],"lack":[121],"bound":[122],"significant":[126],"change":[127],"their":[129],"secondary":[130],"structure":[131],"was":[132],"revealed":[133,140],"CD":[135],"spectra":[136],"analysis.":[137],"Molecular":[138],"modeling":[139],"Arg-310":[141],"be":[145],"critical":[147],"residue":[148],"pocket,":[153],"highly":[156],"conserved":[157],"throughout":[158],"Fpg/Nei":[160],"family.":[161],"A":[162],"R310Q":[163],"mutation":[164],"significantly":[165],"reduced":[166],"activity":[168],"NEIL2.":[170],"We":[171],"thereby":[172],"conclude":[173],"that":[174],"essential":[182],"integrity":[186]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}