{"id":"https://openalex.org/W2020238012","doi":"https://doi.org/10.1359/jbmr.2000.15.1.60","title":"Loss of Osteocyte Integrity in Association with Microdamage and Bone Remodeling After Fatigue In Vivo","display_name":"Loss of Osteocyte Integrity in Association with Microdamage and Bone Remodeling After Fatigue In Vivo","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2020238012","doi":"https://doi.org/10.1359/jbmr.2000.15.1.60","mag":"2020238012","pmid":"https://pubmed.ncbi.nlm.nih.gov/10646115"},"language":"en","primary_location":{"id":"doi:10.1359/jbmr.2000.15.1.60","doi":"https://doi.org/10.1359/jbmr.2000.15.1.60","is_oa":false,"landing_page_url":"https://doi.org/10.1359/jbmr.2000.15.1.60","pdf_url":null,"source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063184897","display_name":"Olivier Verborgt","orcid":"https://orcid.org/0000-0003-4143-8204","observed_orcids":["https://orcid.org/0000-0003-4143-8204"]},"institutions":[{"id":"https://openalex.org/I149213910","display_name":"University of Antwerp","ror":"https://ror.org/008x57b05","country_code":"BE","type":"education","lineage":["https://openalex.org/I149213910"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["BE","US"],"is_corresponding":false,"raw_author_name":"Olivier Verborgt","raw_affiliation_strings":["Current affiliation: Department of Orthopaedics and Traumatology, University of Antwerp, Antwerp, Belgium","Department of Orthopaedics, Mount Sinai School of Medicine, New York, New York, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current affiliation: Department of Orthopaedics and Traumatology, University of Antwerp, Antwerp, Belgium","institution_ids":["https://openalex.org/I149213910"]},{"raw_affiliation_string":"Department of Orthopaedics, Mount Sinai School of Medicine, New York, New York, U.S.A","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112693812","display_name":"GARY J. GIBSON","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154057602","display_name":"Henry Ford Health","ror":"https://ror.org/02kwnkm68","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I154057602"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary J. Gibson","raw_affiliation_strings":["Bone and Joint Center, Henry Ford Health Sciences Center, Detroit, Michigan, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone and Joint Center, Henry Ford Health Sciences Center, Detroit, Michigan, U.S.A","institution_ids":["https://openalex.org/I154057602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040053224","display_name":"Mitchell B. Schaffler","orcid":"https://orcid.org/0000-0001-5780-7073","observed_orcids":["https://orcid.org/0000-0001-5780-7073"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mitchell B. Schaffler","raw_affiliation_strings":["Department of Orthopaedics, Mount Sinai School of Medicine, New York, New York, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Mount Sinai School of Medicine, New York, New York, U.S.A","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5040053224"],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":8.3608,"has_fulltext":false,"cited_by_count":754,"citation_normalized_percentile":{"value":0.9872063,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"15","issue":"1","first_page":"60","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.8314999938011169,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.8314999938011169,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.147599995136261,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteocyte-apoptosis","display_name":"osteocyte apoptosis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/bone-fatigue","display_name":"bone fatigue","score":0.7200000286102295},{"id":"https://openalex.org/keywords/microcracks","display_name":"microcracks","score":0.7649999856948853},{"id":"https://openalex.org/keywords/bone-microdamage","display_name":"bone microdamage","score":0.8769999742507935},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.9079999923706055},{"id":"https://openalex.org/keywords/osteoclastic-bone-resorption","display_name":"osteoclast resorption","score":0.8999999761581421},{"id":"https://openalex.org/keywords/ulna","display_name":"ulna","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C2780973866","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Osteocyte","level":4,"score":0.9266945123672485},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.7870105504989624},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5670225620269775},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3868618607521057},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28733429312705994},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24987870454788208},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19002670049667358},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13825500011444092},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.10103410482406616},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06110677123069763},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.05069822072982788}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010011","descriptor_name":"Osteocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014457","descriptor_name":"Ulna","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016723","descriptor_name":"Bone Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020287","descriptor_name":"In Situ Nick-End Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1359/jbmr.2000.15.1.60","doi":"https://doi.org/10.1359/jbmr.2000.15.1.60","is_oa":false,"landing_page_url":"https://doi.org/10.1359/jbmr.2000.15.1.60","pdf_url":null,"source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},{"id":"pmid:10646115","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10646115","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1659200005","display_name":"Chondrocyte Apoptosis and Release of Angiogenic Factors","funder_award_id":"R01AR044712","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G1927828339","display_name":null,"funder_award_id":"AR41210","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G2639953458","display_name":"Ostecocyte Intergrity and Bone Remodeling","funder_award_id":"R01AR041210","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W117955672","https://openalex.org/W561427352","https://openalex.org/W1568752613","https://openalex.org/W1940692702","https://openalex.org/W1964519636","https://openalex.org/W1968442371","https://openalex.org/W1972652592","https://openalex.org/W1974005588","https://openalex.org/W1982011920","https://openalex.org/W1982784171","https://openalex.org/W1983072511","https://openalex.org/W1987577114","https://openalex.org/W1989963027","https://openalex.org/W1990917512","https://openalex.org/W1999084944","https://openalex.org/W2002453791","https://openalex.org/W2006493954","https://openalex.org/W2008213080","https://openalex.org/W2008698339","https://openalex.org/W2018330233","https://openalex.org/W2026692684","https://openalex.org/W2030528472","https://openalex.org/W2034096812","https://openalex.org/W2037650463","https://openalex.org/W2040558323","https://openalex.org/W2043195735","https://openalex.org/W2043445250","https://openalex.org/W2044333041","https://openalex.org/W2068014772","https://openalex.org/W2068747322","https://openalex.org/W2081145901","https://openalex.org/W2087229400","https://openalex.org/W2091673136","https://openalex.org/W2099437115","https://openalex.org/W2099931271","https://openalex.org/W2100991876","https://openalex.org/W2120159829","https://openalex.org/W2121955451","https://openalex.org/W2122437488","https://openalex.org/W2123097481","https://openalex.org/W2125892636","https://openalex.org/W2128963271","https://openalex.org/W2137549546","https://openalex.org/W2138302361","https://openalex.org/W2139836058","https://openalex.org/W2160648926","https://openalex.org/W2161508058","https://openalex.org/W2166307416","https://openalex.org/W2414368440","https://openalex.org/W2913868291","https://openalex.org/W3025739795","https://openalex.org/W7045885556"],"related_works":["https://openalex.org/W2021115829","https://openalex.org/W1999925297","https://openalex.org/W2073269056","https://openalex.org/W1974005588","https://openalex.org/W2154359813","https://openalex.org/W2166307416","https://openalex.org/W2029737500","https://openalex.org/W2950713275","https://openalex.org/W2517169348","https://openalex.org/W2138486361"],"abstract_inverted_index":{"As":[0],"a":[1,68,285],"result":[2],"of":[3,23,26,47,61,71,114,249,264,288],"fatigue,":[4,241],"bone":[5,27,58,120,125,191,240,250,276,298],"sustains":[6],"microdamage,":[7,271],"which":[8,295],"is":[9,18,29,237,245],"then":[10,77],"repaired":[11],"by":[12,193,239,294],"bone-remodeling":[13],"processes.":[14],"How":[15],"osteoclastic":[16,256],"activity":[17],"targeted":[19],"at":[20,143],"the":[21,32,37,45,210,279,289],"removal":[22,300],"microdamaged":[24],"regions":[25,248,263],"matrix":[28,72,303],"unknown.":[30],"In":[31],"current":[33],"studies,":[34],"we":[35],"tested":[36],"hypothesis":[38,280],"that":[39,155,233,251,281],"changes":[40],"in":[41,119,124,140,156,160,173,215,220],"osteocyte":[42,222,235,265,272,282],"integrity,":[43],"through":[44],"initiation":[46],"regulated":[48],"cell":[49],"death":[50],"(apoptosis),":[51],"are":[52],"associated":[53,96,179],"with":[54,97,170,180,262],"fatigue-related":[55],"microdamage":[56,192],"and":[57,123,176,182,204,218,254,274],"resorption.":[59],"Ulnae":[60],"adult":[62],"rats":[63],"were":[64,102,117,188,224],"fatigue-loaded":[65],"to":[66,90,167,202,247],"produce":[67],"known":[69],"degree":[70],"damage.":[73],"Osteocyte":[74],"integrity":[75],"was":[76],"assessed":[78],"histomorphometrically":[79],"from":[80,146,154],"terminal":[81],"deoxynucleotidyl":[82],"transferase-mediated":[83],"deoxyuridine":[84],"triphosphate-nick":[85],"end":[86],"labeling":[87,139],"(TUNEL)-stained":[88],"sections":[89,101,163],"detect":[91],"cells":[92],"undergoing":[93],"DNA":[94],"fragmentation":[95],"apoptosis;":[98],"toluidine":[99,161],"blue-stained":[100,162],"used":[103],"for":[104,299],"secondary":[105],"morphological":[106],"confirmation.":[107],"Ten":[108],"days":[109],"after":[110,196,258,301],"loading,":[111],"large":[112],"numbers":[113,223],"TUNEL-positive":[115,186],"osteocytes":[116,187],"found":[118],"surrounding":[121,126],"microcracks":[122,147,181],"intracortical":[127,183],"resorption":[128,149,184,257],"spaces":[129],"(approximately":[130],"300%":[131],"increases":[132,172],"over":[133,226],"controls,":[134],"p":[135],"<":[136,199],"0.005).":[137],"TUNEL":[138],"loaded":[141],"ulnae":[142],"sites":[144],"distant":[145],"or":[148,291],"foci":[150],"did":[151],"not":[152],"differ":[153],"control":[157],"bone.":[158],"Osteocytes":[159],"showed":[164],"equivalent":[165],"trends":[166],"TUNEL-stained":[168],"sections,":[169],"significant":[171],"pyknotic":[174],"nuclei":[175],"empty":[177,216],"lacunae":[178,217],"spaces.":[185],"observed":[189,225],"around":[190],"1":[194],"day":[195],"loading":[197],"(p":[198],"0.01":[200],"relative":[201],"baseline),":[203],"their":[205],"number":[206],"remained":[207],"elevated":[208],"throughout":[209],"entire":[211],"experimental":[212],"period.":[213],"Increases":[214],"decreases":[219],"normal":[221],"time":[227],"as":[228],"well.":[229],"These":[230],"studies":[231],"show":[232],"(1)":[234],"apoptosis":[236,244,283],"induced":[238],"(2)":[242],"this":[243],"localized":[246],"contain":[252],"microcracks,":[253],"(3)":[255],"fatigue":[259],"also":[260],"coincides":[261],"apoptosis.":[266],"The":[267],"strong":[268],"associations":[269],"between":[270],"apoptosis,":[273],"subsequent":[275],"remodeling":[277],"support":[278],"provides":[284],"key":[286],"part":[287],"activation":[290],"signaling":[292],"mechanisms":[293],"osteoclasts":[296],"target":[297],"fatigue-induced":[302],"injury.":[304]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":23},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":33},{"year":2019,"cited_by_count":40},{"year":2018,"cited_by_count":33},{"year":2017,"cited_by_count":31},{"year":2016,"cited_by_count":30},{"year":2015,"cited_by_count":41},{"year":2014,"cited_by_count":30},{"year":2013,"cited_by_count":40},{"year":2012,"cited_by_count":33}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
