{"id":"https://openalex.org/W2020350342","doi":"https://doi.org/10.3310/hta15210","title":"A pragmatic single-blind randomised controlled trial and economic evaluation of the use of leukotriene receptor antagonists in primary care at steps 2 and 3 of the national asthma guidelines (ELEVATE study).","display_name":"A pragmatic single-blind randomised controlled trial and economic evaluation of the use of leukotriene receptor antagonists in primary care at steps 2 and 3 of the national asthma guidelines (ELEVATE study).","publication_year":2011,"publication_date":"2011-05-01","ids":{"openalex":"https://openalex.org/W2020350342","doi":"https://doi.org/10.3310/hta15210","mag":"2020350342","pmid":"https://pubmed.ncbi.nlm.nih.gov/21554855"},"language":"en","primary_location":{"id":"doi:10.3310/hta15210","doi":"https://doi.org/10.3310/hta15210","is_oa":true,"landing_page_url":"https://doi.org/10.3310/hta15210","pdf_url":"https://njl-admin.nihr.ac.uk/document/download/2002108","source":{"id":"https://openalex.org/S191206091","display_name":"Health Technology Assessment","issn_l":"1366-5278","issn":["1366-5278","2046-4924","2046-4932"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311817","host_organization_name":"NIHR Journals Library","host_organization_lineage":["https://openalex.org/P4310311817"],"host_organization_lineage_names":["NIHR Journals Library"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Technology Assessment","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://njl-admin.nihr.ac.uk/document/download/2002108","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052175038","display_name":"David Brendan Price","orcid":"https://orcid.org/0000-0002-9728-9992","observed_orcids":["https://orcid.org/0000-0002-9728-9992","https://orcid.org/0000-0002-1195-039X"]},"institutions":[{"id":"https://openalex.org/I195460627","display_name":"University of Aberdeen","ror":"https://ror.org/016476m91","country_code":"GB","type":"education","lineage":["https://openalex.org/I195460627"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"D Price","raw_affiliation_strings":["Centre of Academic Primary Care, University of Aberdeen, Aberdeen, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of Academic Primary Care, University of Aberdeen, Aberdeen, UK","institution_ids":["https://openalex.org/I195460627"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S Musgrave","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1118541","display_name":"University of East Anglia","ror":"https://ror.org/026k5mg93","country_code":"GB","type":"education","lineage":["https://openalex.org/I1118541"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S Musgrave","raw_affiliation_strings":["Norwich Medical School, University of East Anglia, Norwich, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Norwich Medical School, University of East Anglia, Norwich, UK","institution_ids":["https://openalex.org/I1118541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102772703","display_name":"Ed Wilson","orcid":"https://orcid.org/0000-0002-8369-1577","observed_orcids":["https://orcid.org/0000-0002-8369-1577"]},"institutions":[{"id":"https://openalex.org/I1118541","display_name":"University of East Anglia","ror":"https://ror.org/026k5mg93","country_code":"GB","type":"education","lineage":["https://openalex.org/I1118541"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E Wilson","raw_affiliation_strings":["Norwich Medical School, University of East Anglia, Norwich, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Norwich Medical School, University of East Anglia, Norwich, UK","institution_ids":["https://openalex.org/I1118541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002323416","display_name":"Erika J Sims","orcid":"https://orcid.org/0000-0002-7898-0331","observed_orcids":["https://orcid.org/0000-0002-7898-0331"]},"institutions":[{"id":"https://openalex.org/I1118541","display_name":"University of East Anglia","ror":"https://ror.org/026k5mg93","country_code":"GB","type":"education","lineage":["https://openalex.org/I1118541"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E Sims","raw_affiliation_strings":["Norwich Medical School, University of East Anglia, Norwich, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Norwich Medical School, University of East Anglia, Norwich, UK","institution_ids":["https://openalex.org/I1118541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032021654","display_name":"Lee Shepstone","orcid":"https://orcid.org/0000-0001-5524-7818","observed_orcids":["https://orcid.org/0000-0001-5524-7818"]},"institutions":[{"id":"https://openalex.org/I1118541","display_name":"University of East Anglia","ror":"https://ror.org/026k5mg93","country_code":"GB","type":"education","lineage":["https://openalex.org/I1118541"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L Shepstone","raw_affiliation_strings":["Norwich Medical School, University of East Anglia, Norwich, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Norwich Medical School, University of East Anglia, Norwich, UK","institution_ids":["https://openalex.org/I1118541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101793652","display_name":"Annie Blyth","orcid":"https://orcid.org/0000-0001-5380-5353","observed_orcids":["https://orcid.org/0000-0001-5380-5353"]},"institutions":[{"id":"https://openalex.org/I1118541","display_name":"University of East Anglia","ror":"https://ror.org/026k5mg93","country_code":"GB","type":"education","lineage":["https://openalex.org/I1118541"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Blyth","raw_affiliation_strings":["Norwich Medical School, University of East Anglia, Norwich, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Norwich Medical School, University of East Anglia, Norwich, UK","institution_ids":["https://openalex.org/I1118541"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000766438","display_name":"Jamie Murdoch","orcid":"https://orcid.org/0000-0002-9021-3629","observed_orcids":["https://orcid.org/0000-0002-9021-3629"]},"institutions":[{"id":"https://openalex.org/I1118541","display_name":"University of East Anglia","ror":"https://ror.org/026k5mg93","country_code":"GB","type":"education","lineage":["https://openalex.org/I1118541"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J Murdoch","raw_affiliation_strings":["School of Nursing and Midwifery , University of East Anglia , Norwich , UK","Other Applied Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing and Midwifery , University of East Anglia , Norwich , UK","institution_ids":["https://openalex.org/I1118541"]},{"raw_affiliation_string":"Other Applied Health Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113565455","display_name":"Miranda Mugford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1118541","display_name":"University of East Anglia","ror":"https://ror.org/026k5mg93","country_code":"GB","type":"education","lineage":["https://openalex.org/I1118541"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M Mugford","raw_affiliation_strings":["Norwich Medical School , University of East Anglia , Norwich , UK","Other Applied Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Norwich Medical School , University of East Anglia , Norwich , UK","institution_ids":["https://openalex.org/I1118541"]},{"raw_affiliation_string":"Other Applied Health Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031103832","display_name":"Elizabeth F. Juniper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"E Juniper","raw_affiliation_strings":["Department of Clinical Epidemiology and Biostatistics , McMaster University , Hamilton , Ontario , Canada","Other Applied Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Epidemiology and Biostatistics , McMaster University , Hamilton , Ontario , Canada","institution_ids":["https://openalex.org/I98251732"]},{"raw_affiliation_string":"Other Applied Health Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111918655","display_name":"J G Ayres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79619799","display_name":"University of Birmingham","ror":"https://ror.org/03angcq70","country_code":"GB","type":"education","lineage":["https://openalex.org/I79619799"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J Ayres","raw_affiliation_strings":["School of Health & Population Sciences , University of Birmingham , Birmingham , UK","Other Applied Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Health & Population Sciences , University of Birmingham , Birmingham , UK","institution_ids":["https://openalex.org/I79619799"]},{"raw_affiliation_string":"Other Applied Health Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"S Wolfe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Wolfe","raw_affiliation_strings":["Thorpewood GP Surgery , Norwich , UK","Other Applied Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thorpewood GP Surgery , Norwich , UK","institution_ids":[]},{"raw_affiliation_string":"Other Applied Health Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064569292","display_name":"Daryl Freeman","orcid":"https://orcid.org/0000-0003-2056-2716","observed_orcids":["https://orcid.org/0000-0003-2056-2716"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Freeman","raw_affiliation_strings":["Sheringham Medical Practice , Norfolk , UK","Other Applied Health Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sheringham Medical Practice , Norfolk , UK","institution_ids":[]},{"raw_affiliation_string":"Other Applied Health Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041675543","display_name":"Alistair Lipp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Lipp","raw_affiliation_strings":["Great Yarmouth and Waveney Primary Care Trust, Norfolk, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Great Yarmouth and Waveney Primary Care Trust, Norfolk, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034825689","display_name":"R.F.T. Gilbert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Gilbert","raw_affiliation_strings":["Castle GP Partnership, Norwich, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Castle GP Partnership, Norwich, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108093072","display_name":"Ian M. Harvey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1118541","display_name":"University of East Anglia","ror":"https://ror.org/026k5mg93","country_code":"GB","type":"education","lineage":["https://openalex.org/I1118541"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I Harvey","raw_affiliation_strings":["Norwich Medical School, University of East Anglia, Norwich, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Norwich Medical School, University of East Anglia, Norwich, UK","institution_ids":["https://openalex.org/I1118541"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5052175038"],"corresponding_institution_ids":["https://openalex.org/I195460627"],"apc_list":null,"apc_paid":null,"fwci":1.0914,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.76853959,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"15","issue":"21","first_page":"1","last_page":"132"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leukotriene-receptor-antagonists","display_name":"leukotriene receptor antagonists","score":0.9869999885559082},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.6050000190734863},{"id":"https://openalex.org/keywords/inhaled-corticosteroids","display_name":"inhaled corticosteroids","score":0.9490000009536743},{"id":"https://openalex.org/keywords/long-acting-beta-agonists","display_name":"long-acting beta2-agonists","score":0.9129999876022339},{"id":"https://openalex.org/keywords/controller-therapy","display_name":"controller therapy","score":0.6800000071525574},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.8870000243186951},{"id":"https://openalex.org/keywords/asthma-control","display_name":"asthma control","score":0.9039999842643738},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8190000057220459},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.9779999852180481},{"id":"https://openalex.org/keywords/primary-care","display_name":"primary care","score":0.7680000066757202},{"id":"https://openalex.org/keywords/uncontrolled-asthma","display_name":"uncontrolled asthma","score":0.7250000238418579},{"id":"https://openalex.org/keywords/mini-asthma-quality-of-life-questionnaire","display_name":"Mini Asthma Quality of Life Questionnaire","score":0.8029999732971191},{"id":"https://openalex.org/keywords/asthma-control-questionnaire","display_name":"Asthma Control Questionnaire","score":0.9760000109672546}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9074497222900391},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.7181288003921509},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.6556258797645569},{"id":"https://openalex.org/C64332521","wikidata":"https://www.wikidata.org/wiki/Q614165","display_name":"Quality-adjusted life year","level":3,"score":0.5274524688720703},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4962638020515442},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.4957357347011566},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.47787490487098694},{"id":"https://openalex.org/C2776719499","wikidata":"https://www.wikidata.org/wiki/Q424333","display_name":"Salmeterol","level":3,"score":0.4754982888698578},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.4342747926712036},{"id":"https://openalex.org/C515549039","wikidata":"https://www.wikidata.org/wiki/Q1754768","display_name":"Cost-effectiveness analysis","level":3,"score":0.42196208238601685},{"id":"https://openalex.org/C3019080777","wikidata":"https://www.wikidata.org/wiki/Q1754768","display_name":"Cost effectiveness","level":2,"score":0.41912245750427246},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.41318392753601074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26901400089263916},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003362","descriptor_name":"Cost-Benefit Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006113","descriptor_name":"United Kingdom","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006305","descriptor_name":"Health Status Indicators","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011320","descriptor_name":"Primary Health Care","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D011594","descriptor_name":"Psychometrics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016001","descriptor_name":"Confidence Intervals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016037","descriptor_name":"Single-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017410","descriptor_name":"Practice Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018927","descriptor_name":"Anti-Asthmatic Agents","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D018927","descriptor_name":"Anti-Asthmatic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019057","descriptor_name":"Quality-Adjusted Life Years","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020024","descriptor_name":"Leukotriene Antagonists","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D020024","descriptor_name":"Leukotriene Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058666","descriptor_name":"Adrenergic beta-2 Receptor Agonists","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D058666","descriptor_name":"Adrenergic beta-2 Receptor Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3310/hta15210","doi":"https://doi.org/10.3310/hta15210","is_oa":true,"landing_page_url":"https://doi.org/10.3310/hta15210","pdf_url":"https://njl-admin.nihr.ac.uk/document/download/2002108","source":{"id":"https://openalex.org/S191206091","display_name":"Health Technology Assessment","issn_l":"1366-5278","issn":["1366-5278","2046-4924","2046-4932"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311817","host_organization_name":"NIHR Journals Library","host_organization_lineage":["https://openalex.org/P4310311817"],"host_organization_lineage_names":["NIHR Journals Library"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Technology Assessment","raw_type":"journal-article"},{"id":"pmid:21554855","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21554855","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health technology assessment (Winchester, England)","raw_type":"Journal Article"},{"id":"pmh:oai:ueaeprints.uea.ac.uk:31137","doi":null,"is_oa":false,"landing_page_url":"https://ueaeprints.uea.ac.uk/id/eprint/31137/1/HTAmon1521.pdf","pdf_url":"https://ueaeprints.uea.ac.uk/id/eprint/31137/1/HTAmon1521.pdf","source":{"id":"https://openalex.org/S4306400384","display_name":"UEA Digital Repository (University of East Anglia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1118541","host_organization_name":"University of East Anglia","host_organization_lineage":["https://openalex.org/I1118541"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:dc517602d35440ceb16334befb155f77","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/dc517602d35440ceb16334befb155f77","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Health Technology Assessment, Vol 15, Iss 21 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3310/hta15210","doi":"https://doi.org/10.3310/hta15210","is_oa":true,"landing_page_url":"https://doi.org/10.3310/hta15210","pdf_url":"https://njl-admin.nihr.ac.uk/document/download/2002108","source":{"id":"https://openalex.org/S191206091","display_name":"Health Technology Assessment","issn_l":"1366-5278","issn":["1366-5278","2046-4924","2046-4932"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311817","host_organization_name":"NIHR Journals Library","host_organization_lineage":["https://openalex.org/P4310311817"],"host_organization_lineage_names":["NIHR Journals Library"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Technology Assessment","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G3096804764","display_name":null,"funder_award_id":"98/34/05","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G4621550198","display_name":null,"funder_award_id":"98/34/05","funder_id":"https://openalex.org/F4320334661","funder_display_name":"Health Technology Assessment Programme"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320334661","display_name":"Health Technology Assessment Programme","ror":"https://ror.org/0187kwz08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2020350342.pdf","grobid_xml":"https://content.openalex.org/works/W2020350342.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1965526557","https://openalex.org/W1966718625","https://openalex.org/W1968660451","https://openalex.org/W1971099282","https://openalex.org/W1972176879","https://openalex.org/W1979235045","https://openalex.org/W1983600587","https://openalex.org/W1987788191","https://openalex.org/W1988895307","https://openalex.org/W1989260226","https://openalex.org/W1994222210","https://openalex.org/W2002242850","https://openalex.org/W2003292549","https://openalex.org/W2006414917","https://openalex.org/W2009664639","https://openalex.org/W2014608611","https://openalex.org/W2019258544","https://openalex.org/W2033984690","https://openalex.org/W2035216610","https://openalex.org/W2037971296","https://openalex.org/W2038795551","https://openalex.org/W2039439214","https://openalex.org/W2043590977","https://openalex.org/W2043671273","https://openalex.org/W2046698465","https://openalex.org/W2052049014","https://openalex.org/W2058534254","https://openalex.org/W2059181419","https://openalex.org/W2061583454","https://openalex.org/W2070289515","https://openalex.org/W2076171672","https://openalex.org/W2076253316","https://openalex.org/W2081161396","https://openalex.org/W2082695270","https://openalex.org/W2086167722","https://openalex.org/W2086327097","https://openalex.org/W2086417957","https://openalex.org/W2095591678","https://openalex.org/W2097781162","https://openalex.org/W2099364430","https://openalex.org/W2105665234","https://openalex.org/W2108702725","https://openalex.org/W2110431512","https://openalex.org/W2111609315","https://openalex.org/W2117159720","https://openalex.org/W2117256477","https://openalex.org/W2117875389","https://openalex.org/W2118502261","https://openalex.org/W2118590544","https://openalex.org/W2122433348","https://openalex.org/W2126810577","https://openalex.org/W2128053026","https://openalex.org/W2136210090","https://openalex.org/W2146960414","https://openalex.org/W2155345300","https://openalex.org/W2155701010","https://openalex.org/W2162514001","https://openalex.org/W2165465489","https://openalex.org/W2166561686","https://openalex.org/W2170298332","https://openalex.org/W2171331726","https://openalex.org/W2331287401","https://openalex.org/W2332656532","https://openalex.org/W2408094651","https://openalex.org/W2769726248","https://openalex.org/W3120558719","https://openalex.org/W4243182330","https://openalex.org/W6812177305","https://openalex.org/W7073671207","https://openalex.org/W7073818597"],"related_works":["https://openalex.org/W2176039728","https://openalex.org/W1550647847","https://openalex.org/W2328862247","https://openalex.org/W7074160851","https://openalex.org/W2003190574","https://openalex.org/W1600744882","https://openalex.org/W2101864423","https://openalex.org/W7098845551","https://openalex.org/W10626615","https://openalex.org/W2113991761"],"abstract_inverted_index":{"Objectives":[0],"To":[1],"evaluate,":[2],"under":[3],"real-life":[4],"practice":[5],"conditions":[6],"in":[7,49,94,141,301,385,463,535,553,574,652,654],"UK":[8],"primary":[9,98,168,205,238,554],"care,":[10,555],"asthma":[11,42,119,510,578,595],"control":[12],"and":[13,30,56,83,130,155,192,210,229,268,397,429,436,460,527,600,608,648],"cost-effectiveness":[14,73,418],"of":[15,51,135,176,182,216,270,287,417,485,537,594,604],"commencing":[16],"therapy":[17,29,37,161,332,372,451,512,526],"with":[18,22,32,40,90,118,132,149,156,186,244,260,327,577,591],"leukotriene":[19,242,266,325,423,458,479,494,557],"antagonists":[20,146,243,495,517,558],"compared":[21,31,148],"inhaled":[23],"corticosteroids":[24],"(ICSs)":[25],"as":[26,35,151,159,188,195,213,246,330,370,508,523,531,569],"initial":[27,152,247,509,524],"controller":[28,153,248,511,525],"long-acting":[33,157,328,368,461,529],"\u03b22-agonist":[34,124,329,369,462],"add-on":[36,160,331,371,450,532,571],"for":[38,70,236,285,358,667],"patients":[39,113,131,226,448,576,614],"uncontrolled":[41,120],"already":[43],"receiving":[44,422,449,478],"ICS.":[45,127,163],"Comparisons":[46],"were":[47,75,114,139,147,227,299,361,380,442,468,518,615],"made":[48],"terms":[50,536],"short-term":[52],"efficacy":[53],"(2":[54,59],"months)":[55],"longer-term":[57],"effectiveness":[58],"years).":[60],"Design":[61],"The":[62,167,490],"study":[63,78,169,239,618],"comprised":[64],"two":[65,413],"randomised":[66,228],"controlled":[67],"trials,":[68],"powered":[69],"equivalence.":[71],"Incremental":[72],"approaches":[74],"used":[76],"to":[77,106,162,197,273,293,315,322,333,349,377,395,403,452,498,503,521,528,533,572,627],"health-economic":[79],"outcomes":[80,441,593],"utilising":[81],"NHS":[82,428,464],"societal":[84,430,466,483],"costs.":[85],"Setting":[86],"Study":[87],"visits":[88],"coincided":[89],"routine":[91],"patient":[92],"follow-up":[93],"the":[95,142,172,237,253,257,279,283,338,342,355,364,412,440,586,597,601,611,642,663],"patients\u2019":[96],"own":[97],"care":[99],"practices":[100],"by":[101,121,641],"their":[102],"normal":[103],"health-care":[104],"providers":[105],"obtain":[107],"a":[108,189,214,500],"\u2018real-life\u2019":[109],"setting.":[110],"Participants":[111],"Enrolled":[112],"aged":[115],"12\u201380":[116],"years,":[117,212,277,354,476],"(1)":[122],"short-acting":[123],"or":[125,317,465,562,568],"(2)":[126],"Active":[128],"smokers":[129],"small":[133],"impairment":[134],"lung":[136],"function/other":[137],"morbidities":[138],"included":[140],"trial.":[143],"Interventions":[144],"Leukotriene":[145,516],"ICS,":[150,453],"therapy,":[154],"\u03b22-agonist,":[158],"Main":[164],"outcome":[165,170],"measures":[166],"was":[171,184,543,622,639],"Mini":[173,598],"Asthma":[174,302],"Quality":[175,603],"Life":[177],"Questionnaire":[178,304],"(MiniAQLQ).":[179],"An":[180],"analysis":[181],"covariance":[183],"used,":[185],"treatment":[187,414],"fixed":[190],"effect,":[191],"baseline":[193],"value":[194],"covariate,":[196],"analyse":[198],"MiniAQLQ":[199,254,339,359],"scores":[200,255,340],"at":[201,250,307,335,352,390,398,432,470,505,513,539,546],"2":[202,211,251,276,309,318,336,353,391,399,434,437,471,475,540,547],"months":[203,310,392,435],"(the":[204],"time":[206],"point),":[207],"examining":[208],"efficacy,":[209],"measure":[215],"effectiveness,":[217],"using":[218],"an":[219,570],"intention-to-treat":[220],"approach.":[221],"Results":[222],"In":[223],"total,":[224],"687":[225],"650":[230],"participants":[231,421,477],"(95%)":[232],"had":[233,425,481],"evaluable":[234],"data":[235],"outcome.":[240],"Comparing":[241,324],"ICSs":[245,566,573],"therapy:":[249],"months,":[252,337,472],"met":[256,341],"equivalence":[258,286,343,365,542],"criterion,":[259],"adjusted":[261],"difference":[262,312,346,374,389],"(95%":[263],"CI)":[264],"between":[265,411,457],"antagonist":[267,326,424,459,480],"ICS":[269,290,406,522,534],"\u20130.02":[271],"(\u20130.24":[272],"0.20).":[274],"At":[275],"however,":[278],"95%":[280,356],"CIs":[281,357],"excluded":[282],"threshold":[284],"0.3,":[288],"favouring":[289,367],"[\u20130.11":[291],"(\u20130.35":[292],"0.13)].":[294],"No":[295],"significant":[296,382,455],"between-group":[297,383],"differences":[298,384,456],"found":[300,469],"Control":[303],"(ACQ)":[305],"score":[306,360,387],"either":[308],"[adjusted":[311,345,373,388],"0.01":[313],"(\u20130.20":[314],"0.22)]":[316],"years":[319,400,438],"[0.13":[320],"(\u20130.07":[321],"0.33)].":[323],"ICS:":[334],"criterion":[344],"\u20130.10":[347],"(\u20130.29":[348],"0.10)],":[350],"while":[351],"marginally":[362],"over":[363],"threshold,":[366],"\u20130.11":[375],"(\u20130.32":[376],"0.11)].":[378],"There":[379],"no":[381,454,623],"ACQ":[386,587],"0.12":[393],"(\u20130.06":[394],"0.30),":[396],"0.04":[401],"(\u20130.15":[402],"0.22)].":[404],"Daily":[405],"dose":[407],"did":[408],"not":[409,443,544],"differ":[410],"groups.":[415],"Analysis":[416],"revealed":[419],"that":[420,493],"significantly":[426,445],"higher":[427,482],"costs":[431,484],"both":[433],"but":[439],"statistically":[444],"different.":[446],"For":[447],"cost":[467],"but,":[473],"after":[474],"borderline":[486],"statistical":[487],"significance.":[488],"Conclusions":[489],"evidence":[491],"suggests":[492],"are":[496,580],"unlikely":[497],"be":[499,560,650],"cost-effective":[501],"alternative":[502],"ICSs,":[504],"2005":[506],"prices,":[507],"step":[514],"2.":[515],"clinically":[519],"equivalent":[520],"\u03b22-agonists":[530],"QOL":[538],"months;":[541],"proven":[545],"years.":[548],"Future":[549],"research":[550],"should":[551],"establish,":[552],"whether":[556],"will":[559,649],"more":[561,589],"less":[563],"beneficial":[564],"than":[565,596],"alone":[567],"treating":[575],"who":[579],"also":[581],"active":[582],"smokers;":[583],"determine":[584],"why":[585,613],"correlates":[588],"poorly":[590],"economic":[592],"AQLQ":[599],"European":[602],"life-5":[605],"Dimensions":[606],"questionnaire;":[607],"understand":[609],"further":[610,668],"reasons":[612],"switched":[616],"from":[617],"medication":[619],"when":[620],"there":[621],"real":[624],"clinical":[625],"indication":[626],"do":[628],"so.":[629],"Trial":[630],"registration":[631],"Current":[632],"Controlled":[633],"Trials":[634],"ISRCTN99132811.":[635],"Funding":[636],"This":[637],"project":[638,669],"funded":[640],"NIHR":[643],"Health":[644,655],"Technology":[645,656],"Assessment":[646],"programme":[647,665],"published":[651],"full":[653],"Assessment;":[657],"Vol.":[658],"15,":[659],"No.":[660],"21.":[661],"See":[662],"HTA":[664],"website":[666],"information.":[670]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
