{"id":"https://openalex.org/W2020305264","doi":"https://doi.org/10.1002/hed.21212","title":"In vivo and in vitro models of ionizing radiation to the vocal folds","display_name":"In vivo and in vitro models of ionizing radiation to the vocal folds","publication_year":2009,"publication_date":"2009-08-11","ids":{"openalex":"https://openalex.org/W2020305264","doi":"https://doi.org/10.1002/hed.21212","mag":"2020305264","pmid":"https://pubmed.ncbi.nlm.nih.gov/19672960"},"language":"en","primary_location":{"id":"doi:10.1002/hed.21212","doi":"https://doi.org/10.1002/hed.21212","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hed.21212","pdf_url":null,"source":{"id":"https://openalex.org/S4210201749","display_name":"Head & Neck","issn_l":"1043-3074","issn":["1043-3074","1097-0347"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Head &amp; Neck","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016391991","display_name":"Benjamin E. Saltman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Saltman","raw_affiliation_strings":["Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059448441","display_name":"Dennis H. Kraus","orcid":"https://orcid.org/0000-0001-5258-6769","observed_orcids":["https://orcid.org/0000-0001-5258-6769"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis H. Kraus","raw_affiliation_strings":["Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001782511","display_name":"Hazel S. Szeto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hazel Szeto","raw_affiliation_strings":["Department of Pharmacology, Weill Cornell Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Weill Cornell Medical College","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103182267","display_name":"Bhupesh Parashar","orcid":"https://orcid.org/0000-0002-3329-9606","observed_orcids":["https://orcid.org/0000-0002-3329-9606"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhupesh Parashar","raw_affiliation_strings":["Department of Radiation Oncology, Weill Cornell Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Weill Cornell Medical College","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087689377","display_name":"Ronald A. Ghossein","orcid":"https://orcid.org/0000-0003-2802-8489","observed_orcids":["https://orcid.org/0000-0003-2802-8489"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Ghossein","raw_affiliation_strings":["Department of Pathology, Memorial Sloan-Kettering Cancer Center","Dept of Pathology, Memorial Sloan Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Memorial Sloan-Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Dept of Pathology, Memorial Sloan Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068682755","display_name":"Diane Felsen","orcid":"https://orcid.org/0000-0003-1190-9626","observed_orcids":["https://orcid.org/0000-0003-1190-9626"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane Felsen","raw_affiliation_strings":["Institute for Pediatric Urology, Weill Cornell Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Pediatric Urology, Weill Cornell Medical College","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005392308","display_name":"Ryan C. Branski","orcid":"https://orcid.org/0000-0003-1190-9036","observed_orcids":["https://orcid.org/0000-0003-1190-9036"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ryan C. Branski","raw_affiliation_strings":["Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Head and Neck Surgery, Memorial Sloan-Kettering Cancer Center","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5005392308"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":{"value":4760,"currency":"USD","value_usd":4760},"apc_paid":null,"fwci":0.5022,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.69259165,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"32","issue":"5","first_page":"572","last_page":"577"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.701200008392334,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.701200008392334,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10863","display_name":"Voice and Speech Disorders","score":0.15379999577999115,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.12770000100135803,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/head-and-neck-radiotherapy","display_name":"head and neck radiotherapy","score":0.7590000033378601},{"id":"https://openalex.org/keywords/hyperfractionated-radiotherapy","display_name":"hyperfractionated radiotherapy","score":0.8029999732971191},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9390000104904175},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.718999981880188},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.746999979019165},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.8679999709129333},{"id":"https://openalex.org/keywords/laryngeal-histopathology","display_name":"laryngeal histopathology","score":0.7689999938011169},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C18231593","wikidata":"https://www.wikidata.org/wiki/Q186161","display_name":"Ionizing radiation","level":3,"score":0.6850166320800781},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6606172323226929},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6516913175582886},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5590953826904297},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5316752791404724},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5252294540405273},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5093215703964233},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4950646460056305},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.42378100752830505},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4163205921649933},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3863227069377899},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35820573568344116},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3267437219619751},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22154143452644348},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.18979471921920776},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17724257707595825},{"id":"https://openalex.org/C111337013","wikidata":"https://www.wikidata.org/wiki/Q2737837","display_name":"Irradiation","level":2,"score":0.14330002665519714},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11930406093597412},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05841901898384094},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000505","descriptor_name":"Alopecia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003681","descriptor_name":"Dehydration","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004890","descriptor_name":"Erythema","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006984","descriptor_name":"Hypertrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007820","descriptor_name":"Laryngeal Mucosa","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012883","descriptor_name":"Skin Ulcer","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D014827","descriptor_name":"Vocal Cords","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014827","descriptor_name":"Vocal Cords","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019583","descriptor_name":"Dose Fractionation, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020781","descriptor_name":"Matrix Metalloproteinase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/hed.21212","doi":"https://doi.org/10.1002/hed.21212","is_oa":false,"landing_page_url":"https://doi.org/10.1002/hed.21212","pdf_url":null,"source":{"id":"https://openalex.org/S4210201749","display_name":"Head & Neck","issn_l":"1043-3074","issn":["1043-3074","1097-0347"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Head &amp; Neck","raw_type":"journal-article"},{"id":"pmid:19672960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19672960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Head & neck","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8975517730","display_name":"Clinical and Translational Science Center (UL1)","funder_award_id":"UL1RR024996","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1919418848","https://openalex.org/W1964838314","https://openalex.org/W1965751894","https://openalex.org/W1967505669","https://openalex.org/W2006733242","https://openalex.org/W2016368826","https://openalex.org/W2033281779","https://openalex.org/W2035489526","https://openalex.org/W2108879292","https://openalex.org/W2131122365","https://openalex.org/W2138605058","https://openalex.org/W2151818153","https://openalex.org/W2164611472","https://openalex.org/W2176062191","https://openalex.org/W2319022988","https://openalex.org/W2335187016","https://openalex.org/W2418535019"],"related_works":["https://openalex.org/W2177111578","https://openalex.org/W4415321985","https://openalex.org/W2057586420","https://openalex.org/W4213312406","https://openalex.org/W7117723201","https://openalex.org/W2164225761","https://openalex.org/W2066643891","https://openalex.org/W4393381778","https://openalex.org/W2140657474","https://openalex.org/W1933970956"],"abstract_inverted_index":{"BACKGROUND:":[0],"Radiation":[1],"therapy":[2],"(RT)":[3],"to":[4,13,31,42,85,128],"the":[5,14,32,129],"head":[6],"and":[7,18,22,59,68,96,104,106,139,141],"neck":[8],"often":[9],"results":[10],"in":[11,72,147],"damage":[12],"vocal":[15],"folds":[16],"(VF)":[17],"surrounding":[19],"structures.":[20],"Characterization":[21],"treatment":[23],"of":[24,34,61],"these":[25],"sequelae":[26],"is":[27,117],"limited,":[28],"likely":[29],"due":[30],"lack":[33],"experimental":[35],"models.":[36],"METHODS:":[37],"Larynges":[38],"from":[39],"rats":[40],"exposed":[41],"2":[43],"fractionation":[44,89],"schedules":[45],"(40":[46],"Gy":[47],"total)":[48],"were":[49,70],"analyzed":[50],"histologically.":[51],"In":[52,98,132],"vitro,":[53,99],"reactive":[54],"oxygen":[55],"species":[56],"(ROS)":[57],"synthesis,":[58],"transcription":[60],"select":[62],"genes":[63],"associated":[64],"with":[65],"ROS,":[66,138],"inflammation,":[67],"fibrosis":[69],"examined":[71],"VF":[73,86,130],"fibroblasts":[74],"after":[75],"single-dose":[76],"radiation.":[77],"RESULTS:":[78],"Although":[79],"radiation-induced":[80],"histologic":[81,124],"alterations":[82],"are":[83,126],"made":[84,127],"architecture,":[87],"1":[88],"schedule":[90],"was":[91,145],"accompanied":[92],"by":[93],"significant":[94],"morbidity":[95],"mortality.":[97],"radiation":[100],"increased":[101],"ROS":[102],"synthesis":[103],"inflammatory":[105,140],"profibrotic":[107],"gene":[108,143],"expression.":[109],"CONCLUSION:":[110],"Our":[111],"data":[112],"suggest":[113],"that":[114],"hyperfractionated":[115],"RT":[116],"more":[118],"tolerable.":[119],"Utilizing":[120],"this":[121],"model,":[122],"RT-induced":[123],"aberrations":[125],"mucosa.":[131],"addition,":[133],"a":[134],"relationship":[135],"between":[136],"radiation,":[137],"fibrotic":[142],"expression":[144],"observed":[146],"vitro.":[148]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
