{"id":"https://openalex.org/W2020225604","doi":"https://doi.org/10.1097/wad.0b013e31819e6b28","title":"Frequency and Causes of Early-onset Dementia in a Tertiary Referral Center in Athens","display_name":"Frequency and Causes of Early-onset Dementia in a Tertiary Referral Center in Athens","publication_year":2009,"publication_date":"2009-10-01","ids":{"openalex":"https://openalex.org/W2020225604","doi":"https://doi.org/10.1097/wad.0b013e31819e6b28","mag":"2020225604","pmid":"https://pubmed.ncbi.nlm.nih.gov/19568157"},"language":"en","primary_location":{"id":"doi:10.1097/wad.0b013e31819e6b28","doi":"https://doi.org/10.1097/wad.0b013e31819e6b28","is_oa":false,"landing_page_url":"https://doi.org/10.1097/wad.0b013e31819e6b28","pdf_url":null,"source":{"id":"https://openalex.org/S107889856","display_name":"Alzheimer Disease & Associated Disorders","issn_l":"0893-0341","issn":["0893-0341","1546-4156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer Disease &amp; Associated Disorders","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/123456789/28771","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082581713","display_name":"Sokratis G. Papageorgiou","orcid":"https://orcid.org/0000-0001-8863-3635","observed_orcids":["https://orcid.org/0000-0001-8863-3635"]},"institutions":[{"id":"https://openalex.org/I4210141397","display_name":"Eginition Hospital","ror":"https://ror.org/03wed5r38","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141397"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Sokratis G. Papageorgiou","raw_affiliation_strings":["Department of Neurology, Eginition Hospital, Medical School, Athens National University, Greece. sokpapa@med.uoa.gr","Department of Neurology, Eginition Hospital, Medical School, Athens National University, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Eginition Hospital, Medical School, Athens National University, Greece. sokpapa@med.uoa.gr","institution_ids":["https://openalex.org/I4210141397"]},{"raw_affiliation_string":"Department of Neurology, Eginition Hospital, Medical School, Athens National University, Athens, Greece","institution_ids":["https://openalex.org/I4210141397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029072830","display_name":"Theodoros Kontaxis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141397","display_name":"Eginition Hospital","ror":"https://ror.org/03wed5r38","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141397"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Theodoros Kontaxis","raw_affiliation_strings":["Department of Neurology, Eginition Hospital, Medical School, Athens National University, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Eginition Hospital, Medical School, Athens National University, Athens, Greece","institution_ids":["https://openalex.org/I4210141397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059645877","display_name":"Anastasios Bonakis","orcid":"https://orcid.org/0000-0003-0509-5910","observed_orcids":["https://orcid.org/0000-0003-0509-5910"]},"institutions":[{"id":"https://openalex.org/I4210141397","display_name":"Eginition Hospital","ror":"https://ror.org/03wed5r38","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141397"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Anastasios Bonakis","raw_affiliation_strings":["Department of Neurology, Eginition Hospital, Medical School, Athens National University, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Eginition Hospital, Medical School, Athens National University, Athens, Greece","institution_ids":["https://openalex.org/I4210141397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111869377","display_name":"Nikolaos Kalfakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141397","display_name":"Eginition Hospital","ror":"https://ror.org/03wed5r38","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141397"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Nikolaos Kalfakis","raw_affiliation_strings":["Department of Neurology, Eginition Hospital, Medical School, Athens National University, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Eginition Hospital, Medical School, Athens National University, Athens, Greece","institution_ids":["https://openalex.org/I4210141397"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103447613","display_name":"Demetrios Vassilopoulos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141397","display_name":"Eginition Hospital","ror":"https://ror.org/03wed5r38","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210141397"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Demetrios Vassilopoulos","raw_affiliation_strings":["Department of Neurology, Eginition Hospital, Medical School, Athens National University, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Eginition Hospital, Medical School, Athens National University, Athens, Greece","institution_ids":["https://openalex.org/I4210141397"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210141397"],"apc_list":null,"apc_paid":null,"fwci":1.9643,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.84701273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"23","issue":"4","first_page":"347","last_page":"351"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14434","display_name":"Historical and Modern Theater Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/early-onset-dementia","display_name":"early-onset dementia","score":1.0},{"id":"https://openalex.org/keywords/late-onset-dementia","display_name":"late-onset dementia","score":0.9919999837875366},{"id":"https://openalex.org/keywords/frontotemporal-lobar-degeneration","display_name":"frontotemporal lobar degeneration","score":0.9359999895095825},{"id":"https://openalex.org/keywords/secondary-dementia","display_name":"secondary dementia","score":0.7799999713897705},{"id":"https://openalex.org/keywords/parkinson-s-disease-dementia","display_name":"Parkinson's disease dementia","score":0.796999990940094},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9200000166893005},{"id":"https://openalex.org/keywords/time-to-diagnosis","display_name":"time to diagnosis","score":0.8360000252723694},{"id":"https://openalex.org/keywords/dementia-severity","display_name":"dementia severity","score":0.4359999895095825},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.8824727535247803},{"id":"https://openalex.org/C2776135927","wikidata":"https://www.wikidata.org/wiki/Q5242559","display_name":"Referral","level":2,"score":0.6775669455528259},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.6602377891540527},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6573854684829712},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5085698366165161},{"id":"https://openalex.org/C2777767895","wikidata":"https://www.wikidata.org/wiki/Q4691924","display_name":"Age of onset","level":3,"score":0.4885333776473999},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4850394129753113},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.42357492446899414},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.412568062543869},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21305224299430847},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.0490477979183197}],"mesh":[{"descriptor_ui":"D000046","descriptor_name":"Academic Medical Centers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006115","descriptor_name":"Greece","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012017","descriptor_name":"Referral and Consultation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/wad.0b013e31819e6b28","doi":"https://doi.org/10.1097/wad.0b013e31819e6b28","is_oa":false,"landing_page_url":"https://doi.org/10.1097/wad.0b013e31819e6b28","pdf_url":null,"source":{"id":"https://openalex.org/S107889856","display_name":"Alzheimer Disease & Associated Disorders","issn_l":"0893-0341","issn":["0893-0341","1546-4156"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer Disease &amp; Associated Disorders","raw_type":"journal-article"},{"id":"pmid:19568157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19568157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer disease and associated disorders","raw_type":"Comparative Study"},{"id":"pmh:oai:dspace.lib.ntua.gr:123456789/28771","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/123456789/28771","pdf_url":null,"source":{"id":"https://openalex.org/S4377196837","display_name":"DSpace - NTUA (National Technical University of Athens)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I174458059","host_organization_name":"National Technical University of Athens","host_organization_lineage":["https://openalex.org/I174458059"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ALZHEIMER DISEASE &amp; ASSOCIATED DISORDERS","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:dspace.lib.ntua.gr:123456789/28771","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/123456789/28771","pdf_url":null,"source":{"id":"https://openalex.org/S4377196837","display_name":"DSpace - NTUA (National Technical University of Athens)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I174458059","host_organization_name":"National Technical University of Athens","host_organization_lineage":["https://openalex.org/I174458059"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ALZHEIMER DISEASE &amp; ASSOCIATED DISORDERS","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W188949016","https://openalex.org/W589274621","https://openalex.org/W1847168837","https://openalex.org/W1971565607","https://openalex.org/W1974583546","https://openalex.org/W1980827933","https://openalex.org/W1985905268","https://openalex.org/W1989274511","https://openalex.org/W1991952617","https://openalex.org/W2000259640","https://openalex.org/W2002404084","https://openalex.org/W2005072207","https://openalex.org/W2012656038","https://openalex.org/W2016982759","https://openalex.org/W2023131797","https://openalex.org/W2034660342","https://openalex.org/W2038420040","https://openalex.org/W2039379003","https://openalex.org/W2056966839","https://openalex.org/W2059881220","https://openalex.org/W2108410348","https://openalex.org/W2111963393","https://openalex.org/W2112150247","https://openalex.org/W2136557657","https://openalex.org/W2138330137","https://openalex.org/W2140888027","https://openalex.org/W2143460188","https://openalex.org/W2147718105","https://openalex.org/W2156220037","https://openalex.org/W4247755733"],"related_works":["https://openalex.org/W2067976609","https://openalex.org/W2073277416","https://openalex.org/W2098140633","https://openalex.org/W2330371647","https://openalex.org/W3008625684","https://openalex.org/W2137477406","https://openalex.org/W2059881220","https://openalex.org/W1966219752","https://openalex.org/W2000259640","https://openalex.org/W2897608920"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,52,67,76,81,112,123,133,138,141,156,168,231,237],"frequency":[4],"and":[5,57,66,80,114,148,155,167,239],"causes":[6,202],"of":[7,54,69,90,102,143,158,170,227,234],"early-onset":[8],"dementia":[9,18,38,62,83,151,235],"(EOD)":[10],"in":[11,14,31,59,117,132,137,187,196,206,236],"consecutive":[12,92],"patients":[13,55,99,144,159,180,207,219],"a":[15,46,88,225],"highly":[16],"specialized":[17,188],"referral":[19,43],"center,":[20],"focusing":[21],"on":[22],"unusual":[23],"cases,":[24],"particularly":[25],"with":[26,145,160,199,208,211,220],"early":[27],"and/or":[28],"rapid":[29],"onset,":[30],"Athens,":[32],"Greece.":[33],"METHODS:":[34],"Patients":[35,210],"referred":[36],"for":[37,224],"diagnosis":[39,56],"according":[40],"to":[41,73,127,184],"specific":[42],"criteria":[44],"during":[45],"3":[47],"years":[48],"period.":[49],"We":[50,176],"examined":[51],"distribution":[53],"differences":[58,108],"sex,":[60],"education,":[61],"severity,":[63],"cognitive":[64,118],"function,":[65],"duration":[68,124],"disease":[70,147,150],"(from":[71],"onset":[72,126],"referral)":[74],"between":[75,111],"EOD":[77,98,113,134,139,179,197,212],"(<65":[78],"y)":[79],"late-onset":[82],"(LOD)":[84],"groups.":[85],"RESULTS:":[86],"From":[87],"total":[89],"260":[91],"demented":[93,104],"patients,":[94],"there":[95],"were":[96,109,152],"114":[97],"or":[100,119],"44%":[101],"all":[103],"patients.":[105],"No":[106],"significant":[107],"observed":[110],"LOD":[115],"groups":[116],"behavioral":[120],"measures.":[121],"However,":[122],"from":[125],"consultation":[128],"was":[129,164,173],"significantly":[130],"longer":[131,216],"group.":[135],"Also,":[136],"group,":[140],"rates":[142],"Alzheimer":[146],"Parkinson":[149],"relatively":[153,165],"low":[154],"rate":[157],"frontotemporal":[161],"lobar":[162],"degeneration":[163],"high":[166],"proportion":[169],"secondary":[171],"dementias":[172],"high.":[174],"CONCLUSIONS:":[175],"conclude":[177],"that":[178],"are":[181,193,203],"more":[182],"likely":[183],"be":[185],"seen":[186],"settings.":[189],"The":[190],"underlying":[191],"diseases":[192],"considerably":[194],"different":[195],"compared":[198],"LOD.":[200,221],"Secondary":[201],"often":[204],"found":[205],"EOD.":[209],"had":[213],"an":[214],"unexpectedly":[215],"time-to-diagnosis":[217],"than":[218],"This":[222],"argues":[223],"need":[226],"better":[228],"education":[229],"about":[230],"clinical":[232],"presentation":[233],"young":[238],"middle":[240],"aged.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}