{"id":"https://openalex.org/W2020241920","doi":"https://doi.org/10.1055/s-2005-837520","title":"Four-Year Follow-Up of Acromegalic Patients Treated with the New Long-Acting Formulation of Lanreotide (Lanreotide Autogel)","display_name":"Four-Year Follow-Up of Acromegalic Patients Treated with the New Long-Acting Formulation of Lanreotide (Lanreotide Autogel)","publication_year":2005,"publication_date":"2005-03-23","ids":{"openalex":"https://openalex.org/W2020241920","doi":"https://doi.org/10.1055/s-2005-837520","mag":"2020241920","pmid":"https://pubmed.ncbi.nlm.nih.gov/15789272"},"language":"en","primary_location":{"id":"doi:10.1055/s-2005-837520","doi":"https://doi.org/10.1055/s-2005-837520","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2005-837520","pdf_url":null,"source":{"id":"https://openalex.org/S67343978","display_name":"Experimental and Clinical Endocrinology & Diabetes","issn_l":"0947-7349","issn":["0947-7349","1439-3646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Clinical Endocrinology &amp; Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077304807","display_name":"Bodo Gutt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B. Gutt","raw_affiliation_strings":["Department of Internal Medicine Innenstadt, University of Munich, Germany. Bodo.Gutt@med.uni-muenchen.de","Department of Internal Medicine \u2018Innenstadt\u2019, University of Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine Innenstadt, University of Munich, Germany. Bodo.Gutt@med.uni-muenchen.de","institution_ids":["https://openalex.org/I8204097"]},{"raw_affiliation_string":"Department of Internal Medicine \u2018Innenstadt\u2019, University of Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057394610","display_name":"Martin Bidlingmaier","orcid":"https://orcid.org/0000-0002-4681-6668","observed_orcids":["https://orcid.org/0000-0002-4681-6668"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Bidlingmaier","raw_affiliation_strings":["Department of Internal Medicine Innenstadt, University of Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine Innenstadt, University of Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Kretschmar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Kretschmar","raw_affiliation_strings":["Department of Internal Medicine Innenstadt, University of Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine Innenstadt, University of Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111733694","display_name":"C Dieterle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. Dieterle","raw_affiliation_strings":["Department of Internal Medicine Innenstadt, University of Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine Innenstadt, University of Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058484772","display_name":"B Steffin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B. Steffin","raw_affiliation_strings":["Department of Internal Medicine Innenstadt, University of Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine Innenstadt, University of Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080112080","display_name":"Jochen Schopohl","orcid":"https://orcid.org/0000-0003-3591-3101","observed_orcids":["https://orcid.org/0000-0003-3591-3101"]},"institutions":[{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Schopohl","raw_affiliation_strings":["Department of Internal Medicine Innenstadt, University of Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine Innenstadt, University of Munich, Germany","institution_ids":["https://openalex.org/I8204097"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I8204097"],"apc_list":null,"apc_paid":null,"fwci":2.8315,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.90418157,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"113","issue":"03","first_page":"139","last_page":"144"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acromegaly","display_name":"acromegaly","score":0.9900000095367432},{"id":"https://openalex.org/keywords/lanreotide-autogel","display_name":"lanreotide autogel","score":0.8700000047683716},{"id":"https://openalex.org/keywords/lanreotide","display_name":"lanreotide","score":0.7480000257492065},{"id":"https://openalex.org/keywords/long-acting-somatostatin-analogue","display_name":"long-acting somatostatin analogue","score":0.9309999942779541},{"id":"https://openalex.org/keywords/subcutaneous-injection","display_name":"subcutaneous injection","score":0.8289999961853027},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"growth hormone","score":0.5360000133514404},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9750000238418579},{"id":"https://openalex.org/keywords/transsphenoidal-surgery","display_name":"transsphenoidal surgery","score":0.7820000052452087},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.7789999842643738},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.949999988079071},{"id":"https://openalex.org/keywords/dose-adjustment","display_name":"dose adjustment","score":0.6159999966621399},{"id":"https://openalex.org/keywords/galenic-formulation","display_name":"galenic formulation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/four-year-follow-up","display_name":"four-year follow-up","score":0.8050000071525574},{"id":"https://openalex.org/keywords/bioequivalence","display_name":"bioequivalence","score":0.414000004529953},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.3240000009536743},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C2779609023","wikidata":"https://www.wikidata.org/wiki/Q1707877","display_name":"Lanreotide","level":5,"score":0.9249907732009888},{"id":"https://openalex.org/C2777433750","wikidata":"https://www.wikidata.org/wiki/Q189580","display_name":"Acromegaly","level":4,"score":0.8083773255348206},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6352540254592896},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5603101849555969},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4036547839641571},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3664267659187317},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.2752973139286041},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2675122618675232}],"mesh":[{"descriptor_ui":"D000172","descriptor_name":"Acromegaly","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000172","descriptor_name":"Acromegaly","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005704","descriptor_name":"Gallbladder","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013004","descriptor_name":"Somatostatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015337","descriptor_name":"Multicenter Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042882","descriptor_name":"Gallstones","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D042882","descriptor_name":"Gallstones","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1055/s-2005-837520","doi":"https://doi.org/10.1055/s-2005-837520","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-2005-837520","pdf_url":null,"source":{"id":"https://openalex.org/S67343978","display_name":"Experimental and Clinical Endocrinology & Diabetes","issn_l":"0947-7349","issn":["0947-7349","1439-3646"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Clinical Endocrinology &amp; Diabetes","raw_type":"journal-article"},{"id":"pmid:15789272","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15789272","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2623294118","https://openalex.org/W1981382809","https://openalex.org/W102014224","https://openalex.org/W2030096779","https://openalex.org/W2167909460","https://openalex.org/W2116114460","https://openalex.org/W31705083","https://openalex.org/W1982049593","https://openalex.org/W2016995223","https://openalex.org/W3023158028"],"abstract_inverted_index":{"Lanreotide":[0,30,51,56,72,98,134,152,198,225,244,277,318],"Autogel":[1,31,73,135],"(Ipsen)":[2],"is":[3,295],"a":[4,10,43,118,125],"long-acting":[5],"somatostatin":[6],"analogue":[7],"(SA)":[8],"in":[9,314],"new":[11,273],"galenic":[12,274],"formulation":[13,275],"suitable":[14],"for":[15,32],"subcutaneous":[16],"(s.c.)":[17],"injection.":[18],"In":[19,270],"our":[20],"department,":[21],"11":[22,180],"patients":[23,36,54,181,201,240,247,315],"with":[24,29,83,91,117,197,265],"therapy-resistant":[25],"acromegaly":[26,287],"were":[27,212],"treated":[28],"48":[33,193],"months.":[34],"10/11":[35],"had":[37,182,202],"previously":[38,93],"undergone":[39],"transsphenoidal":[40],"surgery.":[41],"For":[42],"median":[44,171],"duration":[45],"of":[46,71,106,121,128,133,156,160,163,179,195,218,236,262,268,276,283,286,305],"1.4":[47],"years":[48],"prior":[49],"to":[50,89,151,224,289,298,310],"Autogel,":[52,153,199,245],"the":[53,84,92,104,154,157,170,186,206,234,237,272,281,290],"received":[55,241],"PR":[57,226,292],"30":[58,227],"mg":[59,70,123,228,243,249],"every":[60,80],"7,":[61],"10,":[62],"or":[63,68],"14":[64],"days.":[65],"60,":[66],"90,":[67],"120":[69,129,242],"was":[74,101,137,166,174,220,257],"administered":[75],"by":[76,139],"deep":[77,302],"s.c.":[78,303],"injection":[79,95],"28":[81],"days,":[82],"higher":[85],"dosage":[86],"being":[87],"given":[88,300],"those":[90],"shortest":[94],"interval":[96],"under":[97],"PR.":[99],"Dose":[100],"adjusted":[102],"on":[103,316],"basis":[105],"Growth":[107],"Hormone":[108],"(GH)":[109],"level":[110,173],"after":[111],"4,":[112],"8,":[113],"and":[114,124,146,169,188,216,250],"12":[115],"months":[116,194],"minimum":[119],"dose":[120,127],"60":[122,253],"maximum":[126],"mg.":[130],"The":[131],"efficacy":[132],"treatment":[136,196,229],"evaluated":[138],"measuring":[140],"GH":[141,172,210],"concentrations":[142],"(4":[143],"hour":[144],"profiles)":[145],"IGF-I":[147,164,184,204,219],"levels.":[148],"Before":[149],"switching":[150],"multiple":[155],"upper":[158],"limit":[159],"normal":[161,190,207],"(xULN)":[162],"levels":[165,211],"1.2":[167],"(median)":[168],"1.3":[175,214],"microg/l.":[176],"3":[177],"out":[178],"an":[183,203,266],"within":[185,205],"age-":[187],"sex-adjusted":[189],"range.":[191,208],"After":[192],"six":[200],"Median":[209],"at":[213,221],"microg/l":[215],"xULN":[217],"1.0":[222],"compared":[223,288],"(p":[230],"<":[231],"0.001).":[232],"At":[233],"end":[235],"study,":[238],"8":[239],"2":[246],"90":[248],"1":[251],"patient":[252],"mg,":[254],"respectively.":[255],"There":[256],"slight":[258],"but":[259,294],"significant":[260],"deterioration":[261],"glucose":[263],"metabolism":[264,308],"increase":[267],"HbA1c.":[269],"conclusion,":[271],"improves":[278],"not":[279],"only":[280],"control":[282],"biochemical":[284],"markers":[285],"conventional":[291],"formulation,":[293],"also":[296],"easier":[297],"administer":[299],"its":[301],"method":[304],"administration.":[306],"Glucose":[307],"has":[309],"be":[311],"followed":[312],"carefully":[313],"high-dose":[317],"Autogel.":[319]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
