{"id":"https://openalex.org/W2020456541","doi":"https://doi.org/10.1016/s0968-0896(00)00022-5","title":"Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: structural basis of antifolate resistance","display_name":"Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: structural basis of antifolate resistance","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W2020456541","doi":"https://doi.org/10.1016/s0968-0896(00)00022-5","mag":"2020456541","pmid":"https://pubmed.ncbi.nlm.nih.gov/10882022"},"language":"en","primary_location":{"id":"doi:10.1016/s0968-0896(00)00022-5","doi":"https://doi.org/10.1016/s0968-0896(00)00022-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0968-0896(00)00022-5","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11380/307988","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066566738","display_name":"Giulio Rastelli","orcid":"https://orcid.org/0000-0002-2474-0607","observed_orcids":["https://orcid.org/0000-0002-2474-0607"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulio Rastelli","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, Universita di Modena e Reggio Emilia, Italy","Dipartimento di Scienze Farmaceutiche, Universita di Modena e Reggio Emilia, Via Campi, 183-41100 Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Universita di Modena e Reggio Emilia, Italy","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Universita di Modena e Reggio Emilia, Via Campi, 183-41100 Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062941170","display_name":"Worachart Sirawaraporn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Worachart Sirawaraporn","raw_affiliation_strings":["Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080448599","display_name":"Pornthep Sompornpisut","orcid":"https://orcid.org/0000-0002-8029-332X","observed_orcids":["https://orcid.org/0000-0002-8029-332X"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Pornthep Sompornpisut","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056002165","display_name":"Tirayut Vilaivan","orcid":"https://orcid.org/0000-0002-9184-9506","observed_orcids":["https://orcid.org/0000-0002-9184-9506"]},"institutions":[{"id":"https://openalex.org/I158708052","display_name":"Chulalongkorn University","ror":"https://ror.org/028wp3y58","country_code":"TH","type":"education","lineage":["https://openalex.org/I158708052"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Tirayut Vilaivan","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand","institution_ids":["https://openalex.org/I158708052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091720746","display_name":"Sumalee Kamchonwongpaisan","orcid":"https://orcid.org/0000-0002-4723-5232","observed_orcids":["https://orcid.org/0000-0002-4723-5232"]},"institutions":[{"id":"https://openalex.org/I1332092204","display_name":"National Science and Technology Development Agency","ror":"https://ror.org/04vy95b61","country_code":"TH","type":"government","lineage":["https://openalex.org/I1332092204"]},{"id":"https://openalex.org/I902798049","display_name":"National Center for Genetic Engineering and Biotechnology","ror":"https://ror.org/047aswc67","country_code":"TH","type":"facility","lineage":["https://openalex.org/I1332092204","https://openalex.org/I902798049"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Sumalee Kamchonwongpaisan","raw_affiliation_strings":["National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Bangkok 10400, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Bangkok 10400, Thailand","institution_ids":["https://openalex.org/I1332092204","https://openalex.org/I902798049"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054212908","display_name":"Rachel Quarrell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rachel Quarrell","raw_affiliation_strings":["Dyson Perrins Laboratory, South Parks Road, Oxford University, Oxford OX1 3QY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dyson Perrins Laboratory, South Parks Road, Oxford University, Oxford OX1 3QY, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069348426","display_name":"Gordon Matthew Lowe","orcid":"https://orcid.org/0000-0001-7566-7166","observed_orcids":["https://orcid.org/0000-0001-7566-7166"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gordon Lowe","raw_affiliation_strings":["Dyson Perrins Laboratory, South Parks Road, Oxford University, Oxford OX1 3QY, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dyson Perrins Laboratory, South Parks Road, Oxford University, Oxford OX1 3QY, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020163557","display_name":"Yodhathai Thebtaranonth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Yodhathai Thebtaranonth","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060203261","display_name":"Yongyuth Yuthavong","orcid":"https://orcid.org/0000-0002-3582-8401","observed_orcids":["https://orcid.org/0000-0002-3582-8401"]},"institutions":[{"id":"https://openalex.org/I1332092204","display_name":"National Science and Technology Development Agency","ror":"https://ror.org/04vy95b61","country_code":"TH","type":"government","lineage":["https://openalex.org/I1332092204"]},{"id":"https://openalex.org/I902798049","display_name":"National Center for Genetic Engineering and Biotechnology","ror":"https://ror.org/047aswc67","country_code":"TH","type":"facility","lineage":["https://openalex.org/I1332092204","https://openalex.org/I902798049"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Yongyuth Yuthavong","raw_affiliation_strings":["National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Bangkok 10400, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Bangkok 10400, Thailand","institution_ids":["https://openalex.org/I1332092204","https://openalex.org/I902798049"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5062941170"],"corresponding_institution_ids":["https://openalex.org/I25399158"],"apc_list":{"value":3960,"currency":"USD","value_usd":3960},"apc_paid":null,"fwci":10.461,"has_fulltext":false,"cited_by_count":122,"citation_normalized_percentile":{"value":0.98226622,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"8","issue":"5","first_page":"1117","last_page":"1128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.05480000004172325,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9020000100135803},{"id":"https://openalex.org/keywords/dihydrofolate-reductase","display_name":"dihydrofolate reductase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antifolate-resistance","display_name":"antifolate resistance","score":0.9120000004768372},{"id":"https://openalex.org/keywords/pyrimethamine","display_name":"pyrimethamine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cycloguanil","display_name":"cycloguanil","score":1.0},{"id":"https://openalex.org/keywords/wr99210","display_name":"WR99210","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.7429999709129333},{"id":"https://openalex.org/keywords/drug-resistance-mutations","display_name":"drug resistance mutations","score":0.6259999871253967},{"id":"https://openalex.org/keywords/enzyme-inhibitor-interaction","display_name":"enzyme-inhibitor binding","score":0.6880000233650208},{"id":"https://openalex.org/keywords/homology-modeling","display_name":"homology modeling","score":0.7310000061988831},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.7200000286102295},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"molecular dynamics","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C2781320022","wikidata":"https://www.wikidata.org/wiki/Q417149","display_name":"Dihydrofolate reductase","level":3,"score":0.9352467656135559},{"id":"https://openalex.org/C2781382166","wikidata":"https://www.wikidata.org/wiki/Q50573407","display_name":"Antifolate","level":4,"score":0.8996967077255249},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7779321670532227},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.7342560887336731},{"id":"https://openalex.org/C2777035104","wikidata":"https://www.wikidata.org/wiki/Q421072","display_name":"Pyrimethamine","level":4,"score":0.6951410174369812},{"id":"https://openalex.org/C178910836","wikidata":"https://www.wikidata.org/wiki/Q2196961","display_name":"Molecular model","level":2,"score":0.5545501112937927},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.526874840259552},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.44113945960998535},{"id":"https://openalex.org/C169627665","wikidata":"https://www.wikidata.org/wiki/Q5767913","display_name":"Homology modeling","level":3,"score":0.4395897090435028},{"id":"https://openalex.org/C2776980637","wikidata":"https://www.wikidata.org/wiki/Q427492","display_name":"Enzyme inhibitor","level":3,"score":0.4394623637199402},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.42438310384750366},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35667574405670166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13826575875282288},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.12105178833007812},{"id":"https://openalex.org/C2778397455","wikidata":"https://www.wikidata.org/wiki/Q50429865","display_name":"Antimetabolite","level":3,"score":0.06361442804336548},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002727","descriptor_name":"Proguanil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005493","descriptor_name":"Folic Acid Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005493","descriptor_name":"Folic Acid Antagonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011739","descriptor_name":"Pyrimethamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011739","descriptor_name":"Pyrimethamine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013762","descriptor_name":"Tetrahydrofolate Dehydrogenase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013762","descriptor_name":"Tetrahydrofolate Dehydrogenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0968-0896(00)00022-5","doi":"https://doi.org/10.1016/s0968-0896(00)00022-5","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0968-0896(00)00022-5","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:10882022","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10882022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unimore.it:11380/307988","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/307988","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:iris.unimore.it:11380/307988","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/307988","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.7141000032424927,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307856","display_name":"World Health Organization","ror":"https://ror.org/01f80g185"},{"id":"https://openalex.org/F4320322614","display_name":"Thailand Research Fund","ror":"https://ror.org/03gd1bh37"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1496415706","https://openalex.org/W1503386326","https://openalex.org/W1559242444","https://openalex.org/W1560025632","https://openalex.org/W1596608955","https://openalex.org/W1963679143","https://openalex.org/W1971563309","https://openalex.org/W1976161355","https://openalex.org/W1976176203","https://openalex.org/W1976416379","https://openalex.org/W1976499671","https://openalex.org/W1979306828","https://openalex.org/W1981288151","https://openalex.org/W1982050558","https://openalex.org/W1982102396","https://openalex.org/W1982189115","https://openalex.org/W1984777478","https://openalex.org/W1986191025","https://openalex.org/W1987574860","https://openalex.org/W1991022352","https://openalex.org/W2002311567","https://openalex.org/W2004014978","https://openalex.org/W2004171367","https://openalex.org/W2006705368","https://openalex.org/W2029812950","https://openalex.org/W2029967359","https://openalex.org/W2031154281","https://openalex.org/W2033314986","https://openalex.org/W2036095761","https://openalex.org/W2047009134","https://openalex.org/W2050341196","https://openalex.org/W2051831487","https://openalex.org/W2055043387","https://openalex.org/W2060463809","https://openalex.org/W2065283382","https://openalex.org/W2065930024","https://openalex.org/W2068928435","https://openalex.org/W2079451231","https://openalex.org/W2081487461","https://openalex.org/W2081729133","https://openalex.org/W2093983183","https://openalex.org/W2103636724","https://openalex.org/W2104931530","https://openalex.org/W2122199548","https://openalex.org/W2149263899","https://openalex.org/W2149921398","https://openalex.org/W2150657983","https://openalex.org/W2161117347","https://openalex.org/W2168481655","https://openalex.org/W2314569330","https://openalex.org/W2323070027","https://openalex.org/W2441279826"],"related_works":["https://openalex.org/W2050202689","https://openalex.org/W2153421795","https://openalex.org/W2055408581","https://openalex.org/W2128926522","https://openalex.org/W7100950030","https://openalex.org/W2006705368","https://openalex.org/W1987363127","https://openalex.org/W1986294541","https://openalex.org/W1514990264","https://openalex.org/W4413355913"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}