{"id":"https://openalex.org/W2020178657","doi":"https://doi.org/10.1186/1471-2407-13-603","title":"Promoter methylation of Wnt-antagonists in polypoid and nonpolypoid colorectal adenomas","display_name":"Promoter methylation of Wnt-antagonists in polypoid and nonpolypoid colorectal adenomas","publication_year":2013,"publication_date":"2013-12-01","ids":{"openalex":"https://openalex.org/W2020178657","doi":"https://doi.org/10.1186/1471-2407-13-603","mag":"2020178657","pmid":"https://pubmed.ncbi.nlm.nih.gov/24350795","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3878219"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2407-13-603","doi":"https://doi.org/10.1186/1471-2407-13-603","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-13-603","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-13-603","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-13-603","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018863305","display_name":"Quirinus J.M. Voorham","orcid":"https://orcid.org/0000-0002-2631-7976","observed_orcids":["https://orcid.org/0000-0002-2631-7976"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Quirinus JM Voorham","raw_affiliation_strings":["Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022468485","display_name":"Jerry Janssen","orcid":"https://orcid.org/0000-0001-5855-4119","observed_orcids":["https://orcid.org/0000-0001-5855-4119","https://orcid.org/0000-0003-2536-7864"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jerry Janssen","raw_affiliation_strings":["Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075677040","display_name":"Marianne Tijssen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marianne Tijssen","raw_affiliation_strings":["Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056365475","display_name":"Suzanne Snellenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Suzanne Snellenberg","raw_affiliation_strings":["Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018495590","display_name":"Sandra Mongera","orcid":"https://orcid.org/0000-0001-5368-5654","observed_orcids":["https://orcid.org/0000-0001-5368-5654"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sandra Mongera","raw_affiliation_strings":["Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083943954","display_name":"Nicole C.T. van Grieken","orcid":"https://orcid.org/0000-0001-9992-0760","observed_orcids":["https://orcid.org/0000-0001-9992-0760"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Nicole CT van Grieken","raw_affiliation_strings":["Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019453132","display_name":"Heike Irmgard Grabsch","orcid":"https://orcid.org/0000-0001-9520-6228","observed_orcids":["https://orcid.org/0000-0001-9520-6228"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Heike Grabsch","raw_affiliation_strings":["Pathology and Tumour Biology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Tumour Biology, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109064452","display_name":"Martin Kliment","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Kliment","raw_affiliation_strings":["Gastroenterology, Hospital Vitkovice, Ostrava, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology, Hospital Vitkovice, Ostrava, Czech Republic","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110103591","display_name":"Bjorn J. Rembacken","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bjorn J Rembacken","raw_affiliation_strings":["Centre for Digestive Diseases, Leeds General Infirmary, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Digestive Diseases, Leeds General Infirmary, Leeds, UK","institution_ids":["https://openalex.org/I1295121038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072029105","display_name":"Chris Jacob Johan Mulder","orcid":"https://orcid.org/0000-0002-6332-0365","observed_orcids":["https://orcid.org/0000-0002-6332-0365","https://orcid.org/0000-0001-9386-0832"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Chris JJ Mulder","raw_affiliation_strings":["Departmentt of Gastro-enterology, VU University Medical Center, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departmentt of Gastro-enterology, VU University Medical Center, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108103041","display_name":"Manon van Engeland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Manon van Engeland","raw_affiliation_strings":["Department of Pathology, University Maastricht, Maastricht, The Netherlands","GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University Maastricht, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I2800191616","https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077029853","display_name":"Gerrit A. Meijer","orcid":"https://orcid.org/0000-0003-0330-3130","observed_orcids":["https://orcid.org/0000-0003-0330-3130","https://orcid.org/0000-0002-5408-2094","https://orcid.org/0000-0003-0057-0938"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gerrit A Meijer","raw_affiliation_strings":["Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082492592","display_name":"Renske D.M. Steenbergen","orcid":"https://orcid.org/0000-0002-2327-9839","observed_orcids":["https://orcid.org/0000-0002-2327-9839"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Renske DM Steenbergen","raw_affiliation_strings":["Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078485222","display_name":"Beatriz G. Carvalho","orcid":"https://orcid.org/0000-0003-4903-399X","observed_orcids":["https://orcid.org/0000-0003-4903-399X"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Beatriz Carvalho","raw_affiliation_strings":["Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands. b.carvalho@vumc.nl","Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands. b.carvalho@vumc.nl","institution_ids":["https://openalex.org/I911458345"]},{"raw_affiliation_string":"Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5078485222"],"corresponding_institution_ids":["https://openalex.org/I911458345"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":3.2672,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.92450972,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"13","issue":"1","first_page":"603","last_page":"603"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.4138000011444092,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.4138000011444092,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.4083999991416931,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.10750000178813934,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/colorectal-adenoma","display_name":"colorectal adenoma","score":0.8339999914169312},{"id":"https://openalex.org/keywords/polypoid-adenoma","display_name":"polypoid adenoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sfrp2","display_name":"SFRP2","score":0.8569999933242798},{"id":"https://openalex.org/keywords/wif1","display_name":"WIF1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dkk3","display_name":"DKK3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sox17","display_name":"SOX17","score":1.0},{"id":"https://openalex.org/keywords/apc-mutation","display_name":"APC mutation","score":0.8500000238418579},{"id":"https://openalex.org/keywords/chromosome-5q-loss","display_name":"chromosome 5q loss","score":0.9570000171661377},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8880000114440918}],"concepts":[{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.7821619510650635},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6886561512947083},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6605533361434937},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6288052797317505},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5821213126182556},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5459276437759399},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4574633240699768},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.403791606426239},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32982349395751953},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24551862478256226},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16221198439598083},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15126687288284302},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.08775275945663452}],"mesh":[{"descriptor_ui":"D000094742","descriptor_name":"Secreted Frizzled-Related Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011123","descriptor_name":"Polyploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018925","descriptor_name":"Chemokines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025601","descriptor_name":"Adenomatous Polyposis Coli Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055760","descriptor_name":"SOXF Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2407-13-603","doi":"https://doi.org/10.1186/1471-2407-13-603","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-13-603","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-13-603","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3878219","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3878219","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmid:24350795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24350795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.whiterose.ac.uk:105726","doi":null,"is_oa":false,"landing_page_url":"http://eprints.whiterose.ac.uk/105726/1/Promoter%20methylation%20of%20Wnt-antagonists%20in%20polypoid%20and%20nonpolypoid%20colorectal%20adenomas.pdf","pdf_url":"http://eprints.whiterose.ac.uk/105726/1/Promoter%20methylation%20of%20Wnt-antagonists%20in%20polypoid%20and%20nonpolypoid%20colorectal%20adenomas.pdf","source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/7ea61c22-9180-4802-8fd3-e7fec09f5b56","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/7ea61c22-9180-4802-8fd3-e7fec09f5b56","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Voorham, Q J M, Janssen, J, Tijssen, M, Snellenberg, S, Mongera, S, van Grieken, N C T, Grabsch, H, Kliment, M, Rembacken, B J, Mulder, C J J, van Engeland, M, Meijer, G A, Steenbergen, R D M & Carvalho, B 2013, 'Promoter methylation of Wnt-antagonists in polypoid and nonpolypoid colorectal adenomas', BMC cancer, vol. 13, no. 1, pp. 603-611. https://doi.org/10.1186/1471-2407-13-603","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/efdb9482-dd39-4804-982b-b1ab0cdf6969","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/efdb9482-dd39-4804-982b-b1ab0cdf6969","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, 13(1), 603 - 611. BioMed Central","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/1471-2407-13-603","doi":"https://doi.org/10.1186/1471-2407-13-603","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-13-603","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-13-603","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322777","display_name":"KWF Kankerbestrijding","ror":"https://ror.org/0368jnd28"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2020178657.pdf","grobid_xml":"https://content.openalex.org/works/W2020178657.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W83864767","https://openalex.org/W1591774929","https://openalex.org/W1869362176","https://openalex.org/W1964652501","https://openalex.org/W1969938538","https://openalex.org/W1977823892","https://openalex.org/W1984910916","https://openalex.org/W1993748871","https://openalex.org/W1997452920","https://openalex.org/W2000435171","https://openalex.org/W2001258296","https://openalex.org/W2003440209","https://openalex.org/W2021516840","https://openalex.org/W2021700590","https://openalex.org/W2023002592","https://openalex.org/W2027803670","https://openalex.org/W2029868343","https://openalex.org/W2031453950","https://openalex.org/W2037668591","https://openalex.org/W2038314366","https://openalex.org/W2041289222","https://openalex.org/W2043810045","https://openalex.org/W2048005397","https://openalex.org/W2053186041","https://openalex.org/W2065045375","https://openalex.org/W2079700746","https://openalex.org/W2079819294","https://openalex.org/W2093531978","https://openalex.org/W2099240520","https://openalex.org/W2114570899","https://openalex.org/W2119284420","https://openalex.org/W2125093701","https://openalex.org/W2131028271","https://openalex.org/W2136791720","https://openalex.org/W2143328224","https://openalex.org/W2147377553","https://openalex.org/W2164512508","https://openalex.org/W2167533065","https://openalex.org/W2167638513","https://openalex.org/W2171870339","https://openalex.org/W2398605179","https://openalex.org/W2408856290","https://openalex.org/W2903431075","https://openalex.org/W4248654028"],"related_works":["https://openalex.org/W2327413170","https://openalex.org/W2124955721","https://openalex.org/W2349015738","https://openalex.org/W2171313185","https://openalex.org/W2414471948","https://openalex.org/W4401248969","https://openalex.org/W2437133654","https://openalex.org/W2091280055","https://openalex.org/W2315949327","https://openalex.org/W7096276899"],"abstract_inverted_index":{"BACKGROUND:":[0],"Nonpolypoid":[1],"adenomas":[2,8,31,140,162],"are":[3],"a":[4,14,151,170],"subgroup":[5],"of":[6,27,40,50,60,80,129,137,155,189,196,209],"colorectal":[7,91,95,201],"that":[9],"have":[10],"been":[11],"associated":[12],"with":[13,110,223],"more":[15],"aggressive":[16],"clinical":[17],"behaviour":[18],"compared":[19,143,159,217],"to":[20,77,144,160,218],"their":[21],"polypoid":[22,30,68,105,161,219],"counterparts.":[23],"A":[24],"substantial":[25],"proportion":[26],"nonpolypoid":[28,66,102,158,216],"and":[29,67,86,103,118,141,148,176,179],"lack":[32],"APC":[33,35,42,115,174],"mutations,":[34],"methylation":[36,59,79,117,128,156,181],"or":[37],"chromosomal":[38],"loss":[39],"the":[41,48,123,135,207],"locus":[43],"on":[44,114],"chromosome":[45,119],"5q,":[46],"suggesting":[47],"involvement":[49],"other":[51],"Wnt-pathway":[52,62,190,198,212],"genes.":[53],"The":[54],"present":[55],"study":[56],"investigated":[57],"promoter":[58],"several":[61],"antagonists":[63,191],"in":[64,88,134,157,200,215,221],"both":[65,167,177],"adenomas.":[69,106,202],"METHODS:":[70],"Quantitative":[71],"methylation-specific":[72],"PCR":[73],"(qMSP)":[74],"was":[75,132,182],"used":[76],"evaluate":[78],"four":[81],"Wnt-antagonists,":[82],"SFRP2,":[83],"WIF-1,":[84],"DKK3":[85,149,180],"SOX17":[87],"18":[89,99],"normal":[90,145],"mucosa":[92],"samples,":[93],"9":[94],"cancer":[96],"cell":[97,138],"lines,":[98,139],"carcinomas,":[100],"44":[101,104],"Results":[107],"were":[108],"integrated":[109],"previously":[111],"obtained":[112],"data":[113],"mutation,":[116],"5q":[120],"status":[121],"from":[122],"same":[124],"samples.":[125],"RESULTS:":[126],"Increased":[127],"all":[130],"genes":[131],"found":[133],"majority":[136],"carcinomas":[142],"controls.":[146],"WIF-1":[147,178],"showed":[150],"significantly":[152],"lower":[153],"level":[154],"(p":[163,184],"<":[164,185],"0.01).":[165],"Combining":[166],"adenoma":[168],"types,":[169],"positive":[171],"trend":[172],"between":[173],"mutation":[175],"observed":[183],"0.05).":[186],"CONCLUSIONS:":[187],"Methylation":[188],"represents":[192],"an":[193],"additional":[194],"mechanism":[195],"constitutive":[197],"activation":[199],"Current":[203],"results":[204],"further":[205],"substantiate":[206],"existence":[208],"partially":[210],"alternative":[211],"disruption":[213],"mechanisms":[214],"adenomas,":[220],"line":[222],"previous":[224],"observations.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
