{"id":"https://openalex.org/W2020579554","doi":"https://doi.org/10.1007/bf00796518","title":"A model of cytosolic calcium regulation and autacoids production in vascular endothelial cell","display_name":"A model of cytosolic calcium regulation and autacoids production in vascular endothelial cell","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2020579554","doi":"https://doi.org/10.1007/bf00796518","mag":"2020579554","pmid":"https://pubmed.ncbi.nlm.nih.gov/1358060"},"language":"en","primary_location":{"id":"doi:10.1007/bf00796518","doi":"https://doi.org/10.1007/bf00796518","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00796518","pdf_url":null,"source":{"id":"https://openalex.org/S133907260","display_name":"Basic Research in Cardiology","issn_l":"0003-9217","issn":["0003-9217","0044-295X","0300-8428","1435-1803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic Research in Cardiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106132266","display_name":"Alan Y.K. Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"A. Y. K. Wong","raw_affiliation_strings":["Department of Physiology and Biophysics, Dalhousie University, Halifax, Canada","Department of Physiology and Biophysics, and Medicine, Dalhousie University, Halifax, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, Dalhousie University, Halifax, Canada","institution_ids":["https://openalex.org/I129902397"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, and Medicine, Dalhousie University, Halifax, Canada","institution_ids":["https://openalex.org/I129902397"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053487339","display_name":"Gerald A. Klassen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129902397","display_name":"Dalhousie University","ror":"https://ror.org/01e6qks80","country_code":"CA","type":"education","lineage":["https://openalex.org/I129902397"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"G. A. Klassen","raw_affiliation_strings":["Department of Physiology and Biophysics, and Medicine, Dalhousie University, B3H 4H7, Halifax, N.S., Canada","Department of Physiology and Biophysics, and Medicine, Dalhousie University, Halifax, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Biophysics, and Medicine, Dalhousie University, B3H 4H7, Halifax, N.S., Canada","institution_ids":["https://openalex.org/I129902397"]},{"raw_affiliation_string":"Department of Physiology and Biophysics, and Medicine, Dalhousie University, Halifax, Canada","institution_ids":["https://openalex.org/I129902397"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I129902397"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":0.6266,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.70819361,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"87","issue":"4","first_page":"317","last_page":"332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.6317999958992004,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.6317999958992004,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.13840000331401825,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.08190000057220459,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytosolic-calcium-regulation","display_name":"cytosolic calcium regulation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/vascular-endothelial-cells","display_name":"vascular endothelial cells","score":0.9150000214576721},{"id":"https://openalex.org/keywords/endothelium-derived-relaxing-factor","display_name":"endothelium-derived relaxing factor","score":0.9800000190734863},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.9549999833106995},{"id":"https://openalex.org/keywords/ip3-receptor","display_name":"IP3 receptor","score":0.5540000200271606},{"id":"https://openalex.org/keywords/intracellular-calcium-stores","display_name":"intracellular calcium stores","score":0.7490000128746033},{"id":"https://openalex.org/keywords/calcium-transients","display_name":"calcium transients","score":0.6399999856948853},{"id":"https://openalex.org/keywords/calcium-oscillations","display_name":"calcium oscillations","score":0.8709999918937683},{"id":"https://openalex.org/keywords/calcium-activated-potassium-current","display_name":"calcium-activated potassium current","score":0.8209999799728394},{"id":"https://openalex.org/keywords/hyperpolarization","display_name":"hyperpolarization","score":0.8299999833106995},{"id":"https://openalex.org/keywords/aortic-endothelium","display_name":"aortic endothelium","score":0.8330000042915344},{"id":"https://openalex.org/keywords/endothelium-dependent-relaxation","display_name":"endothelium-dependent relaxation","score":0.6050000190734863},{"id":"https://openalex.org/keywords/mathematical-model","display_name":"mathematical model","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C149588370","wikidata":"https://www.wikidata.org/wiki/Q424673","display_name":"Autacoid","level":3,"score":0.8188347220420837},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.663938581943512},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5682260394096375},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5508449673652649},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.507375180721283},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37216153740882874},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33403950929641724},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32998543977737427},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2360984981060028},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2221507430076599},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2177404761314392},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08498799800872803},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002451","descriptor_name":"Cell Compartmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012898","descriptor_name":"Autacoids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015544","descriptor_name":"Inositol 1,4,5-Trisphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00796518","doi":"https://doi.org/10.1007/bf00796518","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00796518","pdf_url":null,"source":{"id":"https://openalex.org/S133907260","display_name":"Basic Research in Cardiology","issn_l":"0003-9217","issn":["0003-9217","0044-295X","0300-8428","1435-1803"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic Research in Cardiology","raw_type":"journal-article"},{"id":"pmid:1358060","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1358060","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Basic research in cardiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1516463671","https://openalex.org/W1669858368","https://openalex.org/W1964590720","https://openalex.org/W1965209261","https://openalex.org/W1975435918","https://openalex.org/W1977350873","https://openalex.org/W1990044304","https://openalex.org/W2004440363","https://openalex.org/W2004589688","https://openalex.org/W2008790997","https://openalex.org/W2010407890","https://openalex.org/W2010751083","https://openalex.org/W2015996189","https://openalex.org/W2024033655","https://openalex.org/W2025637012","https://openalex.org/W2030537932","https://openalex.org/W2048296510","https://openalex.org/W2059270316","https://openalex.org/W2083587127","https://openalex.org/W2090839129","https://openalex.org/W2091368852","https://openalex.org/W2093911431","https://openalex.org/W2094508354","https://openalex.org/W2116419661","https://openalex.org/W2125942201","https://openalex.org/W2132184473","https://openalex.org/W2169182236","https://openalex.org/W2180403979","https://openalex.org/W2415273680","https://openalex.org/W2417602324"],"related_works":["https://openalex.org/W2075477567","https://openalex.org/W2599495660","https://openalex.org/W2401723180","https://openalex.org/W4380200311","https://openalex.org/W1975435918","https://openalex.org/W131191590","https://openalex.org/W2094508354","https://openalex.org/W2010054683","https://openalex.org/W1975853356","https://openalex.org/W4380203813"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}