{"id":"https://openalex.org/W2020350628","doi":"https://doi.org/10.1056/nejm198409133111101","title":"Cimetidine, Cigarette Smoking, and Recurrence of Duodenal Ulcer","display_name":"Cimetidine, Cigarette Smoking, and Recurrence of Duodenal Ulcer","publication_year":1984,"publication_date":"1984-09-13","ids":{"openalex":"https://openalex.org/W2020350628","doi":"https://doi.org/10.1056/nejm198409133111101","mag":"2020350628","pmid":"https://pubmed.ncbi.nlm.nih.gov/6382004"},"language":"en","primary_location":{"id":"doi:10.1056/nejm198409133111101","doi":"https://doi.org/10.1056/nejm198409133111101","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm198409133111101","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017565574","display_name":"Stephen J. Sontag","orcid":"https://orcid.org/0000-0001-8713-0497","observed_orcids":["https://orcid.org/0000-0001-8713-0497"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen Sontag","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053556585","display_name":"David Yates Graham","orcid":"https://orcid.org/0000-0002-6908-8317","observed_orcids":["https://orcid.org/0000-0002-6908-8317"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Y. Graham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007537166","display_name":"Alphonso A. Belsito","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alphonso Belsito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111840980","display_name":"Jerome Weiss","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jerome Weiss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076411032","display_name":"Alain Farley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alain Farley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009759654","display_name":"Richard Grunt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Grunt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080351072","display_name":"Norman L. Cohen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norman Cohen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108368034","display_name":"Douglas G. Kinnear","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Douglas Kinnear","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091182918","display_name":"William D. Davis","orcid":"https://orcid.org/0000-0002-4059-4590","observed_orcids":["https://orcid.org/0000-0002-4059-4590"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William Davis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108190556","display_name":"AP Archambault","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andre Archambault","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030477110","display_name":"James L. Achord","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Achord","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109856153","display_name":"Walter Thayer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walter Thayer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073600160","display_name":"Richard Gillies","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Gillies","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054950767","display_name":"Joseph J. Sidorov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph Sidorov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030314353","display_name":"Seymour M. Sabesin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seymour M. Sabesin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085143743","display_name":"Walter P. Dyck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walter Dyck","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070474744","display_name":"Bertram Fleshler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bertram Fleshler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111672317","display_name":"I. G. M. Cleator","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iain Cleator","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052281608","display_name":"Julius Wenger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julius Wenger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5017481174","display_name":"Antone R. Opekun","orcid":"https://orcid.org/0000-0003-4837-6480","observed_orcids":["https://orcid.org/0000-0003-4837-6480"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antone Opekun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":36.548,"has_fulltext":false,"cited_by_count":219,"citation_normalized_percentile":{"value":0.99797762,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"311","issue":"11","first_page":"689","last_page":"693"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cimetidine","display_name":"cimetidine","score":0.9559999704360962},{"id":"https://openalex.org/keywords/duodenal-ulcer","display_name":"duodenal ulcer","score":0.9190000295639038},{"id":"https://openalex.org/keywords/ulcer-recurrence","display_name":"ulcer recurrence","score":0.953000009059906},{"id":"https://openalex.org/keywords/cigarette-smoking","display_name":"cigarette smoking","score":0.8809999823570251},{"id":"https://openalex.org/keywords/smoking-cessation","display_name":"smoking cessation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/h2-receptor-antagonists","display_name":"H2 receptor antagonists","score":0.890999972820282},{"id":"https://openalex.org/keywords/ulcer-recurrence-prevention","display_name":"ulcer recurrence prevention","score":0.5879999995231628},{"id":"https://openalex.org/keywords/dose-comparison","display_name":"dose comparison","score":0.5730000138282776},{"id":"https://openalex.org/keywords/endoscopic-recurrence","display_name":"endoscopic recurrence","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9580438137054443},{"id":"https://openalex.org/C2780719153","wikidata":"https://www.wikidata.org/wiki/Q409492","display_name":"Cimetidine","level":2,"score":0.9426813721656799},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8093475103378296},{"id":"https://openalex.org/C2778537899","wikidata":"https://www.wikidata.org/wiki/Q254034","display_name":"Bedtime","level":2,"score":0.7592415809631348},{"id":"https://openalex.org/C2993747882","wikidata":"https://www.wikidata.org/wiki/Q172941","display_name":"Duodenal ulcer","level":2,"score":0.7055148482322693},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.575142502784729},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5656401515007019},{"id":"https://openalex.org/C162156334","wikidata":"https://www.wikidata.org/wiki/Q473420","display_name":"Dose","level":2,"score":0.5462793707847595},{"id":"https://openalex.org/C2778451229","wikidata":"https://www.wikidata.org/wiki/Q212809","display_name":"Endoscopy","level":2,"score":0.44401639699935913},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4270777106285095},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002927","descriptor_name":"Cimetidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002927","descriptor_name":"Cimetidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004381","descriptor_name":"Duodenal Ulcer","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejm198409133111101","doi":"https://doi.org/10.1056/nejm198409133111101","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm198409133111101","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:6382004","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6382004","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W53983912","https://openalex.org/W1561568838","https://openalex.org/W1567097454","https://openalex.org/W1627605192","https://openalex.org/W1803526930","https://openalex.org/W1825314033","https://openalex.org/W1971306657","https://openalex.org/W1983154953","https://openalex.org/W1986062585","https://openalex.org/W1988930563","https://openalex.org/W1998795924","https://openalex.org/W2023258483","https://openalex.org/W2024931474","https://openalex.org/W2025984548","https://openalex.org/W2027063307","https://openalex.org/W2033933183","https://openalex.org/W2049892299","https://openalex.org/W2056431318","https://openalex.org/W2056761801","https://openalex.org/W2067729796","https://openalex.org/W2077319005","https://openalex.org/W2081320355","https://openalex.org/W2083889252","https://openalex.org/W2110615630","https://openalex.org/W2138769882","https://openalex.org/W2140551860","https://openalex.org/W2152296323","https://openalex.org/W2160175439","https://openalex.org/W2312511704","https://openalex.org/W2318051686","https://openalex.org/W2319806643","https://openalex.org/W2409550692","https://openalex.org/W2411227040","https://openalex.org/W2411898875","https://openalex.org/W2994197835","https://openalex.org/W4246506633","https://openalex.org/W4248035121","https://openalex.org/W4298372457","https://openalex.org/W4317563734","https://openalex.org/W4317563763"],"related_works":["https://openalex.org/W1993498597","https://openalex.org/W2442193862","https://openalex.org/W2123612585","https://openalex.org/W2080145526","https://openalex.org/W2417901181","https://openalex.org/W2431480265","https://openalex.org/W1999300490","https://openalex.org/W2473711222","https://openalex.org/W7098381305","https://openalex.org/W2050386945"],"abstract_inverted_index":{"Three":[0],"hundred":[1],"seventy":[2],"patients":[3,67],"with":[4,19,105,155],"recently":[5],"healed":[6],"duodenal":[7,46,208],"ulcer":[8,122,146,224],"entered":[9],"into":[10],"a":[11,29,34,92,180,202],"one-year,":[12],"double-blind,":[13],"randomized":[14],"multicenter":[15],"trial":[16],"comparing":[17],"placebo":[18,120,187],"three":[20,70],"different":[21],"dose":[22],"schedules":[23],"of":[24,44,51,72,145,207,223,228],"cimetidine":[25,73,107,156,172],"(200":[26],"mg":[27,32,38],"twice":[28,33],"day,":[30,35],"300":[31],"and":[36,80,210],"400":[37],"at":[39,174],"bedtime)":[40],"for":[41,65],"the":[42,49,54,66,69,88,119,221],"prevention":[43,222],"recurrent":[45],"ulcer.":[47],"By":[48],"end":[50],"one":[52],"year,":[53],"cumulative":[55],"symptomatic":[56,96],"recurrence":[57,97,123,147,181,206],"rate":[58,98],"as":[59,103,176,182],"demonstrated":[60],"by":[61,153],"endoscopy":[62],"was":[63,111,124,150],"similar":[64],"receiving":[68],"dosages":[71],"(19":[74],"per":[75,78,82,94,131,137,159,163,189,193],"cent,":[76,79,83,138,164,194],"15":[77],"13":[81],"respectively;":[84],"not":[85,195],"significant),":[86],"whereas":[87],"placebo-treated":[89],"group":[90],"had":[91],"34.7":[93],"cent":[95,160,190],"(P":[99],"less":[100,140,166],"than":[101,133,141,167,226],"0.01":[102],"compared":[104],"each":[106],"group).":[108],"Cigarette":[109],"smoking":[110,198,215],"found":[112],"to":[113,161,178,200],"be":[114,201,217],"an":[115],"important":[116,219],"variable;":[117],"among":[118],"recipients":[121],"significantly":[125,151],"more":[126,218],"likely":[127,177],"in":[128,134,148,205,211,220],"smokers":[129,149],"(72":[130],"cent)":[132],"nonsmokers":[135,184],"(21":[136],"P":[139,165],"0.001).":[142],"The":[143],"frequency":[144],"reduced":[152],"treatment":[154],"(from":[157],"72":[158],"34":[162],"0.).":[168],"Smokers":[169],"who":[170,185],"received":[171,186],"were":[173,183],"least":[175],"have":[179],"(34":[188],"vs.":[191],"21":[192],"significant).":[196],"Thus,":[197],"appears":[199],"major":[203],"factor":[204],"ulcer,":[209],"smokers,":[212],"giving":[213],"up":[214],"may":[216],"recurrences":[225],"administration":[227],"cimetidine.":[229]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}