{"id":"https://openalex.org/W2020264015","doi":"https://doi.org/10.1002/eji.1830190215","title":"The autoantigenic response to rabbit cytochrome c","display_name":"The autoantigenic response to rabbit cytochrome c","publication_year":1989,"publication_date":"1989-02-01","ids":{"openalex":"https://openalex.org/W2020264015","doi":"https://doi.org/10.1002/eji.1830190215","mag":"2020264015","pmid":"https://pubmed.ncbi.nlm.nih.gov/2467817"},"language":"en","primary_location":{"id":"doi:10.1002/eji.1830190215","doi":"https://doi.org/10.1002/eji.1830190215","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830190215","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104305807","display_name":"Helen M. Cooper","orcid":"https://orcid.org/0000-0001-9838-5743","observed_orcids":["https://orcid.org/0000-0001-9838-5743","https://orcid.org/0000-0003-4590-9384"]},"institutions":[{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helen M. Cooper","raw_affiliation_strings":["Department of Immunology, Scripps Clinic & Research Foundation, La Jolla"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Scripps Clinic & Research Foundation, La Jolla","institution_ids":["https://openalex.org/I4210146328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113499725","display_name":"Norman R. Klinman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Norman R. Klinman","raw_affiliation_strings":["Department of Immunology, Scripps Clinic & Research Foundation, La Jolla"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Scripps Clinic & Research Foundation, La Jolla","institution_ids":["https://openalex.org/I4210146328"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091812025","display_name":"Yvonne Y.W. Paterson","orcid":"https://orcid.org/0000-0002-9406-4958","observed_orcids":["https://orcid.org/0000-0002-9406-4958"]},"institutions":[{"id":"https://openalex.org/I4210146328","display_name":"Scripps Clinic","ror":"https://ror.org/05kwjwj05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1311914864","https://openalex.org/I4210146328"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yvonne Paterson","raw_affiliation_strings":["Department of Immunology, Scripps Clinic & Research Foundation, La Jolla","Department of Microbiology, 209 Johnson Pavilion, University of Pennsylvania, PA 19104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Scripps Clinic & Research Foundation, La Jolla","institution_ids":["https://openalex.org/I4210146328"]},{"raw_affiliation_string":"Department of Microbiology, 209 Johnson Pavilion, University of Pennsylvania, PA 19104, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5091812025"],"corresponding_institution_ids":["https://openalex.org/I4210146328","https://openalex.org/I79576946"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":0.4932,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.6188717,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"2","first_page":"315","last_page":"322"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cytochrome-c","display_name":"cytochrome c","score":0.9269999861717224},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.703000009059906},{"id":"https://openalex.org/keywords/autoreactive-b-cells","display_name":"autoreactive B cells","score":0.6679999828338623},{"id":"https://openalex.org/keywords/b-cell-tolerance","display_name":"B cell tolerance","score":0.6439999938011169},{"id":"https://openalex.org/keywords/antigen-specificity","display_name":"antigen specificity","score":0.44200000166893005},{"id":"https://openalex.org/keywords/amino-terminal-region","display_name":"amino-terminal region","score":0.8230000138282776},{"id":"https://openalex.org/keywords/antibody-affinity","display_name":"antibody affinity","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7846606969833374},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.6954240798950195},{"id":"https://openalex.org/C2779884254","wikidata":"https://www.wikidata.org/wiki/Q492162","display_name":"Rabbit (cipher)","level":2,"score":0.6908732652664185},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.6405978202819824},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.562614917755127},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5179749727249146},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4847707152366638},{"id":"https://openalex.org/C148292235","wikidata":"https://www.wikidata.org/wiki/Q3774486","display_name":"Cytochrome b","level":4,"score":0.450914204120636},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43764206767082214},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25954991579055786},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.14949172735214233},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12696921825408936},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09061387181282043},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000915","descriptor_name":"Antibody Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000918","descriptor_name":"Antibody Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003574","descriptor_name":"Cytochrome c Group","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003574","descriptor_name":"Cytochrome c Group","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/eji.1830190215","doi":"https://doi.org/10.1002/eji.1830190215","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830190215","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:2467817","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2467817","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G297210299","display_name":null,"funder_award_id":"AI 19499","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W273054708","https://openalex.org/W345458310","https://openalex.org/W948817589","https://openalex.org/W1011888941","https://openalex.org/W1498192086","https://openalex.org/W1499452131","https://openalex.org/W1500863441","https://openalex.org/W1547751414","https://openalex.org/W1588741941","https://openalex.org/W1591291063","https://openalex.org/W1610962799","https://openalex.org/W1624366049","https://openalex.org/W1813514124","https://openalex.org/W1850327026","https://openalex.org/W1910714358","https://openalex.org/W1918956394","https://openalex.org/W1976232165","https://openalex.org/W1982370408","https://openalex.org/W1996052379","https://openalex.org/W1997970219","https://openalex.org/W2016850454","https://openalex.org/W2020899421","https://openalex.org/W2026034374","https://openalex.org/W2028907183","https://openalex.org/W2040535574","https://openalex.org/W2052733766","https://openalex.org/W2059280600","https://openalex.org/W2065335184","https://openalex.org/W2068747743","https://openalex.org/W2075759681","https://openalex.org/W2077170670","https://openalex.org/W2082599984","https://openalex.org/W2089294704","https://openalex.org/W2112970530","https://openalex.org/W2136701955","https://openalex.org/W2143352720","https://openalex.org/W2211978489","https://openalex.org/W2219053411","https://openalex.org/W3144500989","https://openalex.org/W4244207506"],"related_works":["https://openalex.org/W2089294704","https://openalex.org/W2029232096","https://openalex.org/W1564484262","https://openalex.org/W2026034374","https://openalex.org/W2020465750","https://openalex.org/W1555500940","https://openalex.org/W1978605199","https://openalex.org/W1982361447","https://openalex.org/W1606183723","https://openalex.org/W2037482881"],"abstract_inverted_index":{"In":[0],"this":[1],"report":[2],"we":[3],"describe":[4],"the":[5,23,36,40,43,47,53,59,93],"production":[6],"and":[7,72],"characterization":[8],"of":[9,29,35,42,52,58],"autoantibody":[10,60],"responses":[11],"to":[12,46,75],"rabbit":[13,30,63,82],"cytochrome":[14],"c":[15,65,85],"(cyt":[16],"c)":[17],"in":[18],"rabbits":[19],"immunized":[20],"with":[21,62,92],"either":[22],"native":[24],"monomeric":[25],"or":[26],"polymerized":[27],"form":[28],"cyt":[31,64,84],"c.":[32],"Fine-specificity":[33],"analyses":[34],"response":[37,44],"indicated":[38],"that":[39,79,95],"majority":[41],"was":[45,66,73],"evolutionarily":[48],"conserved":[49],"amino-terminal":[50],"region":[51],"molecule.":[54],"The":[55],"relative":[56],"affinity":[57],"interaction":[61],"assessed":[67],"by":[68],"a":[69],"solid-phase":[70],"assay":[71],"found":[74],"be":[76],"lower":[77],"than":[78],"observed":[80],"for":[81],"anti-horse":[83],"antibody":[86],"populations.":[87],"These":[88],"findings":[89],"are":[90],"consistent":[91],"prediction":[94],"low-affinity":[96],"self-reactive":[97],"B":[98],"cells":[99],"may":[100],"escape":[101],"tolerance":[102],"induction.":[103]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
