{"id":"https://openalex.org/W2020452002","doi":"https://doi.org/10.1160/th13-06-0448","title":"Treatment with Angiotensin-(1\u20137) reduces inflammation in carotid atherosclerotic plaques","display_name":"Treatment with Angiotensin-(1\u20137) reduces inflammation in carotid atherosclerotic plaques","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2020452002","doi":"https://doi.org/10.1160/th13-06-0448","mag":"2020452002","pmid":"https://pubmed.ncbi.nlm.nih.gov/24499778"},"language":"en","primary_location":{"id":"doi:10.1160/th13-06-0448","doi":"https://doi.org/10.1160/th13-06-0448","is_oa":true,"landing_page_url":"https://doi.org/10.1160/th13-06-0448","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1160/TH13-06-0448.pdf","source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1160/TH13-06-0448.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107841210","display_name":"S\u00edlvia Q. Savergnini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Silvia Q. Savergnini","raw_affiliation_strings":["Institute of Bioengineering, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","Ecole polytechnique federale de Lausanne (EPFL);"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioengineering, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Ecole polytechnique federale de Lausanne (EPFL);","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024812334","display_name":"Fabrizio Montecucco","orcid":"https://orcid.org/0000-0003-0823-8729","observed_orcids":["https://orcid.org/0000-0003-0823-8729"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]},{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["CH","IT"],"is_corresponding":false,"raw_author_name":"Fabrizio Montecucco","raw_affiliation_strings":["Division of Cardiology, Faculty of Medicine, Foundation for Medical Researches, University of Geneva, Geneva, Switzerland","First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino\u2013IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy","Universit\u00e0 degli Studi di Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Faculty of Medicine, Foundation for Medical Researches, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino\u2013IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy","institution_ids":["https://openalex.org/I4210146472","https://openalex.org/I83816512"]},{"raw_affiliation_string":"Universit\u00e0 degli Studi di Genova","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006211032","display_name":"Alessio Nencioni","orcid":"https://orcid.org/0000-0001-5068-8884","observed_orcids":["https://orcid.org/0000-0001-5068-8884"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessio Nencioni","raw_affiliation_strings":["First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino\u2013IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy","A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino\u2013IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy","institution_ids":["https://openalex.org/I4210146472","https://openalex.org/I83816512"]},{"raw_affiliation_string":"A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068812709","display_name":"Irene Caffa","orcid":"https://orcid.org/0000-0003-1111-9915","observed_orcids":["https://orcid.org/0000-0003-1111-9915"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Irene Caffa","raw_affiliation_strings":["First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino\u2013IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy","Universit\u00e0 degli Studi di Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino\u2013IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy","institution_ids":["https://openalex.org/I4210146472","https://openalex.org/I83816512"]},{"raw_affiliation_string":"Universit\u00e0 degli Studi di Genova","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075260374","display_name":"Debora Soncini","orcid":"https://orcid.org/0000-0001-5156-498X","observed_orcids":["https://orcid.org/0000-0001-5156-498X"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Debora Soncini","raw_affiliation_strings":["First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino\u2013IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy","Universit\u00e0 degli Studi di Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino\u2013IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy","institution_ids":["https://openalex.org/I4210146472","https://openalex.org/I83816512"]},{"raw_affiliation_string":"Universit\u00e0 degli Studi di Genova","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108099875","display_name":"Fabiana Pereira Costa-Fraga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Fabiana P. Costa-Fraga","raw_affiliation_strings":["Institute of Bioengineering, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","Ecole polytechnique federale de Lausanne (EPFL);"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioengineering, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Ecole polytechnique federale de Lausanne (EPFL);","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033327204","display_name":"Frederico B. De Sousa","orcid":"https://orcid.org/0000-0002-7930-6867","observed_orcids":["https://orcid.org/0000-0002-7930-6867"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Frederico B. De Sousa","raw_affiliation_strings":["Department of Chemistry, Federal University of Minas Gerais, Brazil","Universidade Federal de Minas Gerais#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Federal University of Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Universidade Federal de Minas Gerais#TAB#","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055005020","display_name":"Rub\u00e9n D. Sinisterra","orcid":"https://orcid.org/0000-0001-7656-1849","observed_orcids":["https://orcid.org/0000-0001-7656-1849"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ruben D. Sinisterra","raw_affiliation_strings":["Department of Chemistry, Federal University of Minas Gerais, Brazil","Universidade Federal de Minas Gerais#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Federal University of Minas Gerais, Brazil","institution_ids":["https://openalex.org/I110200422"]},{"raw_affiliation_string":"Universidade Federal de Minas Gerais#TAB#","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054156788","display_name":"Luciano dos Santos Aggum Capettini","orcid":"https://orcid.org/0000-0002-6487-9558","observed_orcids":["https://orcid.org/0000-0002-6487-9558"]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Luciano A. S. Capettini","raw_affiliation_strings":["Institute of Bioengineering, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","Ecole polytechnique federale de Lausanne (EPFL);"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioengineering, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Ecole polytechnique federale de Lausanne (EPFL);","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008114310","display_name":"S\u00e9bastien Lenglet","orcid":"https://orcid.org/0000-0002-4853-8163","observed_orcids":["https://orcid.org/0000-0002-4853-8163"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"S\u00e9bastien Lenglet","raw_affiliation_strings":["Division of Cardiology, Faculty of Medicine, Foundation for Medical Researches, University of Geneva, Geneva, Switzerland","University of Geneva;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Faculty of Medicine, Foundation for Medical Researches, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"University of Geneva;","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105976761","display_name":"Katia Galan","orcid":"https://orcid.org/0000-0003-3299-6183","observed_orcids":["https://orcid.org/0000-0003-3299-6183"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Katia Galan","raw_affiliation_strings":["Division of Cardiology, Faculty of Medicine, Foundation for Medical Researches, University of Geneva, Geneva, Switzerland","University of Geneva;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Faculty of Medicine, Foundation for Medical Researches, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"University of Geneva;","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107853176","display_name":"Graziano Pelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Graziano Pelli","raw_affiliation_strings":["Division of Cardiology, Faculty of Medicine, Foundation for Medical Researches, University of Geneva, Geneva, Switzerland","University of Geneva;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Faculty of Medicine, Foundation for Medical Researches, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"University of Geneva;","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000488097","display_name":"Maria Bianca Bertolotto","orcid":"https://orcid.org/0000-0002-4889-8046","observed_orcids":["https://orcid.org/0000-0002-4889-8046"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Bertolotto","raw_affiliation_strings":["First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino\u2013IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy","Universit\u00e0 degli Studi di Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino\u2013IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy","institution_ids":["https://openalex.org/I4210146472","https://openalex.org/I83816512"]},{"raw_affiliation_string":"Universit\u00e0 degli Studi di Genova","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107829240","display_name":"Aldo Pende","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Aldo Pende","raw_affiliation_strings":["First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino\u2013IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy","Universit\u00e0 degli Studi di Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino\u2013IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy","institution_ids":["https://openalex.org/I4210146472","https://openalex.org/I83816512"]},{"raw_affiliation_string":"Universit\u00e0 degli Studi di Genova","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052470519","display_name":"Giovanni Spinella","orcid":"https://orcid.org/0000-0001-6373-0199","observed_orcids":["https://orcid.org/0000-0001-6373-0199"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Spinella","raw_affiliation_strings":["Vascular and Endovascular Surgery Unit, Department of Surgery, San Martino Hospital, Genoa, Italy","Universit\u00e0 degli Studi di Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular and Endovascular Surgery Unit, Department of Surgery, San Martino Hospital, Genoa, Italy","institution_ids":["https://openalex.org/I4210146472"]},{"raw_affiliation_string":"Universit\u00e0 degli Studi di Genova","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022177325","display_name":"Bianca Pane","orcid":"https://orcid.org/0000-0002-5085-8019","observed_orcids":["https://orcid.org/0000-0002-5085-8019"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Bianca Pane","raw_affiliation_strings":["Vascular and Endovascular Surgery Unit, Department of Surgery, San Martino Hospital, Genoa, Italy","Universit\u00e0 degli Studi di Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular and Endovascular Surgery Unit, Department of Surgery, San Martino Hospital, Genoa, Italy","institution_ids":["https://openalex.org/I4210146472"]},{"raw_affiliation_string":"Universit\u00e0 degli Studi di Genova","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042094771","display_name":"Franco Dallegri","orcid":"https://orcid.org/0000-0001-9537-4547","observed_orcids":["https://orcid.org/0000-0001-9537-4547"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Franco Dallegri","raw_affiliation_strings":["First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino\u2013IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy","Universit\u00e0 degli Studi di Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa School of Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino\u2013IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy","institution_ids":["https://openalex.org/I4210146472","https://openalex.org/I83816512"]},{"raw_affiliation_string":"Universit\u00e0 degli Studi di Genova","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110043849","display_name":"Domenico Palombo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Domenico Palombo","raw_affiliation_strings":["Vascular and Endovascular Surgery Unit, Department of Surgery, San Martino Hospital, Genoa, Italy","Universit\u00e0 degli Studi di Genova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular and Endovascular Surgery Unit, Department of Surgery, San Martino Hospital, Genoa, Italy","institution_ids":["https://openalex.org/I4210146472"]},{"raw_affiliation_string":"Universit\u00e0 degli Studi di Genova","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085573148","display_name":"Fran\u00e7ois Mach","orcid":"https://orcid.org/0000-0003-3178-9131","observed_orcids":["https://orcid.org/0000-0003-3178-9131"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Mach","raw_affiliation_strings":["Division of Cardiology, Faculty of Medicine, Foundation for Medical Researches, University of Geneva, Geneva, Switzerland","University of Geneva;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Faculty of Medicine, Foundation for Medical Researches, University of Geneva, Geneva, Switzerland","institution_ids":["https://openalex.org/I114457229"]},{"raw_affiliation_string":"University of Geneva;","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025470988","display_name":"Nikolaos Stergiopulos","orcid":"https://orcid.org/0000-0002-0519-0160","observed_orcids":["https://orcid.org/0000-0002-0519-0160"]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nikolaos Stergiopulos","raw_affiliation_strings":["Institute of Bioengineering, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","Ecole polytechnique federale de Lausanne (EPFL);"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioengineering, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Ecole polytechnique federale de Lausanne (EPFL);","institution_ids":["https://openalex.org/I5124864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089147956","display_name":"Robson A.S. Santos","orcid":"https://orcid.org/0000-0001-8738-5852","observed_orcids":["https://orcid.org/0000-0001-8738-5852"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Robson A. S. Santos","raw_affiliation_strings":["Robson Augusto Souza dos Santos, Departamento de Fisiologia e Biof\u00edsica, Federal University of Minas Gerais, Av. Antonio Carlos, 6627 - UFMG, 31270-901 - Belo Horizonte, MG, Brazil, Tel.: +55 31 3409 2956, E-mail: robsonsant@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robson Augusto Souza dos Santos, Departamento de Fisiologia e Biof\u00edsica, Federal University of Minas Gerais, Av. Antonio Carlos, 6627 - UFMG, 31270-901 - Belo Horizonte, MG, Brazil, Tel.: +55 31 3409 2956, E-mail: robsonsant@gmail.com","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015165662","display_name":"Rafaela da Silva","orcid":"https://orcid.org/0000-0002-3335-2542","observed_orcids":["https://orcid.org/0000-0002-3335-2542","https://orcid.org/0000-0003-0240-8168"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rafaela F. da Silva","raw_affiliation_strings":["Rafaela Fernandes da Silva, Departamento de Fisiologia e Biof\u00edsica, Federal University of Minas Gerais, Av. Antonio Carlos, 6627 - UFMG, 31270-901 - Belo Horizonte, MG, Brazil, Tel.: +55 31 3409 2956, E-mail: rfdasilva@icb.ufmg.br"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rafaela Fernandes da Silva, Departamento de Fisiologia e Biof\u00edsica, Federal University of Minas Gerais, Av. Antonio Carlos, 6627 - UFMG, 31270-901 - Belo Horizonte, MG, Brazil, Tel.: +55 31 3409 2956, E-mail: rfdasilva@icb.ufmg.br","institution_ids":["https://openalex.org/I110200422"]}]},{"author_position":"last","author":{"id":null,"display_name":"Rodrigo A. Fraga-Silva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5124864","display_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","ror":"https://ror.org/02s376052","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I5124864"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Rodrigo A. Fraga-Silva","raw_affiliation_strings":["Institute of Bioengineering, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","Ecole polytechnique federale de Lausanne (EPFL);"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioengineering, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I5124864"]},{"raw_affiliation_string":"Ecole polytechnique federale de Lausanne (EPFL);","institution_ids":["https://openalex.org/I5124864"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I5124864"],"apc_list":null,"apc_paid":null,"fwci":6.9427,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.97542993,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"111","issue":"04","first_page":"736","last_page":"747"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.05559999868273735,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.007300000172108412,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-1-7","display_name":"angiotensin-(1-7)","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mas-receptor","display_name":"Mas receptor","score":0.996999979019165},{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.9380000233650208},{"id":"https://openalex.org/keywords/carotid-plaque","display_name":"carotid plaque","score":0.9279999732971191},{"id":"https://openalex.org/keywords/unstable-plaque","display_name":"plaque vulnerability","score":0.7160000205039978},{"id":"https://openalex.org/keywords/shear-stress","display_name":"shear stress","score":0.8510000109672546},{"id":"https://openalex.org/keywords/oscillatory-shear-stress","display_name":"oscillatory shear stress","score":0.871999979019165},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.6880000233650208},{"id":"https://openalex.org/keywords/neutrophil-infiltration","display_name":"neutrophil infiltration","score":0.8040000200271606},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.9959999918937683},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.7110000252723694},{"id":"https://openalex.org/keywords/apoe-deficient-mice","display_name":"ApoE-deficient mice","score":0.7279999852180481},{"id":"https://openalex.org/keywords/angiotensin-ii-type-1-receptor","display_name":"angiotensin II type 1 receptor","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7413586974143982},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.6227073669433594},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5731425285339355},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5531119108200073},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.5183952450752258},{"id":"https://openalex.org/C123915805","wikidata":"https://www.wikidata.org/wiki/Q15332826","display_name":"Angiotensin II receptor type 1","level":4,"score":0.5150806307792664},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.4985818862915039},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4365561306476593},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.42562341690063477},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.41606706380844116},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3636239469051361},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15928223729133606},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.10923832654953003},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000803","descriptor_name":"Angiotensin I","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000803","descriptor_name":"Angiotensin I","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000803","descriptor_name":"Angiotensin I","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000803","descriptor_name":"Angiotensin I","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000803","descriptor_name":"Angiotensin I","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000803","descriptor_name":"Angiotensin I","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000803","descriptor_name":"Angiotensin I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000803","descriptor_name":"Angiotensin I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000803","descriptor_name":"Angiotensin I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058226","descriptor_name":"Plaque, Atherosclerotic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D058226","descriptor_name":"Plaque, Atherosclerotic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D058226","descriptor_name":"Plaque, Atherosclerotic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D058226","descriptor_name":"Plaque, Atherosclerotic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D058226","descriptor_name":"Plaque, Atherosclerotic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D058226","descriptor_name":"Plaque, Atherosclerotic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1160/th13-06-0448","doi":"https://doi.org/10.1160/th13-06-0448","is_oa":true,"landing_page_url":"https://doi.org/10.1160/th13-06-0448","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1160/TH13-06-0448.pdf","source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},{"id":"pmid:24499778","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24499778","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and haemostasis","raw_type":"Journal Article"},{"id":"pmh:oai:unige.ch:unige:77557","doi":null,"is_oa":false,"landing_page_url":"https://archive-ouverte.unige.ch/unige:77557","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISSN: 0340-6245","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:infoscience.tind.io:198901","doi":null,"is_oa":true,"landing_page_url":"https://infoscience.epfl.ch/handle/20.500.14299/103466","pdf_url":"https://infoscience.epfl.ch/bitstreams/ca286a76-3bdc-474b-90d8-b3e0caa41e63/download","source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"},{"id":"pmh:oai:infoscience.epfl.ch:198901","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/198901","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:iris.unige.it:11567/680766","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11567/680766","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:unige.ch:aou:unige:77557","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:77557","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Thrombosis and haemostasis, vol. 111, no. 4 (2014) p. 736-747","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1160/th13-06-0448","doi":"https://doi.org/10.1160/th13-06-0448","is_oa":true,"landing_page_url":"https://doi.org/10.1160/th13-06-0448","pdf_url":"http://www.thieme-connect.de/products/ejournals/pdf/10.1160/TH13-06-0448.pdf","source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7900000214576721,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1149721474","display_name":"Visualizing biogenesis and molecular mechanisms of Fe-S proteins","funder_award_id":"201603","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G1495610196","display_name":"Anti-inflammatory approaches to reduce ischemia-reperfusion injury during acute myocardial infarction","funder_award_id":"118245","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G2325242462","display_name":null,"funder_award_id":"EU-FP7","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4485822155","display_name":"Role of visfatin on inflammatory atherosclerotic vulnerability for ischemic stroke","funder_award_id":"134963","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G581965161","display_name":null,"funder_award_id":"2012-4","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G8105150848","display_name":null,"funder_award_id":"310030","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8361017002","display_name":null,"funder_award_id":"GR-2008-1135635","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G8690818240","display_name":null,"funder_award_id":"310030","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322980","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","ror":"https://ror.org/00nc55f03"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2020452002.pdf","grobid_xml":"https://content.openalex.org/works/W2020452002.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1740376762","https://openalex.org/W1749607030","https://openalex.org/W1964361575","https://openalex.org/W1973044014","https://openalex.org/W1975529354","https://openalex.org/W1976512520","https://openalex.org/W1990752520","https://openalex.org/W2000817079","https://openalex.org/W2004840558","https://openalex.org/W2007983728","https://openalex.org/W2008961036","https://openalex.org/W2010008626","https://openalex.org/W2012663953","https://openalex.org/W2013013943","https://openalex.org/W2015386277","https://openalex.org/W2017194230","https://openalex.org/W2018545707","https://openalex.org/W2021004501","https://openalex.org/W2025782661","https://openalex.org/W2033199439","https://openalex.org/W2038628089","https://openalex.org/W2039223857","https://openalex.org/W2055306864","https://openalex.org/W2065993051","https://openalex.org/W2066870047","https://openalex.org/W2083157718","https://openalex.org/W2085892056","https://openalex.org/W2096665985","https://openalex.org/W2101816788","https://openalex.org/W2108417414","https://openalex.org/W2116877228","https://openalex.org/W2117760296","https://openalex.org/W2121061143","https://openalex.org/W2122639201","https://openalex.org/W2129777398","https://openalex.org/W2137098033","https://openalex.org/W2137329488","https://openalex.org/W2137667272","https://openalex.org/W2141035535","https://openalex.org/W2144268955","https://openalex.org/W2147194311","https://openalex.org/W2149146712","https://openalex.org/W2157466080","https://openalex.org/W2158129487","https://openalex.org/W2169630686","https://openalex.org/W2316997036","https://openalex.org/W2318466252","https://openalex.org/W2612334191","https://openalex.org/W2615751376"],"related_works":["https://openalex.org/W2093949391","https://openalex.org/W2034924769","https://openalex.org/W1991157605","https://openalex.org/W2158772048","https://openalex.org/W2109896298","https://openalex.org/W2418445678","https://openalex.org/W3135620012","https://openalex.org/W2090731568","https://openalex.org/W2026743167","https://openalex.org/W2020125834"],"abstract_inverted_index":{"Angiotensin":[0],"(Ang)-(1-7),":[1],"acting":[2],"through":[3],"the":[4,23,26,42,45,95,104,109,116,157,183,212,227,242],"receptor":[5,111,132,207],"Mas,":[6],"has":[7,16],"atheroprotective":[8],"effects;":[9],"however,":[10],"its":[11],"role":[12],"on":[13,200,241],"plaque":[14],"vulnerability":[15],"been":[17],"poorly":[18],"studied.":[19],"Here,":[20],"we":[21,40],"investigated":[22],"expression":[24,107,134,197],"of":[25,44,52,58,68,79,103,108,119,215,230,245],"renin-angiotensin":[27],"system":[28],"(RAS)":[29],"components":[30],"in":[31,54,94,115,127,146,156,182,211,237],"stable":[32,217,235],"and":[33,65,88,140,160,166,171,173,198],"unstable":[34,223],"human":[35,216],"carotid":[36,61,70,164,218],"plaques.":[37],"In":[38,188,204],"addition,":[39],"evaluated":[41],"effects":[43,178],"chronic":[46],"treatment":[47],"with":[48,144,151,191,226],"an":[49,99],"oral":[50,228],"formulation":[51,229],"Ang-(1-7)":[53,145,192,231],"a":[55,75,167,233],"mouse":[56],"model":[57],"shear":[59,162,185,246],"stress-determined":[60],"atherosclerotic":[62,238],"plaque.":[63,187],"Upstream":[64],"downstream":[66,117,213],"regions":[67],"internal":[69],"plaques":[71,219],"were":[72,91,179],"obtained":[73],"from":[74],"recently":[76],"published":[77],"cohort":[78],"patients":[80,121],"asymptomatic":[81,120,139],"or":[82],"symptomatic":[83,128,141],"for":[84],"ischaemic":[85],"stroke.":[86],"Angiotensinogen":[87],"renin":[89],"genes":[90],"strongly":[92],"expressed":[93],"entire":[96],"cohort,":[97],"indicating":[98],"intense":[100],"intraplaque":[101,153],"modulation":[102],"RAS.":[105],"Intraplaque":[106],"Mas":[110,206],"mRNA":[112],"was":[113,135,149],"increased":[114,152],"portion":[118],"as":[122,220],"compared":[123,221],"to":[124,222],"corresponding":[125],"region":[126],"patients.":[129,142],"Conversely,":[130],"AT1":[131],"gene":[133],"not":[136,180,194],"modified":[137],"between":[138],"Treatment":[143,225],"ApoE-/-":[147],"mice":[148],"associated":[150],"collagen":[154],"content":[155,170],"aortic":[158],"root":[159],"low":[161],"stress-induced":[163,186],"plaques,":[165,239],"decreased":[168],"MMP-9":[169],"neutrophil":[172],"macrophage":[174],"infiltration.":[175],"These":[176],"beneficial":[177],"observed":[181],"oscillatory":[184],"vitro":[189],"incubation":[190],"did":[193],"affect":[195],"ICAM-1":[196],"apoptosis":[199],"cultured":[201],"endothelial":[202],"cells.":[203],"conclusion,":[205],"is":[208],"up":[209],"regulated":[210],"portions":[214],"lesions.":[224],"enhances":[232],"more":[234],"phenotype":[236],"depending":[240],"local":[243],"pattern":[244],"stress":[247],"forces.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-19T09:35:57.686232","created_date":"2016-06-24T00:00:00"}