{"id":"https://openalex.org/W2020483546","doi":"https://doi.org/10.1634/stemcells.2007-0657","title":"Absence of OCT4 Expression in Somatic Tumor Cell Lines","display_name":"Absence of OCT4 Expression in Somatic Tumor Cell Lines","publication_year":2007,"publication_date":"2007-11-21","ids":{"openalex":"https://openalex.org/W2020483546","doi":"https://doi.org/10.1634/stemcells.2007-0657","mag":"2020483546","pmid":"https://pubmed.ncbi.nlm.nih.gov/18032701"},"language":"en","primary_location":{"id":"doi:10.1634/stemcells.2007-0657","doi":"https://doi.org/10.1634/stemcells.2007-0657","is_oa":false,"landing_page_url":"https://doi.org/10.1634/stemcells.2007-0657","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022812409","display_name":"Tobias Cantz","orcid":"https://orcid.org/0000-0002-1382-9577","observed_orcids":["https://orcid.org/0000-0002-1382-9577"]},"institutions":[{"id":"https://openalex.org/I4210152666","display_name":"Max Planck Institute for Molecular Biomedicine","ror":"https://ror.org/040djv263","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tobias Cantz","raw_affiliation_strings":["Max Planck Institute for Molecular Biomedicine, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Biomedicine, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210152666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109991856","display_name":"G\u00f6ran Key","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152666","display_name":"Max Planck Institute for Molecular Biomedicine","ror":"https://ror.org/040djv263","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"G\u00f6ran Key","raw_affiliation_strings":["Max Planck Institute for Molecular Biomedicine, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Biomedicine, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210152666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090330493","display_name":"Martina Bleidi\u03b2el","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152666","display_name":"Max Planck Institute for Molecular Biomedicine","ror":"https://ror.org/040djv263","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martina Bleidi\u03b2el","raw_affiliation_strings":["Max Planck Institute for Molecular Biomedicine, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Biomedicine, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210152666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038452833","display_name":"Luca Gentile","orcid":"https://orcid.org/0000-0002-7393-7502","observed_orcids":["https://orcid.org/0000-0002-7393-7502"]},"institutions":[{"id":"https://openalex.org/I4210152666","display_name":"Max Planck Institute for Molecular Biomedicine","ror":"https://ror.org/040djv263","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Luca Gentile","raw_affiliation_strings":["Max Planck Institute for Molecular Biomedicine, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Biomedicine, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210152666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100450847","display_name":"Dong\u2010Wook Han","orcid":"https://orcid.org/0000-0001-8314-1981","observed_orcids":["https://orcid.org/0000-0001-8314-1981"]},"institutions":[{"id":"https://openalex.org/I4210152666","display_name":"Max Planck Institute for Molecular Biomedicine","ror":"https://ror.org/040djv263","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dong Wook Han","raw_affiliation_strings":["Max Planck Institute for Molecular Biomedicine, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Biomedicine, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210152666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076176943","display_name":"Alexandra Brenne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152666","display_name":"Max Planck Institute for Molecular Biomedicine","ror":"https://ror.org/040djv263","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152666"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexandra Brenne","raw_affiliation_strings":["Max Planck Institute for Molecular Biomedicine, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Biomedicine, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210152666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078962332","display_name":"Hans Robert Sch\u00f6ler","orcid":"https://orcid.org/0000-0003-2643-5136","observed_orcids":["https://orcid.org/0000-0003-2643-5136","https://orcid.org/0000-0002-7422-8847"]},"institutions":[{"id":"https://openalex.org/I4210152666","display_name":"Max Planck Institute for Molecular Biomedicine","ror":"https://ror.org/040djv263","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210152666"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Hans R. Sch\u00f6ler","raw_affiliation_strings":["Max Planck Institute for Molecular Biomedicine, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max Planck Institute for Molecular Biomedicine, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I4210152666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078962332"],"corresponding_institution_ids":["https://openalex.org/I4210152666"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":4.2348,"has_fulltext":false,"cited_by_count":119,"citation_normalized_percentile":{"value":0.95262504,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"26","issue":"3","first_page":"692","last_page":"697"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oct4","display_name":"Oct4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.7749999761581421},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/oct4-promoter","display_name":"Oct4 promoter","score":0.7049999833106995},{"id":"https://openalex.org/keywords/rt-pcr-confirmation","display_name":"RT-PCR validation","score":0.6980000138282776},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.6639999747276306},{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.7590000033378601},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8320506811141968},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.6338625550270081},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5666275024414062},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5644347071647644},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.5165032744407654},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.49043866991996765},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1372430920600891},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12903296947479248},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11880984902381897}],"mesh":[{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050814","descriptor_name":"Octamer Transcription Factor-3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1634/stemcells.2007-0657","doi":"https://doi.org/10.1634/stemcells.2007-0657","is_oa":false,"landing_page_url":"https://doi.org/10.1634/stemcells.2007-0657","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},{"id":"pmid:18032701","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18032701","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells (Dayton, Ohio)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1957763880","https://openalex.org/W1964174851","https://openalex.org/W1978811387","https://openalex.org/W1981088384","https://openalex.org/W1984470808","https://openalex.org/W1986891175","https://openalex.org/W1993253685","https://openalex.org/W2006719016","https://openalex.org/W2007921976","https://openalex.org/W2015511103","https://openalex.org/W2016161982","https://openalex.org/W2018187946","https://openalex.org/W2018429029","https://openalex.org/W2029387074","https://openalex.org/W2036710224","https://openalex.org/W2037641339","https://openalex.org/W2040511639","https://openalex.org/W2044806144","https://openalex.org/W2050300062","https://openalex.org/W2081777956","https://openalex.org/W2087272148","https://openalex.org/W2141128578","https://openalex.org/W2144108148","https://openalex.org/W2151210821","https://openalex.org/W2154635123","https://openalex.org/W2253724694"],"related_works":["https://openalex.org/W2088596095","https://openalex.org/W2027162391","https://openalex.org/W2418184567","https://openalex.org/W1987060859","https://openalex.org/W7111034018","https://openalex.org/W2142144785","https://openalex.org/W2082989859","https://openalex.org/W2143365922","https://openalex.org/W4250063609","https://openalex.org/W2632904172"],"abstract_inverted_index":{"The":[0],"POU-domain":[1],"transcription":[2,129],"factor":[3,130],"OCT4":[4,41,65,79,88,128,158,177,189,206,220,243],"is":[5,43,192],"associated":[6],"with":[7,106],"the":[8,14,31,75,91,98,107,127,132,188,235],"pluripotent":[9],"state":[10],"of":[11,18,33,35,40,126,134,176,205,225,242],"cells":[12,49,138,153,184],"comprising":[13],"inner":[15],"cell":[16,71,94,101,110,213,247],"mass":[17],"pre-implantation":[19],"embryos":[20],"and":[21,83,97,117,136,151,181,197,210,251],"has":[22],"been":[23],"known":[24],"to":[25,45,59,123,172,219],"play":[26],"a":[27],"critical":[28],"role":[29],"in":[30,47,67,78,90,104,131,149,179,182,195,208,228,240,245],"maintenance":[32],"pluripotency":[34],"embryonic":[36],"stem":[37],"cells.":[38,199],"Reactivation":[39],"expression":[42,66,80,89,207,222,244],"postulated":[44],"occur":[46],"differentiated":[48],"that":[50,202],"have":[51],"undergone":[52],"carcinogenesis,":[53],"or":[54,223],"tumor":[55,70],"formation.":[56],"In":[57,167,231],"contrast":[58],"earlier":[60,82],"studies,":[61,85],"recent":[62,84,203],"reports":[63,204],"describe":[64],"several":[68],"human":[69,108],"lines.":[72],"To":[73],"resolve":[74],"apparent":[76],"discrepancy":[77],"between":[81],"we":[86,169,233],"determined":[87],"cervical":[92],"carcinoma":[93],"line":[95,102,111],"HeLa":[96,135,150,180,196],"breast":[99],"cancer":[100,212],"MCF7":[103,137,152,183,198],"comparison":[105],"teratoma":[109],"nTera":[112],"by":[113,139,163,185,249],"immunofluorescence,":[114],"Western":[115,164],"blot,":[116],"RT-PCR":[118],"analyses.":[119],"We":[120,200],"were":[121,170],"unable":[122,171],"detect":[124,173],"staining":[125,148],"nucleus":[133],"immunofluorescence":[140,229,250],"using":[141],"two":[142],"different":[143],"monoclonal":[144],"antibodies.":[145],"Faint":[146],"cytoplasmic":[147],"was":[154],"observed;":[155],"however,":[156],"no":[157],"signal":[159],"could":[160,215],"be":[161,217],"detected":[162],"blot":[165],"analysis.":[166],"addition,":[168],"significant":[174],"levels":[175],"mRNA":[178],"RT-PCR.":[186,252],"Furthermore,":[187],"promoter":[190],"region":[191],"highly":[193],"methylated":[194],"argue":[201],"these":[209],"other":[211],"lines":[214,248],"actually":[216],"attributed":[218],"pseudogene":[221],"misinterpretation":[224],"background":[226],"signals":[227],"experiments.":[230],"conclusion,":[232],"emphasize":[234],"need":[236],"for":[237],"adequate":[238],"controls":[239],"investigations":[241],"somatic":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":13}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}