{"id":"https://openalex.org/W2020601735","doi":"https://doi.org/10.1016/0024-3205(66)90036-1","title":"Acth induced changes in tryptophan turnover along induceable pathways in man","display_name":"Acth induced changes in tryptophan turnover along induceable pathways in man","publication_year":1966,"publication_date":"1966-07-01","ids":{"openalex":"https://openalex.org/W2020601735","doi":"https://doi.org/10.1016/0024-3205(66)90036-1","mag":"2020601735","pmid":"https://pubmed.ncbi.nlm.nih.gov/4290913"},"language":"en","primary_location":{"id":"doi:10.1016/0024-3205(66)90036-1","doi":"https://doi.org/10.1016/0024-3205(66)90036-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0024-3205(66)90036-1","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072784821","display_name":"Arnold J. Mandell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arnold J. Mandell","raw_affiliation_strings":["Biochemical Correlates Laboratory, The Neuropsychiatric Institute, University of California Center for the Health Sciences Los Angeles, California 90024, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemical Correlates Laboratory, The Neuropsychiatric Institute, University of California Center for the Health Sciences Los Angeles, California 90024, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004369157","display_name":"Robert T. Rub\u00edn","orcid":"https://orcid.org/0000-0002-0304-4303","observed_orcids":["https://orcid.org/0000-0002-0304-4303"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert T. Rubin","raw_affiliation_strings":["Biochemical Correlates Laboratory, The Neuropsychiatric Institute, University of California Center for the Health Sciences Los Angeles, California 90024, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemical Correlates Laboratory, The Neuropsychiatric Institute, University of California Center for the Health Sciences Los Angeles, California 90024, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":3810,"currency":"USD","value_usd":3810},"apc_paid":null,"fwci":2.0,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.83950617,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"13","first_page":"1153","last_page":"1161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.63919997215271,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.63919997215271,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.1388999968767166,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.1088000014424324,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.968999981880188},{"id":"https://openalex.org/keywords/glucocorticoid-induction","display_name":"glucocorticoid induction","score":0.8159999847412109},{"id":"https://openalex.org/keywords/enzyme-induction","display_name":"enzyme induction","score":0.9549999833106995},{"id":"https://openalex.org/keywords/tryptophan-metabolism","display_name":"tryptophan metabolism","score":0.8970000147819519}],"concepts":[{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.8581279516220093},{"id":"https://openalex.org/C195580219","wikidata":"https://www.wikidata.org/wiki/Q7251511","display_name":"Protein turnover","level":3,"score":0.6559341549873352},{"id":"https://openalex.org/C2908944834","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan Metabolism","level":4,"score":0.6288666725158691},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.5687950253486633},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5621914863586426},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.5615076422691345},{"id":"https://openalex.org/C26077564","wikidata":"https://www.wikidata.org/wiki/Q1910318","display_name":"Turnover","level":2,"score":0.4927535355091095},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49211543798446655},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4631376266479492},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42136067152023315},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37105873227119446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3359924554824829},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14153927564620972},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.1349048614501953},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.1344345510005951},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002247","descriptor_name":"Carbon Isotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006897","descriptor_name":"Hydroxyindoleacetic Acid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007210","descriptor_name":"Indoleacetic Acids","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007737","descriptor_name":"Kynurenine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015065","descriptor_name":"17-Hydroxycorticosteroids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015065","descriptor_name":"17-Hydroxycorticosteroids","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0024-3205(66)90036-1","doi":"https://doi.org/10.1016/0024-3205(66)90036-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0024-3205(66)90036-1","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},{"id":"pmid:4290913","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4290913","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W991319","https://openalex.org/W2521962","https://openalex.org/W32757146","https://openalex.org/W35912116","https://openalex.org/W156351032","https://openalex.org/W168614738","https://openalex.org/W194138430","https://openalex.org/W1811133374","https://openalex.org/W1878768299","https://openalex.org/W1909254787","https://openalex.org/W1974569863","https://openalex.org/W2036480355","https://openalex.org/W2078722540","https://openalex.org/W2402790929"],"related_works":["https://openalex.org/W2072831081","https://openalex.org/W2082459394","https://openalex.org/W2414625666","https://openalex.org/W2336390494","https://openalex.org/W2414538539","https://openalex.org/W2090346253","https://openalex.org/W2089223401","https://openalex.org/W1481219033","https://openalex.org/W2039540415","https://openalex.org/W2183846352"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}