{"id":"https://openalex.org/W2020663791","doi":"https://doi.org/10.1182/blood-2004-08-3036","title":"Both perforin and Fas ligand are required for the regulation of alloreactive CD8+ T cells during acute graft-versus-host disease","display_name":"Both perforin and Fas ligand are required for the regulation of alloreactive CD8+ T cells during acute graft-versus-host disease","publication_year":2004,"publication_date":"2004-10-06","ids":{"openalex":"https://openalex.org/W2020663791","doi":"https://doi.org/10.1182/blood-2004-08-3036","mag":"2020663791","pmid":"https://pubmed.ncbi.nlm.nih.gov/15466930"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2004-08-3036","doi":"https://doi.org/10.1182/blood-2004-08-3036","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2004-08-3036","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025889209","display_name":"Yoshinobu Maeda","orcid":"https://orcid.org/0000-0003-1634-5487","observed_orcids":["https://orcid.org/0000-0003-1634-5487"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Yoshinobu Maeda","raw_affiliation_strings":["From the Departments of Internal Medicine, and Pediatrics, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL; the Department of Pathology, University of Florida College of Medicine, Gainesville, FL; and the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL","the Department of Pathology, University of Florida College of Medicine, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine, and Pediatrics, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL; the Department of Pathology, University of Florida College of Medicine, Gainesville, FL; and the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I33213144","https://openalex.org/I4210097767","https://openalex.org/I4390039285"]},{"raw_affiliation_string":"the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","institution_ids":["https://openalex.org/I4210097767"]},{"raw_affiliation_string":"the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"the Department of Pathology, University of Florida College of Medicine, Gainesville, FL","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084690615","display_name":"Robert B. Levy","orcid":"https://orcid.org/0000-0003-3664-6578","observed_orcids":["https://orcid.org/0000-0003-3664-6578"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Robert B. Levy","raw_affiliation_strings":["From the Departments of Internal Medicine, and Pediatrics, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL; the Department of Pathology, University of Florida College of Medicine, Gainesville, FL; and the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL","the Department of Pathology, University of Florida College of Medicine, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine, and Pediatrics, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL; the Department of Pathology, University of Florida College of Medicine, Gainesville, FL; and the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I33213144","https://openalex.org/I4210097767","https://openalex.org/I4390039285"]},{"raw_affiliation_string":"the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","institution_ids":["https://openalex.org/I4210097767"]},{"raw_affiliation_string":"the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"the Department of Pathology, University of Florida College of Medicine, Gainesville, FL","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078441495","display_name":"Pavan R. Reddy","orcid":"https://orcid.org/0000-0001-7264-8429","observed_orcids":["https://orcid.org/0000-0001-7264-8429"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Pavan Reddy","raw_affiliation_strings":["From the Departments of Internal Medicine, and Pediatrics, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL; the Department of Pathology, University of Florida College of Medicine, Gainesville, FL; and the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL","the Department of Pathology, University of Florida College of Medicine, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine, and Pediatrics, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL; the Department of Pathology, University of Florida College of Medicine, Gainesville, FL; and the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I33213144","https://openalex.org/I4210097767","https://openalex.org/I4390039285"]},{"raw_affiliation_string":"the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","institution_ids":["https://openalex.org/I4210097767"]},{"raw_affiliation_string":"the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"the Department of Pathology, University of Florida College of Medicine, Gainesville, FL","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100322216","display_name":"Chen Liu","orcid":"https://orcid.org/0009-0003-0430-6146","observed_orcids":["https://orcid.org/0009-0003-0430-6146","https://orcid.org/0009-0008-6552-1719"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Chen Liu","raw_affiliation_strings":["From the Departments of Internal Medicine, and Pediatrics, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL; the Department of Pathology, University of Florida College of Medicine, Gainesville, FL; and the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL","the Department of Pathology, University of Florida College of Medicine, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine, and Pediatrics, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL; the Department of Pathology, University of Florida College of Medicine, Gainesville, FL; and the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I33213144","https://openalex.org/I4210097767","https://openalex.org/I4390039285"]},{"raw_affiliation_string":"the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","institution_ids":["https://openalex.org/I4210097767"]},{"raw_affiliation_string":"the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"the Department of Pathology, University of Florida College of Medicine, Gainesville, FL","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023237485","display_name":"Shawn G. Clouthier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Shawn G. Clouthier","raw_affiliation_strings":["From the Departments of Internal Medicine, and Pediatrics, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL; the Department of Pathology, University of Florida College of Medicine, Gainesville, FL; and the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL","the Department of Pathology, University of Florida College of Medicine, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine, and Pediatrics, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL; the Department of Pathology, University of Florida College of Medicine, Gainesville, FL; and the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I33213144","https://openalex.org/I4210097767","https://openalex.org/I4390039285"]},{"raw_affiliation_string":"the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","institution_ids":["https://openalex.org/I4210097767"]},{"raw_affiliation_string":"the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"the Department of Pathology, University of Florida College of Medicine, Gainesville, FL","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041455800","display_name":"Takanori Teshima","orcid":"https://orcid.org/0000-0002-0941-271X","observed_orcids":["https://orcid.org/0000-0002-0941-271X"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Takanori Teshima","raw_affiliation_strings":["From the Departments of Internal Medicine, and Pediatrics, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL; the Department of Pathology, University of Florida College of Medicine, Gainesville, FL; and the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL","the Department of Pathology, University of Florida College of Medicine, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine, and Pediatrics, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL; the Department of Pathology, University of Florida College of Medicine, Gainesville, FL; and the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I33213144","https://openalex.org/I4210097767","https://openalex.org/I4390039285"]},{"raw_affiliation_string":"the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","institution_ids":["https://openalex.org/I4210097767"]},{"raw_affiliation_string":"the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"the Department of Pathology, University of Florida College of Medicine, Gainesville, FL","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023099227","display_name":"James L.M. Ferrara","orcid":"https://orcid.org/0000-0001-8595-3940","observed_orcids":["https://orcid.org/0000-0001-8595-3940"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I4210097767","display_name":"Kyushu University Hospital","ror":"https://ror.org/00ex2fc97","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I135598925","https://openalex.org/I4210097767"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"James L. M. Ferrara","raw_affiliation_strings":["From the Departments of Internal Medicine, and Pediatrics, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL; the Department of Pathology, University of Florida College of Medicine, Gainesville, FL; and the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL","the Department of Pathology, University of Florida College of Medicine, Gainesville, FL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Internal Medicine, and Pediatrics, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI; the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL; the Department of Pathology, University of Florida College of Medicine, Gainesville, FL; and the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I33213144","https://openalex.org/I4210097767","https://openalex.org/I4390039285"]},{"raw_affiliation_string":"the Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan","institution_ids":["https://openalex.org/I4210097767"]},{"raw_affiliation_string":"the Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"the Department of Pathology, University of Florida College of Medicine, Gainesville, FL","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":2.091,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.86204958,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"105","issue":"5","first_page":"2023","last_page":"2027"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9375,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.05559999868273735,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perforin","display_name":"perforin","score":0.8230000138282776},{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":1.0},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9599999785423279},{"id":"https://openalex.org/keywords/alloreactivity","display_name":"alloreactivity","score":0.7580000162124634},{"id":"https://openalex.org/keywords/t-cell-homeostasis","display_name":"T cell homeostasis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/t-cell-contraction","display_name":"T cell contraction","score":0.8899999856948853},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.781000018119812},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8539999723434448},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/allogeneic-bone-marrow-transplantation","display_name":"allogeneic bone marrow transplantation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mhc-class-i-mismatch","display_name":"MHC class I mismatch","score":0.843999981880188},{"id":"https://openalex.org/keywords/t-cell-mediated-cytotoxicity","display_name":"T cell cytotoxicity","score":0.7820000052452087}],"concepts":[{"id":"https://openalex.org/C2776062744","wikidata":"https://www.wikidata.org/wiki/Q21103279","display_name":"Perforin","level":4,"score":0.8645575046539307},{"id":"https://openalex.org/C66008609","wikidata":"https://www.wikidata.org/wiki/Q14866113","display_name":"Fas ligand","level":4,"score":0.8124350905418396},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.7559791803359985},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.74946129322052},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5391630530357361},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5074953436851501},{"id":"https://openalex.org/C2779972918","wikidata":"https://www.wikidata.org/wiki/Q1194520","display_name":"Graft-versus-host disease","level":3,"score":0.49759843945503235},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36900416016578674},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.35517075657844543},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.30709660053253174},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2304467260837555},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17746049165725708},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.17465084791183472},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.1278696060180664},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.045627981424331665}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006648","descriptor_name":"Histocompatibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016026","descriptor_name":"Bone Marrow Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017710","descriptor_name":"Lymphocyte Transfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052899","descriptor_name":"Pore Forming Cytotoxic Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053222","descriptor_name":"Fas Ligand Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054353","descriptor_name":"Perforin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood-2004-08-3036","doi":"https://doi.org/10.1182/blood-2004-08-3036","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2004-08-3036","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:15466930","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15466930","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2378406364","display_name":null,"funder_award_id":"K08 AI052863-01","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G2428422459","display_name":null,"funder_award_id":"RR11576","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3117785939","display_name":null,"funder_award_id":"CA 49542","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4380987211","display_name":"ANIMAL MODEL TO STUDY THE ROLE OF CYTOTOXICITY IN GVHD","funder_award_id":"R01RR011576","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G495254849","display_name":"Mechanisms of IL-18 Mediated Regulation of GVHD and GVL","funder_award_id":"5k08ai052863-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G837354029","display_name":null,"funder_award_id":"AI 46689","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8803877893","display_name":"Allogeneic MiHA Induced Marrow Allograft Resistance","funder_award_id":"R01AI046689","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309249","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1482540117","https://openalex.org/W1497661870","https://openalex.org/W1502924554","https://openalex.org/W1518645086","https://openalex.org/W1544331058","https://openalex.org/W1617728256","https://openalex.org/W1920557811","https://openalex.org/W1966924980","https://openalex.org/W1973107648","https://openalex.org/W1984275656","https://openalex.org/W1991241987","https://openalex.org/W1992613163","https://openalex.org/W1998690402","https://openalex.org/W1999830963","https://openalex.org/W2008297993","https://openalex.org/W2010749211","https://openalex.org/W2021362028","https://openalex.org/W2027456984","https://openalex.org/W2050484752","https://openalex.org/W2053820487","https://openalex.org/W2054702356","https://openalex.org/W2056924500","https://openalex.org/W2064411005","https://openalex.org/W2065413461","https://openalex.org/W2067564880","https://openalex.org/W2068005505","https://openalex.org/W2071871975","https://openalex.org/W2087521550","https://openalex.org/W2088801927","https://openalex.org/W2093913291","https://openalex.org/W2122509690","https://openalex.org/W2122541507","https://openalex.org/W2138235536","https://openalex.org/W2153728526","https://openalex.org/W2154612583","https://openalex.org/W4256235973"],"related_works":["https://openalex.org/W2994453995","https://openalex.org/W2006703121","https://openalex.org/W2027456984","https://openalex.org/W2008297993","https://openalex.org/W2142713036","https://openalex.org/W2054702356","https://openalex.org/W2292012922","https://openalex.org/W2148661343","https://openalex.org/W2398419231","https://openalex.org/W2071871975"],"abstract_inverted_index":{"Fas":[0],"ligand":[1],"(FasL)":[2],"and":[3,44,81,86,106,143,151,166,170,174],"perforin":[4,43,173],"pathways":[5],"not":[6],"only":[7],"are":[8,18,39,176],"the":[9,28,125,179],"major":[10,57],"mechanisms":[11],"of":[12,23,68,78,127,181],"T":[13,25,36,71,94,112,130,138,162,184],"cell-mediated":[14],"cytotoxicity":[15],"but":[16],"also":[17],"involved":[19],"in":[20,41,55,123,149,152],"homeostatic":[21],"regulation":[22],"these":[24,155],"cells.":[26,185],"In":[27,134],"present":[29],"study,":[30],"we":[31],"tested":[32],"whether":[33],"CD8+":[34,70,111,129,137,161,183],"donor":[35,159],"cells":[37,72,95,113,131,139,163],"that":[38,158,171],"deficient":[40,48],"both":[42,172],"FasL":[45,175],"(cytotoxic":[46],"double":[47],"[cdd])":[49],"could":[50],"induce":[51],"graft-versus-host":[52],"disease":[53],"(GVHD)":[54],"a":[56,120],"histocompatibility":[58],"complex":[59],"class":[60],"I-mismatched":[61],"lethally":[62],"irradiated":[63],"murine":[64],"model.":[65],"Interestingly,":[66],"recipients":[67],"cdd":[69,136,160],"demonstrated":[73],"significantly":[74],"greater":[75],"serum":[76],"levels":[77],"interferon":[79],"gamma":[80],"tumor":[82],"necrosis":[83],"factor":[84],"alpha":[85],"histopathologic":[87],"damage":[88],"from":[89],"GVHD":[90],"than":[91],"wild-type":[92],"(wt)":[93],"on":[96],"day":[97],"30":[98],"after":[99,116],"allogeneic":[100],"bone":[101],"marrow":[102],"transplantation":[103,117],"(P<.05).":[104],"Wt":[105],"either":[107],"perforin-deficient":[108],"or":[109],"FasL-deficient":[110],"expanded":[114,128],"early":[115],"followed":[118],"by":[119],"contraction":[121,180],"phase":[122],"which":[124],"majority":[126],"were":[132],"eliminated.":[133],"contrast,":[135],"exhibited":[140],"prolonged":[141],"expansion":[142],"reduced":[144],"apoptosis":[145],"to":[146],"alloantigen":[147],"stimulation":[148],"vivo":[150],"vitro.":[153],"Together":[154],"results":[156],"suggest":[157],"expand":[164],"continuously":[165],"cause":[167],"lethal":[168],"GVHD,":[169],"required":[177],"for":[178],"allo-reactive":[182]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
