{"id":"https://openalex.org/W2020479420","doi":"https://doi.org/10.1159/000332599","title":"Regulation of Physiologic Actions of LRRK2: Focus on Autophagy","display_name":"Regulation of Physiologic Actions of LRRK2: Focus on Autophagy","publication_year":2011,"publication_date":"2011-12-23","ids":{"openalex":"https://openalex.org/W2020479420","doi":"https://doi.org/10.1159/000332599","mag":"2020479420","pmid":"https://pubmed.ncbi.nlm.nih.gov/22204929","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3363354"},"language":"en","primary_location":{"id":"doi:10.1159/000332599","doi":"https://doi.org/10.1159/000332599","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000332599","pdf_url":null,"source":{"id":"https://openalex.org/S101887095","display_name":"Neurodegenerative Diseases","issn_l":"1660-2854","issn":["1660-2854","1660-2862"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurodegenerative Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3363354","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001904809","display_name":"Andrew W. Ferree","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Ferree","raw_affiliation_strings":["Department of Pharmacology, Boston University School of Medicine, Boston, Mass 02118-2526, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Boston University School of Medicine, Boston, Mass 02118-2526, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037960740","display_name":"Maria D. Guillily","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Guillily","raw_affiliation_strings":["Boston University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100444593","display_name":"Hu Li","orcid":"https://orcid.org/0000-0001-5957-5472","observed_orcids":["https://orcid.org/0000-0001-5957-5472"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hu Li","raw_affiliation_strings":["Biomedical Engineering, Boston University School of Medicine, Boston, Mass.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Boston University School of Medicine, Boston, Mass.,","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021411845","display_name":"Katelyn Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katelyn Smith","raw_affiliation_strings":["Boston University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023769754","display_name":"Aki Takashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160102","display_name":"National Center for Geriatrics and Gerontology","ror":"https://ror.org/05h0rw812","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210160102"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Aki Takashima","raw_affiliation_strings":["National Center for Geriatrics and Gerontology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Geriatrics and Gerontology","institution_ids":["https://openalex.org/I4210160102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112791305","display_name":"Rachel M. Squillace","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387156154","display_name":"ARIAD Pharmaceuticals (United States)","ror":"https://ror.org/01dwtyk53","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I4387156154","https://openalex.org/I44892455"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Squillace","raw_affiliation_strings":["ARIAD Pharmaceuticals, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ARIAD Pharmaceuticals, Inc","institution_ids":["https://openalex.org/I4387156154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111534053","display_name":"Manfred Weigele","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387156154","display_name":"ARIAD Pharmaceuticals (United States)","ror":"https://ror.org/01dwtyk53","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I4387156154","https://openalex.org/I44892455"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manfred Weigele","raw_affiliation_strings":["ARIAD Pharmaceuticals, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ARIAD Pharmaceuticals, Inc","institution_ids":["https://openalex.org/I4387156154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065209470","display_name":"James J. Collins","orcid":"https://orcid.org/0000-0002-5560-8246","observed_orcids":["https://orcid.org/0000-0002-5560-8246"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James J. Collins","raw_affiliation_strings":["Boston University","Howard Hughes Medical Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Howard Hughes Medical Institute","institution_ids":["https://openalex.org/I1344073410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071579004","display_name":"Benjamin L. Wolozin","orcid":"https://orcid.org/0000-0003-2068-1475","observed_orcids":["https://orcid.org/0000-0003-2068-1475"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Wolozin","raw_affiliation_strings":["Boston University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.314,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.94432071,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"10","issue":"1-4","first_page":"238","last_page":"241"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lrrk2","display_name":"LRRK2","score":0.996999979019165},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lrrk2-mutations","display_name":"LRRK2 mutations","score":0.878000020980835},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.5460000038146973},{"id":"https://openalex.org/keywords/mtor-inhibition","display_name":"mTOR inhibition","score":0.7329999804496765},{"id":"https://openalex.org/keywords/ridaforolimus","display_name":"ridaforolimus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9269999861717224},{"id":"https://openalex.org/keywords/motor-impairment","display_name":"motor impairment","score":0.6079999804496765},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.6940000057220459},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.7170000076293945},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C2780427247","wikidata":"https://www.wikidata.org/wiki/Q409961","display_name":"LRRK2","level":4,"score":0.9523336887359619},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9154908061027527},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.7844961285591125},{"id":"https://openalex.org/C28362024","wikidata":"https://www.wikidata.org/wiki/Q2067413","display_name":"Thrashing","level":2,"score":0.6924149394035339},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.650486946105957},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.6124703884124756},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5520697236061096},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.491356760263443},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4590334892272949},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4127543568611145},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3896588087081909},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3558114171028137},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3260633051395416},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32353121042251587},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20937636494636536},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.16092592477798462},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C173608175","wikidata":"https://www.wikidata.org/wiki/Q232661","display_name":"Parallel computing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071158","descriptor_name":"Leucine-Rich Repeat Serine-Threonine Protein Kinase-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1159/000332599","doi":"https://doi.org/10.1159/000332599","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000332599","pdf_url":null,"source":{"id":"https://openalex.org/S101887095","display_name":"Neurodegenerative Diseases","issn_l":"1660-2854","issn":["1660-2854","1660-2862"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurodegenerative Diseases","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2611434","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3363354","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3363354","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3363354","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurodegener Dis","raw_type":"Text"},{"id":"pmid:22204929","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22204929","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-degenerative diseases","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2611434","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3363354","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6672039116","display_name":"LRRK2 and Neurodegeneration","funder_award_id":"R01NS060872","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7929399525","display_name":"Interaction Between Genes and the Mitochondria in Parkin","funder_award_id":"R01ES015567","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306136","display_name":"Michael J. Fox Foundation for Parkinson's Research","ror":"https://ror.org/03arq3225"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1981111142","https://openalex.org/W1992365739","https://openalex.org/W1997163042","https://openalex.org/W2032206743","https://openalex.org/W2034433559","https://openalex.org/W2044525257","https://openalex.org/W2072216745","https://openalex.org/W2074383422","https://openalex.org/W2074813364","https://openalex.org/W2087360216","https://openalex.org/W2091879895","https://openalex.org/W2100894616","https://openalex.org/W2103147849","https://openalex.org/W2120181899","https://openalex.org/W2136216054","https://openalex.org/W2164521538"],"related_works":["https://openalex.org/W2602005668","https://openalex.org/W2917093034","https://openalex.org/W3027854502","https://openalex.org/W2319002174","https://openalex.org/W2460136299","https://openalex.org/W1980236349","https://openalex.org/W1994444930","https://openalex.org/W4214706961","https://openalex.org/W2100066063","https://openalex.org/W1969182787"],"abstract_inverted_index":{"BACKGROUND:":[0],"Mutations":[1],"in":[2,38,84,172,179,199],"LRRK2":[3,18,39,53,127,171,198],"are":[4],"associated":[5],"with":[6,14,110,131,144],"familial":[7],"and":[8,72,187],"sporadic":[9],"Parkinson's":[10],"disease":[11],"(PD).":[12],"Subjects":[13],"PD":[15],"caused":[16],"by":[17,35,51,100],"mutations":[19,37],"show":[20],"pleiotropic":[21,43],"pathology":[22,44],"that":[23,148,177],"can":[24],"involve":[25],"inclusions":[26],"containing":[27],"\u03b1-synuclein,":[28],"tau":[29,92,116,133],"or":[30,93,129],"neither":[31],"protein.":[32],"The":[33,78],"mechanisms":[34,50],"which":[36,52],"lead":[40],"to":[41,62,157,182,189],"this":[42],"remain":[45],"unknown.":[46],"OBJECTIVES:":[47],"To":[48],"investigate":[49,63],"might":[54],"cause":[55],"PD.":[56,200],"METHODS:":[57],"We":[58],"used":[59],"systems":[60],"biology":[61],"the":[64,135,139,154,158,175,183,195],"transcriptomes":[65],"from":[66],"human":[67,69],"brains,":[68],"blood":[70],"cells":[71],"Caenorhabditis":[73],"elegans":[74,88,113,143],"expressing":[75,89,114],"wild-type":[76],"LRRK2.":[77,111],"role":[79,169],"of":[80,86,141,185,197],"autophagy":[81,106,180],"was":[82,98],"tested":[83],"lines":[85,140],"C.":[87,112,142],"LRRK2,":[90,186],"V337M":[91,115,132],"both":[94],"proteins.":[95],"Neuronal":[96],"function":[97],"measured":[99],"quantifying":[101],"thrashing.":[102],"RESULTS:":[103],"Genes":[104],"regulating":[105],"were":[107],"coordinately":[108],"regulated":[109],"showed":[117],"reduced":[118],"thrashing,":[119],"as":[120,161],"has":[121],"been":[122],"noted":[123],"previously.":[124],"Coexpressing":[125],"mutant":[126],"(R1441C":[128],"G2019S)":[130],"increased":[134,153],"motor":[136],"deficits.":[137],"Treating":[138],"an":[145],"mTOR":[146],"inhibitor":[147],"enhances":[149],"autophagic":[150],"flux,":[151],"ridaforolimus,":[152],"thrashing":[155],"behavior":[156],"same":[159],"level":[160],"nontransgenic":[162],"nematodes.":[163],"CONCLUSION:":[164],"These":[165],"data":[166],"support":[167],"a":[168,190],"for":[170],"autophagy,":[173],"raise":[174],"possibility":[176],"deficits":[178],"contribute":[181],"pathophysiology":[184,196],"point":[188],"potential":[191],"therapeutic":[192],"approach":[193],"addressing":[194]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}