{"id":"https://openalex.org/W2020462702","doi":"https://doi.org/10.1016/s0968-0896(01)00114-6","title":"Novel (4-Piperidin-1-yl)-phenyl Sulfonamides as Potent and Selective Human \u03b23 Agonists","display_name":"Novel (4-Piperidin-1-yl)-phenyl Sulfonamides as Potent and Selective Human \u03b23 Agonists","publication_year":2001,"publication_date":"2001-08-01","ids":{"openalex":"https://openalex.org/W2020462702","doi":"https://doi.org/10.1016/s0968-0896(01)00114-6","mag":"2020462702","pmid":"https://pubmed.ncbi.nlm.nih.gov/11504641"},"language":"en","primary_location":{"id":"doi:10.1016/s0968-0896(01)00114-6","doi":"https://doi.org/10.1016/s0968-0896(01)00114-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0968-0896(01)00114-6","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028657690","display_name":"Baihua Hu","orcid":"https://orcid.org/0000-0002-1340-5811","observed_orcids":["https://orcid.org/0000-0002-1340-5811"]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Baihua Hu","raw_affiliation_strings":["Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA. hub@war.wyeth.com","Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA. hub@war.wyeth.com","institution_ids":["https://openalex.org/I4403928396"]},{"raw_affiliation_string":"Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020330814","display_name":"John W. Ellingboe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Ellingboe","raw_affiliation_strings":["Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109115194","display_name":"Stella Ching-Hsien Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stella Han","raw_affiliation_strings":["Cardiovascular/Metabolic Diseases Research, Wyeth-Ayerst Research, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular/Metabolic Diseases Research, Wyeth-Ayerst Research, Pearl River, NY 10965, USA","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049529862","display_name":"Elwood E. Largis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elwood Largis","raw_affiliation_strings":["Cardiovascular/Metabolic Diseases Research, Wyeth-Ayerst Research, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular/Metabolic Diseases Research, Wyeth-Ayerst Research, Pearl River, NY 10965, USA","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112251971","display_name":"Kitae Lim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kitae Lim","raw_affiliation_strings":["Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029496393","display_name":"Michael S. Malamas","orcid":"https://orcid.org/0000-0002-4785-7525","observed_orcids":["https://orcid.org/0000-0002-4785-7525"]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Malamas","raw_affiliation_strings":["Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007734469","display_name":"Ruth Mulvey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth Mulvey","raw_affiliation_strings":["Cardiovascular/Metabolic Diseases Research, Wyeth-Ayerst Research, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular/Metabolic Diseases Research, Wyeth-Ayerst Research, Pearl River, NY 10965, USA","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110676739","display_name":"Chuansheng Niu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chuansheng Niu","raw_affiliation_strings":["Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077402423","display_name":"Alexander Oliphant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Oliphant","raw_affiliation_strings":["Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017508406","display_name":"Jeffrey C. Pelletier","orcid":"https://orcid.org/0000-0002-0397-0681","observed_orcids":["https://orcid.org/0000-0002-0397-0681"]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Pelletier","raw_affiliation_strings":["Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022393282","display_name":"Thiruvikraman Singanallore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thiruvikraman Singanallore","raw_affiliation_strings":["Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111591794","display_name":"Fuk\u2010Wah Sum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fuk-Wah Sum","raw_affiliation_strings":["Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010608318","display_name":"Jeff Tillett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff Tillett","raw_affiliation_strings":["Cardiovascular/Metabolic Diseases Research, Wyeth-Ayerst Research, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular/Metabolic Diseases Research, Wyeth-Ayerst Research, Pearl River, NY 10965, USA","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088864971","display_name":"Victoria D. Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria Wong","raw_affiliation_strings":["Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Sciences, Wyeth-Ayerst Research, Pearl River, NY 10965, USA","institution_ids":["https://openalex.org/I4403928396"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028657690"],"corresponding_institution_ids":["https://openalex.org/I4403928396"],"apc_list":{"value":3960,"currency":"USD","value_usd":3960},"apc_paid":null,"fwci":0.3847,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.52143787,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":"8","first_page":"2045","last_page":"2059"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta3-adrenergic-agonists","display_name":"beta3-adrenergic agonists","score":0.8709999918937683},{"id":"https://openalex.org/keywords/sulfonamides","display_name":"sulfonamides","score":0.8230000138282776},{"id":"https://openalex.org/keywords/receptor-selectivity","display_name":"receptor selectivity","score":0.7440000176429749},{"id":"https://openalex.org/keywords/catechol-derivatives","display_name":"catechol derivatives","score":0.652999997138977},{"id":"https://openalex.org/keywords/n-alkylation","display_name":"N-alkylation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6579999923706055},{"id":"https://openalex.org/keywords/full-agonists","display_name":"full agonists","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9426599740982056},{"id":"https://openalex.org/C2781039511","wikidata":"https://www.wikidata.org/wiki/Q3208529","display_name":"Sulfonamide","level":2,"score":0.7911496162414551},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.6914187669754028},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.6440240144729614},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6387534141540527},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6183254718780518},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.6033844351768494},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.5866315364837646},{"id":"https://openalex.org/C2777713698","wikidata":"https://www.wikidata.org/wiki/Q282440","display_name":"Catechol","level":2,"score":0.49505606293678284},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.4368918538093567},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.42233338952064514},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4025678038597107},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2561723589897156},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1578550934791565},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000318","descriptor_name":"Adrenergic beta-Agonists","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000318","descriptor_name":"Adrenergic beta-Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000318","descriptor_name":"Adrenergic beta-Agonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058667","descriptor_name":"Adrenergic beta-3 Receptor Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0968-0896(01)00114-6","doi":"https://doi.org/10.1016/s0968-0896(01)00114-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0968-0896(01)00114-6","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:11504641","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11504641","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W53367862","https://openalex.org/W86458189","https://openalex.org/W118678250","https://openalex.org/W1941976899","https://openalex.org/W1946645080","https://openalex.org/W1963847575","https://openalex.org/W1966043663","https://openalex.org/W1971301188","https://openalex.org/W1973410730","https://openalex.org/W1973726662","https://openalex.org/W1975514703","https://openalex.org/W1980740890","https://openalex.org/W1988682952","https://openalex.org/W1991167830","https://openalex.org/W2019100110","https://openalex.org/W2019626197","https://openalex.org/W2023187052","https://openalex.org/W2025686640","https://openalex.org/W2028671417","https://openalex.org/W2029845102","https://openalex.org/W2030310138","https://openalex.org/W2034819124","https://openalex.org/W2044937711","https://openalex.org/W2060598138","https://openalex.org/W2063082171","https://openalex.org/W2064079551","https://openalex.org/W2069444081","https://openalex.org/W2085615430","https://openalex.org/W2093273801","https://openalex.org/W2097314252","https://openalex.org/W2322463216","https://openalex.org/W2324689985","https://openalex.org/W2412605060","https://openalex.org/W2464682502","https://openalex.org/W2953164723","https://openalex.org/W4234164820","https://openalex.org/W4406057066"],"related_works":["https://openalex.org/W2158668825","https://openalex.org/W1989294349","https://openalex.org/W2083160178","https://openalex.org/W2067254566","https://openalex.org/W2045354334","https://openalex.org/W2950413049","https://openalex.org/W4250302984","https://openalex.org/W2156078621","https://openalex.org/W2168587099","https://openalex.org/W2174855058"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}