{"id":"https://openalex.org/W2020666149","doi":"https://doi.org/10.1039/c1ob06496g","title":"Cyclopropane-based stereochemical diversity-oriented conformational restriction strategy: Histamine H 3 and/or H 4 receptor ligands with the 2,3-methanobutane backbone","display_name":"Cyclopropane-based stereochemical diversity-oriented conformational restriction strategy: Histamine H 3 and/or H 4 receptor ligands with the 2,3-methanobutane backbone","publication_year":2011,"publication_date":"2011-10-13","ids":{"openalex":"https://openalex.org/W2020666149","doi":"https://doi.org/10.1039/c1ob06496g","mag":"2020666149","pmid":"https://pubmed.ncbi.nlm.nih.gov/22120611"},"language":"en","primary_location":{"id":"doi:10.1039/c1ob06496g","doi":"https://doi.org/10.1039/c1ob06496g","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c1ob06496g","pdf_url":null,"source":{"id":"https://openalex.org/S179810352","display_name":"Organic & Biomolecular Chemistry","issn_l":"1477-0520","issn":["1477-0520","1477-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Org. Biomol. Chem.","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047370577","display_name":"Mizuki Watanabe","orcid":"https://orcid.org/0000-0001-7209-5713","observed_orcids":["https://orcid.org/0000-0001-7209-5713"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mizuki Watanabe","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takaaki Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takaaki Kobayashi","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027918582","display_name":"Takatsugu Hirokawa","orcid":"https://orcid.org/0000-0002-3180-5050","observed_orcids":["https://orcid.org/0000-0002-3180-5050"]},"institutions":[{"id":"https://openalex.org/I73613424","display_name":"National Institute of Advanced Industrial Science and Technology","ror":"https://ror.org/01703db54","country_code":"JP","type":"government","lineage":["https://openalex.org/I73613424"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takatsugu Hirokawa","raw_affiliation_strings":["Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Aomi, Koutou-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology, Aomi, Koutou-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I73613424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013873963","display_name":"Akira Yoshida","orcid":"https://orcid.org/0000-0002-5463-6114","observed_orcids":["https://orcid.org/0000-0002-5463-6114"]},"institutions":[{"id":"https://openalex.org/I1298590031","display_name":"Shizuoka University","ror":"https://ror.org/01w6wtk13","country_code":"JP","type":"education","lineage":["https://openalex.org/I1298590031"]},{"id":"https://openalex.org/I150240954","display_name":"University of Shizuoka","ror":"https://ror.org/04rvw0k47","country_code":"JP","type":"education","lineage":["https://openalex.org/I150240954"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Yoshida","raw_affiliation_strings":["Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE), School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE), School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Japan","institution_ids":["https://openalex.org/I1298590031","https://openalex.org/I150240954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102925769","display_name":"Yoshihiko Ito","orcid":"https://orcid.org/0000-0002-1563-8782","observed_orcids":["https://orcid.org/0000-0002-1563-8782"]},"institutions":[{"id":"https://openalex.org/I1298590031","display_name":"Shizuoka University","ror":"https://ror.org/01w6wtk13","country_code":"JP","type":"education","lineage":["https://openalex.org/I1298590031"]},{"id":"https://openalex.org/I150240954","display_name":"University of Shizuoka","ror":"https://ror.org/04rvw0k47","country_code":"JP","type":"education","lineage":["https://openalex.org/I150240954"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiko Ito","raw_affiliation_strings":["Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE), School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE), School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Japan","institution_ids":["https://openalex.org/I1298590031","https://openalex.org/I150240954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051609821","display_name":"Shizuo Yamada","orcid":"https://orcid.org/0000-0002-5915-9863","observed_orcids":["https://orcid.org/0000-0002-5915-9863"]},"institutions":[{"id":"https://openalex.org/I1298590031","display_name":"Shizuoka University","ror":"https://ror.org/01w6wtk13","country_code":"JP","type":"education","lineage":["https://openalex.org/I1298590031"]},{"id":"https://openalex.org/I150240954","display_name":"University of Shizuoka","ror":"https://ror.org/04rvw0k47","country_code":"JP","type":"education","lineage":["https://openalex.org/I150240954"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shizuo Yamada","raw_affiliation_strings":["Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE), School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence (COE), School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Japan","institution_ids":["https://openalex.org/I1298590031","https://openalex.org/I150240954"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073278560","display_name":"Naoki Orimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120269","display_name":"Taiho Pharmaceutical (Japan)","ror":"https://ror.org/02v50dx14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210120269"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoki Orimoto","raw_affiliation_strings":["Hanno Research Center, Taiho Pharmaceutical Co. Lrd., Misugidai, Hanno, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hanno Research Center, Taiho Pharmaceutical Co. Lrd., Misugidai, Hanno, Japan","institution_ids":["https://openalex.org/I4210120269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111554768","display_name":"Yasundo Yamasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120269","display_name":"Taiho Pharmaceutical (Japan)","ror":"https://ror.org/02v50dx14","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210120269"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasundo Yamasaki","raw_affiliation_strings":["Hanno Research Center, Taiho Pharmaceutical Co. Lrd., Misugidai, Hanno, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hanno Research Center, Taiho Pharmaceutical Co. Lrd., Misugidai, Hanno, Japan","institution_ids":["https://openalex.org/I4210120269"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014236394","display_name":"Mitsuhiro Arisawa","orcid":"https://orcid.org/0000-0002-7937-670X","observed_orcids":["https://orcid.org/0000-0002-7937-670X"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuhiro Arisawa","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036418983","display_name":"Satoshi Shuto","orcid":"https://orcid.org/0000-0001-7850-8064","observed_orcids":["https://orcid.org/0000-0001-7850-8064"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Satoshi Shuto","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, Japan","institution_ids":["https://openalex.org/I205349734"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5036418983"],"corresponding_institution_ids":["https://openalex.org/I205349734"],"apc_list":null,"apc_paid":null,"fwci":1.0524,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.7376181,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"4","first_page":"736","last_page":"745"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.35179999470710754,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.35179999470710754,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11611","display_name":"Cyclopropane Reaction Mechanisms","score":0.11129999905824661,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.11050000041723251,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclopropanes","display_name":"cyclopropanes","score":0.75},{"id":"https://openalex.org/keywords/conformational-restriction","display_name":"conformational restriction","score":0.9570000171661377},{"id":"https://openalex.org/keywords/stereochemical-diversity","display_name":"stereochemical diversity","score":0.8980000019073486},{"id":"https://openalex.org/keywords/histamine-h3-receptor","display_name":"histamine H3 receptor","score":0.9739999771118164},{"id":"https://openalex.org/keywords/histamine-h4-receptor","display_name":"histamine H4 receptor","score":1.0},{"id":"https://openalex.org/keywords/histamine-analogs","display_name":"histamine analogs","score":0.7820000052452087},{"id":"https://openalex.org/keywords/receptor-antagonists","display_name":"receptor antagonists","score":0.6539999842643738},{"id":"https://openalex.org/keywords/ligand-design","display_name":"ligand design","score":0.4880000054836273}],"concepts":[{"id":"https://openalex.org/C2779200411","wikidata":"https://www.wikidata.org/wiki/Q80250","display_name":"Cyclopropane","level":3,"score":0.9353918433189392},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8553632497787476},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.7778711915016174},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4731910228729248},{"id":"https://openalex.org/C2778717364","wikidata":"https://www.wikidata.org/wiki/Q134192","display_name":"Butane","level":3,"score":0.4722401797771454},{"id":"https://openalex.org/C63180777","wikidata":"https://www.wikidata.org/wiki/Q288395","display_name":"Histamine H3 receptor","level":4,"score":0.4670730233192444},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4596755802631378},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.4557184875011444},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.40798741579055786},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11273995041847229},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.10757631063461304},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.08935031294822693}],"mesh":[{"descriptor_ui":"D000074040","descriptor_name":"Receptors, Histamine H4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003521","descriptor_name":"Cyclopropanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003521","descriptor_name":"Cyclopropanes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011968","descriptor_name":"Receptors, Histamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017442","descriptor_name":"Histamine Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017442","descriptor_name":"Histamine Agonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018100","descriptor_name":"Receptors, Histamine H3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1039/c1ob06496g","doi":"https://doi.org/10.1039/c1ob06496g","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c1ob06496g","pdf_url":null,"source":{"id":"https://openalex.org/S179810352","display_name":"Organic & Biomolecular Chemistry","issn_l":"1477-0520","issn":["1477-0520","1477-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Org. Biomol. Chem.","raw_type":"journal-article"},{"id":"pmid:22120611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22120611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic & biomolecular chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4269421855","display_name":"Investigation of the mechanism of insulin secretion via Ca","funder_award_id":"23659049","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7610643194","display_name":"Useful \u03b2-turn mimetics having three-dimensional diversity","funder_award_id":"21390028","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8280259044","display_name":"Design and development of supported catalysts due to computational physics and experiments for save and reuse of rare elements for catalyst","funder_award_id":"23246013","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W334918","https://openalex.org/W193227735","https://openalex.org/W1825353903","https://openalex.org/W1964284609","https://openalex.org/W1965022564","https://openalex.org/W1972560726","https://openalex.org/W1973062644","https://openalex.org/W1982879175","https://openalex.org/W2003089715","https://openalex.org/W2027295410","https://openalex.org/W2028589398","https://openalex.org/W2033607465","https://openalex.org/W2035588083","https://openalex.org/W2044856625","https://openalex.org/W2068293422","https://openalex.org/W2073338384","https://openalex.org/W2077687762","https://openalex.org/W2080231167","https://openalex.org/W2080316208","https://openalex.org/W2085596664","https://openalex.org/W2092436603","https://openalex.org/W2093417059","https://openalex.org/W2095276358","https://openalex.org/W2104477830","https://openalex.org/W2114068014","https://openalex.org/W2139335899","https://openalex.org/W2141601357","https://openalex.org/W2149963584","https://openalex.org/W2162376680","https://openalex.org/W2406352893","https://openalex.org/W2949441422","https://openalex.org/W2951503991","https://openalex.org/W2951619792","https://openalex.org/W2952809771","https://openalex.org/W4236998915"],"related_works":["https://openalex.org/W1965022564","https://openalex.org/W2033607465","https://openalex.org/W2027295410","https://openalex.org/W2011495225","https://openalex.org/W2898181512","https://openalex.org/W2093417059","https://openalex.org/W2124231383","https://openalex.org/W1973100783","https://openalex.org/W1993545839","https://openalex.org/W3047508944"],"abstract_inverted_index":{"The":[0],"stereochemical":[1,191],"diversity-oriented":[2],"conformational":[3,178],"restriction":[4,179],"strategy":[5],"can":[6,201],"be":[7,128],"an":[8],"efficient":[9],"method":[10],"for":[11,15],"developing":[12],"specific":[13],"ligands":[14],"drug":[16],"target":[17],"proteins.":[18],"To":[19],"develop":[20],"potent":[21,97,130],"histamine":[22,35],"H(3)":[23,77,100,120,131],"and/or":[24],"H(4)":[25,83],"receptor":[26,101,121,132],"ligands,":[27],"a":[28,37,65,90,96,114,129,139,176,203],"series":[29],"of":[30,34,141,184,195,205],"conformationally":[31],"restricted":[32],"analogs":[33],"with":[36,143,208],"chiral":[38,59],"trans-":[39],"or":[40],"cis-4-amino-2,3-methano-1-(1H-imidazol-4-yl)butane":[41],"structure":[42],"was":[43,125],"designed":[44],"based":[45],"on":[46,148,154],"this":[47,198],"strategy.":[48],"These":[49],"stereochemically":[50],"diverse":[51],"compounds":[52,142,196,207],"were":[53,159],"synthesized":[54],"from":[55],"previously":[56,165],"developed":[57],"versatile":[58],"cyclopropane":[60,150,187],"units.":[61],"Among":[62],"these":[63,185],"analogs,":[64],"trans-cyclopropane-type":[66],"compound,":[67,92],"(2S,3R)-4-(4-chlorobenzylamino)-2,3-methano-1-(1H-imidazol-4-yl)butane":[68],"(5b),":[69],"has":[70],"remarkable":[71],"antagonistic":[72],"activity":[73],"to":[74,127,163],"both":[75],"the":[76,118,149,155,164,169,182,190],"(K(i)":[78,84,104,134],"=":[79,85,105,135],"4.4":[80],"nM)":[81,87],"and":[82,89,98,152,192],"5.5":[86],"receptors,":[88],"cis-cyclopropane-type":[91],"(2R,3R)-4-amino-2,3-methano-1-(1H-imidazol-4-yl)butane":[93],"(6a),":[94],"is":[95],"selective":[99],"partial":[102],"agonist":[103],"5.4":[106],"nM).":[107,137],"Although":[108],"(2S,3R)-4-amino-2,3-methano-1-(1H-imidazol-4-yl)butane":[109],"(5a)":[110],"does":[111],"not":[112],"have":[113],"hydrophobic":[115],"group":[116],"which":[117,200],"usual":[119],"antagonists":[122],"have,":[123],"it":[124],"found":[126],"antagonist":[133],"20.1":[136],"Thus,":[138],"variety":[140,204],"different":[144,209],"pharmacological":[145,210],"properties":[146],"depending":[147],"backbones":[151,188],"also":[153,172],"side-chain":[156],"functional":[157],"groups":[158],"identified.":[160],"In":[161],"addition":[162],"used":[166],"1,2-methanobutane":[167],"backbone,":[168],"2,3-methanobutane":[170],"backbone":[171],"worked":[173],"effectively":[174],"as":[175],"cyclopropane-based":[177],"structure.":[180],"Therefore,":[181],"combination":[183],"two":[186],"increases":[189],"three-dimensional":[193],"diversity":[194],"in":[197],"strategy,":[199],"provide":[202],"useful":[206],"properties.":[211]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}