{"id":"https://openalex.org/W2020448998","doi":"https://doi.org/10.1074/jbc.273.2.1240","title":"Ligand Binding to Macrophage Scavenger Receptor-A Induces Urokinase-type Plasminogen Activator Expression by a Protein Kinase-dependent Signaling Pathway","display_name":"Ligand Binding to Macrophage Scavenger Receptor-A Induces Urokinase-type Plasminogen Activator Expression by a Protein Kinase-dependent Signaling Pathway","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W2020448998","doi":"https://doi.org/10.1074/jbc.273.2.1240","mag":"2020448998","pmid":"https://pubmed.ncbi.nlm.nih.gov/9422792"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.273.2.1240","doi":"https://doi.org/10.1074/jbc.273.2.1240","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.2.1240","pdf_url":"http://www.jbc.org/article/S0021925818395991/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925818395991/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113773671","display_name":"Hsien\u2010Yeh Hsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hsien-Yeh Hsu","raw_affiliation_strings":["Department of Medicine, Cornell University Medical College, New York, New York 10021, USA. hyhsu@ym.edu.tu","Departments of Medicine, Cornell University Medical College, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Cornell University Medical College, New York, New York 10021, USA. hyhsu@ym.edu.tu","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Departments of Medicine, Cornell University Medical College, New York, New York 10021","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108660778","display_name":"David P. Hajjar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David P. Hajjar","raw_affiliation_strings":["Departments of Pathology, Cornell University Medical College, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, Cornell University Medical College, New York, New York 10021","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K.M. Faisal Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K.M. Faisal Khan","raw_affiliation_strings":["Departments of Pathology, Cornell University Medical College, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, Cornell University Medical College, New York, New York 10021","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110881081","display_name":"Domenick J. Falcone","orcid":"https://orcid.org/0009-0002-2641-0481","observed_orcids":["https://orcid.org/0009-0002-2641-0481"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Domenick J. Falcone","raw_affiliation_strings":["Departments of Cell Biology and Anatomy, Cornell University Medical College, New York, New York 10021","Departments of Pathology, Cornell University Medical College, New York, New York 10021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Cell Biology and Anatomy, Cornell University Medical College, New York, New York 10021","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Departments of Pathology, Cornell University Medical College, New York, New York 10021","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110881081","https://openalex.org/A5113773671"],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.8693,"has_fulltext":true,"cited_by_count":99,"citation_normalized_percentile":{"value":0.91507177,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"273","issue":"2","first_page":"1240","last_page":"1246"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.7562999725341797,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.7562999725341797,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.09480000287294388,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.05290000140666962,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.9570000171661377},{"id":"https://openalex.org/keywords/ligand-binding","display_name":"ligand binding","score":0.7950000166893005},{"id":"https://openalex.org/keywords/receptor-signaling","display_name":"receptor signaling","score":0.6940000057220459},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.9940000176429749},{"id":"https://openalex.org/keywords/acetylated-low-density-lipoprotein","display_name":"acetylated low density lipoprotein","score":0.8999999761581421},{"id":"https://openalex.org/keywords/fucoidan","display_name":"fucoidan","score":0.9990000128746033},{"id":"https://openalex.org/keywords/phospholipase-c-gamma1","display_name":"phospholipase C-gamma1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9700000286102295},{"id":"https://openalex.org/keywords/thp-1-macrophages","display_name":"THP-1 macrophages","score":0.8849999904632568},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.7670000195503235},{"id":"https://openalex.org/keywords/receptor-transfection","display_name":"receptor transfection","score":0.34700000286102295}],"concepts":[{"id":"https://openalex.org/C41443022","wikidata":"https://www.wikidata.org/wiki/Q27796666","display_name":"Scavenger receptor","level":4,"score":0.6253871917724609},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.6226486563682556},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6216620206832886},{"id":"https://openalex.org/C56219504","wikidata":"https://www.wikidata.org/wiki/Q7900869","display_name":"Urokinase receptor","level":3,"score":0.5874212980270386},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5231874585151672},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5047653913497925},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.46530160307884216},{"id":"https://openalex.org/C2776892390","wikidata":"https://www.wikidata.org/wiki/Q7119591","display_name":"Urokinase","level":2,"score":0.43232059478759766},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4300720989704132},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.4297829568386078},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3661436438560486},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2459074854850769},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12084734439849854},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07504743337631226},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.0},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011134","descriptor_name":"Polysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051116","descriptor_name":"Receptors, Scavenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051117","descriptor_name":"Scavenger Receptors, Class A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.273.2.1240","doi":"https://doi.org/10.1074/jbc.273.2.1240","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.2.1240","pdf_url":"http://www.jbc.org/article/S0021925818395991/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:9422792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9422792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.273.2.1240","doi":"https://doi.org/10.1074/jbc.273.2.1240","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.273.2.1240","pdf_url":"http://www.jbc.org/article/S0021925818395991/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1027461681","display_name":"Cell Interactions in Vascular Injury and Atherogenesis","funder_award_id":"P01HL046403","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3656166876","display_name":"MACROPHAGE PROTEASE CASCADE AND VASCULAR REMODELING","funder_award_id":"R01HL040819","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7613229649","display_name":"MITOGEN MEDIATED REGULATION OF CHOLESTEROL METABOLISM","funder_award_id":"K14HL003158","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7825562263","display_name":"Cardiovascular Biology and Atherosclerosis","funder_award_id":"T32HL007423","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000154806","display_name":null,"funder_award_id":"HL46403","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2020448998.pdf","grobid_xml":"https://content.openalex.org/works/W2020448998.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W40622382","https://openalex.org/W95550904","https://openalex.org/W152815097","https://openalex.org/W1484860178","https://openalex.org/W1510227107","https://openalex.org/W1512333191","https://openalex.org/W1528368632","https://openalex.org/W1538835725","https://openalex.org/W1543637383","https://openalex.org/W1567665062","https://openalex.org/W1576671418","https://openalex.org/W1579490691","https://openalex.org/W1586297781","https://openalex.org/W1608305635","https://openalex.org/W1651802458","https://openalex.org/W1704017123","https://openalex.org/W1775749144","https://openalex.org/W1818313483","https://openalex.org/W1853643611","https://openalex.org/W1857052429","https://openalex.org/W1963852241","https://openalex.org/W1973674513","https://openalex.org/W1975642651","https://openalex.org/W1985417086","https://openalex.org/W1985621460","https://openalex.org/W1993002482","https://openalex.org/W2005175065","https://openalex.org/W2005436386","https://openalex.org/W2008351843","https://openalex.org/W2009933101","https://openalex.org/W2010701664","https://openalex.org/W2017864481","https://openalex.org/W2031908200","https://openalex.org/W2032207767","https://openalex.org/W2032359283","https://openalex.org/W2035816658","https://openalex.org/W2036702421","https://openalex.org/W2038484123","https://openalex.org/W2040309284","https://openalex.org/W2049401036","https://openalex.org/W2055421163","https://openalex.org/W2058060182","https://openalex.org/W2060333964","https://openalex.org/W2066072901","https://openalex.org/W2070242909","https://openalex.org/W2075473225","https://openalex.org/W2078564480","https://openalex.org/W2080037386","https://openalex.org/W2084884686","https://openalex.org/W2087797124","https://openalex.org/W2089330676","https://openalex.org/W2099955838","https://openalex.org/W2100092765","https://openalex.org/W2107611361","https://openalex.org/W2121390857","https://openalex.org/W2137570167","https://openalex.org/W2149960019","https://openalex.org/W2155189322","https://openalex.org/W2156475226","https://openalex.org/W2162458714","https://openalex.org/W2192686175","https://openalex.org/W2265277925","https://openalex.org/W2326202471","https://openalex.org/W2345409582","https://openalex.org/W2396444855","https://openalex.org/W2417992589"],"related_works":["https://openalex.org/W2043968008","https://openalex.org/W1567665062","https://openalex.org/W19455091","https://openalex.org/W169311468","https://openalex.org/W1999247409","https://openalex.org/W2362944150","https://openalex.org/W1921813710","https://openalex.org/W7099308662","https://openalex.org/W1967743270","https://openalex.org/W1973315354"],"abstract_inverted_index":{"Macrophage":[0],"scavenger":[1],"receptor-type":[2],"A":[3],"(MSR-A)":[4],"has":[5],"been":[6],"implicated":[7],"in":[8,120],"the":[9,15,68,109,182,195,213,223],"transmission":[10],"of":[11,17,81,111,127,137,151,215,222],"cell":[12],"signals":[13],"and":[14,24,40,58,84,93,116,133,146,154,207],"regulation":[16,214],"diverse":[18],"cellular":[19],"functions":[20],"(Falcone,":[21],"D.":[22,35],"J.,":[23,36],"Ferenc,":[25],"M.":[26],"J.":[27,29,42,45,60],"(1988)":[28],"Cell.":[30],"Physiol.":[31],"135,":[32],"387-396;":[33],"Falcone,":[34],"McCaffrey,":[37],"T.":[38,51],"A.,":[39],"Vergilio,":[41],"A.":[43],"(1991)":[44,52],"Biol.":[46],"Chem.":[47],"266,":[48],"22726-22732;":[49],"Palkama,":[50],"Immunology":[53],"74,":[54],"432-438;":[55],"Krieger,":[56],"M.,":[57],"Herz,":[59],"(1994)":[61],"Annu.":[62],"Rev.":[63],"Biochem.":[64],"63,":[65],"601-637);":[66],"however,":[67],"signaling":[69,169,199],"mechanisms":[70],"are":[71],"unknown.":[72],"In":[73],"studies":[74],"reported":[75],"here,":[76],"we":[77],"demonstrate":[78],"that":[79,187],"binding":[80,110,176,204],"both":[82],"lipoprotein":[83,115],"non-lipoprotein":[85],"ligands":[86,221],"to":[87,101,118,164,205],"MSR-A":[88,119,165,206],"induced":[89,201],"protein":[90,95,143],"tyrosine":[91,125,138,144,152,172],"phosphorylation":[92,126,145,173],"increased":[94],"kinase":[96,139,153],"C":[97],"(PKC)":[98],"activity":[99,158],"leading":[100],"up-regulated":[102],"urokinase-type":[103],"plasminogen":[104],"activator":[105],"(uPA)":[106],"expression.":[107],"Specifically,":[108],"acetylated":[112],"low":[113],"density":[114],"fucoidan":[117],"human":[121],"THP-1":[122,161],"macrophages":[123,162],"triggered":[124],"many":[128],"proteins":[129],"including":[130],"phospholipase":[131],"C-gamma1":[132],"phosphatidylinositol-3-OH":[134],"kinase.":[135],"Inhibitors":[136],"dramatically":[140],"reduced":[141,156],"MSR-induced":[142],"PKC":[147,155],"activity.":[148],"Moreover,":[149],"inhibitors":[150],"uPA":[157,217],"expressed":[159],"by":[160,180,202,219],"exposed":[163],"ligands.":[166],"The":[167],"intracellular":[168],"response":[170],"for":[171,194,212],"following":[174],"ligand":[175,203],"was":[177],"further":[178],"demonstrated":[179],"using":[181],"stable":[183],"MSR-transfected":[184],"Bowes":[185],"cells":[186],"express":[188],"surface":[189],"MSR-A.":[190,224],"These":[191],"findings":[192],"establish":[193],"first":[196],"time":[197],"a":[198,209],"pathway":[200],"suggest":[208],"molecular":[210],"model":[211],"macrophage":[216],"expression":[218],"specific":[220]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}