{"id":"https://openalex.org/W2020558434","doi":"https://doi.org/10.1016/j.pain.2004.06.015","title":"Bone cancer pain: the effects of the bisphosphonate alendronate on pain, skeletal remodeling, tumor growth and tumor necrosis","display_name":"Bone cancer pain: the effects of the bisphosphonate alendronate on pain, skeletal remodeling, tumor growth and tumor necrosis","publication_year":2004,"publication_date":"2004-07-30","ids":{"openalex":"https://openalex.org/W2020558434","doi":"https://doi.org/10.1016/j.pain.2004.06.015","mag":"2020558434","pmid":"https://pubmed.ncbi.nlm.nih.gov/15327821"},"language":"en","primary_location":{"id":"doi:10.1016/j.pain.2004.06.015","doi":"https://doi.org/10.1016/j.pain.2004.06.015","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pain.2004.06.015","pdf_url":null,"source":{"id":"https://openalex.org/S140848990","display_name":"Pain","issn_l":"0304-3959","issn":["0304-3959","1872-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111888855","display_name":"Molly A. Sevcik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I2800403580","display_name":"University of Minnesota System","ror":"https://ror.org/03grvy078","country_code":"US","type":"education","lineage":["https://openalex.org/I2800403580"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Molly A. Sevcik","raw_affiliation_strings":["Department of Preventive Sciences, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Sciences, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I2800403580"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068140482","display_name":"Nancy M. Luger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy M. Luger","raw_affiliation_strings":["Departments of Preventive Sciences, Psychiatry, Neuroscience, and Cancer Center, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Preventive Sciences, Psychiatry, Neuroscience, and Cancer Center, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091298084","display_name":"David B. Mach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David B. Mach","raw_affiliation_strings":["Departments of Preventive Sciences, Psychiatry, Neuroscience, and Cancer Center, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Preventive Sciences, Psychiatry, Neuroscience, and Cancer Center, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113490936","display_name":"Mary Ann C. Sabino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Ann C. Sabino","raw_affiliation_strings":["Departments of Preventive Sciences, Psychiatry, Neuroscience, and Cancer Center, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Preventive Sciences, Psychiatry, Neuroscience, and Cancer Center, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070784009","display_name":"Christopher Michael Peters","orcid":"https://orcid.org/0000-0001-5268-9506","observed_orcids":["https://orcid.org/0000-0001-5268-9506"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher M. Peters","raw_affiliation_strings":["Departments of Preventive Sciences, Psychiatry, Neuroscience, and Cancer Center, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Preventive Sciences, Psychiatry, Neuroscience, and Cancer Center, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069547559","display_name":"Joseph R. Ghilardi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph R. Ghilardi","raw_affiliation_strings":["Departments of Preventive Sciences, Psychiatry, Neuroscience, and Cancer Center, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA","Research Service 151, Minneapolis, MN 55417, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Preventive Sciences, Psychiatry, Neuroscience, and Cancer Center, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Research Service 151, Minneapolis, MN 55417, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019115039","display_name":"Matthew J. Schwei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew J. Schwei","raw_affiliation_strings":["Departments of Preventive Sciences, Psychiatry, Neuroscience, and Cancer Center, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Preventive Sciences, Psychiatry, Neuroscience, and Cancer Center, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066307857","display_name":"Heidi R\u00f6hrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heidi R\u00f6hrich","raw_affiliation_strings":["Departments of Preventive Sciences, Psychiatry, Neuroscience, and Cancer Center, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Preventive Sciences, Psychiatry, Neuroscience, and Cancer Center, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108228832","display_name":"Carmen De Felipe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111262870","display_name":"Universitat de Miguel Hern\u00e1ndez d'Elx","ror":"https://ror.org/01azzms13","country_code":"ES","type":"education","lineage":["https://openalex.org/I111262870"]},{"id":"https://openalex.org/I4210087099","display_name":"Instituto de Neurociencias","ror":"https://ror.org/000nhpy59","country_code":"ES","type":"facility","lineage":["https://openalex.org/I111262870","https://openalex.org/I134820265","https://openalex.org/I4210087099"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carmen De Felipe","raw_affiliation_strings":["Instituto de Neurociencias, Universidad Miguel Hernandez-CSIC, San Juan de Alicante, Spain","Miguel Hern\u00e1ndez University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Neurociencias, Universidad Miguel Hernandez-CSIC, San Juan de Alicante, Spain","institution_ids":["https://openalex.org/I4210087099"]},{"raw_affiliation_string":"Miguel Hern\u00e1ndez University","institution_ids":["https://openalex.org/I111262870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111955119","display_name":"Michael A. Kuskowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117246","display_name":"Minneapolis VA Health Care System","ror":"https://ror.org/02ry60714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Kuskowski","raw_affiliation_strings":["GRECC, VA Medical Center, Minneapolis, MN 55417, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GRECC, VA Medical Center, Minneapolis, MN 55417, USA","institution_ids":["https://openalex.org/I4210117246","https://openalex.org/I4210140408"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080551226","display_name":"Patrick W. Mantyh","orcid":"https://orcid.org/0000-0002-0126-138X","observed_orcids":["https://orcid.org/0000-0002-0126-138X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patrick W. Mantyh","raw_affiliation_strings":["Corresponding author. Address: Departments of Preventive Sciences, Psychiatry, Neuroscience, and Cancer Center, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA. Tel.: +1\u2013612\u2013626\u20132560; fax: +1\u2013612\u2013626\u20132565","Departments of Preventive Sciences, Psychiatry, Neuroscience, and Cancer Center, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA","Research Service 151, Minneapolis, MN 55417, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corresponding author. Address: Departments of Preventive Sciences, Psychiatry, Neuroscience, and Cancer Center, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA. Tel.: +1\u2013612\u2013626\u20132560; fax: +1\u2013612\u2013626\u20132565","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Departments of Preventive Sciences, Psychiatry, Neuroscience, and Cancer Center, University of Minnesota, 515 Delaware Street, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Research Service 151, Minneapolis, MN 55417, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5080551226"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":null,"apc_paid":null,"fwci":4.5947,"has_fulltext":false,"cited_by_count":96,"citation_normalized_percentile":{"value":0.95018279,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"111","issue":"1","first_page":"169","last_page":"180"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12108","display_name":"Management of metastatic bone disease","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-cancer-pain","display_name":"bone cancer pain","score":0.9300000071525574},{"id":"https://openalex.org/keywords/alendronate","display_name":"alendronate","score":0.9909999966621399},{"id":"https://openalex.org/keywords/bisphosphonates","display_name":"bisphosphonates","score":0.9990000128746033},{"id":"https://openalex.org/keywords/osteolytic-bone-metastasis","display_name":"osteolytic bone metastasis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.8669999837875366},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.9169999957084656},{"id":"https://openalex.org/keywords/tumor-necrosis","display_name":"tumor necrosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.7919999957084656},{"id":"https://openalex.org/keywords/metastatic-lung-cancer","display_name":"metastatic lung cancer","score":0.8429999947547913},{"id":"https://openalex.org/keywords/metastatic-prostate-cancer","display_name":"metastatic prostate cancer","score":0.9800000190734863},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8310086727142334},{"id":"https://openalex.org/C2777251235","wikidata":"https://www.wikidata.org/wiki/Q412205","display_name":"Bisphosphonate","level":3,"score":0.6891368627548218},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.6852243542671204},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.5549898743629456},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5304182171821594},{"id":"https://openalex.org/C2776139714","wikidata":"https://www.wikidata.org/wiki/Q3480107","display_name":"Bone pain","level":2,"score":0.49928808212280273},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.45819103717803955},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.45646893978118896},{"id":"https://openalex.org/C2911223091","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone Density Conservation Agents","level":4,"score":0.45090997219085693},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.383539617061615},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3594842553138733},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.355118989944458},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.2921738624572754},{"id":"https://openalex.org/C2779329777","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone density","level":3,"score":0.14103952050209045}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010014","descriptor_name":"Osteolysis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010014","descriptor_name":"Osteolysis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010014","descriptor_name":"Osteolysis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019386","descriptor_name":"Alendronate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051700","descriptor_name":"Activating Transcription Factor 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.pain.2004.06.015","doi":"https://doi.org/10.1016/j.pain.2004.06.015","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.pain.2004.06.015","pdf_url":null,"source":{"id":"https://openalex.org/S140848990","display_name":"Pain","issn_l":"0304-3959","issn":["0304-3959","1872-6623"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"journal-article"},{"id":"pmid:15327821","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15327821","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pain","raw_type":"Journal Article"},{"id":"pmh:oai:digital.csic.es:10261/288874","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/288874","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"art\u00edculo"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G188920109","display_name":"NEUROCHEMISTRY OF NOCICEPTION","funder_award_id":"R01DA011986","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G2797665760","display_name":"MINNESOTA DENTIST SCIENTIST AWARD PROGRAM","funder_award_id":"K16DE000270","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G3261739245","display_name":null,"funder_award_id":"NS23970","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6171010131","display_name":null,"funder_award_id":"1F30-DE01471-01A1","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"},{"id":"https://openalex.org/G6276142813","display_name":null,"funder_award_id":"5 K16 DE00270-12","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W56539144","https://openalex.org/W126372163","https://openalex.org/W564852975","https://openalex.org/W1511198581","https://openalex.org/W1552563052","https://openalex.org/W1577265851","https://openalex.org/W1589933893","https://openalex.org/W1720952724","https://openalex.org/W1867981554","https://openalex.org/W1896223819","https://openalex.org/W1913723147","https://openalex.org/W1918337600","https://openalex.org/W1938796902","https://openalex.org/W1944967894","https://openalex.org/W1967771383","https://openalex.org/W1967875617","https://openalex.org/W1972227666","https://openalex.org/W1974300877","https://openalex.org/W1974642350","https://openalex.org/W1977203209","https://openalex.org/W1979253120","https://openalex.org/W1998901000","https://openalex.org/W1999085114","https://openalex.org/W2000144084","https://openalex.org/W2005039015","https://openalex.org/W2005865069","https://openalex.org/W2006825597","https://openalex.org/W2007783033","https://openalex.org/W2009067227","https://openalex.org/W2010187077","https://openalex.org/W2010486222","https://openalex.org/W2011195852","https://openalex.org/W2013001448","https://openalex.org/W2013255360","https://openalex.org/W2016275229","https://openalex.org/W2028991114","https://openalex.org/W2029755902","https://openalex.org/W2030266268","https://openalex.org/W2033421804","https://openalex.org/W2036545264","https://openalex.org/W2038345192","https://openalex.org/W2047509071","https://openalex.org/W2051192926","https://openalex.org/W2051337621","https://openalex.org/W2053916112","https://openalex.org/W2056994468","https://openalex.org/W2061235833","https://openalex.org/W2061539449","https://openalex.org/W2066362290","https://openalex.org/W2067417180","https://openalex.org/W2069826660","https://openalex.org/W2074781113","https://openalex.org/W2077386452","https://openalex.org/W2089158347","https://openalex.org/W2090305787","https://openalex.org/W2091552137","https://openalex.org/W2093571282","https://openalex.org/W2094127804","https://openalex.org/W2095376056","https://openalex.org/W2102482103","https://openalex.org/W2102969047","https://openalex.org/W2107705149","https://openalex.org/W2129296139","https://openalex.org/W2130549848","https://openalex.org/W2135607542","https://openalex.org/W2136112016","https://openalex.org/W2168222534","https://openalex.org/W2169491449","https://openalex.org/W3027417816","https://openalex.org/W4253401993","https://openalex.org/W6640777412","https://openalex.org/W6675323744","https://openalex.org/W6679090616","https://openalex.org/W6684967989"],"related_works":["https://openalex.org/W1990420807","https://openalex.org/W2014729952","https://openalex.org/W1990798640","https://openalex.org/W2076335691","https://openalex.org/W2997265525","https://openalex.org/W2601867282","https://openalex.org/W2132939303","https://openalex.org/W2011227892","https://openalex.org/W2074781113","https://openalex.org/W2035974542"],"abstract_inverted_index":{"Patients":[0],"with":[1],"metastatic":[2],"breast,":[3],"lung":[4],"or":[5],"prostate":[6],"cancer":[7,12,35,81,92],"frequently":[8],"have":[9],"significant":[10],"bone":[11,34,37,80,91,94],"pain.":[13],"In":[14],"the":[15,27,29,57,61,72,74,79,97,105],"present":[16],"report":[17],"we":[18],"address,":[19],"in":[20,23],"a":[21,132],"single":[22],"vivo":[24],"mouse":[25],"model,":[26],"effects":[28],"bisphosphonate":[30],"alendronate":[31,67,108],"has":[32],"on":[33],"pain,":[36,93,135],"remodeling":[38,137],"and":[39,42,46,89,96,119,138,156],"tumor":[40,54,75,114,117,120,139],"growth":[41,118,140],"necrosis.":[43],"Following":[44],"injection":[45],"confinement":[47],"of":[48,60,63,99,147,154],"green":[49],"fluorescent":[50],"protein-transfected":[51],"murine":[52],"osteolytic":[53],"cells":[55],"into":[56],"marrow":[58],"space":[59],"femur":[62],"male":[64],"C3H/HeJ":[65],"mice,":[66],"was":[68,76],"administered":[69],"chronically":[70],"from":[71],"time":[73],"established":[77],"until":[78],"pain":[82],"became":[83],"severe.":[84],"Alendronate":[85],"therapy":[86],"reduced":[87],"ongoing":[88],"movement-evoked":[90],"destruction":[95,98],"sensory":[100],"nerve":[101],"fibers":[102],"that":[103,126],"innervate":[104],"bone.":[106],"Whereas,":[107],"treatment":[109],"did":[110],"not":[111],"change":[112],"viable":[113],"burden,":[115],"both":[116],"necrosis":[121],"increased.":[122],"These":[123],"data":[124],"emphasize":[125],"it":[127],"is":[128],"essential":[129],"to":[130],"utilize":[131],"model":[133],"where":[134],"skeletal":[136],"can":[141,149],"be":[142],"simultaneously":[143],"assessed,":[144],"as":[145],"each":[146],"these":[148],"significantly":[150],"impact":[151],"patient":[152],"quality":[153],"life":[155],"survival.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}