{"id":"https://openalex.org/W2020643760","doi":"https://doi.org/10.1158/1538-7445.am2013-1319","title":"Abstract 1319: Regulation of AR transcriptional activity and prostate cancer cellular proliferation by DACH1/Eya1/Six1 pathway.","display_name":"Abstract 1319: Regulation of AR transcriptional activity and prostate cancer cellular proliferation by DACH1/Eya1/Six1 pathway.","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2020643760","doi":"https://doi.org/10.1158/1538-7445.am2013-1319","mag":"2020643760"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2013-1319","doi":"https://doi.org/10.1158/1538-7445.am2013-1319","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-1319","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100378537","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0002-5398-0802","observed_orcids":["https://orcid.org/0000-0002-5398-0802","https://orcid.org/0000-0001-5412-9860"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I4210106595","display_name":"Sidney Kimmel Cancer Center","ror":"https://ror.org/010h6g454","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["1Thomas Jefferson Univ. Kimmel Cancer Ctr., Philadelphia, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Thomas Jefferson Univ. Kimmel Cancer Ctr., Philadelphia, PA;","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I4210106595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111884885","display_name":"Shaoxin Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I4210106595","display_name":"Sidney Kimmel Cancer Center","ror":"https://ror.org/010h6g454","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shaoxin Cai","raw_affiliation_strings":["1Thomas Jefferson Univ. Kimmel Cancer Ctr., Philadelphia, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Thomas Jefferson Univ. Kimmel Cancer Ctr., Philadelphia, PA;","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I4210106595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100451992","display_name":"Ke Chen","orcid":"https://orcid.org/0000-0002-2098-1921","observed_orcids":["https://orcid.org/0000-0002-2098-1921"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I4210106595","display_name":"Sidney Kimmel Cancer Center","ror":"https://ror.org/010h6g454","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ke Chen","raw_affiliation_strings":["1Thomas Jefferson Univ. Kimmel Cancer Ctr., Philadelphia, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Thomas Jefferson Univ. Kimmel Cancer Ctr., Philadelphia, PA;","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I4210106595"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sean Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean Li","raw_affiliation_strings":["2Boston Children's Hospital, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Boston Children's Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016235708","display_name":"Richard G. Pestell","orcid":"https://orcid.org/0000-0003-3244-8777","observed_orcids":["https://orcid.org/0000-0003-3244-8777"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I4210106595","display_name":"Sidney Kimmel Cancer Center","ror":"https://ror.org/010h6g454","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Pestell","raw_affiliation_strings":["1Thomas Jefferson Univ. Kimmel Cancer Ctr., Philadelphia, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Thomas Jefferson Univ. Kimmel Cancer Ctr., Philadelphia, PA;","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I4210106595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044031959","display_name":"Kongming Wu","orcid":"https://orcid.org/0000-0003-2499-1032","observed_orcids":["https://orcid.org/0000-0003-2499-1032"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I4210106595","display_name":"Sidney Kimmel Cancer Center","ror":"https://ror.org/010h6g454","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210106595"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kongming Wu","raw_affiliation_strings":["1Thomas Jefferson Univ. Kimmel Cancer Ctr., Philadelphia, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Thomas Jefferson Univ. Kimmel Cancer Ctr., Philadelphia, PA;","institution_ids":["https://openalex.org/I149251103","https://openalex.org/I4210106595"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"8_Supplement","first_page":"1319","last_page":"1319"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dach1","display_name":"DACH1","score":0.9599999785423279},{"id":"https://openalex.org/keywords/eya1","display_name":"EYA1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/six1","display_name":"Six1","score":0.996999979019165},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.9419999718666077},{"id":"https://openalex.org/keywords/androgen-signaling","display_name":"androgen signaling","score":0.718999981880188},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7300000190734863},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.492000013589859},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.6840000152587891},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.6909999847412109},{"id":"https://openalex.org/keywords/p300","display_name":"P300","score":0.5139999985694885},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.746999979019165},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.7704672813415527},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.7313169240951538},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.6278765797615051},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5817955732345581},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.5590951442718506},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5514906644821167},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.5503992438316345},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.540446400642395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5314138531684875},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.5277774333953857},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.41075006127357483},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40340089797973633},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3209466338157654},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3013771176338196},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.29755905270576477},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.29375773668289185},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1570979356765747},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12203547358512878},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.08690512180328369},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06884342432022095}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2013-1319","doi":"https://doi.org/10.1158/1538-7445.am2013-1319","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-1319","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7099225029","https://openalex.org/W2505794361","https://openalex.org/W2146843027","https://openalex.org/W2319131144","https://openalex.org/W2514430565","https://openalex.org/W2048352529","https://openalex.org/W2202414509","https://openalex.org/W1971982921","https://openalex.org/W1531847199","https://openalex.org/W2136780580"],"abstract_inverted_index":{"Abstract":[0],"Prostate":[1],"cancer":[2,287,313],"progression":[3],"from":[4],"androgen":[5,39,200,282],"responsive":[6,57,204],"to":[7,181],"androgen-depletion":[8],"therapy":[9],"resistance":[10],"is":[11],"a":[12,24,179],"major":[13,25],"cause":[14],"of":[15,52,61,64,83,93,102,135,150,155,167,195,215,219,233,270,307,322,327],"treatment":[16],"failures.":[17],"Novel":[18],"therapies":[19],"targeting":[20],"this":[21],"patient":[22],"are":[23],"clinical":[26],"challenge.":[27],"We":[28,85],"previously":[29,87],"reported":[30],"that":[31,89,277],"the":[32,43,50,71,100,145,156,225,228,234,242,251,278,323,328],"cell":[33,111,142],"fate":[34],"determination":[35],"factor":[36],"DACH1":[37,66,90,103,114,136,151,160,261,268],"inhibits":[38],"signaling":[40],"though":[41],"binding":[42],"AR":[44,56,62,222,235,244,271,308],"and":[45,74,126,164,174,185,224,253,284,290,311],"enhancing":[46],"co-repressor":[47,248],"recruitment":[48],"in":[49,104,122,140],"context":[51],"local":[53],"chromatin":[54],"at":[55,250],"genes.":[58],"The":[59,76],"repression":[60,77,226,269],"function":[63,176,249],"by":[65,70,80,130,316],"was":[67,78],"partly":[68],"rescued":[69],"co-activators":[72],"p300":[73],"SRC.":[75],"enhanced":[79,247],"ectopic":[81],"expression":[82,134,149],"HDACs.":[84],"had":[86],"shown":[88],"inhibited":[91,137,152,161,241],"proliferation":[92,139,289,315],"androgen-dependent":[94],"LnCAP":[95,205],"cells.":[96,159,170],"To":[97],"further":[98],"explore":[99],"significance":[101],"human":[105],"prostate":[106,286,312],"cancer,":[107],"we":[108,190],"established":[109],"stable":[110],"lines":[112],"expressing":[113],"or":[115,239],"its":[116],"DS":[117,146],"domain":[118],"deleted":[119],"mutant":[120],"(\u0394DS)":[121],"androgen-independent":[123,157],"C4-2":[124],"cells":[125,129],"AR-negative":[127,168],"PC-3":[128,169],"retrovirus":[131],"infection.":[132],"Stable":[133],"cellular":[138,183,288,314],"both":[141,281],"lines,":[143],"requiring":[144],"domain.":[147,231],"Ectopic":[148],"colony":[153],"formation":[154,187],"22RV1":[158],"migration,":[162],"invasion":[163],"tumor":[165],"growth":[166],"Since":[171],"DACH1,":[172],"Eya1":[173,220,246,266],"Six1":[175],"together":[177],"as":[178],"network":[180],"control":[182],"differentiation":[184],"organ":[186],"during":[188],"development,":[189],"examined":[191],"whether":[192],"other":[193],"components":[194],"RDGN":[196,279],"pathway,":[197],"could":[198],"regulate":[199],"signaling.":[201],"In":[202],"hormone":[203],"cells,":[206],"ligand":[207],"stimulation":[208],"(DHT,":[209],"50nM)":[210],"induced":[211],"17":[212],"folds":[213],"activation":[214],"MMTV":[216,254],"Luc,":[217],"co-expression":[218],"reduced":[221],"transactivation,":[223],"required":[227],"EYA":[229],"phophatase":[230],"Expressions":[232],"co-repressors,":[236],"HDAC1,":[237],"HDAC3":[238],"SirT1":[240],"ligand-induced":[243,263],"activity.":[245,272],"PSA":[252],"promoters.":[255],"Consistent":[256],"with":[257],"our":[258,274],"previous":[259],"publication,":[260],"repressed":[262],"activity":[264,310],">70%,":[265],"modified":[267],"Together,":[273],"studies":[275],"demonstrated":[276],"regulates":[280],"dependent":[283],"independent":[285],"tumorigenesis.":[291],"Citation":[292],"Format:":[293],"Jing":[294],"Wang,":[295],"Shaoxin":[296],"Cai,":[297],"Ke":[298],"Chen,":[299],"Sean":[300],"Li,":[301],"Richard":[302],"Pestell,":[303],"Kongming":[304],"Wu.":[305],"Regulation":[306],"transcriptional":[309],"DACH1/Eya1/Six1":[317],"pathway.":[318],"[abstract].":[319],"In:":[320],"Proceedings":[321],"104th":[324],"Annual":[325],"Meeting":[326],"American":[329],"Association":[330],"for":[331],"Cancer":[332,342],"Research;":[333],"2013":[334],"Apr":[335],"6-10;":[336],"Washington,":[337],"DC.":[338],"Philadelphia":[339],"(PA):":[340],"AACR;":[341],"Res":[343],"2013;73(8":[344],"Suppl):Abstract":[345],"nr":[346],"1319.":[347],"doi:10.1158/1538-7445.AM2013-1319":[348]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}
