{"id":"https://openalex.org/W2020532274","doi":"https://doi.org/10.1016/s1471-4906(01)01984-6","title":"Antinuclear autoantibodies as potential antineoplastic agents","display_name":"Antinuclear autoantibodies as potential antineoplastic agents","publication_year":2001,"publication_date":"2001-08-01","ids":{"openalex":"https://openalex.org/W2020532274","doi":"https://doi.org/10.1016/s1471-4906(01)01984-6","mag":"2020532274","pmid":"https://pubmed.ncbi.nlm.nih.gov/11473830"},"language":"en","primary_location":{"id":"doi:10.1016/s1471-4906(01)01984-6","doi":"https://doi.org/10.1016/s1471-4906(01)01984-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1471-4906(01)01984-6","pdf_url":null,"source":{"id":"https://openalex.org/S84926904","display_name":"Trends in Immunology","issn_l":"1471-4906","issn":["1471-4906","1471-4981"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103237936","display_name":"Vladimir P. Torchilin","orcid":"https://orcid.org/0000-0003-4245-5196","observed_orcids":["https://orcid.org/0000-0003-4245-5196"]},"institutions":[{"id":"https://openalex.org/I12912129","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781","country_code":"US","type":"education","lineage":["https://openalex.org/I12912129"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vladimir P. Torchilin","raw_affiliation_strings":["Dept of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA. vtorchil@lynx.neu.edu","Dept of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA. vtorchil@lynx.neu.edu","institution_ids":["https://openalex.org/I12912129"]},{"raw_affiliation_string":"Dept of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA","institution_ids":["https://openalex.org/I12912129"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061034711","display_name":"Leonid Z. Iakoubov","orcid":"https://orcid.org/0000-0001-9666-2110","observed_orcids":["https://orcid.org/0000-0001-9666-2110"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leonid Z. Iakoubov","raw_affiliation_strings":["c/o Procyon Biopharma Inc., 1650 Trans-Canada Highway, Suite 200, Dorval, Quebec, Canada H9P 1H7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"c/o Procyon Biopharma Inc., 1650 Trans-Canada Highway, Suite 200, Dorval, Quebec, Canada H9P 1H7","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084290698","display_name":"Zeev E. Estrov","orcid":"https://orcid.org/0000-0002-1623-3613","observed_orcids":["https://orcid.org/0000-0002-1623-3613"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zeev Estrov","raw_affiliation_strings":["Dept of Bioimmunotherapy, M.D. Anderson Cancer Center, The University of Texas, 1515 Holcombe Rd, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept of Bioimmunotherapy, M.D. Anderson Cancer Center, The University of Texas, 1515 Holcombe Rd, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103237936"],"corresponding_institution_ids":["https://openalex.org/I12912129"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":0.7006,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.53229974,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"22","issue":"8","first_page":"424","last_page":"427"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.4514000117778778,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.4514000117778778,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.22840000689029694,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.1664000004529953,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antinuclear-antibodies","display_name":"antinuclear antibodies","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.9160000085830688},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7360000014305115},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.9779999852180481},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.5879999995231628},{"id":"https://openalex.org/keywords/monoclonal-autoantibodies","display_name":"monoclonal autoantibodies","score":0.8320000171661377},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.6740000247955322},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C149443304","wikidata":"https://www.wikidata.org/wiki/Q185390","display_name":"Anti-nuclear antibody","level":4,"score":0.7761999368667603},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.7286442518234253},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.7012892961502075},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.5604967474937439},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5036434531211853},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5017385482788086},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4882395565509796},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4153570830821991},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.26828792691230774},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17618906497955322}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000974","descriptor_name":"Antibodies, Antinuclear","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000974","descriptor_name":"Antibodies, Antinuclear","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1471-4906(01)01984-6","doi":"https://doi.org/10.1016/s1471-4906(01)01984-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1471-4906(01)01984-6","pdf_url":null,"source":{"id":"https://openalex.org/S84926904","display_name":"Trends in Immunology","issn_l":"1471-4906","issn":["1471-4906","1471-4981"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Immunology","raw_type":"journal-article"},{"id":"pmid:11473830","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11473830","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W78319224","https://openalex.org/W141253545","https://openalex.org/W311185857","https://openalex.org/W1554543161","https://openalex.org/W1628836607","https://openalex.org/W1634728584","https://openalex.org/W1807797373","https://openalex.org/W1917754692","https://openalex.org/W1964847117","https://openalex.org/W1969841962","https://openalex.org/W1971796295","https://openalex.org/W1973727813","https://openalex.org/W1974620735","https://openalex.org/W1978079675","https://openalex.org/W1983825482","https://openalex.org/W1997797597","https://openalex.org/W1998136765","https://openalex.org/W2004480635","https://openalex.org/W2004593317","https://openalex.org/W2013691673","https://openalex.org/W2015164514","https://openalex.org/W2025987074","https://openalex.org/W2030063736","https://openalex.org/W2032437474","https://openalex.org/W2034379055","https://openalex.org/W2047149688","https://openalex.org/W2061643328","https://openalex.org/W2066987196","https://openalex.org/W2068660434","https://openalex.org/W2070787533","https://openalex.org/W2071152014","https://openalex.org/W2074127325","https://openalex.org/W2081889939","https://openalex.org/W2083437069","https://openalex.org/W2085163546","https://openalex.org/W2093846994","https://openalex.org/W2103972021","https://openalex.org/W2106930088","https://openalex.org/W2114001003","https://openalex.org/W2128152608","https://openalex.org/W2128159151","https://openalex.org/W2171347113","https://openalex.org/W2316917533","https://openalex.org/W2325372898","https://openalex.org/W2408991306","https://openalex.org/W2409038382","https://openalex.org/W2409737989","https://openalex.org/W2411854169","https://openalex.org/W2412408006","https://openalex.org/W2414353020","https://openalex.org/W2418363696","https://openalex.org/W2419537858","https://openalex.org/W6610895081"],"related_works":["https://openalex.org/W2804983558","https://openalex.org/W2409737989","https://openalex.org/W2011040735","https://openalex.org/W3031661936","https://openalex.org/W1608511089","https://openalex.org/W2008281879","https://openalex.org/W2328246862","https://openalex.org/W2570354750","https://openalex.org/W4385885495","https://openalex.org/W4415911162"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}