{"id":"https://openalex.org/W2020362182","doi":"https://doi.org/10.2174/1570163811310020006","title":"Systems Biology Approaches in Identifying the Targets of Natural Compounds for Cancer Therapy","display_name":"Systems Biology Approaches in Identifying the Targets of Natural Compounds for Cancer Therapy","publication_year":2013,"publication_date":"2013-02-01","ids":{"openalex":"https://openalex.org/W2020362182","doi":"https://doi.org/10.2174/1570163811310020006","mag":"2020362182","pmid":"https://pubmed.ncbi.nlm.nih.gov/23237676"},"language":"en","primary_location":{"id":"doi:10.2174/1570163811310020006","doi":"https://doi.org/10.2174/1570163811310020006","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1570163811310020006","pdf_url":null,"source":{"id":"https://openalex.org/S68676814","display_name":"Current Drug Discovery Technologies","issn_l":"1570-1638","issn":["1570-1638","1875-6220"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Discovery Technologies","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108240378","display_name":"Yi Liang Tan","orcid":"https://orcid.org/0000-0002-1544-1250","observed_orcids":["https://orcid.org/0000-0002-1544-1250"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Tan","raw_affiliation_strings":["Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, MA 02215, USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102933502","display_name":"Qiong Wu","orcid":"https://orcid.org/0000-0002-0304-5330","observed_orcids":["https://orcid.org/0000-0002-0304-5330"]},"institutions":[{"id":"https://openalex.org/I169351748","display_name":"Bengbu Medical College","ror":"https://ror.org/01f8qvj05","country_code":"CN","type":"education","lineage":["https://openalex.org/I169351748"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiong Wu","raw_affiliation_strings":["Bengbu Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bengbu Medical College","institution_ids":["https://openalex.org/I169351748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031659092","display_name":"Jun Xia","orcid":"https://orcid.org/0000-0003-3222-2882","observed_orcids":["https://orcid.org/0000-0003-3222-2882"]},"institutions":[{"id":"https://openalex.org/I169351748","display_name":"Bengbu Medical College","ror":"https://ror.org/01f8qvj05","country_code":"CN","type":"education","lineage":["https://openalex.org/I169351748"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Xia","raw_affiliation_strings":["Bengbu Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bengbu Medical College","institution_ids":["https://openalex.org/I169351748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041301571","display_name":"Lucio Miele","orcid":"https://orcid.org/0000-0002-5853-7287","observed_orcids":["https://orcid.org/0000-0002-5853-7287"]},"institutions":[{"id":"https://openalex.org/I368840534","display_name":"University of Mississippi","ror":"https://ror.org/02teq1165","country_code":"US","type":"education","lineage":["https://openalex.org/I368840534","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucio Miele","raw_affiliation_strings":["University of Mississippi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Mississippi","institution_ids":["https://openalex.org/I368840534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109278193","display_name":"Fazlul H. Sarkar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fazlul H Sarkar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100449990","display_name":"Zhiwei Wang","orcid":"https://orcid.org/0009-0009-5516-2916","observed_orcids":["https://orcid.org/0009-0009-5516-2916"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiwei Wang","raw_affiliation_strings":["Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, MA 02215, USA.,Israel","Harvard University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, MA 02215, USA.,Israel","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard University","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8533,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.6790487,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"10","issue":"2","first_page":"139","last_page":"146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.03060000017285347,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natural-compounds","display_name":"natural compounds","score":0.9860000014305115},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7609999775886536},{"id":"https://openalex.org/keywords/drug-target-identification","display_name":"drug target identification","score":0.8180000185966492},{"id":"https://openalex.org/keywords/systems-biology","display_name":"systems biology","score":0.9670000076293945},{"id":"https://openalex.org/keywords/dna-microarrays","display_name":"DNA microarrays","score":0.8870000243186951},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.7490000128746033},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.8159999847412109},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.9229999780654907}],"concepts":[{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.6727786064147949},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5013158321380615},{"id":"https://openalex.org/C2776608160","wikidata":"https://www.wikidata.org/wiki/Q4785462","display_name":"Natural (archaeology)","level":2,"score":0.441545307636261},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44073885679244995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.398304283618927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32029786705970764},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07692074775695801},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/1570163811310020006","doi":"https://doi.org/10.2174/1570163811310020006","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1570163811310020006","pdf_url":null,"source":{"id":"https://openalex.org/S68676814","display_name":"Current Drug Discovery Technologies","issn_l":"1570-1638","issn":["1570-1638","1875-6220"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Discovery Technologies","raw_type":"journal-article"},{"id":"pmid:23237676","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23237676","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current drug discovery technologies","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5259760061","display_name":"RO1: A novel and targeted approach to inhibit invasion and angiogenesis","funder_award_id":"R01CA131151","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8074806580","display_name":"FoxM1: A molecular target in pancreatic cancer","funder_award_id":"R01CA132794","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8579852739","display_name":"Prevention of Tumor Progression by a Novel Approach","funder_award_id":"R01CA154321","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2609070191","https://openalex.org/W2609659483","https://openalex.org/W4386563297","https://openalex.org/W2758542296","https://openalex.org/W2898622864","https://openalex.org/W2176698689","https://openalex.org/W2966627014","https://openalex.org/W6964207729","https://openalex.org/W2026060503","https://openalex.org/W4200134826"],"abstract_inverted_index":{"Natural":[0],"compounds":[1,84],"have":[2,40],"been":[3],"known":[4],"to":[5,42],"exert":[6],"inhibitory":[7],"effects":[8],"on":[9,33],"the":[10,18,47,63,71,79,90,100],"development":[11],"and":[12,68,110],"progression":[13],"of":[14,20,49,73,82,94,99],"human":[15,95],"cancers.":[16,96,123],"However,":[17],"targets":[19,48,81,102],"these":[21,74],"naturally":[22],"occurring":[23],"agents":[24],"are":[25],"largely":[26],"elusive.":[27],"Recently,":[28],"systems":[29,65],"biology":[30,66],"approaches":[31],"based":[32],"high-throughput":[34],"technologies":[35,76],"such":[36],"as":[37],"DNA":[38],"microarrays":[39],"begun":[41],"be":[43,104],"utilized":[44],"for":[45,77,85,106,114],"investigating":[46],"drugs":[50],"including":[51],"natural":[52,83],"compounds.":[53],"Therefore,":[54],"in":[55,89,119],"this":[56],"review":[57],"article,":[58],"we":[59],"will":[60,69,103],"briefly":[61],"introduce":[62],"several":[64],"approaches,":[67],"discuss":[70],"application":[72],"new":[75],"identifying":[78],"therapeutic":[80,112],"supporting":[86],"their":[87],"roles":[88],"prevention":[91],"and/or":[92],"treatment":[93,117],"Furthermore,":[97],"identification":[98],"novel":[101],"useful":[105],"designing":[107],"more":[108],"effective":[109],"targeted":[111],"strategies":[113],"achieving":[115],"better":[116],"outcome":[118],"patients":[120],"diagnosed":[121],"with":[122]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
