{"id":"https://openalex.org/W2020204285","doi":"https://doi.org/10.1073/pnas.0808347106","title":"Distinct modes of gene regulation by a cell-specific transcriptional activator","display_name":"Distinct modes of gene regulation by a cell-specific transcriptional activator","publication_year":2009,"publication_date":"2009-02-27","ids":{"openalex":"https://openalex.org/W2020204285","doi":"https://doi.org/10.1073/pnas.0808347106","mag":"2020204285","pmid":"https://pubmed.ncbi.nlm.nih.gov/19251649","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2657397"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.0808347106","doi":"https://doi.org/10.1073/pnas.0808347106","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0808347106","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2657397","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103580259","display_name":"Tanushri Sengupta","orcid":"https://orcid.org/0009-0009-4902-4007","observed_orcids":["https://orcid.org/0009-0009-4902-4007"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanushri Sengupta","raw_affiliation_strings":["Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029; and","MSSM - Icahn School of Medicine at Mount Sinai [New York] (1 Gustave L. Levy Place\r\nNew York, NY 10029-5674 - United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029; and","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"MSSM - Icahn School of Medicine at Mount Sinai [New York] (1 Gustave L. Levy Place\r\nNew York, NY 10029-5674 - United States)","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033415460","display_name":"Nathalie Cohet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nathalie Cohet","raw_affiliation_strings":["Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 5534, Universit\u00e9 Lyon, F-69622 Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 5534, Universit\u00e9 Lyon, F-69622 Lyon, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087929889","display_name":"Fran\u00e7ois Morl\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Morl\u00e9","raw_affiliation_strings":["Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 5534, Universit\u00e9 Lyon, F-69622 Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 5534, Universit\u00e9 Lyon, F-69622 Lyon, France","institution_ids":["https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002966230","display_name":"James J. Bieker","orcid":"https://orcid.org/0000-0001-5128-7476","observed_orcids":["https://orcid.org/0000-0001-5128-7476"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James J. Bieker","raw_affiliation_strings":["Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029; and","MSSM - Icahn School of Medicine at Mount Sinai [New York] (1 Gustave L. Levy Place\r\nNew York, NY 10029-5674 - United States)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029; and","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"MSSM - Icahn School of Medicine at Mount Sinai [New York] (1 Gustave L. Levy Place\r\nNew York, NY 10029-5674 - United States)","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3185,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.7765244,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"106","issue":"11","first_page":"4213","last_page":"4218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.33889999985694885,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0357000008225441,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eklf","display_name":"EKLF","score":0.9179999828338623},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.5989999771118164},{"id":"https://openalex.org/keywords/tissue-specific-expression","display_name":"tissue-specific gene expression","score":0.8029999732971191},{"id":"https://openalex.org/keywords/beta-globin-gene","display_name":"beta-globin gene","score":0.925000011920929},{"id":"https://openalex.org/keywords/downstream-promoter-element","display_name":"downstream promoter element","score":0.8519999980926514},{"id":"https://openalex.org/keywords/beta-thalassemia-mutations","display_name":"beta-thalassemia mutations","score":0.9350000023841858},{"id":"https://openalex.org/keywords/superactivation","display_name":"superactivation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/alpha-hemoglobin-stabilizing-protein","display_name":"AHSP","score":0.9399999976158142},{"id":"https://openalex.org/keywords/transcription-factor-interaction","display_name":"transcription factor interaction","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6315716505050659},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5705255270004272},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5644447803497314},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.5082747340202332},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5040539503097534},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.49470254778862},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4577109217643738},{"id":"https://openalex.org/C132376346","wikidata":"https://www.wikidata.org/wiki/Q7315962","display_name":"Response element","level":5,"score":0.4465901851654053},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4397790729999542},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.38788503408432007},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21288135647773743},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035362","descriptor_name":"Transcription Factor TFIID","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035381","descriptor_name":"TATA-Binding Protein Associated Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051741","descriptor_name":"Kruppel-Like Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D055544","descriptor_name":"beta-Globins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D055544","descriptor_name":"beta-Globins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.0808347106","doi":"https://doi.org/10.1073/pnas.0808347106","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.0808347106","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2657397","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2657397","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:19251649","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19251649","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00425215v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00425215","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America, 2009, 106 (11), pp.4213-8. ⟨10.1073/pnas.0808347106⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2657397","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2657397","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3505319752","display_name":"Function of Putative Determinant in Hematopoiesis","funder_award_id":"R01DK046865","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1508246134","https://openalex.org/W1884135206","https://openalex.org/W1969895740","https://openalex.org/W1974623937","https://openalex.org/W1979028385","https://openalex.org/W1981291811","https://openalex.org/W1993398475","https://openalex.org/W1997194722","https://openalex.org/W1998607972","https://openalex.org/W1999921488","https://openalex.org/W2001221569","https://openalex.org/W2001738211","https://openalex.org/W2011270891","https://openalex.org/W2012061944","https://openalex.org/W2012818607","https://openalex.org/W2013150998","https://openalex.org/W2022349580","https://openalex.org/W2023553296","https://openalex.org/W2029581772","https://openalex.org/W2044511711","https://openalex.org/W2047366906","https://openalex.org/W2054852737","https://openalex.org/W2066785029","https://openalex.org/W2067276251","https://openalex.org/W2070083583","https://openalex.org/W2071000969","https://openalex.org/W2071984843","https://openalex.org/W2077132193","https://openalex.org/W2079102916","https://openalex.org/W2085428320","https://openalex.org/W2088511569","https://openalex.org/W2094563726","https://openalex.org/W2097920884","https://openalex.org/W2101494714","https://openalex.org/W2110468079","https://openalex.org/W2110910543","https://openalex.org/W2112715309","https://openalex.org/W2117704072","https://openalex.org/W2119375414","https://openalex.org/W2124220434","https://openalex.org/W2124528320","https://openalex.org/W2125805036","https://openalex.org/W2127217227","https://openalex.org/W2133449910","https://openalex.org/W2134367629","https://openalex.org/W2140089594","https://openalex.org/W2147372875","https://openalex.org/W2150051572","https://openalex.org/W2160208722","https://openalex.org/W2164364100","https://openalex.org/W2168864213","https://openalex.org/W2170698318","https://openalex.org/W2170778160","https://openalex.org/W2179700842","https://openalex.org/W2397782999","https://openalex.org/W4239029175"],"related_works":["https://openalex.org/W2074222567","https://openalex.org/W24057152","https://openalex.org/W1967047395","https://openalex.org/W1868405784","https://openalex.org/W2029859815","https://openalex.org/W2179700842","https://openalex.org/W2411291059","https://openalex.org/W1866388848","https://openalex.org/W3022261541","https://openalex.org/W1420632864"],"abstract_inverted_index":{"The":[0],"architectural":[1],"layout":[2],"of":[3,31,43,69,71,93,123,138,142,150,160,192,209,217],"a":[4,12,47,59,115,157,176],"eukaryotic":[5],"RNA":[6],"polymerase":[7],"II":[8],"core":[9,220],"promoter":[10,119,131,179,199],"plays":[11],"role":[13,20],"in":[14,21],"general":[15,35],"transcriptional":[16,162,211],"activation.":[17,200],"However,":[18,156],"its":[19,32,104,130,218],"tissue-specific":[22,210],"expression":[23,92],"is":[24,58,64,164],"not":[25,174,186],"known.":[26],"For":[27],"example,":[28],"differing":[29],"modes":[30,208],"recognition":[33],"by":[34,102,126,166],"transcription":[36,50,61],"machinery":[37],"can":[38],"provide":[39],"an":[40],"additional":[41],"layer":[42],"control":[44],"within":[45],"which":[46,86,172],"single":[48],"tissue-restricted":[49],"factor":[51,56,62,83],"may":[52],"operate.":[53],"Erythroid":[54],"Kruppel-like":[55],"(EKLF)":[57],"hematopoietic-specific":[60],"that":[63,76,204],"critical":[65],"for":[66,91],"the":[67,108,145,167,215],"activation":[68,163,212],"subset":[70],"erythroid":[72],"genes.":[73],"We":[74],"find":[75],"EKLF":[77,100,139,161,188,205],"interacts":[78,113],"with":[79,114],"TATA":[80],"binding":[81],"protein-associated":[82],"9":[84],"(TAF9),":[85],"leads":[87],"to":[88,106,144],"important":[89],"consequences":[90],"adult":[94],"beta-globin.":[95],"First,":[96],"TAF9":[97,112,143,151,184,193],"functionally":[98],"supports":[99],"activity":[101,132,189],"enhancing":[103],"ability":[105],"activate":[107],"beta-globin":[109,117,146],"gene.":[110],"Second,":[111],"conserved":[116],"downstream":[118,178],"element,":[120],"and":[121,133,190],"ablation":[122],"this":[124,182],"interaction":[125],"beta-thalassemia-causing":[127],"mutations":[128],"decreases":[129],"disables":[134],"superactivation.":[135],"Third,":[136],"depletion":[137,149,191],"prevents":[140],"recruitment":[141],"promoter,":[147],"whereas":[148],"drastically":[152],"impairs":[153],"beta-promoter":[154],"activity.":[155],"TAF9-independent":[158],"mode":[159],"exhibited":[165],"alpha-hemoglobin-stabilizing":[168],"protein":[169],"(AHSP)":[170],"gene,":[171],"does":[173,185],"contain":[175],"discernable":[177],"element.":[180],"In":[181],"case,":[183],"enhance":[187],"has":[194],"no":[195],"effect":[196],"on":[197,214],"AHSP":[198],"These":[201],"studies":[202],"demonstrate":[203],"directs":[206],"different":[207],"depending":[213],"architecture":[216],"target":[219],"promoter.":[221]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}