{"id":"https://openalex.org/W2020260197","doi":"https://doi.org/10.1073/pnas.1132039100","title":"A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis","display_name":"A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis","publication_year":2003,"publication_date":"2003-04-29","ids":{"openalex":"https://openalex.org/W2020260197","doi":"https://doi.org/10.1073/pnas.1132039100","mag":"2020260197","pmid":"https://pubmed.ncbi.nlm.nih.gov/12721358","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/156240"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1132039100","doi":"https://doi.org/10.1073/pnas.1132039100","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1132039100","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/156240","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004652247","display_name":"Richard L. Veech","orcid":"https://orcid.org/0000-0003-2709-939X","observed_orcids":["https://orcid.org/0000-0003-2709-939X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210121815","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard L. Veech","raw_affiliation_strings":["Laboratory of Metabolism and Molecular Biology, Department of Health and Human Services, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 12501 Washington Avenue, Rockville, MD 20852","Laboratory of Metabolism and Molecular Biology, Department of Health and Human Services, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 12501 Washington Avenue, Rockville, MD 20852, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Metabolism and Molecular Biology, Department of Health and Human Services, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 12501 Washington Avenue, Rockville, MD 20852","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210121815"]},{"raw_affiliation_string":"Laboratory of Metabolism and Molecular Biology, Department of Health and Human Services, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 12501 Washington Avenue, Rockville, MD 20852, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210121815"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004652247"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210121815"],"apc_list":null,"apc_paid":null,"fwci":2.5271,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.88032345,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"100","issue":"10","first_page":"5578","last_page":"5580"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.6371999979019165,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.11630000174045563,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.07500000298023224,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hexose-monophosphate-pathway","display_name":"hexose monophosphate pathway","score":0.9800000190734863},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.6439999938011169},{"id":"https://openalex.org/keywords/metabolic-regulation","display_name":"metabolic regulation","score":0.5130000114440918},{"id":"https://openalex.org/keywords/short-term-regulation","display_name":"short-term regulation","score":0.46000000834465027},{"id":"https://openalex.org/keywords/long-term-regulation","display_name":"long-term regulation","score":0.9890000224113464}],"concepts":[{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.6919272541999817},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.6465212106704712},{"id":"https://openalex.org/C301363","wikidata":"https://www.wikidata.org/wiki/Q4637383","display_name":"Eukaryotic Small Ribosomal Subunit","level":5,"score":0.6432835459709167},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.5635675191879272},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.518557608127594},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5168278813362122},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.5067782998085022},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.49746015667915344},{"id":"https://openalex.org/C106774688","wikidata":"https://www.wikidata.org/wiki/Q6588997","display_name":"P-site","level":5,"score":0.43632298707962036},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37032103538513184},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34843510389328003},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.1952265501022339},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.07012081146240234},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002952","descriptor_name":"Citric Acid Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006903","descriptor_name":"Hydroxymethylglutaryl CoA Reductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006904","descriptor_name":"Hydroxymethylglutaryl-CoA Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010427","descriptor_name":"Pentose Phosphate Pathway","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011770","descriptor_name":"Pyruvate Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.1132039100","doi":"https://doi.org/10.1073/pnas.1132039100","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1132039100","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:178271","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/156240","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:156240","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/156240","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:12721358","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12721358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Comment"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:178271","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/156240","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.47999998927116394,"display_name":"Quality education","id":"https://metadata.un.org/sdg/4"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W152486275","https://openalex.org/W1485030470","https://openalex.org/W1488748351","https://openalex.org/W1578325385","https://openalex.org/W1586233686","https://openalex.org/W1738677317","https://openalex.org/W2023326549","https://openalex.org/W2028102364","https://openalex.org/W2039928578","https://openalex.org/W2039999119","https://openalex.org/W2065002581","https://openalex.org/W2073315259","https://openalex.org/W2083819344","https://openalex.org/W2087166296","https://openalex.org/W2129192121","https://openalex.org/W6673034092"],"related_works":["https://openalex.org/W2029341777","https://openalex.org/W2025977122","https://openalex.org/W2095441368","https://openalex.org/W2013007679","https://openalex.org/W2063482980","https://openalex.org/W2100532576","https://openalex.org/W2053807889","https://openalex.org/W2049616333","https://openalex.org/W2054899422","https://openalex.org/W1973372344"],"abstract_inverted_index":{"The":[0],"ribosome":[1],"is":[2,27],"a":[3,28],"macromolecular":[4],"machine":[5],"that":[6,13],"undergoes":[7],"global":[8],"conformational":[9],"rearrangements":[10],"during":[11],"translation,":[12,37],"involve":[14],"coupled":[15],"movements":[16],"of":[17,36,49],"ribosomal":[18,54,66],"subunits,":[19],"tRNAs,":[20],"and":[21,40,46,52],"the":[22,50,64],"L1":[23],"stalk.":[24],"However,":[25],"there":[26],"disagreement":[29],"between":[30],"different":[31],"...The":[32],"two":[33],"main":[34],"steps":[35],"peptidyl":[38,62],"transfer,":[39,63],"translocation":[41],"are":[42],"accompanied":[43],"by":[44],"counterclockwise":[45],"clockwise":[47],"rotations":[48],"large":[51],"small":[53,65],"subunits":[55],"with":[56],"respect":[57],"to":[58],"each":[59],"other.":[60],"Upon":[61],"subunit":[67],"...":[68]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}