{"id":"https://openalex.org/W2020479263","doi":"https://doi.org/10.1073/pnas.89.21.10109","title":"\"7-tetrahydrobiopterin,\" a naturally occurring analogue of tetrahydrobiopterin, is a cofactor for and a potential inhibitor of the aromatic amino acid hydroxylases.","display_name":"\"7-tetrahydrobiopterin,\" a naturally occurring analogue of tetrahydrobiopterin, is a cofactor for and a potential inhibitor of the aromatic amino acid hydroxylases.","publication_year":1992,"publication_date":"1992-11-01","ids":{"openalex":"https://openalex.org/W2020479263","doi":"https://doi.org/10.1073/pnas.89.21.10109","mag":"2020479263","pmid":"https://pubmed.ncbi.nlm.nih.gov/1359535","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/50287"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.89.21.10109","doi":"https://doi.org/10.1073/pnas.89.21.10109","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.89.21.10109","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC50287","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M D Davis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M D Davis","raw_affiliation_strings":["Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108246061","display_name":"Paula Ribeiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Ribeiro","raw_affiliation_strings":["Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000323303","display_name":"Jennifer P. Tipper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Tipper","raw_affiliation_strings":["Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108437014","display_name":"Seymour Kaufman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Kaufman","raw_affiliation_strings":["Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neurochemistry, National Institute of Mental Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0152,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.8608156,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"89","issue":"21","first_page":"10109","last_page":"10113"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetrahydrobiopterin","display_name":"tetrahydrobiopterin","score":0.9350000023841858},{"id":"https://openalex.org/keywords/aromatic-amino-acid-hydroxylases","display_name":"aromatic amino acid hydroxylases","score":0.9589999914169312},{"id":"https://openalex.org/keywords/phenylalanine-hydroxylase","display_name":"phenylalanine hydroxylase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tryptophan-hydroxylase","display_name":"tryptophan hydroxylase","score":0.9919999837875366},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":1.0},{"id":"https://openalex.org/keywords/enzyme-cofactors","display_name":"enzyme cofactors","score":0.5410000085830688},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.8410000205039978},{"id":"https://openalex.org/keywords/hyperphenylalaninemia","display_name":"hyperphenylalaninemia","score":0.9409999847412109},{"id":"https://openalex.org/keywords/pterins","display_name":"pterins","score":0.8190000057220459},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C207009774","wikidata":"https://www.wikidata.org/wiki/Q420604","display_name":"Phenylalanine hydroxylase","level":4,"score":0.9712871313095093},{"id":"https://openalex.org/C2776145790","wikidata":"https://www.wikidata.org/wiki/Q419808","display_name":"Tetrahydrobiopterin","level":4,"score":0.9592872858047485},{"id":"https://openalex.org/C159167319","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine hydroxylase","level":3,"score":0.8591725826263428},{"id":"https://openalex.org/C2780968477","wikidata":"https://www.wikidata.org/wiki/Q5898279","display_name":"Hyperphenylalaninemia","level":4,"score":0.8061150908470154},{"id":"https://openalex.org/C2775951788","wikidata":"https://www.wikidata.org/wiki/Q418293","display_name":"Tryptophan hydroxylase","level":5,"score":0.735550582408905},{"id":"https://openalex.org/C2776055822","wikidata":"https://www.wikidata.org/wiki/Q386702","display_name":"Pterin","level":4,"score":0.7255403399467468},{"id":"https://openalex.org/C2777431362","wikidata":"https://www.wikidata.org/wiki/Q170545","display_name":"Phenylalanine","level":3,"score":0.6888409852981567},{"id":"https://openalex.org/C2777992278","wikidata":"https://www.wikidata.org/wiki/Q705605","display_name":"Aromatic amino acids","level":3,"score":0.6825005412101746},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.6649245619773865},{"id":"https://openalex.org/C2777451243","wikidata":"https://www.wikidata.org/wiki/Q408256","display_name":"Biopterin","level":5,"score":0.6300980448722839},{"id":"https://openalex.org/C197957613","wikidata":"https://www.wikidata.org/wiki/Q407280","display_name":"Cofactor","level":3,"score":0.5659732818603516},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.5546676516532898},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.547782301902771},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5444633960723877},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.48421263694763184},{"id":"https://openalex.org/C2909129545","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine 3-Monooxygenase","level":4,"score":0.4829080104827881},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.33372753858566284},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.11710658669471741},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001708","descriptor_name":"Biopterins","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D001708","descriptor_name":"Biopterins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001708","descriptor_name":"Biopterins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010651","descriptor_name":"Phenylalanine Hydroxylase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010651","descriptor_name":"Phenylalanine Hydroxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014365","descriptor_name":"Tryptophan Hydroxylase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014365","descriptor_name":"Tryptophan Hydroxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.89.21.10109","doi":"https://doi.org/10.1073/pnas.89.21.10109","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.89.21.10109","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:45944","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC50287","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:50287","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/50287","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:1359535","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1359535","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:45944","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC50287","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W128341634","https://openalex.org/W1491056713","https://openalex.org/W1508211961","https://openalex.org/W1534631627","https://openalex.org/W1539302371","https://openalex.org/W1550127831","https://openalex.org/W1556966074","https://openalex.org/W1571821264","https://openalex.org/W1596611034","https://openalex.org/W1599646613","https://openalex.org/W1986566626","https://openalex.org/W1988145081","https://openalex.org/W1992081954","https://openalex.org/W2017571452","https://openalex.org/W2025624295","https://openalex.org/W2028037776","https://openalex.org/W2045799225","https://openalex.org/W2047931678","https://openalex.org/W2057903494","https://openalex.org/W2059353739","https://openalex.org/W2061183247","https://openalex.org/W2086955825","https://openalex.org/W2117481239","https://openalex.org/W2202561880","https://openalex.org/W2341431564","https://openalex.org/W2397558538"],"related_works":["https://openalex.org/W2017571452","https://openalex.org/W2006100561","https://openalex.org/W2023953960","https://openalex.org/W2009565470","https://openalex.org/W1989766948","https://openalex.org/W2036123110","https://openalex.org/W1996885631","https://openalex.org/W1980924030","https://openalex.org/W2953159454","https://openalex.org/W2003100919"],"abstract_inverted_index":{"The":[0],"ability":[1],"of":[2,24,78,81,95,103,125,140,168,174,188,194],"2-amino-4-hydroxy-7-[dihydroxylpropyl-(L-erythro)-5,6,7,8-tetrahyd":[3],"ropterin]":[4],"(\"7-tetrahydrobiopterin\"":[5],"or":[6,97,196],"7-BH4)":[7],"to":[8],"substitute":[9],"for":[10,40,54,119,131],"the":[11,22,25,37,55,60,76,93,101,116,129,151,166,178,192],"natural":[12,56],"cofactor":[13],"tetrahydrobiopterin":[14],"(BH4)":[15],"has":[16],"been":[17],"studied":[18],"in":[19,21,75,92,100,154,159,199],"vitro":[20],"reactions":[23],"three":[26],"mammalian":[27],"aromatic":[28],"amino":[29],"acid":[30],"hydroxylases.":[31],"With":[32,105],"rat":[33,107,112],"liver":[34],"phenylalanine":[35,169],"hydroxylase,":[36,115],"apparent":[38],"Km":[39,117,130],"7-BH4":[41,72,120,134,158,189],"is":[42,48,63,121,135,182],"160":[43],"microM,":[44],"a":[45,98,136],"value":[46,118],"that":[47,53,150,185],"approximately":[49],"60-fold":[50],"greater":[51,127],"than":[52,128],"cofactor.":[57],"In":[58],"contrast,":[59],"hydroxylase":[61,110,170,198],"reaction":[62],"severely":[64],"inhibited":[65],"by":[66,89,171],"as":[67,69],"little":[68],"1":[70],"microM":[71],"when":[73],"assayed":[74],"presence":[77],"physiological":[79],"concentrations":[80],"BH4.":[82,132],"This":[83],"inhibition":[84,167],"can":[85],"be":[86],"overcome":[87],"either":[88],"an":[90],"increase":[91],"concentration":[94,102],"BH4":[96],"decrease":[99],"phenylalanine.":[104],"both":[106,141],"brain":[108],"tryptophan":[109,142,197],"and":[111,143],"pheochromocytoma":[113],"tyrosine":[114,144,195],"about":[122],"one":[123],"order":[124],"magnitude":[126],"Accordingly,":[133],"poor":[137],"competitive":[138],"inhibitor":[139],"hydroxylase.":[145],"Thus,":[146],"our":[147],"results":[148],"suggest":[149],"observed":[152],"hyperphenylalaninemia":[153],"patients":[155],"who":[156],"excrete":[157],"their":[160],"urine":[161],"may":[162],"arise":[163],"directly":[164],"from":[165],"low":[172,186],"levels":[173,187],"this":[175],"pterin.":[176],"On":[177],"other":[179],"hand,":[180],"it":[181],"less":[183],"likely":[184],"would":[190],"affect":[191],"activity":[193],"vivo.":[200]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}