{"id":"https://openalex.org/W2020540413","doi":"https://doi.org/10.1111/j.1537-2995.2007.01284.x","title":"Detection of misfolded prion protein in blood with conformationally sensitive peptides","display_name":"Detection of misfolded prion protein in blood with conformationally sensitive peptides","publication_year":2007,"publication_date":"2007-07-25","ids":{"openalex":"https://openalex.org/W2020540413","doi":"https://doi.org/10.1111/j.1537-2995.2007.01284.x","mag":"2020540413","pmid":"https://pubmed.ncbi.nlm.nih.gov/17655586"},"language":"en","primary_location":{"id":"doi:10.1111/j.1537-2995.2007.01284.x","doi":"https://doi.org/10.1111/j.1537-2995.2007.01284.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1537-2995.2007.01284.x","pdf_url":null,"source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Tao Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343864894","display_name":"American Red Cross","ror":"https://ror.org/0284e2q78","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343864894"]},{"id":"https://openalex.org/I4210125368","display_name":"Adlyfe (United States)","ror":"https://ror.org/02gjczz49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125368"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tao Pan","raw_affiliation_strings":["Adlyfe Inc., 9430 Key West Avenue, Rockville, MD 20850, USA","7815 Exeter Road, Bethesda, Maryland","From Adlyfe Inc., Rockville","the American Red Cross Holland Laboratory, Rockville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Adlyfe Inc., 9430 Key West Avenue, Rockville, MD 20850, USA","institution_ids":["https://openalex.org/I4210125368"]},{"raw_affiliation_string":"7815 Exeter Road, Bethesda, Maryland","institution_ids":[]},{"raw_affiliation_string":"From Adlyfe Inc., Rockville","institution_ids":["https://openalex.org/I4210125368"]},{"raw_affiliation_string":"the American Red Cross Holland Laboratory, Rockville","institution_ids":["https://openalex.org/I1343864894"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014054151","display_name":"Jasmeet Sethi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343864894","display_name":"American Red Cross","ror":"https://ror.org/0284e2q78","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343864894"]},{"id":"https://openalex.org/I4210125368","display_name":"Adlyfe (United States)","ror":"https://ror.org/02gjczz49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125368"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jasmeet Sethi","raw_affiliation_strings":["From Adlyfe Inc., Rockville; the American Red Cross Holland Laboratory, Rockville; and 7815 Exeter Road, Bethesda, Maryland","7815 Exeter Road, Bethesda, Maryland","From Adlyfe Inc., Rockville","the American Red Cross Holland Laboratory, Rockville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Adlyfe Inc., Rockville; the American Red Cross Holland Laboratory, Rockville; and 7815 Exeter Road, Bethesda, Maryland","institution_ids":["https://openalex.org/I1343864894","https://openalex.org/I4210125368"]},{"raw_affiliation_string":"7815 Exeter Road, Bethesda, Maryland","institution_ids":[]},{"raw_affiliation_string":"From Adlyfe Inc., Rockville","institution_ids":["https://openalex.org/I4210125368"]},{"raw_affiliation_string":"the American Red Cross Holland Laboratory, Rockville","institution_ids":["https://openalex.org/I1343864894"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010188932","display_name":"Craig Nelsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343864894","display_name":"American Red Cross","ror":"https://ror.org/0284e2q78","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343864894"]},{"id":"https://openalex.org/I4210125368","display_name":"Adlyfe (United States)","ror":"https://ror.org/02gjczz49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125368"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig Nelsen","raw_affiliation_strings":["From Adlyfe Inc., Rockville; the American Red Cross Holland Laboratory, Rockville; and 7815 Exeter Road, Bethesda, Maryland","7815 Exeter Road, Bethesda, Maryland","From Adlyfe Inc., Rockville","the American Red Cross Holland Laboratory, Rockville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Adlyfe Inc., Rockville; the American Red Cross Holland Laboratory, Rockville; and 7815 Exeter Road, Bethesda, Maryland","institution_ids":["https://openalex.org/I1343864894","https://openalex.org/I4210125368"]},{"raw_affiliation_string":"7815 Exeter Road, Bethesda, Maryland","institution_ids":[]},{"raw_affiliation_string":"From Adlyfe Inc., Rockville","institution_ids":["https://openalex.org/I4210125368"]},{"raw_affiliation_string":"the American Red Cross Holland Laboratory, Rockville","institution_ids":["https://openalex.org/I1343864894"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110101086","display_name":"Alan S. Rudolph","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343864894","display_name":"American Red Cross","ror":"https://ror.org/0284e2q78","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343864894"]},{"id":"https://openalex.org/I4210125368","display_name":"Adlyfe (United States)","ror":"https://ror.org/02gjczz49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125368"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Rudolph","raw_affiliation_strings":["From Adlyfe Inc., Rockville; the American Red Cross Holland Laboratory, Rockville; and 7815 Exeter Road, Bethesda, Maryland","7815 Exeter Road, Bethesda, Maryland","From Adlyfe Inc., Rockville","the American Red Cross Holland Laboratory, Rockville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Adlyfe Inc., Rockville; the American Red Cross Holland Laboratory, Rockville; and 7815 Exeter Road, Bethesda, Maryland","institution_ids":["https://openalex.org/I1343864894","https://openalex.org/I4210125368"]},{"raw_affiliation_string":"7815 Exeter Road, Bethesda, Maryland","institution_ids":[]},{"raw_affiliation_string":"From Adlyfe Inc., Rockville","institution_ids":["https://openalex.org/I4210125368"]},{"raw_affiliation_string":"the American Red Cross Holland Laboratory, Rockville","institution_ids":["https://openalex.org/I1343864894"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026399324","display_name":"Larisa \u010cerven\u0306\u00e1kov\u00e1","orcid":"https://orcid.org/0000-0003-0614-2619","observed_orcids":["https://orcid.org/0000-0003-0614-2619"]},"institutions":[{"id":"https://openalex.org/I1343864894","display_name":"American Red Cross","ror":"https://ror.org/0284e2q78","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343864894"]},{"id":"https://openalex.org/I4210125368","display_name":"Adlyfe (United States)","ror":"https://ror.org/02gjczz49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125368"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larisa Cervenakova","raw_affiliation_strings":["From Adlyfe Inc., Rockville; the American Red Cross Holland Laboratory, Rockville; and 7815 Exeter Road, Bethesda, Maryland","7815 Exeter Road, Bethesda, Maryland","From Adlyfe Inc., Rockville","the American Red Cross Holland Laboratory, Rockville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Adlyfe Inc., Rockville; the American Red Cross Holland Laboratory, Rockville; and 7815 Exeter Road, Bethesda, Maryland","institution_ids":["https://openalex.org/I1343864894","https://openalex.org/I4210125368"]},{"raw_affiliation_string":"7815 Exeter Road, Bethesda, Maryland","institution_ids":[]},{"raw_affiliation_string":"From Adlyfe Inc., Rockville","institution_ids":["https://openalex.org/I4210125368"]},{"raw_affiliation_string":"the American Red Cross Holland Laboratory, Rockville","institution_ids":["https://openalex.org/I1343864894"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111754420","display_name":"Paul Brown","orcid":"https://orcid.org/0000-0001-5778-3921","observed_orcids":["https://orcid.org/0000-0001-5778-3921"]},"institutions":[{"id":"https://openalex.org/I1343864894","display_name":"American Red Cross","ror":"https://ror.org/0284e2q78","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343864894"]},{"id":"https://openalex.org/I4210125368","display_name":"Adlyfe (United States)","ror":"https://ror.org/02gjczz49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125368"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Brown","raw_affiliation_strings":["From Adlyfe Inc., Rockville; the American Red Cross Holland Laboratory, Rockville; and 7815 Exeter Road, Bethesda, Maryland","7815 Exeter Road, Bethesda, Maryland","From Adlyfe Inc., Rockville","the American Red Cross Holland Laboratory, Rockville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Adlyfe Inc., Rockville; the American Red Cross Holland Laboratory, Rockville; and 7815 Exeter Road, Bethesda, Maryland","institution_ids":["https://openalex.org/I1343864894","https://openalex.org/I4210125368"]},{"raw_affiliation_string":"7815 Exeter Road, Bethesda, Maryland","institution_ids":[]},{"raw_affiliation_string":"From Adlyfe Inc., Rockville","institution_ids":["https://openalex.org/I4210125368"]},{"raw_affiliation_string":"the American Red Cross Holland Laboratory, Rockville","institution_ids":["https://openalex.org/I1343864894"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063918229","display_name":"Cindy Orser","orcid":"https://orcid.org/0000-0002-6027-3268","observed_orcids":["https://orcid.org/0000-0002-6027-3268"]},"institutions":[{"id":"https://openalex.org/I1343864894","display_name":"American Red Cross","ror":"https://ror.org/0284e2q78","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343864894"]},{"id":"https://openalex.org/I4210125368","display_name":"Adlyfe (United States)","ror":"https://ror.org/02gjczz49","country_code":"US","type":"company","lineage":["https://openalex.org/I4210125368"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Cindy S. Orser","raw_affiliation_strings":["From Adlyfe Inc., Rockville; the American Red Cross Holland Laboratory, Rockville; and 7815 Exeter Road, Bethesda, Maryland","7815 Exeter Road, Bethesda, Maryland","From Adlyfe Inc., Rockville","the American Red Cross Holland Laboratory, Rockville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Adlyfe Inc., Rockville; the American Red Cross Holland Laboratory, Rockville; and 7815 Exeter Road, Bethesda, Maryland","institution_ids":["https://openalex.org/I1343864894","https://openalex.org/I4210125368"]},{"raw_affiliation_string":"7815 Exeter Road, Bethesda, Maryland","institution_ids":[]},{"raw_affiliation_string":"From Adlyfe Inc., Rockville","institution_ids":["https://openalex.org/I4210125368"]},{"raw_affiliation_string":"the American Red Cross Holland Laboratory, Rockville","institution_ids":["https://openalex.org/I1343864894"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063918229"],"corresponding_institution_ids":["https://openalex.org/I1343864894","https://openalex.org/I4210125368"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":1.4193,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.79010844,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"47","issue":"8","first_page":"1418","last_page":"1425"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prion-protein","display_name":"prion protein","score":0.7829999923706055},{"id":"https://openalex.org/keywords/prion-disease","display_name":"prion disease","score":0.9120000004768372},{"id":"https://openalex.org/keywords/variant-creutzfeldt-jakob-disease","display_name":"variant Creutzfeldt-Jakob disease","score":0.9789999723434448},{"id":"https://openalex.org/keywords/blood-borne-transmission","display_name":"blood-borne transmission","score":0.7490000128746033},{"id":"https://openalex.org/keywords/preclinical-diagnosis","display_name":"preclinical diagnosis","score":0.8519999980926514}],"concepts":[{"id":"https://openalex.org/C2776797465","wikidata":"https://www.wikidata.org/wiki/Q703961","display_name":"Transmissible spongiform encephalopathy","level":5,"score":0.6573760509490967},{"id":"https://openalex.org/C3019804061","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"Prion protein","level":3,"score":0.5912759304046631},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5550577044487},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4940260052680969},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.4804931879043579},{"id":"https://openalex.org/C2776735649","wikidata":"https://www.wikidata.org/wiki/Q170102","display_name":"Scrapie","level":4,"score":0.45658060908317566},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36794912815093994},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35589075088500977},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33487021923065186},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2254757285118103},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1931864619255066},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11683481931686401}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007562","descriptor_name":"Creutzfeldt-Jakob Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012453","descriptor_name":"Saimiri","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1537-2995.2007.01284.x","doi":"https://doi.org/10.1111/j.1537-2995.2007.01284.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1537-2995.2007.01284.x","pdf_url":null,"source":{"id":"https://openalex.org/S186746772","display_name":"Transfusion","issn_l":"0041-1132","issn":["0041-1132","0372-1248","1537-2995","1878-2000"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"journal-article"},{"id":"pmid:17655586","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17655586","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transfusion","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6305543467","display_name":"A Catalytic Conformational Prion Sensor","funder_award_id":"R44HL070399","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W575274498","https://openalex.org/W1517840400","https://openalex.org/W1534728973","https://openalex.org/W1967261289","https://openalex.org/W1993236921","https://openalex.org/W2023455220","https://openalex.org/W2025353708","https://openalex.org/W2059138896","https://openalex.org/W2062743922","https://openalex.org/W2065491387","https://openalex.org/W2074255015","https://openalex.org/W2077816664","https://openalex.org/W2078025540","https://openalex.org/W2083540358","https://openalex.org/W2086797744","https://openalex.org/W2103270514","https://openalex.org/W2107037134","https://openalex.org/W2121674689","https://openalex.org/W2132770777","https://openalex.org/W2135545560","https://openalex.org/W2145334425","https://openalex.org/W2147937741","https://openalex.org/W2154713296","https://openalex.org/W2162119312","https://openalex.org/W2414792524","https://openalex.org/W2418883384","https://openalex.org/W2769281473","https://openalex.org/W4234607286"],"related_works":["https://openalex.org/W2023455220","https://openalex.org/W2144880563","https://openalex.org/W7096162738","https://openalex.org/W1995741726","https://openalex.org/W2042524112","https://openalex.org/W2000703103","https://openalex.org/W4300514438","https://openalex.org/W7095509186","https://openalex.org/W1437299811","https://openalex.org/W1987349846"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,38,70,85,209],"long-standing":[2],"goal":[3],"of":[4,19,49,56,64,72,92,117,125,139,161,181,195,221,233,236],"a":[5,45,54,89,109,179,192,213],"preclinical":[6,229],"diagnostic":[7,41],"test":[8,217],"for":[9,133,218],"transmissible":[10],"spongiform":[11],"encephalopathy":[12],"(TSE)":[13],"has":[14],"recently":[15],"become":[16],"urgent":[17],"because":[18],"the":[20,62,65,73,97,173,219],"discovery":[21],"that":[22,52,223],"humans":[23],"with":[24,96,113,142,163,191],"variant":[25],"Creutzfeldt-Jakob":[26],"disease":[27,30],"can":[28],"transmit":[29],"via":[31],"blood":[32],"transfusions.":[33],"STUDY":[34],"DESIGN":[35],"AND":[36],"METHODS:":[37],"misfolded":[39,66],"protein":[40,68],"(MPD)":[42],"assay":[43,74,140,157,174,211],"employs":[44],"pyrene-labeled":[46],"palindromic":[47],"sequence":[48],"prion":[50,67],"peptides":[51],"undergoes":[53],"cascade":[55],"coil":[57],"to":[58,75,127,169,188],"beta-sheet":[59],"conversion":[60],"in":[61,78,100,146,202,227],"presence":[63],"(PrP(TSE)).":[69],"ability":[71],"detect":[76],"PrP(TSE)":[77,134,222],"brain,":[79],"serum,":[80,172],"and":[81,120,152,155,183,215,230,238],"plasma":[82,170,204],"was":[83,106,135],"tested.":[84],"basic":[86],"protocol":[87],"involved":[88],"several-hour":[90],"incubation":[91],"200-microL":[93],"sample":[94],"volumes":[95],"peptide":[98,165],"reagent":[99],"96-well":[101],"plates,":[102],"after":[103],"which":[104],"fluorescence":[105,110],"monitored":[107],"by":[108,137,159],"plate":[111],"reader":[112],"an":[114],"excitation":[115],"wavelength":[116,123],"350":[118],"nm":[119],"emission":[121],"scanning":[122],"range":[124],"365":[126],"600":[128],"nm.":[129],"RESULTS:":[130],"Target":[131],"specificity":[132],"documented":[136],"correlation":[138],"signal":[141],"Western":[143],"blot":[144],"signals":[145,158],"brain":[147],"tissue":[148],"from":[149,178,205],"TSE-infected,":[150],"normal,":[151],"knockout":[153],"mice":[154],"negative":[156],"use":[160],"reagents":[162],"different":[164],"sequences.":[166],"When":[167],"applied":[168],"or":[171],"discriminated":[175],"between":[176],"samples":[177],"variety":[180],"experimental":[182],"natural":[184],"TSE":[185,234],"infections":[186],"compared":[187],"uninfected":[189],"controls,":[190],"sensitivity":[193],"threshold":[194],"approximately":[196],"1":[197],"infectious":[198],"dose":[199],"per":[200],"mL":[201],"pooled":[203],"TSE-infected":[206],"mice.":[207],"CONCLUSIONS:":[208],"MPD":[210],"is":[212],"sensitive":[214],"specific":[216],"detection":[220],"may":[224],"be":[225],"useful":[226],"both":[228],"clinical":[231],"diagnosis":[232],"diseases":[235],"animals":[237],"humans.":[239]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}