{"id":"https://openalex.org/W2020357781","doi":"https://doi.org/10.1073/pnas.82.6.1623","title":"Fine structural mapping of a critical NH2-terminal region of p60src.","display_name":"Fine structural mapping of a critical NH2-terminal region of p60src.","publication_year":1985,"publication_date":"1985-03-01","ids":{"openalex":"https://openalex.org/W2020357781","doi":"https://doi.org/10.1073/pnas.82.6.1623","mag":"2020357781","pmid":"https://pubmed.ncbi.nlm.nih.gov/2984663","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/397324"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.82.6.1623","doi":"https://doi.org/10.1073/pnas.82.6.1623","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.82.6.1623","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/397324","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024739591","display_name":"David S. Pellman","orcid":"https://orcid.org/0000-0001-5306-8031","observed_orcids":["https://orcid.org/0000-0001-5306-8031"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Pellman","raw_affiliation_strings":["The Rockefeller University, New York, NY 10021","The University of Chicago Pritzker School of Medicine, Chicago, IL 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rockefeller University, New York, NY 10021","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"The University of Chicago Pritzker School of Medicine, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061013684","display_name":"Ellen A. Garber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E A Garber","raw_affiliation_strings":["The Rockefeller University, New York, NY 10021","The University of Chicago Pritzker School of Medicine, Chicago, IL 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rockefeller University, New York, NY 10021","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"The University of Chicago Pritzker School of Medicine, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061209953","display_name":"Frederick R. Cross","orcid":"https://orcid.org/0000-0002-4387-4133","observed_orcids":["https://orcid.org/0000-0002-4387-4133"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F R Cross","raw_affiliation_strings":["The Rockefeller University, New York, NY 10021","The University of Chicago Pritzker School of Medicine, Chicago, IL 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rockefeller University, New York, NY 10021","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"The University of Chicago Pritzker School of Medicine, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068776411","display_name":"Hidesabur\u00f4 Hanafusa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Hanafusa","raw_affiliation_strings":["The Rockefeller University, New York, NY 10021","The University of Chicago Pritzker School of Medicine, Chicago, IL 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Rockefeller University, New York, NY 10021","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"The University of Chicago Pritzker School of Medicine, Chicago, IL 60637","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.6768,"has_fulltext":false,"cited_by_count":117,"citation_normalized_percentile":{"value":0.9783593,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"82","issue":"6","first_page":"1623","last_page":"1627"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8389000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8389000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.1445000022649765,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p60src","display_name":"p60src","score":0.9950000047683716},{"id":"https://openalex.org/keywords/rous-sarcoma-virus","display_name":"Rous sarcoma virus","score":0.890999972820282},{"id":"https://openalex.org/keywords/protein-myristoylation","display_name":"myristoylation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/membrane-association","display_name":"membrane association","score":0.8999999761581421},{"id":"https://openalex.org/keywords/nh2-terminal-sequence","display_name":"NH2-terminal sequence","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.902999997138977},{"id":"https://openalex.org/keywords/plasma-membrane","display_name":"plasma membrane","score":0.5720000267028809},{"id":"https://openalex.org/keywords/oncogene-structure","display_name":"oncogene structure","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C2777441520","wikidata":"https://www.wikidata.org/wiki/Q1444330","display_name":"Rous sarcoma virus","level":3,"score":0.9139548540115356},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.6463102102279663},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.6104453206062317},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5737437009811401},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.572142481803894},{"id":"https://openalex.org/C77207865","wikidata":"https://www.wikidata.org/wiki/Q25794","display_name":"Myristoylation","level":3,"score":0.540834367275238},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5012624263763428},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.49820375442504883},{"id":"https://openalex.org/C196347352","wikidata":"https://www.wikidata.org/wiki/Q24771787","display_name":"SH3 domain","level":4,"score":0.4796636402606964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4504741132259369},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39235955476760864},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35043594241142273},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.19410201907157898},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.18687185645103455},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15820178389549255}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001358","descriptor_name":"Avian Sarcoma Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005814","descriptor_name":"Genes, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009227","descriptor_name":"Myristic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015688","descriptor_name":"Oncogene Protein pp60(v-src)","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.82.6.1623","doi":"https://doi.org/10.1073/pnas.82.6.1623","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.82.6.1623","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:397324","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/397324","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:2984663","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2984663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Comparative Study"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:397324","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/397324","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1386263060","display_name":null,"funder_award_id":"F32AIO7233","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4688842540","display_name":"CELLULAR ALTERATION INDUCED BY ROUS SARCOMA VIRUS","funder_award_id":"R01CA014935","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1488236923","https://openalex.org/W1547224370","https://openalex.org/W1910548170","https://openalex.org/W1922625104","https://openalex.org/W1976508520","https://openalex.org/W2008226643","https://openalex.org/W2010002190","https://openalex.org/W2018432553","https://openalex.org/W2046280987","https://openalex.org/W2052692052","https://openalex.org/W2057902888","https://openalex.org/W2058531019","https://openalex.org/W2062483982","https://openalex.org/W2064529356","https://openalex.org/W2073618078","https://openalex.org/W2076243780","https://openalex.org/W2079159599","https://openalex.org/W2086145650","https://openalex.org/W2089396478","https://openalex.org/W2181907544"],"related_works":["https://openalex.org/W1922625104","https://openalex.org/W2309804568","https://openalex.org/W2016388741","https://openalex.org/W2418503249","https://openalex.org/W1998250646","https://openalex.org/W2161651018","https://openalex.org/W2052692052","https://openalex.org/W1529922998","https://openalex.org/W2166185276","https://openalex.org/W1984786709"],"abstract_inverted_index":{"We":[0,52,158],"have":[1,53,201],"recently":[2],"demonstrated":[3],"that":[4,62,113,161,185],"an":[5],"NH2-terminal":[6],"sequence":[7,45,68,163],"required":[8,48,164,192],"for":[9,49,70,92,141,165,193],"myristylation":[10,166,187],"and":[11,87,118,149,153,167,184,188,224],"membrane":[12,125,151,168,189,225],"association":[13,169,190],"of":[14,58,104,126,170,180,208,215],"the":[15,66,109,123,154,175,181,209],"Rous":[16,59],"sarcoma":[17,60],"virus":[18,61,155],"transforming":[19,204],"protein,":[20,183],"p60src,":[21],"is":[22,46,172],"contained":[23],"within":[24,174],"amino":[25,73,84,93,142,178],"acids":[26,85,94,143,179],"2-14":[27],"[Cross,":[28],"F.R.,":[29],"Garber,":[30],"E.":[31],"A.,":[32],"Pellman,":[33],"D.":[34],"&":[35],"Hanafusa,":[36],"H.":[37],"(1984)":[38],"Mol.":[39],"Cell.":[40],"Biol.":[41],"4,":[42],"1834-1842].":[43],"This":[44,145],"also":[47],"cell":[50,194],"transformation.":[51,195],"now":[54],"constructed":[55],"five":[56],"mutants":[57,106],"contain":[63],"alterations":[64],"in":[65,112],"src":[67,77,102,134,182,213],"coding":[69],"these":[71,105],"14":[72],"acids.":[74],"Mutants":[75],"encoding":[76],"proteins":[78,103,214],"with":[79,122,136,197],"a":[80,133,137,162],"peptide":[81,90,139],"insertion":[82],"between":[83],"1":[86],"2,":[88],"or":[89,97],"substitutions":[91],"2-4,":[95],"3-4,":[96],"7-15,":[98],"were":[99,115,219],"transformation-defective.":[100],"The":[101,129,212],"differed":[107],"from":[108,206],"wild-type":[110],"protein":[111,135,146],"they":[114],"not":[116,120],"myristylated":[117,148,223],"did":[119],"fractionate":[121],"plasma":[124,150],"infected":[127],"cells.":[128,157],"fifth":[130],"mutant":[131],"encoded":[132],"short":[138],"substituted":[140],"11-15.":[144],"was":[147],"associated,":[152],"transformed":[156],"therefore":[159],"conclude":[160],"p60src":[171,186],"located":[173],"first":[176],"7-10":[177],"are":[191],"Consistent":[196],"this":[198],"idea,":[199],"we":[200],"isolated":[202],"four":[203,217],"revertants":[205,218],"one":[207],"transformation-defective":[210],"mutants.":[211],"all":[216],"found":[220],"to":[221],"be":[222],"associated.":[226]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
