{"id":"https://openalex.org/W2020586908","doi":"https://doi.org/10.1186/ar2813","title":"Tumor necrosis factor alpha-dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent aggrecanase activity in vitro","display_name":"Tumor necrosis factor alpha-dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent aggrecanase activity in vitro","publication_year":2009,"publication_date":"2009-09-24","ids":{"openalex":"https://openalex.org/W2020586908","doi":"https://doi.org/10.1186/ar2813","mag":"2020586908","pmid":"https://pubmed.ncbi.nlm.nih.gov/19778432","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2787293"},"language":"en","primary_location":{"id":"doi:10.1186/ar2813","doi":"https://doi.org/10.1186/ar2813","is_oa":true,"landing_page_url":"https://doi.org/10.1186/ar2813","pdf_url":"https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/ar2813","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research &amp; Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/ar2813","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026262119","display_name":"Henning Voigt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Henning Voigt","raw_affiliation_strings":["Institute of Anatomy, Christian-Albrechts-University Kiel, Olshausenstr. 40, Kiel, 24098, Germany. henning-voigt@web.de","Institute of Anatomy Christian Albrechts\u2010University Kiel Kiel Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, Christian-Albrechts-University Kiel, Olshausenstr. 40, Kiel, 24098, Germany. henning-voigt@web.de","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Institute of Anatomy Christian Albrechts\u2010University Kiel Kiel Germany","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110115837","display_name":"Angelika K. Lemke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Angelika K Lemke","raw_affiliation_strings":["Institute of Anatomy, Christian-Albrechts-University Kiel, Olshausenstr. 40, Kiel, 24098, Germany","Institute of Anatomy Christian Albrechts\u2010University Kiel Kiel Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, Christian-Albrechts-University Kiel, Olshausenstr. 40, Kiel, 24098, Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Institute of Anatomy Christian Albrechts\u2010University Kiel Kiel Germany","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009550643","display_name":"Rolf Mentlein","orcid":"https://orcid.org/0000-0002-6350-3911","observed_orcids":["https://orcid.org/0000-0002-6350-3911"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rolf Mentlein","raw_affiliation_strings":["Institute of Anatomy, Christian-Albrechts-University Kiel, Olshausenstr. 40, Kiel, 24098, Germany","Institute of Anatomy Christian Albrechts\u2010University Kiel Kiel Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, Christian-Albrechts-University Kiel, Olshausenstr. 40, Kiel, 24098, Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Institute of Anatomy Christian Albrechts\u2010University Kiel Kiel Germany","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028678590","display_name":"Michael Sch\u00fcnke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Sch\u00fcnke","raw_affiliation_strings":["Institute of Anatomy, Christian-Albrechts-University Kiel, Olshausenstr. 40, Kiel, 24098, Germany","Institute of Anatomy Christian Albrechts\u2010University Kiel Kiel Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, Christian-Albrechts-University Kiel, Olshausenstr. 40, Kiel, 24098, Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Institute of Anatomy Christian Albrechts\u2010University Kiel Kiel Germany","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109092554","display_name":"Bodo Kurz","orcid":"https://orcid.org/0009-0005-9589-4354","observed_orcids":["https://orcid.org/0009-0005-9589-4354"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Bodo Kurz","raw_affiliation_strings":["Institute of Anatomy, Christian-Albrechts-University Kiel, Olshausenstr. 40, Kiel, 24098, Germany","Institute of Anatomy Christian Albrechts\u2010University Kiel Kiel Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Anatomy, Christian-Albrechts-University Kiel, Olshausenstr. 40, Kiel, 24098, Germany","institution_ids":["https://openalex.org/I32021983"]},{"raw_affiliation_string":"Institute of Anatomy Christian Albrechts\u2010University Kiel Kiel Germany","institution_ids":["https://openalex.org/I32021983"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109092554"],"corresponding_institution_ids":["https://openalex.org/I32021983"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":1.1673,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.77693073,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"11","issue":"5","first_page":"R141","last_page":"R141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.8223000168800354,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.8223000168800354,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.10459999740123749,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.0414000004529953,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/aggrecan-cleavage","display_name":"aggrecan cleavage","score":0.9739999771118164},{"id":"https://openalex.org/keywords/glycosaminoglycan-release","display_name":"glycosaminoglycan release","score":0.9459999799728394},{"id":"https://openalex.org/keywords/meniscus","display_name":"meniscus","score":0.9169999957084656},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.6340000033378601},{"id":"https://openalex.org/keywords/aggrecanase","display_name":"aggrecanase","score":0.7369999885559082},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-3","display_name":"matrix metalloproteinase-3","score":0.8859999775886536},{"id":"https://openalex.org/keywords/adamts4","display_name":"ADAMTS-4","score":0.9940000176429749},{"id":"https://openalex.org/keywords/meniscal-degeneration","display_name":"meniscal degeneration","score":0.734000027179718},{"id":"https://openalex.org/keywords/joint-inflammation","display_name":"joint inflammation","score":0.7049999833106995},{"id":"https://openalex.org/keywords/proteoglycan-degradation","display_name":"proteoglycan degradation","score":0.7160000205039978},{"id":"https://openalex.org/keywords/timp-3","display_name":"TIMP-3","score":0.8180000185966492},{"id":"https://openalex.org/keywords/l-nmma","display_name":"L-NMMA","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C2776157581","wikidata":"https://www.wikidata.org/wiki/Q4692239","display_name":"Aggrecanase","level":5,"score":0.8291571140289307},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.643947422504425},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6345886588096619},{"id":"https://openalex.org/C197534660","wikidata":"https://www.wikidata.org/wiki/Q21121862","display_name":"Aggrecan","level":5,"score":0.6180395483970642},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.6095550060272217},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5606863498687744},{"id":"https://openalex.org/C189178095","wikidata":"https://www.wikidata.org/wiki/Q15834833","display_name":"Meniscus","level":3,"score":0.5400218963623047},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.47815951704978943},{"id":"https://openalex.org/C2777573673","wikidata":"https://www.wikidata.org/wiki/Q905750","display_name":"Nitrous oxide","level":2,"score":0.4229356646537781},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4229177236557007},{"id":"https://openalex.org/C2780423099","wikidata":"https://www.wikidata.org/wiki/Q6806071","display_name":"Medial meniscus","level":4,"score":0.4157271981239319},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36236345767974854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33778417110443115},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.3086814880371094},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2766132652759552},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2530874013900757},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2113298773765564},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18759968876838684},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.13204166293144226},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.0},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009609","descriptor_name":"Nitrous Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019714","descriptor_name":"Tissue Inhibitor of Metalloproteinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051445","descriptor_name":"Fibrocartilage","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053674","descriptor_name":"Aggrecans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/ar2813","doi":"https://doi.org/10.1186/ar2813","is_oa":true,"landing_page_url":"https://doi.org/10.1186/ar2813","pdf_url":"https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/ar2813","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research &amp; Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2787293","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2787293","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Res Ther","raw_type":"Text"},{"id":"pmid:19778432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19778432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis research & therapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/ar2813","doi":"https://doi.org/10.1186/ar2813","is_oa":true,"landing_page_url":"https://doi.org/10.1186/ar2813","pdf_url":"https://arthritis-research.biomedcentral.com/counter/pdf/10.1186/ar2813","source":{"id":"https://openalex.org/S149170128","display_name":"Arthritis Research & Therapy","issn_l":"1478-6354","issn":["1478-6354","1478-6362"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Arthritis Research &amp; Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2020586908.pdf","grobid_xml":"https://content.openalex.org/works/W2020586908.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W567930160","https://openalex.org/W644108170","https://openalex.org/W1525740558","https://openalex.org/W1586227843","https://openalex.org/W1922662285","https://openalex.org/W1965282306","https://openalex.org/W1969179229","https://openalex.org/W1971918787","https://openalex.org/W1974384135","https://openalex.org/W1977918153","https://openalex.org/W1981956984","https://openalex.org/W1983690452","https://openalex.org/W1997522892","https://openalex.org/W2003678590","https://openalex.org/W2007706083","https://openalex.org/W2010335941","https://openalex.org/W2031854867","https://openalex.org/W2037846454","https://openalex.org/W2040879571","https://openalex.org/W2041327764","https://openalex.org/W2042994078","https://openalex.org/W2043965285","https://openalex.org/W2044545243","https://openalex.org/W2051822687","https://openalex.org/W2063560538","https://openalex.org/W2063588194","https://openalex.org/W2068843202","https://openalex.org/W2071583399","https://openalex.org/W2077679509","https://openalex.org/W2078180135","https://openalex.org/W2079568970","https://openalex.org/W2079896426","https://openalex.org/W2079968413","https://openalex.org/W2080673945","https://openalex.org/W2083784930","https://openalex.org/W2084892041","https://openalex.org/W2087193732","https://openalex.org/W2092863938","https://openalex.org/W2093394571","https://openalex.org/W2103819978","https://openalex.org/W2110792647","https://openalex.org/W2128503400","https://openalex.org/W2152487395","https://openalex.org/W2164933897","https://openalex.org/W2167031471","https://openalex.org/W2167869180","https://openalex.org/W2245165785","https://openalex.org/W2323027542","https://openalex.org/W2398137194","https://openalex.org/W4360790438"],"related_works":["https://openalex.org/W1995151196","https://openalex.org/W2062744404","https://openalex.org/W2015187230","https://openalex.org/W1992205660","https://openalex.org/W2039878276","https://openalex.org/W2078180135","https://openalex.org/W2026142554","https://openalex.org/W2106189080","https://openalex.org/W2614249886","https://openalex.org/W2081969734"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Little":[1],"is":[2,222,246],"known":[3],"about":[4],"factors":[5],"that":[6,218],"induce":[7],"meniscus":[8,234,245],"damage.":[9],"Since":[10],"joint":[11],"inflammation":[12],"appears":[13],"to":[14,207,259],"be":[15,238,260],"a":[16,108,122,157,247],"causative":[17],"factor":[18,29],"for":[19,224,250],"meniscal":[20,241],"destruction,":[21],"we":[22],"investigated":[23],"the":[24,89,166,171,202,233,244,253,267],"influence":[25],"of":[26,62,80,88,99,105,170,180,197,264],"tumor":[27],"necrosis":[28],"(TNFalpha)":[30],"on":[31],"glycosaminoglycan":[32],"(GAG)":[33],"release":[34,65,98,191,210,231,263],"and":[35,86,121,124,138,149,192,211,229,235],"aggrecan":[36,90,173,227],"cleavage":[37,228],"in":[38,40,107,160,165,232,240,262],"an":[39],"vitro":[41],"model.":[42],"METHODS:":[43],"Meniscal":[44],"explant":[45],"disks":[46],"(3":[47],"mm":[48,52],"diameter":[49],"x":[50],"1":[51],"thickness)":[53],"were":[54,93,151],"isolated":[55],"from":[56],"2-year-old":[57],"cattle.":[58],"After":[59],"3":[60],"days":[61],"TNFalpha-treatment":[63],"GAG":[64,100,190,209,230],"(DMMB":[66],"assay),":[67,77],"biosynthetic":[68],"activity":[69,220],"(sulfate":[70],"incorporation),":[71],"nitric":[72],"oxide":[73],"(NO)":[74],"production":[75,104,256],"(Griess":[76],"gene":[78],"expression":[79],"matrix-degrading":[81],"enzymes":[82],"(quantitative":[83],"RT-PCR,":[84],"zymography),":[85],"immunostaining":[87],"fragment":[91],"NITEGE":[92,175,193,212],"determined.":[94],"RESULTS:":[95],"TNFalpha":[96,116],"induced":[97],"as":[101,103,143,145],"well":[102,144],"NO":[106,199,255],"dose-dependent":[109],"manner,":[110],"while":[111],"sulfate":[112],"incorporation":[113],"was":[114,136,176],"decreased.":[115],"increased":[117],"matrix":[118],"metalloproteinase":[119,125],"(MMP)-3":[120],"disintegrin":[123],"with":[126,201],"thrombospondin":[127],"motifs":[128],"(ADAMTS)-4":[129],"mRNA":[130],"expression,":[131,162],"whereas":[132,195],"collagen":[133,140],"type":[134,141],"I":[135],"decreased,":[137],"aggrecan,":[139],"II":[142],"MMP-1,":[146],"-2,":[147],"-13":[148],"ADAMTS-5":[150],"variably":[152],"affected.":[153],"Zymography":[154],"also":[155],"showed":[156],"TNFalpha-dependent":[158,168,189,198,226,248,254],"increase":[159],"MMP-3":[161],"but":[163,183],"pre-dominantly":[164],"pro-form.":[167],"formation":[169],"aggrecanase-specific":[172],"neoepitope":[174],"induced.":[177],"Tissue":[178],"inhibitor":[179,204],"metalloproteinases":[181],"(TIMP)-3,":[182],"not":[184,258],"TIMP-1":[185],"or":[186],"-2":[187],"inhibited":[188],"production,":[194],"inhibition":[196],"generation":[200],"NO-synthetase":[203],"L-NMMA":[205],"failed":[206],"inhibit":[208],"production.":[213],"CONCLUSIONS:":[214],"Our":[215],"study":[216],"shows":[217],"aggrecanase":[219],"(a)":[221],"responsible":[223],"early":[225],"(b)":[236],"might":[237],"involved":[239,261],"degeneration.":[242],"Additionally,":[243],"source":[249],"MMP-3.":[251],"However,":[252],"seems":[257],"proteoglycans":[265],"under":[266],"given":[268],"circumstances.":[269]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
