{"id":"https://openalex.org/W2020386120","doi":"https://doi.org/10.1016/j.biopsych.2006.10.017","title":"Genotype and Childhood Sexual Trauma Moderate Neurocognitive Performance: A Possible Role for Brain-Derived Neurotrophic Factor and Apolipoprotein E Variants","display_name":"Genotype and Childhood Sexual Trauma Moderate Neurocognitive Performance: A Possible Role for Brain-Derived Neurotrophic Factor and Apolipoprotein E Variants","publication_year":2007,"publication_date":"2007-01-09","ids":{"openalex":"https://openalex.org/W2020386120","doi":"https://doi.org/10.1016/j.biopsych.2006.10.017","mag":"2020386120","pmid":"https://pubmed.ncbi.nlm.nih.gov/17210134"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopsych.2006.10.017","doi":"https://doi.org/10.1016/j.biopsych.2006.10.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biopsych.2006.10.017","pdf_url":null,"source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033435451","display_name":"Jonathan B. Savitz","orcid":"https://orcid.org/0000-0001-8143-182X","observed_orcids":["https://orcid.org/0000-0001-8143-182X"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I4405266898","display_name":"Institute of Infectious Disease and Molecular Medicine","ror":"https://ror.org/00900dw59","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Jonathan Savitz","raw_affiliation_strings":["MRC/UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa. savitzj@mail.nih.gov","MRC/UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC/UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa. savitzj@mail.nih.gov","institution_ids":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]},{"raw_affiliation_string":"MRC/UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine","institution_ids":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108167392","display_name":"Lize van der Merwe","orcid":"https://orcid.org/0000-0001-9705-8126","observed_orcids":["https://orcid.org/0000-0001-9705-8126"]},"institutions":[{"id":"https://openalex.org/I10947320","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69","country_code":"ZA","type":"other","lineage":["https://openalex.org/I10947320"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Lize van der Merwe","raw_affiliation_strings":["Biostatistics Unit, Medical Research Council of South Africa, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics Unit, Medical Research Council of South Africa, Cape Town, South Africa","institution_ids":["https://openalex.org/I10947320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073216705","display_name":"Dan Joseph Stein","orcid":"https://orcid.org/0000-0001-7218-7810","observed_orcids":["https://orcid.org/0000-0001-7218-7810","https://orcid.org/0000-0002-4720-8867","https://orcid.org/0000-0002-0741-1780","https://orcid.org/0000-0001-7022-1106","https://orcid.org/0000-0002-4461-3568"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dan J. Stein","raw_affiliation_strings":["Department of Psychiatry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056005467","display_name":"Mark Solms","orcid":"https://orcid.org/0000-0003-4828-3882","observed_orcids":["https://orcid.org/0000-0003-4828-3882"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Mark Solms","raw_affiliation_strings":["Departments of Psychology and Neurology, University of Cape Town"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychology and Neurology, University of Cape Town","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063841533","display_name":"Raj Ramesar","orcid":"https://orcid.org/0000-0001-5688-1634","observed_orcids":["https://orcid.org/0000-0001-5688-1634"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I4405266898","display_name":"Institute of Infectious Disease and Molecular Medicine","ror":"https://ror.org/00900dw59","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Rajkumar Ramesar","raw_affiliation_strings":["MRC/UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC/UCT Human Genetics Research Unit, Institute of Infectious Disease and Molecular Medicine","institution_ids":["https://openalex.org/I157614274","https://openalex.org/I4405266898"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5033435451"],"corresponding_institution_ids":["https://openalex.org/I157614274","https://openalex.org/I4405266898"],"apc_list":{"value":5489,"currency":"USD","value_usd":5489},"apc_paid":null,"fwci":3.2566,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.90949007,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"62","issue":"5","first_page":"391","last_page":"399"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.8227999806404114,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.8227999806404114,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10426","display_name":"Child Abuse and Trauma","score":0.0544000007212162,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.03920000046491623,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/child-sexual-abuse","display_name":"child sexual abuse","score":0.9399999976158142},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.8220000267028809},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.8989999890327454},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.9399999976158142},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9670000076293945},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.8169999718666077},{"id":"https://openalex.org/keywords/verbal-memory","display_name":"verbal memory","score":0.609000027179718},{"id":"https://openalex.org/keywords/visual-memory","display_name":"visual memory","score":0.8679999709129333},{"id":"https://openalex.org/keywords/recognition-memory","display_name":"recognition memory","score":0.9710000157356262},{"id":"https://openalex.org/keywords/endophenotypes","display_name":"endophenotypes","score":0.8199999928474426},{"id":"https://openalex.org/keywords/neuropsychological-performance","display_name":"neuropsychological performance","score":0.6859999895095825},{"id":"https://openalex.org/keywords/family-based-cohort","display_name":"family-based cohort","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C172467417","wikidata":"https://www.wikidata.org/wiki/Q1670397","display_name":"Neurocognitive","level":3,"score":0.8853341341018677},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.6367085576057434},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6189668774604797},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.5600674748420715},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.538361132144928},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4855444133281708},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.42242273688316345},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3890726566314697},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3872299790382385},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34225308895111084},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3379000127315521},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3220471143722534},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.3212682604789734},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2554011344909668},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.22991135716438293},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2139204740524292},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2029818594455719},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002650","descriptor_name":"Child Abuse, Sexual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011594","descriptor_name":"Psychometrics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biopsych.2006.10.017","doi":"https://doi.org/10.1016/j.biopsych.2006.10.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biopsych.2006.10.017","pdf_url":null,"source":{"id":"https://openalex.org/S205482884","display_name":"Biological Psychiatry","issn_l":"0006-3223","issn":["0006-3223","1873-2402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Psychiatry","raw_type":"journal-article"},{"id":"pmid:17210134","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17210134","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological psychiatry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W1484497860","https://openalex.org/W1551100748","https://openalex.org/W1586217971","https://openalex.org/W1701655062","https://openalex.org/W1914011667","https://openalex.org/W1965669283","https://openalex.org/W1966933652","https://openalex.org/W1968888226","https://openalex.org/W1974631933","https://openalex.org/W1980353834","https://openalex.org/W1980587541","https://openalex.org/W1981845216","https://openalex.org/W1984045285","https://openalex.org/W1984575214","https://openalex.org/W1986494972","https://openalex.org/W1992326063","https://openalex.org/W1994950269","https://openalex.org/W1995437836","https://openalex.org/W1997917663","https://openalex.org/W2003586939","https://openalex.org/W2009050065","https://openalex.org/W2012436641","https://openalex.org/W2015098351","https://openalex.org/W2019166302","https://openalex.org/W2023682802","https://openalex.org/W2023731405","https://openalex.org/W2027973075","https://openalex.org/W2030705868","https://openalex.org/W2033333756","https://openalex.org/W2035126508","https://openalex.org/W2035304341","https://openalex.org/W2040577070","https://openalex.org/W2040866200","https://openalex.org/W2045217506","https://openalex.org/W2054019486","https://openalex.org/W2062682953","https://openalex.org/W2063616597","https://openalex.org/W2064212981","https://openalex.org/W2064225954","https://openalex.org/W2069127093","https://openalex.org/W2071128065","https://openalex.org/W2076950116","https://openalex.org/W2080206396","https://openalex.org/W2082464174","https://openalex.org/W2083819651","https://openalex.org/W2084057171","https://openalex.org/W2088842558","https://openalex.org/W2089540230","https://openalex.org/W2089580877","https://openalex.org/W2089953140","https://openalex.org/W2092281603","https://openalex.org/W2094436185","https://openalex.org/W2097583483","https://openalex.org/W2105874139","https://openalex.org/W2106240132","https://openalex.org/W2111038577","https://openalex.org/W2117527509","https://openalex.org/W2118439943","https://openalex.org/W2124793618","https://openalex.org/W2125618201","https://openalex.org/W2130417276","https://openalex.org/W2130685024","https://openalex.org/W2142031449","https://openalex.org/W2146738944","https://openalex.org/W2147817341","https://openalex.org/W2162054698","https://openalex.org/W2162196924","https://openalex.org/W2163305295","https://openalex.org/W2164424529","https://openalex.org/W2164710696","https://openalex.org/W2170760271","https://openalex.org/W2360484118","https://openalex.org/W2551018111","https://openalex.org/W2733332164","https://openalex.org/W4210821588","https://openalex.org/W4211142904","https://openalex.org/W4244977113","https://openalex.org/W4285719527","https://openalex.org/W6645827570"],"related_works":["https://openalex.org/W600358667","https://openalex.org/W3011466572","https://openalex.org/W1985992192","https://openalex.org/W7134007144","https://openalex.org/W2051742272","https://openalex.org/W2738214964","https://openalex.org/W2072484905","https://openalex.org/W1999541346","https://openalex.org/W2157696194","https://openalex.org/W3116330614"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}