{"id":"https://openalex.org/W2020491908","doi":"https://doi.org/10.1089/hum.2004.15.989","title":"Nitroprusside Increases Gene Transfer Associated with Intracoronary Delivery of Adenovirus","display_name":"Nitroprusside Increases Gene Transfer Associated with Intracoronary Delivery of Adenovirus","publication_year":2004,"publication_date":"2004-10-01","ids":{"openalex":"https://openalex.org/W2020491908","doi":"https://doi.org/10.1089/hum.2004.15.989","mag":"2020491908","pmid":"https://pubmed.ncbi.nlm.nih.gov/15585114"},"language":"en","primary_location":{"id":"doi:10.1089/hum.2004.15.989","doi":"https://doi.org/10.1089/hum.2004.15.989","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hum.2004.15.989","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102925906","display_name":"David M. Roth","orcid":"https://orcid.org/0000-0001-5735-0050","observed_orcids":["https://orcid.org/0000-0001-5735-0050"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Roth","raw_affiliation_strings":["Collateral Therapeutics, San Diego, CA 92130","Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92103","Veterans Affairs San Diego Healthcare System, San Diego, CA 92161","Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92103.; Veterans Affairs San Diego Healthcare System, San Diego, CA 92161"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collateral Therapeutics, San Diego, CA 92130","institution_ids":[]},{"raw_affiliation_string":"Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92103","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Veterans Affairs San Diego Healthcare System, San Diego, CA 92161","institution_ids":["https://openalex.org/I4210099595"]},{"raw_affiliation_string":"Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92103.; Veterans Affairs San Diego Healthcare System, San Diego, CA 92161","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210099595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112810711","display_name":"N. Chin Lai","orcid":"https://orcid.org/0009-0006-7390-1119","observed_orcids":["https://orcid.org/0009-0006-7390-1119"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Chin Lai","raw_affiliation_strings":["Department of Medicine, University of California, San Diego, La Jolla, CA 92103"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, San Diego, La Jolla, CA 92103","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083905221","display_name":"Mei Hua Gao","orcid":"https://orcid.org/0000-0002-3826-7662","observed_orcids":["https://orcid.org/0000-0002-3826-7662"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mei Hua Gao","raw_affiliation_strings":["Department of Medicine, University of California, San Diego, La Jolla, CA 92103"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, San Diego, La Jolla, CA 92103","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023745540","display_name":"Suzanne Fine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suzanne Fine","raw_affiliation_strings":["Collateral Therapeutics, San Diego, CA 92130"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collateral Therapeutics, San Diego, CA 92130","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003724428","display_name":"M. Dan McKirnan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Dan McKirnan","raw_affiliation_strings":["Collateral Therapeutics, San Diego, CA 92130"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collateral Therapeutics, San Diego, CA 92130","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"David A. Roth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Roth","raw_affiliation_strings":["Collateral Therapeutics, San Diego, CA 92130","Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92103","Veterans Affairs San Diego Healthcare System, San Diego, CA 92161"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collateral Therapeutics, San Diego, CA 92130","institution_ids":[]},{"raw_affiliation_string":"Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92103","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Veterans Affairs San Diego Healthcare System, San Diego, CA 92161","institution_ids":["https://openalex.org/I4210099595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051781429","display_name":"H. Kirk Hammond","orcid":"https://orcid.org/0000-0002-6432-5934","observed_orcids":["https://orcid.org/0000-0002-6432-5934"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Kirk Hammond","raw_affiliation_strings":["Department of Medicine, University of California, San Diego, La Jolla, CA 92103","Veterans Affairs San Diego Healthcare System, San Diego, CA 92161","Department of Medicine, University of California, San Diego, La Jolla, CA 92103.; Veterans Affairs San Diego Healthcare System, San Diego, CA 92161"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, San Diego, La Jolla, CA 92103","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Veterans Affairs San Diego Healthcare System, San Diego, CA 92161","institution_ids":["https://openalex.org/I4210099595"]},{"raw_affiliation_string":"Department of Medicine, University of California, San Diego, La Jolla, CA 92103.; Veterans Affairs San Diego Healthcare System, San Diego, CA 92161","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210099595"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8265,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.70437216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"15","issue":"10","first_page":"989","last_page":"994"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-nitroprusside","display_name":"sodium nitroprusside","score":0.9990000128746033},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.8579999804496765},{"id":"https://openalex.org/keywords/intracoronary-infusion","display_name":"intracoronary infusion","score":0.8309999704360962},{"id":"https://openalex.org/keywords/cardiac-gene-transfer","display_name":"cardiac gene transfer","score":0.9190000295639038},{"id":"https://openalex.org/keywords/nitric-oxide-donors","display_name":"nitric oxide donors","score":0.8109999895095825},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.6000000238418579},{"id":"https://openalex.org/keywords/pigs","display_name":"pigs","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C2779178603","wikidata":"https://www.wikidata.org/wiki/Q356257","display_name":"Adenylyl cyclase","level":3,"score":0.5964815616607666},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.5684677362442017},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.49756553769111633},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.4825124740600586},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48125430941581726},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.4503629207611084},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4287635385990143},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.41384655237197876},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38071534037590027},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.32769668102264404},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26116400957107544},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21954119205474854},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.0754123330116272},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.07245340943336487},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009599","descriptor_name":"Nitroprusside","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009599","descriptor_name":"Nitroprusside","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020030","descriptor_name":"Nitric Oxide Donors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/hum.2004.15.989","doi":"https://doi.org/10.1089/hum.2004.15.989","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hum.2004.15.989","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},{"id":"pmid:15585114","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15585114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human gene therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3020380486","display_name":null,"funder_award_id":"1P501HL-66941","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1485498287","https://openalex.org/W1547749433","https://openalex.org/W1903145737","https://openalex.org/W1973464565","https://openalex.org/W1985695559","https://openalex.org/W1992890921","https://openalex.org/W2004554331","https://openalex.org/W2007098938","https://openalex.org/W2014402245","https://openalex.org/W2014414897","https://openalex.org/W2016626897","https://openalex.org/W2018284472","https://openalex.org/W2029375351","https://openalex.org/W2031102459","https://openalex.org/W2074131116","https://openalex.org/W2085093754","https://openalex.org/W2097340844","https://openalex.org/W2098421791","https://openalex.org/W2102593198","https://openalex.org/W2133551523","https://openalex.org/W2136812723","https://openalex.org/W2162844134","https://openalex.org/W2163399518","https://openalex.org/W2163473787","https://openalex.org/W2165902254","https://openalex.org/W2169503005","https://openalex.org/W2170511068","https://openalex.org/W2171284332","https://openalex.org/W2244161543","https://openalex.org/W2299966384","https://openalex.org/W2318990189","https://openalex.org/W2403719174","https://openalex.org/W4211094368"],"related_works":["https://openalex.org/W2165902254","https://openalex.org/W2312258002","https://openalex.org/W2097340844","https://openalex.org/W2081483020","https://openalex.org/W7095110601","https://openalex.org/W2035575505","https://openalex.org/W1513646726","https://openalex.org/W2073762202","https://openalex.org/W2016626897","https://openalex.org/W1987031292"],"abstract_inverted_index":{"Efficient":[0],"gene":[1,17,39,140],"transfer":[2,40,141],"by":[3,109],"vectors":[4],"that":[5,23],"can":[6],"be":[7],"easily":[8],"delivered":[9],"to":[10,41,134],"target":[11],"organs":[12],"is":[13,128],"desirable":[14],"in":[15,58,98,101,117],"clinical":[16],"therapy.":[18],"We":[19],"tested":[20],"the":[21,27,34,42,102,136],"hypothesis":[22],"intracoronary":[24,65,88,143],"infusion":[25,66,89,127],"of":[26,36,46,67,85,90,138,145],"nitric":[28],"oxide":[29],"donor":[30],"nitroprusside":[31,86,112,126],"would":[32],"increase":[33,97,135],"efficiency":[35],"adenovirus":[37,48,146],"vector-mediated":[38],"heart.":[43],"Intracoronary":[44,111,125],"delivery":[45,76,144],"an":[47],"encoding":[49],"murine":[50],"adenylyl":[51,79],"cyclase":[52,80],"type":[53],"VI":[54],"(Ad.AC(VI))":[55],"was":[56,82,92,107],"performed":[57],"adult":[59],"pigs":[60],"with":[61,94,142],"and":[62,77,120,131],"without":[63],"simultaneous":[64],"nitroprusside.":[68],"Animals":[69],"were":[70],"killed":[71],"12-14":[72],"days":[73],"after":[74],"Ad.AC(VI)":[75,91],"myocardial":[78],"activity":[81],"measured.":[83],"Addition":[84],"during":[87,123],"associated":[93],"a":[95,129],"4-fold":[96],"cAMP-generating":[99],"capacity":[100],"left":[103],"ventricle.":[104],"Transgene":[105],"expression":[106],"confirmed":[108],"immunoblotting.":[110],"produced":[113],"mild":[114],"dose-dependent":[115],"changes":[116],"blood":[118],"pressure":[119],"heart":[121],"rate":[122],"infusion.":[124],"safe":[130],"effective":[132],"means":[133],"extent":[137],"cardiac":[139],"vectors.":[147]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
