{"id":"https://openalex.org/W2020644346","doi":"https://doi.org/10.1016/j.etap.2006.04.001","title":"Effects of tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on the activation of ERK1/2 MAP kinases and the proliferation of human mammary epithelial cells","display_name":"Effects of tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on the activation of ERK1/2 MAP kinases and the proliferation of human mammary epithelial cells","publication_year":2006,"publication_date":"2006-05-05","ids":{"openalex":"https://openalex.org/W2020644346","doi":"https://doi.org/10.1016/j.etap.2006.04.001","mag":"2020644346","pmid":"https://pubmed.ncbi.nlm.nih.gov/21783722"},"language":"en","primary_location":{"id":"doi:10.1016/j.etap.2006.04.001","doi":"https://doi.org/10.1016/j.etap.2006.04.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.etap.2006.04.001","pdf_url":null,"source":{"id":"https://openalex.org/S108944336","display_name":"Environmental Toxicology and Pharmacology","issn_l":"1382-6689","issn":["1382-6689","1872-7077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Toxicology and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zhi-Bo Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111971639","display_name":"Qiqihar University","ror":"https://ror.org/01khf5d59","country_code":"CN","type":"education","lineage":["https://openalex.org/I111971639"]},{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhi-Bo Chen","raw_affiliation_strings":["College of Life Science, Jilin Univercity, Chang Chun 130023, PR China; College of Life Science and Engineering, Qiqihar Univercity, Qiqihar 161000, PR China","College of Life Science and Engineering, Qiqihar Univercity, Qiqihar 161000, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science, Jilin Univercity, Chang Chun 130023, PR China; College of Life Science and Engineering, Qiqihar Univercity, Qiqihar 161000, PR China","institution_ids":["https://openalex.org/I111971639","https://openalex.org/I194450716"]},{"raw_affiliation_string":"College of Life Science and Engineering, Qiqihar Univercity, Qiqihar 161000, PR China","institution_ids":["https://openalex.org/I111971639"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100353285","display_name":"Chang Liu","orcid":"https://orcid.org/0000-0002-7033-9478","observed_orcids":["https://orcid.org/0000-0002-7033-9478"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang Liu","raw_affiliation_strings":["College of Life Science, Jilin Univercity, Chang Chun 130023, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science, Jilin Univercity, Chang Chun 130023, PR China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061982381","display_name":"Feng-Qing Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103627","display_name":"BaiCheng Normal University","ror":"https://ror.org/01djkf495","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210103627"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng-Qing Chen","raw_affiliation_strings":["Department of Biology, Baicheng Teacher College, Baicheng 137000, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Baicheng Teacher College, Baicheng 137000, PR China","institution_ids":["https://openalex.org/I4210103627"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064978814","display_name":"Shanyu Li","orcid":"https://orcid.org/0000-0001-9794-008X","observed_orcids":["https://orcid.org/0000-0001-9794-008X"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan-Yu Li","raw_affiliation_strings":["College of Life Science, Jilin Univercity, Chang Chun 130023, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science, Jilin Univercity, Chang Chun 130023, PR China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qiao Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101936","display_name":"Central People's Hospital of Zhanjiang","ror":"https://ror.org/00zzrkp92","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101936"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiao Liang","raw_affiliation_strings":["Department of Pharmacy, Zhanjiang Central Hospital, Zhanjiang, Guangdong, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Zhanjiang Central Hospital, Zhanjiang, Guangdong, PR China","institution_ids":["https://openalex.org/I4210101936"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072994413","display_name":"Lanying Liu","orcid":"https://orcid.org/0000-0003-2477-4353","observed_orcids":["https://orcid.org/0000-0003-2477-4353"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lan-Ying Liu","raw_affiliation_strings":["College of Life Science, Jilin Univercity, Chang Chun 130023, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science, Jilin Univercity, Chang Chun 130023, PR China","institution_ids":["https://openalex.org/I194450716"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3540,"currency":"USD","value_usd":3540},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"22","issue":"3","first_page":"283","last_page":"291"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.4325999915599823,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.4325999915599823,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.24690000712871552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.050999999046325684,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nnk","display_name":"NNK","score":0.9700000286102295},{"id":"https://openalex.org/keywords/tobacco-specific-carcinogens","display_name":"tobacco-specific carcinogens","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mek1-2","display_name":"MEK1/2","score":0.9129999876022339},{"id":"https://openalex.org/keywords/mammary-epithelial-cell-proliferation","display_name":"mammary epithelial cell proliferation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/alpha7-nicotinic-acetylcholine-receptor","display_name":"alpha7 nicotinic acetylcholine receptor","score":0.875},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.7670000195503235},{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":0.7099999785423279},{"id":"https://openalex.org/keywords/atenolol","display_name":"atenolol","score":0.8100000023841858},{"id":"https://openalex.org/keywords/mecamylamine","display_name":"mecamylamine","score":0.8709999918937683},{"id":"https://openalex.org/keywords/alpha-bungarotoxin","display_name":"alpha-bungarotoxin","score":0.9190000295639038},{"id":"https://openalex.org/keywords/uo126","display_name":"UO126","score":0.8119999766349792},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5905359387397766},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5825149416923523},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5782230496406555},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5014348030090332},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.49801206588745117},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.4628666043281555},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.42234504222869873},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35878056287765503},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33896058797836304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30836188793182373},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18291857838630676}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.etap.2006.04.001","doi":"https://doi.org/10.1016/j.etap.2006.04.001","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.etap.2006.04.001","pdf_url":null,"source":{"id":"https://openalex.org/S108944336","display_name":"Environmental Toxicology and Pharmacology","issn_l":"1382-6689","issn":["1382-6689","1872-7077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Toxicology and Pharmacology","raw_type":"journal-article"},{"id":"pmid:21783722","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21783722","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental toxicology and pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W32456633","https://openalex.org/W135081402","https://openalex.org/W163148260","https://openalex.org/W392560602","https://openalex.org/W1257486597","https://openalex.org/W1494846231","https://openalex.org/W1557848513","https://openalex.org/W1580384359","https://openalex.org/W1593754635","https://openalex.org/W1794594157","https://openalex.org/W1902752790","https://openalex.org/W1969427066","https://openalex.org/W1969512053","https://openalex.org/W1981813507","https://openalex.org/W1988151751","https://openalex.org/W1994433769","https://openalex.org/W2022026458","https://openalex.org/W2033987148","https://openalex.org/W2035490871","https://openalex.org/W2041800958","https://openalex.org/W2052016477","https://openalex.org/W2070611230","https://openalex.org/W2071981236","https://openalex.org/W2085768679","https://openalex.org/W2087757403","https://openalex.org/W2098723642","https://openalex.org/W2100837269","https://openalex.org/W2108858077","https://openalex.org/W2110454012","https://openalex.org/W2112497917","https://openalex.org/W2118336444","https://openalex.org/W2120136426","https://openalex.org/W2120140063","https://openalex.org/W2136509556","https://openalex.org/W2141497758","https://openalex.org/W2154458783","https://openalex.org/W2157521137","https://openalex.org/W2159358964","https://openalex.org/W2159594827","https://openalex.org/W2160139329","https://openalex.org/W2165857243","https://openalex.org/W2281718990","https://openalex.org/W2415828970","https://openalex.org/W2432869290","https://openalex.org/W4232777855","https://openalex.org/W6677966177","https://openalex.org/W6695372340","https://openalex.org/W6717838523"],"related_works":["https://openalex.org/W2381508157","https://openalex.org/W2159358964","https://openalex.org/W7113556895","https://openalex.org/W1996480893","https://openalex.org/W2035490871","https://openalex.org/W2105891535","https://openalex.org/W2072966334","https://openalex.org/W2082369344","https://openalex.org/W595867533","https://openalex.org/W1580384359"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
