{"id":"https://openalex.org/W2020198561","doi":"https://doi.org/10.1115/sbc2012-80536","title":"Extra-Fibrilar Matrix Properties of Human Annulus Fibrosus are Location and Age Dependent","display_name":"Extra-Fibrilar Matrix Properties of Human Annulus Fibrosus are Location and Age Dependent","publication_year":2012,"publication_date":"2012-06-20","ids":{"openalex":"https://openalex.org/W2020198561","doi":"https://doi.org/10.1115/sbc2012-80536","mag":"2020198561"},"language":"en","primary_location":{"id":"doi:10.1115/sbc2012-80536","doi":"https://doi.org/10.1115/sbc2012-80536","is_oa":false,"landing_page_url":"https://doi.org/10.1115/sbc2012-80536","pdf_url":null,"source":{"id":"https://openalex.org/S4306503435","display_name":"ASME Summer Bioengineering Conference (SBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASME 2012 Summer Bioengineering Conference, Parts A and B","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091596877","display_name":"Daniel Humberto Cort\u00e9s","orcid":"https://orcid.org/0000-0003-2114-9413","observed_orcids":["https://orcid.org/0000-0003-2114-9413"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel H. Cortes","raw_affiliation_strings":["University of Delaware, Newark, DE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Delaware, Newark, DE","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060807441","display_name":"Woojin M. Han","orcid":"https://orcid.org/0000-0002-1383-5686","observed_orcids":["https://orcid.org/0000-0002-1383-5686"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]},{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Woojin M. Han","raw_affiliation_strings":["University of Delaware, Newark, DE","University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Delaware, Newark, DE","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047354770","display_name":"Lachlan J. Smith","orcid":"https://orcid.org/0000-0001-5823-6073","observed_orcids":["https://orcid.org/0000-0001-5823-6073"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lachlan J. Smith","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015297374","display_name":"Dawn M. Elliott","orcid":"https://orcid.org/0000-0003-4792-1029","observed_orcids":["https://orcid.org/0000-0003-4792-1029"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dawn M. Elliott","raw_affiliation_strings":["University of Delaware, Newark, DE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Delaware, Newark, DE","institution_ids":["https://openalex.org/I86501945"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.08355091,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"169","last_page":"170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/annulus-fibrosus","display_name":"annulus fibrosus","score":0.9070000052452087},{"id":"https://openalex.org/keywords/intervertebral-disc-degeneration","display_name":"intervertebral disc degeneration","score":0.9700000286102295},{"id":"https://openalex.org/keywords/disc-aging","display_name":"disc aging","score":0.8690000176429749},{"id":"https://openalex.org/keywords/protein-cross-linking","display_name":"protein cross-linking","score":0.7699999809265137},{"id":"https://openalex.org/keywords/proteoglycan-depletion","display_name":"proteoglycan depletion","score":0.9120000004768372},{"id":"https://openalex.org/keywords/tissue-stiffness","display_name":"tissue stiffness","score":0.8870000243186951},{"id":"https://openalex.org/keywords/mechanical-properties","display_name":"mechanical properties","score":0.6790000200271606},{"id":"https://openalex.org/keywords/collagen-types","display_name":"collagen types","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C2777755357","wikidata":"https://www.wikidata.org/wiki/Q502781","display_name":"Intervertebral disc","level":2,"score":0.7460638284683228},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.6781316995620728},{"id":"https://openalex.org/C2781438746","wikidata":"https://www.wikidata.org/wiki/Q1463401","display_name":"Genipin","level":3,"score":0.6738936901092529},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.591326892375946},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5807760953903198},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5455668568611145},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5340916514396667},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5311825275421143},{"id":"https://openalex.org/C2779372316","wikidata":"https://www.wikidata.org/wiki/Q569057","display_name":"Stiffness","level":2,"score":0.5298086404800415},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.482004314661026},{"id":"https://openalex.org/C150936888","wikidata":"https://www.wikidata.org/wiki/Q4769748","display_name":"Annulus (botany)","level":2,"score":0.46173015236854553},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4093252420425415},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.38445594906806946},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3020893931388855},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1625138223171234},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15118423104286194},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10658827424049377},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.10403656959533691},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09827888011932373},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.07333230972290039},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1115/sbc2012-80536","doi":"https://doi.org/10.1115/sbc2012-80536","is_oa":false,"landing_page_url":"https://doi.org/10.1115/sbc2012-80536","pdf_url":null,"source":{"id":"https://openalex.org/S4306503435","display_name":"ASME Summer Bioengineering Conference (SBC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ASME 2012 Summer Bioengineering Conference, Parts A and B","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1573325432","https://openalex.org/W2064490819","https://openalex.org/W7170080079","https://openalex.org/W1964148859","https://openalex.org/W4404374706","https://openalex.org/W2075015150","https://openalex.org/W4409452163","https://openalex.org/W2176848788","https://openalex.org/W1606409991","https://openalex.org/W2361477191"],"abstract_inverted_index":{"Aging":[0],"and":[1,15,50,69,132,169],"degeneration":[2,24],"of":[3,40,66,81,92,108,124,146,196],"the":[4,38,41,63,67,93,100,106,125,143,147,174,185,191,193,197],"intervertebral":[5,170],"discs":[6],"are":[7,21,58],"cell":[8],"mediated":[9],"processes":[10,20,136],"that":[11,32,78],"include":[12,45],"biochemical,":[13],"mechanical":[14,64,144,194],"structural":[16],"changes.":[17],"Although":[18,181],"these":[19,134,155],"similar,":[22],"disc":[23,68,96,186],"is":[25,151],"defined":[26],"as":[27],"an":[28,79,90],"accelerated":[29],"aging":[30,131],"process":[31],"results":[33],"in":[34,37,62,95,190],"a":[35,103,115,122],"detriment":[36],"function":[39],"disc.":[42],"Biochemical":[43],"changes":[44,51,57,61],"protein":[46,82],"cross-linking,":[47],"proteoglycan":[48,109],"depletion":[49],"on":[52,105,117,142],"collagen":[53],"type.":[54],"These":[55],"compositional":[56],"related":[59],"to":[60,113,121,153],"properties":[65,145,195],"its":[70],"tissues.":[71],"For":[72],"instance,":[73],"it":[74,150],"has":[75,110],"been":[76,111,188,204],"shown":[77,112],"increase":[80,91],"cross-linking":[83],"by":[84],"glycation":[85],"or":[86],"genipin":[87],"treatment":[88],"causes":[89],"stiffness":[94,119],"tissues":[97],"[1,2].":[98],"On":[99],"other":[101],"hand,":[102],"decrease":[104,116],"amount":[107],"cause":[114],"tissue":[118],"due":[120],"reduction":[123],"osmotic":[126],"pressure":[127],"[3,4].":[128],"However,":[129],"during":[130],"degeneration,":[133],"two":[135],"occur":[137],"simultaneously":[138],"with":[139],"opposing":[140],"effects":[141,156],"tissue.":[148],"Consequently,":[149],"important":[152],"analyze":[154],"separately.":[157],"Additionally,":[158],"many":[159],"multiphasic":[160,182],"models":[161,183],"for":[162,184],"soft":[163],"charged":[164],"tissues,":[165],"such":[166],"articular":[167],"cartilage":[168],"disc,":[171],"also":[172],"consider":[173],"ionic":[175],"phases":[176],"separately":[177],"from":[178],"non-charged":[179,198],"solids.":[180],"have":[187,202],"used":[189],"past,":[192],"extra-fibrillar":[199],"matrix":[200],"(EFM)":[201],"not":[203],"measured":[205],"directly.":[206]},"counts_by_year":[],"updated_date":"2026-10-05T09:50:58.205359","created_date":"2016-06-24T00:00:00"}
