{"id":"https://openalex.org/W2020622590","doi":"https://doi.org/10.1158/0008-5472.can-03-3309","title":"Identification of Aryl Hydrocarbon Receptor as a Putative Wnt/\u03b2-Catenin Pathway Target Gene in Prostate Cancer Cells","display_name":"Identification of Aryl Hydrocarbon Receptor as a Putative Wnt/\u03b2-Catenin Pathway Target Gene in Prostate Cancer Cells","publication_year":2004,"publication_date":"2004-04-01","ids":{"openalex":"https://openalex.org/W2020622590","doi":"https://doi.org/10.1158/0008-5472.can-03-3309","mag":"2020622590","pmid":"https://pubmed.ncbi.nlm.nih.gov/15059908"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-03-3309","doi":"https://doi.org/10.1158/0008-5472.can-03-3309","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-03-3309","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051209563","display_name":"Dennis R. Chesire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis R. Chesire","raw_affiliation_strings":["1Brady Urological Institute,","Brady Urological Institute, #N#Johns Hopkins Oncology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brady Urological Institute,","institution_ids":[]},{"raw_affiliation_string":"Brady Urological Institute, #N#Johns Hopkins Oncology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108678047","display_name":"Thomas A. Dunn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas A. Dunn","raw_affiliation_strings":["1Brady Urological Institute,","Brady Urological Institute, #N#Johns Hopkins Oncology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brady Urological Institute,","institution_ids":[]},{"raw_affiliation_string":"Brady Urological Institute, #N#Johns Hopkins Oncology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031539547","display_name":"Charles M. Ewing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles M. Ewing","raw_affiliation_strings":["1Brady Urological Institute,","Brady Urological Institute, #N#Johns Hopkins Oncology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brady Urological Institute,","institution_ids":[]},{"raw_affiliation_string":"Brady Urological Institute, #N#Johns Hopkins Oncology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077552075","display_name":"Jun Luo","orcid":"https://orcid.org/0000-0002-1414-473X","observed_orcids":["https://orcid.org/0000-0002-1414-473X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Luo","raw_affiliation_strings":["1Brady Urological Institute,","Brady Urological Institute, #N#Johns Hopkins Oncology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brady Urological Institute,","institution_ids":[]},{"raw_affiliation_string":"Brady Urological Institute, #N#Johns Hopkins Oncology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068348417","display_name":"William B. Isaacs","orcid":"https://orcid.org/0000-0001-6599-6775","observed_orcids":["https://orcid.org/0000-0001-6599-6775"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William B. Isaacs","raw_affiliation_strings":["1Brady Urological Institute,","2Johns Hopkins Oncology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland","Brady Urological Institute, #N#Johns Hopkins Oncology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Brady Urological Institute,","institution_ids":[]},{"raw_affiliation_string":"2Johns Hopkins Oncology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Brady Urological Institute, #N#Johns Hopkins Oncology Center, Johns Hopkins Medical Institutions, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1832,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.74672075,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"64","issue":"7","first_page":"2523","last_page":"2533"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":0.9980000257492065},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.949999988079071},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lapc4-cells","display_name":"LAPC4 cells","score":0.9649999737739563},{"id":"https://openalex.org/keywords/lithium-chloride","display_name":"lithium chloride","score":0.796999990940094},{"id":"https://openalex.org/keywords/wnt3a","display_name":"Wnt3a","score":0.7289999723434448},{"id":"https://openalex.org/keywords/dioxins","display_name":"dioxins","score":0.6399999856948853},{"id":"https://openalex.org/keywords/2-3-7-8-tetrachlorodibenzo-p-dioxin","display_name":"2,3,7,8-tetrachlorodibenzo-p-dioxin","score":0.9309999942779541},{"id":"https://openalex.org/keywords/nuclear-beta-catenin","display_name":"nuclear \u03b2-catenin","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.9096547365188599},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6639087796211243},{"id":"https://openalex.org/C33594762","wikidata":"https://www.wikidata.org/wiki/Q155750","display_name":"Aryl hydrocarbon receptor","level":4,"score":0.6317134499549866},{"id":"https://openalex.org/C2779131293","wikidata":"https://www.wikidata.org/wiki/Q18048098","display_name":"WNT3A","level":4,"score":0.529655396938324},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.520095705986023},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5162089467048645},{"id":"https://openalex.org/C2779324961","wikidata":"https://www.wikidata.org/wiki/Q1634046","display_name":"Beta-catenin","level":4,"score":0.5160812735557556},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.46512413024902344},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45814889669418335},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4562160074710846},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41998034715652466},{"id":"https://openalex.org/C93501484","wikidata":"https://www.wikidata.org/wiki/Q14913982","display_name":"TCF4","level":5,"score":0.418517529964447},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.37009844183921814},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2911853492259979},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12318876385688782},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.12315919995307922}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007739","descriptor_name":"L Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007739","descriptor_name":"L Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007739","descriptor_name":"L Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.can-03-3309","doi":"https://doi.org/10.1158/0008-5472.can-03-3309","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-03-3309","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:15059908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15059908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G582469399","display_name":null,"funder_award_id":"CA58236","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6257854233","display_name":"SPORE in Prostate Cancer","funder_award_id":"5p50ca058236-23","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W1509251446","https://openalex.org/W1554815317","https://openalex.org/W1556931007","https://openalex.org/W1817812480","https://openalex.org/W1965674043","https://openalex.org/W1967137553","https://openalex.org/W1968334101","https://openalex.org/W1969808979","https://openalex.org/W1970833195","https://openalex.org/W1970919014","https://openalex.org/W1971344122","https://openalex.org/W1972240614","https://openalex.org/W1974488680","https://openalex.org/W1974621567","https://openalex.org/W1975853332","https://openalex.org/W1976427653","https://openalex.org/W1979993283","https://openalex.org/W1981752846","https://openalex.org/W1988376244","https://openalex.org/W1990287298","https://openalex.org/W1991671544","https://openalex.org/W1993583152","https://openalex.org/W1999928710","https://openalex.org/W2002404925","https://openalex.org/W2004792595","https://openalex.org/W2010145074","https://openalex.org/W2011177690","https://openalex.org/W2017593144","https://openalex.org/W2022247770","https://openalex.org/W2022810442","https://openalex.org/W2023002592","https://openalex.org/W2024451865","https://openalex.org/W2029318868","https://openalex.org/W2032550191","https://openalex.org/W2033728702","https://openalex.org/W2034692872","https://openalex.org/W2043599946","https://openalex.org/W2056404812","https://openalex.org/W2060034746","https://openalex.org/W2062578421","https://openalex.org/W2064129352","https://openalex.org/W2064230641","https://openalex.org/W2067526109","https://openalex.org/W2069029149","https://openalex.org/W2076476669","https://openalex.org/W2078591745","https://openalex.org/W2082135441","https://openalex.org/W2086320165","https://openalex.org/W2090939833","https://openalex.org/W2098970296","https://openalex.org/W2102470051","https://openalex.org/W2102512718","https://openalex.org/W2103002602","https://openalex.org/W2108727531","https://openalex.org/W2109069210","https://openalex.org/W2111828251","https://openalex.org/W2112763851","https://openalex.org/W2117457278","https://openalex.org/W2118453722","https://openalex.org/W2129946268","https://openalex.org/W2133916339","https://openalex.org/W2139966647","https://openalex.org/W2140403106","https://openalex.org/W2143650397","https://openalex.org/W2144212847","https://openalex.org/W2144634347","https://openalex.org/W2146038288","https://openalex.org/W2146167376","https://openalex.org/W2147864074","https://openalex.org/W2157452165","https://openalex.org/W2159133430","https://openalex.org/W2164404916","https://openalex.org/W2166254889","https://openalex.org/W2171996338","https://openalex.org/W2184874063","https://openalex.org/W4253422011"],"related_works":["https://openalex.org/W2045695521","https://openalex.org/W2056404812","https://openalex.org/W2095283725","https://openalex.org/W2069736491","https://openalex.org/W2116718088","https://openalex.org/W2139966647","https://openalex.org/W2043144737","https://openalex.org/W2586687042","https://openalex.org/W145146781","https://openalex.org/W2741031341"],"abstract_inverted_index":{"Recent":[0],"genetic":[1],"and":[2,39,69,135,146,158,174,259],"functional":[3],"analyses":[4,160],"have":[5],"implicated":[6],"the":[7,23,41,165,168,219,228],"wnt/beta-catenin":[8,127,222,269],"signaling":[9,27,223,233,270],"pathway":[10,128],"in":[11,21,28,55,89,95,171,224,271],"prostate":[12,272],"cancer":[13],"(CaP)":[14],"pathogenesis.":[15],"Thus,":[16],"there":[17],"is":[18,33,40,194],"much":[19],"interest":[20],"understanding":[22],"consequences":[24],"of":[25,37,43,48,53,109,113,125,133,153,187,221,240,257],"wnt":[26,191,232],"CaP;":[29],"target":[30,101],"gene":[31,102],"expression":[32,104,132],"one":[34,265],"important":[35],"area":[36],"inquiry":[38],"focus":[42],"this":[44],"report.":[45],"Adenoviral-mediated":[46],"overexpression":[47,108],"a":[49,150,213],"mutant,":[50],"hyperactive":[51],"form":[52],"beta-catenin":[54,193,208],"CWR22-Rv1":[56,90],"CaP":[57,97,154,225],"cells":[58,91,114],"led":[59],"to":[60,163,230,243,255],"increased":[61,99],"aryl":[62],"hydrocarbon":[63],"receptor":[64],"(AhR,":[65],"or":[66,118,192],"dioxin":[67],"receptor)":[68],"transmembrane":[70,136],"protein":[71,137,144,176,199],"2":[72,138],"RNA":[73,103,189],"transcript":[74],"expression,":[75],"as":[76,92,94],"detected":[77],"by":[78,190],"cDNA-microarray":[79],"analyses.":[80],"Validating":[81],"these":[82,202],"results,":[83],"reverse":[84],"transcription-PCR":[85],"assays":[86],"demonstrated":[87,205],"that":[88,181,206],"well":[93],"LAPC-4":[96],"cells,":[98],"putative":[100],"occurs":[105],"with":[106,115,119,196,236],"transient":[107],"mutant":[110],"beta-catenin,":[111],"treatment":[112],"lithium":[116],"chloride,":[117],"wnt3a-conditioned":[120],"medium,":[121],"three":[122],"distinct":[123],"modes":[124],"experimental":[126],"activation.":[129],"This":[130],"beta-catenin-associated":[131],"AhR":[134,172,175,188,198,241,245,254],"does":[139],"not":[140,211],"require":[141],"de":[142],"novo":[143],"synthesis":[145],"may":[147,210,234,263],"only":[148],"involve":[149],"certain":[151],"subset":[152],"cell":[155],"lines.":[156],"Western":[157],"immunofluorescence":[159],"were":[161],"undertaken":[162],"assess":[164],"relationship":[166],"between":[167],"wnt/beta-catenin-stimulated":[169],"increase":[170],"transcripts":[173],"expression;":[177],"we":[178],"provide":[179],"evidence":[180],"an":[182,237],"association":[183],"exists":[184],"whereby":[185],"up-regulation":[186],"coupled":[195],"augmented":[197],"levels.":[200],"Intriguingly,":[201],"studies":[203],"also":[204],"nuclear":[207],"staining":[209],"be":[212],"sole":[214],"deciding":[215],"factor":[216],"when":[217],"predicting":[218],"status":[220],"cells.":[226],"Finally,":[227],"extent":[229],"which":[231],"synergize":[235],"environmental":[238],"agonist":[239],"(2,3,7,8-tetrachlorodibenzo-p-dioxin)":[242],"potentiate":[244],"transcriptional":[246],"activity":[247],"was":[248],"examined.":[249],"Considering":[250],"previous":[251],"work":[252],"linking":[253],"processes":[256],"development":[258],"carcinogenesis,":[260],"our":[261],"data":[262],"highlight":[264],"particular":[266],"role":[267],"for":[268],"tumor":[273],"biology.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}