{"id":"https://openalex.org/W2020285458","doi":"https://doi.org/10.1097/00000542-197810000-00005","title":"Effects of Ablation of Serotonin or Norepinephrine Brain-stem Areas on Halothane and Cyclopropane MACs in Rats","display_name":"Effects of Ablation of Serotonin or Norepinephrine Brain-stem Areas on Halothane and Cyclopropane MACs in Rats","publication_year":1978,"publication_date":"1978-10-01","ids":{"openalex":"https://openalex.org/W2020285458","doi":"https://doi.org/10.1097/00000542-197810000-00005","mag":"2020285458","pmid":"https://pubmed.ncbi.nlm.nih.gov/697079"},"language":"en","primary_location":{"id":"doi:10.1097/00000542-197810000-00005","doi":"https://doi.org/10.1097/00000542-197810000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000542-197810000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030022752","display_name":"Michael F. Roizen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael\u00a0F. Roizen","raw_affiliation_strings":["Assistant Professor of Anesthesia and Clinical Pharmacology, University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor of Anesthesia and Clinical Pharmacology, University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034429046","display_name":"Paul F. White","orcid":"https://orcid.org/0000-0003-2275-819X","observed_orcids":["https://orcid.org/0000-0003-2275-819X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul\u00a0F. White","raw_affiliation_strings":["Resident in Medicine, University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Resident in Medicine, University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111687328","display_name":"Edmond I. Eger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edmond\u00a0I. Eger","raw_affiliation_strings":["Professor of Anesthesia, University of California, San Francisco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor of Anesthesia, University of California, San Francisco","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108912848","display_name":"Michael Brownstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]},{"id":"https://openalex.org/I4210160792","display_name":"National Institute of Mental Health","ror":"https://ror.org/04t0s7x83","country_code":"JP","type":"government","lineage":["https://openalex.org/I4210103779","https://openalex.org/I4210160792"]},{"id":"https://openalex.org/I4210167247","display_name":"National Institute of Mental Health","ror":"https://ror.org/05xj56w78","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210167247"]}],"countries":["CZ","JP","US"],"is_corresponding":false,"raw_author_name":"Michael Brownstein","raw_affiliation_strings":["Staff Associate, Laboratory of Clinical Science, National Institute of Mental Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Staff Associate, Laboratory of Clinical Science, National Institute of Mental Health","institution_ids":["https://openalex.org/I4210158500","https://openalex.org/I4210160792","https://openalex.org/I4210167247"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.772,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.8135017,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"49","issue":"4","first_page":"252","last_page":"255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.024900000542402267,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12930","display_name":"Biomedical and Chemical Research","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.7689999938011169},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":1.0},{"id":"https://openalex.org/keywords/brainstem","display_name":"brainstem","score":0.8830000162124634},{"id":"https://openalex.org/keywords/halothane","display_name":"halothane","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cyclopropanes","display_name":"cyclopropanes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/minimum-alveolar-concentration","display_name":"minimum alveolar concentration","score":0.9240000247955322},{"id":"https://openalex.org/keywords/general-anesthesia","display_name":"general anesthesia","score":0.6600000262260437},{"id":"https://openalex.org/keywords/neural-transmission","display_name":"neural transmission","score":0.6520000100135803},{"id":"https://openalex.org/keywords/neurotransmitter-concentrations","display_name":"neurotransmitter concentrations","score":0.574999988079071},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8947598934173584},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.7494226098060608},{"id":"https://openalex.org/C2779200411","wikidata":"https://www.wikidata.org/wiki/Q80250","display_name":"Cyclopropane","level":3,"score":0.7247945666313171},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.6958111524581909},{"id":"https://openalex.org/C2776932660","wikidata":"https://www.wikidata.org/wiki/Q32921","display_name":"Halothane","level":2,"score":0.6419271230697632},{"id":"https://openalex.org/C2778902805","wikidata":"https://www.wikidata.org/wiki/Q322177","display_name":"Ablation","level":2,"score":0.48752495646476746},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4189404249191284},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3705423176288605},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.334443598985672},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.1158168613910675},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0631004273891449},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C2780378348","wikidata":"https://www.wikidata.org/wiki/Q25351438","display_name":"Ring (chemistry)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003521","descriptor_name":"Cyclopropanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006221","descriptor_name":"Halothane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008125","descriptor_name":"Locus Coeruleus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008452","descriptor_name":"Maximum Allowable Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011903","descriptor_name":"Raphe Nuclei","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00000542-197810000-00005","doi":"https://doi.org/10.1097/00000542-197810000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000542-197810000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:697079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/697079","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2117346440","https://openalex.org/W2322110370","https://openalex.org/W1992493552","https://openalex.org/W2084745527","https://openalex.org/W1976095999","https://openalex.org/W2005936187","https://openalex.org/W2888697270","https://openalex.org/W2110563498","https://openalex.org/W2078707183","https://openalex.org/W1964079642"],"abstract_inverted_index":{"General":[0],"anesthesia":[1],"may":[2],"result":[3],"from":[4,16],"interruption":[5],"of":[6,12,20],"neural":[7],"transmission":[8],"in":[9,35],"descrete":[10],"areas":[11],"brain":[13],"rather":[14],"than":[15],"a":[17],"generalized":[18],"depression":[19],"transmission.":[21],"Preliminary":[22],"experiments":[23],"have":[24],"demonstrated":[25],"that":[26],"anesthetics":[27],"selectively":[28],"alter":[29],"neurotransmitter":[30],"concentrations,":[31],"or":[32],"glucose":[33],"metabolism,":[34],"specifi":[36]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
