{"id":"https://openalex.org/W2020217153","doi":"https://doi.org/10.1016/j.neuint.2010.01.005","title":"Involvement of induction and mitochondrial targeting of orphan nuclear receptor Nur77 in 6-OHDA-induced SH-SY5Y cell death","display_name":"Involvement of induction and mitochondrial targeting of orphan nuclear receptor Nur77 in 6-OHDA-induced SH-SY5Y cell death","publication_year":2010,"publication_date":"2010-01-25","ids":{"openalex":"https://openalex.org/W2020217153","doi":"https://doi.org/10.1016/j.neuint.2010.01.005","mag":"2020217153","pmid":"https://pubmed.ncbi.nlm.nih.gov/20096738"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuint.2010.01.005","doi":"https://doi.org/10.1016/j.neuint.2010.01.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuint.2010.01.005","pdf_url":null,"source":{"id":"https://openalex.org/S53315755","display_name":"Neurochemistry International","issn_l":"0197-0186","issn":["0197-0186","1872-9754"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemistry International","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008555323","display_name":"Haja No","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Haja No","raw_affiliation_strings":["College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Buk-gu, Gwangju 500-757, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Buk-gu, Gwangju 500-757, South Korea","institution_ids":["https://openalex.org/I111277659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025473277","display_name":"Yeojin Bang","orcid":"https://orcid.org/0000-0002-5134-6920","observed_orcids":["https://orcid.org/0000-0002-5134-6920"]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yeojin Bang","raw_affiliation_strings":["College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, South Korea","institution_ids":["https://openalex.org/I111277659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103405698","display_name":"Juhee Lim","orcid":"https://orcid.org/0000-0002-3605-812X","observed_orcids":["https://orcid.org/0000-0002-3605-812X"]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Juhee Lim","raw_affiliation_strings":["College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, South Korea","institution_ids":["https://openalex.org/I111277659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049832715","display_name":"Sa Suk Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sa Suk Kim","raw_affiliation_strings":["College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, South Korea","institution_ids":["https://openalex.org/I111277659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019470350","display_name":"Hueng\u2010Sik Choi","orcid":"https://orcid.org/0000-0002-3163-1572","observed_orcids":["https://orcid.org/0000-0002-3163-1572"]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hueng-Sik Choi","raw_affiliation_strings":["College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, South Korea","Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500-757, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, South Korea","institution_ids":["https://openalex.org/I111277659"]},{"raw_affiliation_string":"Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500-757, South Korea","institution_ids":["https://openalex.org/I111277659"]}]},{"author_position":"last","author":{"id":null,"display_name":"Hyun Jin Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111277659","display_name":"Chonnam National University","ror":"https://ror.org/05kzjxq56","country_code":"KR","type":"education","lineage":["https://openalex.org/I111277659"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hyun Jin Choi","raw_affiliation_strings":["College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, South Korea","Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500-757, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy and Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, South Korea","institution_ids":["https://openalex.org/I111277659"]},{"raw_affiliation_string":"Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500-757, South Korea","institution_ids":["https://openalex.org/I111277659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I111277659"],"apc_list":{"value":4170,"currency":"USD","value_usd":4170},"apc_paid":null,"fwci":1.1681,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.74971114,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"56","issue":"4","first_page":"620","last_page":"626"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nr4a1","display_name":"Nur77","score":0.9990000128746033},{"id":"https://openalex.org/keywords/orphan-nuclear-receptor","display_name":"orphan nuclear receptor","score":0.9879999756813049},{"id":"https://openalex.org/keywords/6-hydroxydopamine","display_name":"6-hydroxydopamine","score":0.9509999752044678},{"id":"https://openalex.org/keywords/sh-sy5y-cells","display_name":"SH-SY5Y cells","score":0.9359999895095825},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.7599999904632568},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7889999747276306},{"id":"https://openalex.org/keywords/mitochondrial-targeting","display_name":"mitochondrial targeting","score":0.6259999871253967},{"id":"https://openalex.org/keywords/nuclear-export","display_name":"nuclear export","score":0.9610000252723694},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9380000233650208},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.6069999933242798},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.5590000152587891},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C35552991","wikidata":"https://www.wikidata.org/wiki/Q12063746","display_name":"Nerve growth factor IB","level":5,"score":0.9434581398963928},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6265360116958618},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6022276878356934},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5655694007873535},{"id":"https://openalex.org/C2779161069","wikidata":"https://www.wikidata.org/wiki/Q2496179","display_name":"Orphan receptor","level":4,"score":0.5456027984619141},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.4968562424182892},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49514880776405334},{"id":"https://openalex.org/C23525593","wikidata":"https://www.wikidata.org/wiki/Q15312389","display_name":"Neuron-derived orphan receptor 1","level":5,"score":0.4941413700580597},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.48982927203178406},{"id":"https://openalex.org/C2779083432","wikidata":"https://www.wikidata.org/wiki/Q7390126","display_name":"SH-SY5Y","level":4,"score":0.4740935266017914},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.43955329060554504},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32122376561164856},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.22537031769752502},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.19444191455841064},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16806036233901978},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.09038937091827393},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.058699995279312134},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007770","descriptor_name":"L-Lactate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013565","descriptor_name":"Sympatholytics","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016627","descriptor_name":"Oxidopamine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057105","descriptor_name":"Nuclear Receptor Subfamily 4, Group A, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.neuint.2010.01.005","doi":"https://doi.org/10.1016/j.neuint.2010.01.005","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuint.2010.01.005","pdf_url":null,"source":{"id":"https://openalex.org/S53315755","display_name":"Neurochemistry International","issn_l":"0197-0186","issn":["0197-0186","1872-9754"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemistry International","raw_type":"journal-article"},{"id":"pmid:20096738","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20096738","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurochemistry international","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1651198610","https://openalex.org/W1828213054","https://openalex.org/W1841847537","https://openalex.org/W1975648951","https://openalex.org/W1980655244","https://openalex.org/W1984695968","https://openalex.org/W1990458209","https://openalex.org/W1991804565","https://openalex.org/W1995148595","https://openalex.org/W2011827443","https://openalex.org/W2023373433","https://openalex.org/W2033161660","https://openalex.org/W2047821877","https://openalex.org/W2058342631","https://openalex.org/W2062605045","https://openalex.org/W2079231229","https://openalex.org/W2088257156","https://openalex.org/W2091187148","https://openalex.org/W2093557429","https://openalex.org/W2094155854","https://openalex.org/W2094757629","https://openalex.org/W2096855269","https://openalex.org/W2120935628","https://openalex.org/W2132373383","https://openalex.org/W2134770450","https://openalex.org/W2138604527","https://openalex.org/W2138962306","https://openalex.org/W2144301386","https://openalex.org/W2149811610","https://openalex.org/W2155235678","https://openalex.org/W2156831079","https://openalex.org/W2164314374","https://openalex.org/W2166122010","https://openalex.org/W2430140711"],"related_works":["https://openalex.org/W7130610389","https://openalex.org/W1984423498","https://openalex.org/W3129009349","https://openalex.org/W2082214510","https://openalex.org/W1980047927","https://openalex.org/W2049870433","https://openalex.org/W984869658","https://openalex.org/W1997047566","https://openalex.org/W4295308811","https://openalex.org/W2095295161"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}