{"id":"https://openalex.org/W2020177796","doi":"https://doi.org/10.1073/pnas.82.11.3925","title":"The small cardioactive peptides A and B of Aplysia are derived from a common precursor molecule.","display_name":"The small cardioactive peptides A and B of Aplysia are derived from a common precursor molecule.","publication_year":1985,"publication_date":"1985-06-01","ids":{"openalex":"https://openalex.org/W2020177796","doi":"https://doi.org/10.1073/pnas.82.11.3925","mag":"2020177796","pmid":"https://pubmed.ncbi.nlm.nih.gov/3858852","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/397902"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.82.11.3925","doi":"https://doi.org/10.1073/pnas.82.11.3925","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.82.11.3925","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/397902","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089340454","display_name":"Anne C. Mahon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A C Mahon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017387548","display_name":"Philip E. Lloyd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P E Lloyd","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113989635","display_name":"Klaudiusz R. Weiss","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K R Weiss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021940878","display_name":"Irving Kupfermann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Kupfermann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108495381","display_name":"Richard H. Scheller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R H Scheller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.6515,"has_fulltext":false,"cited_by_count":101,"citation_normalized_percentile":{"value":0.96059412,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"82","issue":"11","first_page":"3925","last_page":"3929"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12142","display_name":"Marine Invertebrate Physiology and Ecology","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1911","display_name":"Paleontology"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aplysia","display_name":"Aplysia","score":0.9729999899864197},{"id":"https://openalex.org/keywords/neuropeptide-precursors","display_name":"neuropeptide precursors","score":0.8069999814033508},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.7379999756813049},{"id":"https://openalex.org/keywords/proteolytic-cleavage-sites","display_name":"proteolytic cleavage sites","score":0.7940000295639038},{"id":"https://openalex.org/keywords/central-nervous-system-neurons","display_name":"central nervous system neurons","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.865842878818512},{"id":"https://openalex.org/C2778178740","wikidata":"https://www.wikidata.org/wiki/Q136564","display_name":"Aplysia","level":2,"score":0.7934446930885315},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6965105533599854},{"id":"https://openalex.org/C189482833","wikidata":"https://www.wikidata.org/wiki/Q869146","display_name":"cDNA library","level":4,"score":0.6889687180519104},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.5760787725448608},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5486028790473938},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5451197028160095},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5197967290878296},{"id":"https://openalex.org/C47289529","wikidata":"https://www.wikidata.org/wiki/Q908550","display_name":"Open reading frame","level":4,"score":0.48839062452316284},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4542830288410187},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.42866265773773193},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.42292821407318115},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14454111456871033},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001048","descriptor_name":"Aplysia","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007447","descriptor_name":"Invertebrate Hormones","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.82.11.3925","doi":"https://doi.org/10.1073/pnas.82.11.3925","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.82.11.3925","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:397902","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/397902","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:3858852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3858852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:397902","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/397902","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1000223840","display_name":null,"funder_award_id":"MH00304","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G908089377","display_name":null,"funder_award_id":"MH-367330","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1558516755","https://openalex.org/W1676558247","https://openalex.org/W1966286636","https://openalex.org/W1972784483","https://openalex.org/W1979120694","https://openalex.org/W1985719277","https://openalex.org/W2006220140","https://openalex.org/W2047684202","https://openalex.org/W2052368267","https://openalex.org/W2067032380","https://openalex.org/W2073478450","https://openalex.org/W2075816835","https://openalex.org/W2078926357","https://openalex.org/W2083196835","https://openalex.org/W2094559536","https://openalex.org/W2138270253","https://openalex.org/W2146923243","https://openalex.org/W2470430228"],"related_works":["https://openalex.org/W2052377021","https://openalex.org/W1892939230","https://openalex.org/W1985719277","https://openalex.org/W2071874931","https://openalex.org/W1676558247","https://openalex.org/W2067032380","https://openalex.org/W2083335634","https://openalex.org/W2123610021","https://openalex.org/W7100906939","https://openalex.org/W1979120694"],"abstract_inverted_index":{"We":[0],"have":[1],"identified":[2,40],"cells":[3,76,107],"in":[4,53,102,127,167,170],"the":[5,10,20,38,62,66,88,103,156],"central":[6,34],"nervous":[7],"system":[8],"of":[9,33,48,90,142,155],"marine":[11],"mollusc":[12],"Aplysia":[13],"that":[14,36,77],"react":[15],"with":[16,81,117,159,166],"antibody":[17],"raised":[18],"against":[19],"small":[21],"cardioactive":[22],"peptide":[23],"B":[24],"(SCPB).":[25],"Antisera":[26],"to":[27,56,86,98],"this":[28,162],"neuropeptide":[29],"stained":[30],"a":[31,54,58,113,131,148,181],"subset":[32],"neurons":[35,50,70],"include":[37],"large":[39],"buccal":[41,114],"neurons,":[42],"B1":[43,71,104],"and":[44,72,74,105,129,146,160,169,180,187],"B2.":[45],"The":[46,120,136,153,174],"distribution":[47],"SCP-containing":[49],"was":[51,84,108],"used":[52,85],"strategy":[55],"isolate":[57],"cDNA":[59,92,95,115,122],"clone":[60,96],"encoding":[61],"precursor":[63,138,157],"protein":[64,139,158],"for":[65,178],"peptide.":[67],"RNA":[68],"from":[69,75],"B2":[73,106],"did":[78],"not":[79],"stain":[80],"SCPB":[82,179],"antisera":[83],"direct":[87],"synthesis":[89],"radiolabeled":[91],"probes.":[93,119],"A":[94],"complimentary":[97],"mRNA":[99],"specifically":[100],"expressed":[101],"isolated":[109],"by":[110,190],"differentially":[111],"screening":[112],"library":[116],"these":[118],"cloned":[121],"segment":[123],"is":[124,140],"1394":[125],"nucleotides":[126],"length":[128],"contains":[130],"408-base-pair":[132],"open":[133],"reading":[134],"frame.":[135],"predicted":[137],"composed":[141],"136":[143],"amino":[144,175],"acids":[145],"has":[147],"characteristic":[149],"hydrophobic":[150],"leader":[151,163],"sequence.":[152],"sizes":[154],"without":[161],"sequence":[164],"agree":[165],"vivo":[168],"vitro":[171],"labeling":[172],"studies.":[173],"acid":[176],"sequences":[177],"related":[182],"peptide,":[183],"SCPA,":[184],"are":[185,188],"present":[186],"flanked":[189],"known":[191],"proteolytic":[192],"processing":[193],"sites.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}